ENTREMED INC
SC 13D/A, 1999-02-04
MEDICAL LABORATORIES
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                  SCHEDULE 13D
                                 (Rule 13d-101)


                    INFORMATION TO BE INCLUDED IN STATEMENTS
                 FILED PURSUANT TO RULE 13d-1(a) AND AMENDMENTS
                     THERETO FILED PURSUANT TO RULE 13d-2(a)
                               (Amendment No. 2)1

                                 ENTREMED, INC.
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                                (Name of Issuer)

                    COMMON STOCK, PAR VALUE $0.01 PER SHARE
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                         (Title of Class of Securities)

                                   29382F103
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                                 (CUSIP Number)

                GEORGE R. WHITTEMORE, MILLS VALUE ADVISER, INC.,
         707 EAST MAIN STREET, RICHMOND, VIRGINIA 23219 (804) 344-3804
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          (Name, Address and Telephone Number of Person Authorized to
                      Receive Notices and Communications)

                                JANUARY 27, 1999
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            (Date of Event which Requires Filing of this Statement)

         If the filing person has  previously  filed a statement on Schedule 13G
to report the  acquisition  that is the  subject of this  Schedule  13D,  and is
filing this schedule because of Rule 13d-1(e),  13d-1(f) or 13d-1(g),  check the
following box |_|.

         Note:  Schedules  filed in paper format shall include a signed original
and five copies of the schedule,  including all exhibits.  See Rule 13d-7(b) for
other parties to whom copies are to be sent.


                         (Continued on following pages)

                              (Page 1 of 11 Pages)




         1 The remainder  of this cover page shall be filled out for a reporting
person's  initial  filing on this  form with  respect  to the  subject  class of
securities,  and for any subsequent amendment containing information which would
alter disclosures provided in a prior cover page.

         The information  required on the remainder of this cover page shall not
be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934, as amended (the "Act"),  or otherwise subject to the liabilities of
that section of the Act but shall be subject to all other  provisions of the Act
(however, see the Notes).

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<PAGE>

- ----------------------------                       -----------------------------
    CUSIP No. 29382F103          SCHEDULE 13D           Page 2 of 11 Pages
- ----------------------------                       -----------------------------

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1        NAME OF REPORTING PERSONS
         I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

         Mills Value Adviser, Inc.
         I.R.S. ID #54-1410376
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2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            (a)    |_|
                                                                      (b)    |_|
         Not Applicable
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3        SEC USE ONLY


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4        SOURCE OF FUNDS*

         OO
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5        CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEM 2(d) or 2(e)                                                   |_|

         Not Applicable
- --------------------------------------------------------------------------------
6        CITIZENSHIP OR PLACE OF ORGANIZATION

         Virginia

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       NUMBER OF              7        SOLE VOTING POWER

        SHARES                         33,000
                            ----------------------------------------------------
                              8        SHARED VOTING POWER
     BENEFICIALLY
                                       -0-
                            ----------------------------------------------------
     OWNED BY EACH            9        SOLE DISPOSITIVE POWER

       REPORTING                       904,797
                            ----------------------------------------------------
                              10       SHARED DISPOSITIVE POWER
     PERSON WITH
                                       -0-
- --------------------------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         904,797
- --------------------------------------------------------------------------------
12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*
                                                                             |_|
         Not Applicable
- --------------------------------------------------------------------------------
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

         7.3%
- --------------------------------------------------------------------------------
14       TYPE OF REPORTING PERSON*

         IA (INVESTMENT ADVISER)
- --------------------------------------------------------------------------------

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>

                                 AMENDMENT NO. 2
                                       TO
                                  SCHEDULE 13D
                                       FOR
                            MILLS VALUE ADVISER, INC.

         This  Amendment  No. 2 hereby amends and  supplements  the Schedule 13D
(the "Schedule  13D"),  dated  November 12, 1998,  filed with the Securities and
Exchange  Commission (the "Commission") on November 13, 1998 and Amendment No. 1
to the Schedule 13D, dated January 4, 1999, filed with the Commission on January
29, 1999  ("Amendment No. 1") with respect to the common stock,  par value $0.01
per share ("Common Stock"), of Entremed, Inc. (the "Issuer").

Item 1.       Security and Issuer

              This Amendment No. 2 relates to the common stock,  par value $0.01
              per share,  of EntreMed,  Inc.,  9610 Medical Center Drive,  Suite
              200, Rockville, Maryland 20850.


Item 2.       Identity and Background

              Mills Value Adviser, Inc.

              Mills Value  Adviser,  Inc. (the  "Corporation")  is a corporation
              organized  under the laws of the  Commonwealth  of  Virginia.  Its
              principal  business is providing  investment  advisory services to
              its clients.  The address of its principal  business and principal
              office is 707 East Main  Street,  Richmond,  VA 23219.  During the
              past five years,  the  Corporation  has not been  convicted in any
              criminal  proceeding,  excluding  traffic  violations  or  similar
              misdemeanors.

              On March 28,  1996,  the  Corporation  and Charles A. Mills,  III,
              Chairman of the Board of the Corporation in Cases # SEC 960020 and
              SEC 960022  entered  into an  admission  and  consent  order which
              accepted an order of  settlement  alleging  violations of Virginia
              Code  Sections  13.1-504 A and  13.1-504 C by the  Virginia  State
              Corporation  Commission.  In  particular,  the order of settlement
              alleged that the Corporation  temporarily  transacted  business in
              the  Commonwealth  of  Virginia  as  an  unregistered   investment
              advisor; that the Corporation temporarily employed an unregistered
              investment advisor representative;  and that Mr. Mills temporarily
              transacted   business  in  the  Commonwealth  of  Virginia  as  an
              unregistered investment advisor.  Without admitting or denying the
              allegations,  the  Corporation  paid  $200.00  and Mr.  Mills paid
              $2,500.00 to the



                               Page 3 of 11 Pages
<PAGE>

              Commonwealth of Virginia.  The Corporation has undertaken measures
              to  prevent a lapse in  required  registrations  or other  similar
              occurrence.

              Charles A. Mills, III

              (A)      Charles A. Mills, III

              (B)      707 East Main Street, Richmond, VA 23219

              (C)      Charles A.  Mills,  III is  Chairman  of the Board of the
                       Corporation  and also a director and Chairman of Anderson
                       & Strudwick,  Incorporated, a stock brokerage firm, whose
                       address is the same as the Corporation's.

              (D)      During the past five years, Charles A. Mills, III has not
                       been  convicted  in  a  criminal  proceeding,   excluding
                       traffic violations or similar misdemeanors.

              (E)      On March 28, 1996, the  Corporation and Charles A. Mills,
                       III,  Chairman of the Board of the Corporation in Cases #
                       SEC 960020 and SEC 960022  entered into an admission  and
                       consent  order  which  accepted  an order  of  settlement
                       alleging  violations of Virginia Code Sections 13.1-504 A
                       and  13.1-504  C  by  the  Virginia   State   Corporation
                       Commission.  In  particular,   the  order  of  settlement
                       alleged  that  the  Corporation   temporarily  transacted
                       business   in  the   Commonwealth   of   Virginia  as  an
                       unregistered  investment  advisor;  that the  Corporation
                       temporarily  employed an unregistered  investment advisor
                       representative; and that Mr. Mills temporarily transacted
                       business   in  the   Commonwealth   of   Virginia  as  an
                       unregistered  investment  advisor.  Without  admitting or
                       denying the allegations, the Corporation paid $200.00 and
                       Mr. Mills paid $2,500.00 to the Commonwealth of Virginia.
                       The  Corporation  has  undertaken  measures  to prevent a
                       lapse  in  required   registrations   or  other   similar
                       occurrence.

              (F)      Charles A. Mills,  III is a citizen of the United  States
                       of America.

              George R. Whittemore

              (A)      George R. Whittemore

              (B)      707 East Main Street, Richmond, VA 23219




                               Page 4 of 11 Pages
<PAGE>

              (C)      George R.  Whittemore  is President and a Director of the
                       Corporation  and  Senior  Vice  President  of  Anderson &
                       Strudwick,  Incorporated,  a stock brokerage firm,  whose
                       address is the same as the Corporation's.

              (D)      During the past five years,  George R. Whittemore has not
                       been  convicted  in  a  criminal  proceeding,   excluding
                       traffic violations or similar misdemeanors.

              (E)      During the past five years,  George R. Whittemore has not
                       been a  party  to a civil  proceeding  of a  judicial  or
                       administrative body of competent jurisdiction and has not
                       been  subject  to  a  judgment,  decree  or  final  order
                       enjoining   future   violations  of,  or  prohibiting  or
                       mandating   activities   subject  to,  federal  or  state
                       securities  laws or finding any violation with respect to
                       such laws.

              (F)      George R. Whittemore is a citizen of the United States of
                       America.

              Blair J. Frantzen

              (A)      Blair J. Frantzen

              (B)      707 East Main Street, Richmond, VA 23219

              (C)      Blair J. Frantzen is  Secretary/Treasurer  and a Director
                       of the  Corporation  and a Vice  President  of Anderson &
                       Strudwick,  Incorporated,  a stock brokerage firm,  whose
                       address is the same as the Corporation's.

              (D)      During the past five  years,  Blair J.  Frantzen  has not
                       been  convicted  in  a  criminal  proceeding,   excluding
                       traffic violations or similar misdemeanors.

              (E)      During the past five  years,  Blair J.  Frantzen  has not
                       been a  party  to a civil  proceeding  of a  judicial  or
                       administrative body of competent jurisdiction and has not
                       been  subject  to  a  judgment,  decree  or  final  order
                       enjoining   future   violations  of,  or  prohibiting  or
                       mandating   activities   subject  to,  federal  or  state
                       securities  laws or finding any violation with respect to
                       such laws.

              (F)      Blair J.  Frantzen  is a citizen of the United  States of
                       America.



                               Page 5 of 11 Pages
<PAGE>

              Todd J. Peters

              (A)      Todd J. Peters

              (B)      707 East Main Street, Richmond, Virginia 23219

              (C)      Todd  J.  Peters  is  Vice   President  and  Director  of
                       Marketing of the Corporation.

              (D)      During the past five  years,  Todd J. Peters has not been
                       convicted  in a criminal  proceeding,  excluding  traffic
                       violations or similar misdemeanors.

              (E)      During the past five years, Todd J. Peters has not been a
                       party   to  a  civil   proceeding   of  a   judicial   or
                       administrative body of competent jurisdiction and has not
                       been  subject  to  a  judgment,  decree  or  final  order
                       enjoining   future   violations  of,  or  prohibiting  or
                       mandating   activities   subject  to,  federal  or  state
                       securities  laws or finding any violation with respect to
                       such laws.

              (F)      Todd J.  Peters  is a  citizen  of the  United  States of
                       America.

              George W. Anderson

              (A)      George W. Anderson

              (B)      707 East Main Street, Richmond, VA 23219

              (C)      George W.  Anderson is a Director of the  Corporation  as
                       well as a Senior Vice  President of Anderson & Strudwick,
                       Incorporated,  a stock  brokerage  firm, and President of
                       Anderson & Strudwick Holding  Corporation,  both of whose
                       addresses are the same as the Corporation's.

              (D)      During the past five years,  George W.  Anderson  has not
                       been  convicted  in  a  criminal  proceeding,   excluding
                       traffic violations or similar misdemeanors.

              (E)      During the past five years,  George W.  Anderson  has not
                       been a  party  to a civil  proceeding  of a  judicial  or
                       administrative body of competent jurisdiction and has not
                       been  subject  to  a  judgment,  decree  or  final  order
                       enjoining   future   violations  of,  or  prohibiting  or
                       mandating   activities   subject  to,  federal  or  state
                       securities  laws or finding any violation with respect to
                       such laws.



                               Page 6 of 11 Pages
<PAGE>

              (F)      George W.  Anderson is a citizen of the United  States of
                       America.


Item 3.       Source and Amount of Funds and Other Consideration

              The total  amount of the funds  used in making the  purchases  was
              $24,366,396 of which $4,124,715 represent purchases since the date
              of the event  that  required  the filing of  Amendment  No. 1. The
              source of the funds used in making the  purchases  was from client
              accounts over which the Corporation has  discretionary  investment
              authority.


Item 4.       Purpose of Transaction

              The   Corporation,    an   investment   advisory   firm,   through
              discretionary  investment  authority granted to it by its clients,
              has purchased  shares of Common Stock for  investment  purposes on
              behalf of its clients.

              There are no plans or proposals which the Corporation,  Charles A.
              Mills,  III,  George R.  Whittemore,  Blair J.  Frantzen,  Todd J.
              Peters  or  George W.  Anderson  may have that  relate to or would
              result in:

              (A)      The acquisition by any person of additional securities of
                       the  Issuer,  or the  disposition  of  securities  of the
                       Issuer, except as otherwise disclosed herein;

              (B)      An extraordinary corporate transaction, such as a merger,
                       reorganization  or  liquidation,  involving the Issuer or
                       any of its subsidiaries;

              (C)      A sale or transfer of a material  amount of assets of the
                       Issuer or of any of its subsidiaries;

              (D)      Any  change  in  the  present   board  of   directors  or
                       management   of  the  Issuer,   including  any  plans  or
                       proposals to change the number or term of directors or to
                       fill any existing vacancies on the board;

              (E)      Any  material  change in the  present  capitalization  or
                       dividend policy of the Issuer;

              (F)      Any other  material  change in the  Issuer's  business or
                       corporate structure;



                               Page 7 of 11 Pages
<PAGE>

              (G)      Changes in the Issuer's  charter,  bylaws or  instruments
                       corresponding  thereto or other  actions which may impede
                       the acquisition of control of the Issuer by any person;

              (H)      Causing  a  class  of  securities  of  the  Issuer  to be
                       delisted from a national  securities exchange or to cease
                       to  be  authorized  to  be  quoted  in  an   inter-dealer
                       quotation  system  of a  registered  national  securities
                       association;

              (I)      A class  of  equity  securities  of the  Issuer  becoming
                       eligible  for  termination  of  registration  pursuant to
                       Section 12(g)(4) of the Securities  Exchange Act of 1934,
                       as amended; or

              (J)      Any action similar to any of those enumerated above.


Item 5.       Interest in Securities of the Issuer

              (A)      The  aggregate  number  and  percentage  of Common  Stock
                       beneficially  owned by the Corporation are 904,797 shares
                       and 7.3%, respectively.

              (B)      The  Corporation  has the power to vote or to direct  the
                       vote of 33,000 shares  identified  pursuant to Item 5(a).
                       The  Corporation  has the  sole  power to  dispose  or to
                       direct the disposition of all shares identified  pursuant
                       to Item 5(a).

              (C)      Transactions  in the  securities  identified  pursuant to
                       Item 5(a) since the date of the event that  required  the
                       filing of Amendment No. 1 are as follows:


    Beneficial      Transaction       Amount of       Price Per       Where/How
      Owner            Date          Transaction        Share          Effected
                                                    
       MVA           01/11/99         $252,672          $25.26       Open Market
       MVA           01/12/99         $783,087          $26.10       Open Market
       MVA           01/13/99         $534,082          $26.70       Open Market
       MVA           01/14/99         $952,442          $31.74       Open Market
       MVA           01/15/99         $686,822          $34.34       Open Market
       MVA           01/26/99          $16,427          $27.37       Open Market
       MVA           01/27/99         $899,183          $29.97       Open Market
                                                   

              (D)      Not applicable.

              (E)      Not applicable.



                               Page 8 of 11 Pages
<PAGE>

              Charles A. Mills, III

              (A)      The  aggregate  number  and  percentage  of Common  Stock
                       beneficially  owned by Charles A. Mills,  III, are 17,000
                       shares  and  less  than  1%,  respectively,  and  are not
                       included in the shares reported as beneficially  owned by
                       the  Corporation.  Mr.  Mills also  beneficially  owns 10
                       shares of Common  Stock for which he acts as trustee  for
                       his children.  Furthermore,  Mr. Mills may also be deemed
                       to beneficially  own 100,000 shares of Common Stock owned
                       of record by Independent  Property  Operators of America,
                       LLC, of which Mr.  Mills  serves as Chairman of the Board
                       and exercises investment discretion.

              (B)      Charles A. Mills, III, in his individual  capacity and in
                       his  capacity as trustee,  has the sole power to vote and
                       the sole  power to dispose  of 17,010  shares  identified
                       pursuant to Item 5(a).  In addition,  Mr.  Mills,  in his
                       capacity as Chairman of the Board of Independent Property
                       Operators of America, LLC, may be deemed to have the sole
                       power to vote and the sole  power to  dispose  of 100,000
                       shares identified pursuant to Item 5(a).

              (C)      None

              (D)      Not applicable.

              (E)      Not applicable.

              George R. Whittemore

              (A)      None

              (B)      None

              (C)      None

              (D)      Not applicable.

              (E)      Not applicable.

              Blair J. Frantzen

              (A)      None

              (B)      None




                               Page 9 of 11 Pages
<PAGE>

              (C)      None

              (D)      Not applicable.

              (E)      Not applicable.

              Todd J. Peters

              (A)      None

              (B)      None

              (C)      None

              (D)      Not applicable.

              (E)      Not applicable.

              George W. Anderson

              (A)      None

              (B)      None

              (C)      None

              (D)      Not applicable.

              (E)      Not applicable.


Item 6.       Contracts,  Arrangements,  Understandings  or  Relationships  with
              Respect to Securities of the Issuer

              None


Item 7.       Material to be Filed as Exhibits

              None




                              Page 10 of 11 Pages
<PAGE>

                                   SIGNATURES

         After reasonable  inquiry and to the best of my knowledge and belief, I
certify  that the  information  set forth in this  statement  on Schedule 13D is
true, complete and correct.

                                               MILLS VALUE ADVISER, INC.



Date: January 27, 1999                         /s/ CHARLES A. MILLS, III        
                                               ---------------------------------
                                               CHARLES A. MILLS, III
                                               Chairman of the Board



Date: January 27, 1999                         /s/ GEORGE R. WHITTEMORE         
                                               ---------------------------------
                                               GEORGE R. WHITTEMORE
                                               President/Director



Date: January 27, 1999                         /s/ BLAIR J. FRANTZEN            
                                               ---------------------------------
                                               BLAIR J. FRANTZEN
                                               Secretary/Treasurer/Dir.



Date: January 27, 1999                         /s/ GEORGE W. ANDERSON           
                                               ---------------------------------
                                               GEORGE W. ANDERSON
                                               Director



Date: January 27, 1999                         /s/ TODD J. PETERS               
                                               ---------------------------------
                                               TODD J. PETERS
                                               Vice President



Attention:    Intentional  misstatements or omissions of fact constitute Federal
              criminal violations (see 18 U.S.C. 1001).





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