ENTREMED INC
SC 13D/A, 1999-02-04
MEDICAL LABORATORIES
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D
                                 (Rule 13d-101)

                    INFORMATION TO BE INCLUDED IN STATEMENTS
                 FILED PURSUANT TO RULE 13d-1(a) AND AMENDMENTS
                    THERETO FILED PURSUANT TO RULE 13d-2(a)
                               (Amendment No. 1)1

                                 ENTREMED, INC.
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                                (Name of Issuer)

                    COMMON STOCK, PAR VALUE $0.01 PER SHARE
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                         (Title of Class of Securities)

                                   29382F103
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                                 (CUSIP Number)

                GEORGE R. WHITTEMORE, MILLS VALUE ADVISER, INC.,
         707 EAST MAIN STREET, RICHMOND, VIRGINIA 23219 (804) 344-3804
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          (Name, Address and Telephone Number of Person Authorized to
                      Receive Notices and Communications)

                                JANUARY 27, 1999
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            (Date of Event which Requires Filing of this Statement)

         If the filing person has  previously  filed a statement on Schedule 13G
to report the  acquisition  that is the  subject of this  Schedule  13D,  and is
filing this schedule because of Rule 13d-1(e),  13d-1(f) or 13d-1(g),  check the
following box |_|.

         Note:  Schedules  filed in paper format shall include a signed original
and five copies of the schedule,  including all exhibits.  See Rule 13d-7(b) for
other parties to whom copies are to be sent.


                         (Continued on following pages)

                               (Page 1 of 7 Pages)




         1 The  remainder of this cover page shall be filled out for a reporting
person's  initial  filing on this  form with  respect  to the  subject  class of
securities,  and for any subsequent amendment containing information which would
alter disclosures provided in a prior cover page.

         The information  required on the remainder of this cover page shall not
be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934, as amended (the "Act"),  or otherwise subject to the liabilities of
that section of the Act but shall be subject to all other  provisions of the Act
(however, see the Notes).

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<PAGE>

- ----------------------------                        ----------------------------
    CUSIP No. 29382F103           SCHEDULE 13D            Page 2 of 7 Pages
- ----------------------------                        ----------------------------

- --------- ----------------------------------------------------------------------
1         NAME OF REPORTING PERSONS
          I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

          James T. Martin
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2         CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*           (a)    |_|
                                                                      (b)    |_|
          Not Applicable
- --------- ----------------------------------------------------------------------
3         SEC USE ONLY


- --------- ----------------------------------------------------------------------
4         SOURCE OF FUNDS*

          PF
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5         CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
          ITEM 2(d) or 2(e)                                                  |_|

          Not Applicable
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6         CITIZENSHIP OR PLACE OF ORGANIZATION

          Bermuda
- ------------------------- ------- ----------------------------------------------
       NUMBER OF          7       SOLE VOTING POWER

         SHARES                   755,090
                          ------- ----------------------------------------------
                          8       SHARED VOTING POWER
      BENEFICIALLY
                                  -0-
                          ------- ----------------------------------------------
     OWNED BY EACH        9       SOLE DISPOSITIVE POWER

       REPORTING                  755,090
                          ------- ----------------------------------------------
                          10      SHARED DISPOSITIVE POWER
      PERSON WITH
                                  -0-
- ------------------------- ------- ----------------------------------------------
11        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

          755,090
- --------- ----------------------------------------------------------------------
12        CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*
                                                                             |_|
          Not Applicable
- --------- ----------------------------------------------------------------------
13        PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

          6.0%
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14        TYPE OF REPORTING PERSON*

          IN
- --------- ----------------------------------------------------------------------

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>

                                 AMENDMENT NO. 1
                                       TO
                                  SCHEDULE 13D
                                       FOR
                                 JAMES T. MARTIN


         This  Amendment  No. 1 hereby amends and  supplements  the Schedule 13D
(the  "Schedule  13D"),  dated January 11, 1999,  filed with the  Securities and
Exchange  Commission on January 29, 1999, with respect to the common stock,  par
value $0.01 per share ("Common Stock"), of EntreMed, Inc. (the "Issuer").

Item 1.       Security and Issuer

              This Amendment No. 1 relates to the common stock,  par value $0.01
              per share,  of EntreMed,  Inc.,  9610 Medical Center Drive,  Suite
              200, Rockville, Maryland 20850.

Item 2.       Identity and Background

              (A)      James T. Martin

              (B)      Tuppeny House 
                       Tuckerstown, Bermuda

              (C)      James T. Martin is a lecturer, author and consultant.

              (D)      During the past five years,  James T. Martin has not been
                       convicted  in a criminal  proceeding,  excluding  traffic
                       violations or similar misdemeanors.

              (E)      During the past five years,  James T. Martin has not been
                       a  party  to  a  civil   proceeding   of  a  judicial  or
                       administrative body of competent jurisdiction and has not
                       been  subject  to  a  judgment,  decree  or  final  order
                       enjoining   future   violations  of,  or  prohibiting  or
                       mandating   activities   subject  to,  federal  or  state
                       securities  laws or finding any violation with respect to
                       such laws.

              (F)      James T. Martin is a citizen of Bermuda (subject of Great
                       Britain).




                               Page 3 of 7 Pages
<PAGE>

Item 3.       Source and Amount of Funds and Other Consideration

              The total  amount of the funds  used in making the  purchases  was
              $20,867,262 of which $3,855,616 represent purchases since the date
              of the event that  required  the filing of the  Schedule  13D. The
              sources of the funds used in making the  purchases  were  personal
              funds.

Item 4.       Purpose of Transaction

              James  T.  Martin  has  purchased   shares  of  Common  Stock  for
              investment purposes.

              There are no plans or  proposals  which  James T.  Martin may have
              that relate to or would result in:

              (A)      The acquisition by any person of additional securities of
                       the  Issuer,  or the  disposition  of  securities  of the
                       Issuer, except as otherwise disclosed herein;

              (B)      An extraordinary corporate transaction, such as a merger,
                       reorganization  or  liquidation,  involving the Issuer or
                       any of its subsidiaries;

              (C)      A sale or transfer of a material  amount of assets of the
                       Issuer or of any of its subsidiaries;

              (D)      Any  change  in  the  present   board  of   directors  or
                       management   of  the  Issuer,   including  any  plans  or
                       proposals to change the number or term of directors or to
                       fill any existing vacancies on the board;

              (E)      Any  material  change in the  present  capitalization  or
                       dividend policy of the Issuer;

              (F)      Any other  material  change in the  Issuer's  business or
                       corporate structure;

              (G)      Changes in the Issuer's  charter,  bylaws or  instruments
                       corresponding  thereto or other  actions which may impede
                       the acquisition of control of the Issuer by any person;



                               Page 4 of 7 Pages
<PAGE>

              (H)      Causing  a  class  of  securities  of  the  Issuer  to be
                       delisted from a national  securities exchange or to cease
                       to  be  authorized  to  be  quoted  in  an   inter-dealer
                       quotation  system  of a  registered  national  securities
                       association;

              (I)      A class  of  equity  securities  of the  Issuer  becoming
                       eligible  for  termination  of  registration  pursuant to
                       Section 12(g)(4) of the Securities  Exchange Act of 1934,
                       as amended; or

              (J)      Any action similar to any of those enumerated above.

Item 5.       Interest in Securities of the Issuer

              (A)      The  aggregate  number  and  percentage  of Common  Stock
                       beneficially  owned by James T. Martin are 755,090 Shares
                       and 6.0%, respectively.

              (B)      James T.  Martin  has the sole power to vote or to direct
                       the vote of all the shares  identified  pursuant  to Item
                       5(a). Mr. Martin does not have any power to dispose or to
                       direct  the  disposition  of all  the  shares  identified
                       pursuant to Item 5(a).

              (C)      Transactions  in the  securities  identified  pursuant to
                       Item 5(a) since the date of the event that  required  the
                       filing of the Schedule 13D are as follows:

        Beneficial       Trans.        Amount of      Price Per       Where/How
          Owner           Date        Transaction       Share         Effected

       J.T. Martin      01/12/99       $783,087        $26.10        Open Market
       J.T. Martin      01/13/99       $534,082        $26.70        Open Market
       J.T. Martin      01/14/99       $952,442        $31.74        Open Market
       J.T. Martin      01/15/99       $686,822        $34.34        Open Market
       J.T. Martin      01/27/99       $899,183        $29.97        Open Market

              (D)      Not applicable.

              (E)      Not applicable.


Item 6.       Contracts,  Arrangements,  Understandings  or  Relationships  with
              Respect to Securities of the Issuer

              None



                               Page 5 of 7 Pages
<PAGE>

Item 7.       Material to be Filed as Exhibits

              None




                               Page 6 of 7 Pages
<PAGE>

                                   SIGNATURES

         After reasonable  inquiry and to the best of my knowledge and belief, I
certify  that the  information  set forth in this  statement  on Schedule 13D is
true, complete and correct.


                                            James T. Martin



Date:  January 27, 1999                     /s/ James T. Martin                 
                                            ------------------------------------
                                            James T. Martin




Attention:    Intentional  misstatements or omissions of fact constitute Federal
              criminal violations (see 18 U.S.C. 1001).




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