ANIKA THERAPEUTICS INC
POS AM, 1997-08-28
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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As filed with the Securities and Exchange Commission on August 28, 1997 

                         Registration Statement No. 333-3730           




                  SECURITIES AND EXCHANGE COMMISSION
                        Washington, D.C. 20549
                       _________________________

                   POST-EFFECTIVE AMENDMENT NO. 1 TO

                               FORM S-3

                        REGISTRATION STATEMENT
                                UNDER 
                      THE SECURITIES ACT OF 1933
                       _________________________

                       Anika Therapeutics, Inc.
        (Exact Name of Registrant as Specified in Its Charter)

            Massachusetts                             04-3145961
      (State of Incorporation)         (I.R.S. Employer Identification Number)
                        236 West Cummings Park
                      Woburn, Massachusetts 01801
                            (617) 932-6616

(Address, Including Zip Code, and Telephone Number, Including Area Code, of
                Registrant's Principal Executive Offices)
                    _______________________________

                           J. Melville Engle
                              President 
                       Anika Therapeutics, Inc.
                        236 West Cummings Park
                      Woburn, Massachusetts 01801
                            (617) 932-6616

(Name, Address, Including Zip Code, and Telephone Number, Including Area Code,
                         of Agent For Service)
                     ____________________________

                            With copies to:
                         H. DAVID HENKEN, ESQ.
                         Goodwin, Procter & Hoar  LLP
                                Exchange Place
                                53 State Street
                       Boston, Massachusetts 02109-2881
                                (617) 570-1000
                                   
Approximate date of commencement of proposed sale to the public: N/A

 If the only securities being registered on this form are being offered pursuant
 to dividend or interest reinvestment plans, please check the following box. 

 If any of the securities being registered on this form are to be offered on a
 delayed or continuous basis pursuant to Rule 415 under the Securities Act of 
 1933, other than securities offered only in connection with dividend or
 interest reinvestment plans, check the following box. x

 If this Form is filed to register additional securities for an offering
 pursuant to Rule 462(b) under the Securities Act, please check the following
 box and list the Securities Act registration statement number of the earlier
 effective registration statement for the same offering.  ______________

 If this Form is a post-effective amendment filed pursuant to Rule 462(c) under
 the Securities Act, check the following box and list the Securities Act
 registration statement number of the earlier effective registration statement
 for the same offering.   ______________

 If delivery of the prospectus is expected to be made pursuant to Rule 434,
 please check the following box.  
                     ____________________________



<PAGE>

                       ANIKA THERAPEUTICS, INC.

                     DEREGISTRATION OF SECURITIES


                       -------------------------


 Anika Therapeutics, Inc. (the "Registrant") previously filed Registration
 Statement No. 333-3730 on Form S-3 (the "Registration Statement") covering
 1,658,700 shares of its common stock $ .01 par value per share (the "Common
 Stock").  The offering contemplated by the Registration Statement was 
 terminated on August 28, 1997.  Accordingly, the Registrant hereby files this
 Post-Effective Amendment No. 1 to the Registration Statement to deregister a
 total of 203,700 shares of its Common Stock originally registered by the
 Registration Statement which remained unsold as of the termination of the
 offering.


<PAGE>                                   
                               SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, as amended (the
 "Securities Act"),Anika Therapeutics, Inc. certifies that it has duly caused
 this Post-Effective Amendment No. 1 to the Registration Statement to be signed
 on its behalf  by the undersigned, thereunto duly authorized, in Boston,
 Massachusetts, on the 26th day of August, 1997.

                                      ANIKA THERAPEUTICS, INC.


                                      By:/s/ Sean F. Moran
                                         ------------------
                                         Sean F. Moran
                                         Vice President of Finance and Treasurer
                                         (Principal Financial and Accounting
                                         Officer)
                                         

      Pursuant to the requirements of the Securities Act, this Post-Effective
   Amendment No. 1 to the Registration Statement has been signed by the
   following persons in the capacities and on the dates indicated. 
<TABLE>
<CAPTION>
      Signature                 Capacity                     Date

<S>                        <C>                               <C>
                                

                                
      *                    Chairman of the Board             August 26, 1997
 David A. Swann     
                               
      *                    Director                          August 26, 1997
 Joseph L. Bower 


      *                    Director                          August 26, 1997
 Eugene A. Davidson


      *                    Director                          August 26, 1997
 Jonathan D. Donaldson


      *                    Director                          August 26, 1997
 Samuel McKay


      *                    Director                          August 26, 1997
 Harvey Sadow


      *                    Director                          August 26, 1997
 Steven E. Wheeler

                           President (Principal Executive    August 27, 1997
 /s/ J. Melville Engle          Officer) and Director
 ---------------------
 J. Melville Engle            


                           Vice President of Finance and     August 27, 1997
 /s/ Sean F. Moran            Treasurer (Principal Financial
 -----------------            and Accounting Officer)
 Sean F. Moran
             


                                         
*By:        /s/ Sean F. Moran            
            -----------------
            Sean F. Moran              
            Attorney-in-fact

</TABLE>


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