ANIKA THERAPEUTICS INC
11-K, 2000-06-28
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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<PAGE>

                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549
                      -------------------------------------

                                    FORM 11-K

                                  ANNUAL REPORT
                        PURSUANT TO SECTION 15(d) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

(Mark One:)
[x] Annual report pursuant to Section 15(d) of the Securities Exchange Act of
1934 (no fee required)

    For the fiscal year ended December 31, 1999

                                       OR

[ ] Transition report pursuant to Section 15(d) of the Securities Exchange Act
of 1934 (No Fee Required)

     For the transition period from ____________ to ____________

                        Commission file number: 000-21326

     A. Full title of the plan and the address of the plan, if different from
that of the issuer named below:

                            Anika Therapeutics, Inc.
                      Employee Savings and Retirement Plan

     B. Name of issuer of the securities held pursuant to the plan and the
address of its principal executive office:

                            Anika Therapeutics, Inc.
                             236 West Cummings Park
                                Woburn, MA 01801
                                 (781) 932-6616

<PAGE>

                              REQUIRED INFORMATION

Item 4. Plan financial statements and schedule for the year ended December 31,
1999, prepared in accordance with the financial reporting requirements of ERISA.


                                                               PAGE NUMBER
                                                             IN THIS REPORT

Statements of Net Assets Available for Benefits as of
 December 31, 1999 and 1998                                        F-1

Statement of Changes in Net Assets Available for Benefits
 for the year ended December 31, 1999                              F-2

Notes to Financial Statements.                                     F-3

Supplemental Schedule:
Schedule I:  Schedule of Assets held for Investment as of
 December 31, 1999                                                 F-8


                                    Signature

     THE PLAN. Pursuant to the requirements of the Securities Exchange Act of
1934, the trustees have duly caused this annual report to be signed on their
behalf by the undersigned hereunto duly authorized.

                                            Anika Therapeutics, Inc.
                                            Employee Savings and Retirement Plan

                                             By: /s/ Douglas R. Potter
                                                 ------------------------------
                                                 (Douglas R. Potter, Trustee)
Dated: June 28, 2000


<PAGE>




                            ANIKA THERAPEUTICS, INC.
                       EMPLOYEE SAVINGS & RETIREMENT PLAN

                 STATEMENTS OF NET ASSETS AVAILABLE FOR BENEFITS
                        AS OF DECEMBER 31, 1999 AND 1998

                                                        1999         1998
                                                   ------------  -----------
    CASH                                           $     10,067  $     8,053

    INVESTMENTS (Notes 2, 3, 5)
       Participant directed, at fair value -
          Money market fund                             139,950       85,703
          Employer common stock                         402,361      370,565
          Mutual funds                                1,402,960      944,818
          Participant loans                             100,232       79,444
                                                   ------------  -----------
             Total investments                        2,045,503    1,480,530

    CONTRIBUTIONS RECEIVABLE                          -                1,920

    Less:
    Participant forfeitures                              13,627       10,489
                                                   ------------  -----------

    NET ASSETS AVAILABLE FOR BENEFITS               $ 2,041,943  $ 1,480,014
                                                    ===========  ===========


        The accompanying notes are an integral part of these statements.

                                       F-1

<PAGE>

                            ANIKA THERAPEUTICS, INC.
                       EMPLOYEE SAVINGS & RETIREMENT PLAN

            STATEMENT OF CHANGES IN NET ASSETS AVAILABLE FOR BENEFITS
                      FOR THE YEAR ENDED DECEMBER 31, 1999


                                                                       1999
                                                                   -----------
Interest & dividends                                                  $ 99,884

Contributions by:
  Employees                                                            237,138
  Employer                                                             153,719
  Rollover contributions                                                55,119
                                                                   -----------
    Total contributions                                                445,976
                                                                   -----------
      Total additions                                                  545,860

Less:
  Distributions to former participants                                 244,408
                                                                   -----------
   Net increase (decrease) before realized and unrealized gains
     and losses                                                        301,452
Net realized and unrealized investment gains and losses                260,477
                                                                   -----------
   Net increase in net assets                                          561,929
Net assets available for benefits, beginning of year                 1,480,014
                                                                   -----------
Net assets available for benefits, end of year                     $ 2,041,943
                                                                   ===========

         The accompanying notes are an integral part of this statement.

                                       F-2


<PAGE>

                            ANIKA THERAPEUTICS, INC.
                       EMPLOYEE SAVINGS & RETIREMENT PLAN

                          NOTES TO FINANCIAL STATEMENTS

1. PLAN DESCRIPTION

GENERAL

The Anika Therapeutics, Inc. Employee Savings and Retirement Plan (the Plan),
established July 1, 1993 and as amended and restated effective January 1, 1998,
is a defined contribution plan under which substantially all employees who are
at least age 21 and are regularly scheduled to perform 1,000 hours of service in
a Plan year, are eligible to participate. The Plan is intended to assist Anika
Therapeutics, Inc. (the Employer) in its efforts to attract and retain competent
employees. The Plan is subject to the provisions of the Employee Retirement
Income Security Act of 1974.

BENEFITS PAID

Benefits under the Plan are payable upon normal (after age 65) or early (after
age 55) retirement, death, disability, severe financial hardship or termination
of service, and are based on the balance in the participant's account.
Distributions of vested account balances will be made in the form of a single
lump-sum payment or in some other optional form of payment, as defined in the
Plan.

ADMINISTRATION

The Plan is administered by the Retirement Committee, which is appointed by the
Employer's Board of Directors (the Board). Two members of the Employer's senior
management have been appointed by the Board to serve as trustees of the Plan.
Information about the Plan agreement, such as provisions for allocations to
participants' accounts, vesting, benefits and withdrawals is contained in the
Summary Plan Description. Copies of this document are available from the
Retirement Committee. Retirement Alliance, Inc. has been appointed as record
keeper of the Plan.

ADMINISTRATIVE EXPENSES

All investment-related expenses for the years ended December 31, 1999 and 1998
were charged against Plan earnings. Substantially all other expenses were paid
by the Employer.

                                       F-3


<PAGE>


CONTRIBUTIONS

Participants may elect to defer, subject to certain limitations, from 1 percent
to 13 percent of annual compensation as contributions to the Plan. The Employer
makes matching contributions of 100% of each contributing participant's deferred
contribution up to 5% of each participant's salary. The Plan allows for the
Board to authorize additional contributions allocated to participants based on
salary. During the year ended December 31, 1999, there were no additional
contributions authorized.

VESTING

Participants employed prior to October 1, 1996 are 100 percent vested in their
entire account balance at all times. Participants employed on or after October
1, 1996 are immediately vested in their voluntary contributions plus actual
earnings thereon. Vesting in the employer matching contributions and profit
sharing contributions are based on years of credited service and are subject to
the following vesting schedule:

                    Years of Credited         Vested
                         Service             Interest

                            1                    20%
                            2                    40%
                            3                    60%
                            4                    80%
                            5                   100%

The nonvested portion of a participant's account at the time of termination is
used to offset future Employer contributions.

PLAN TERMINATION

Although it has not expressed any intent to do so, the Employer may terminate
the Plan at any time, either wholly or partially, by notice in writing to the
participants. Upon termination, participant accounts will become 100 percent
vested. The Employer may temporarily discontinue contributions to the Plan,
either wholly or partially, without terminating the Plan.

                                       F-4

<PAGE>

2. USE OF ESTIMATES AND SIGNIFICANT ACCOUNTING POLICIES

USE OF ESTIMATES

The preparation of financial statements in conformity with generally accepted
accounting principles requires management to make estimates and assumptions that
affect the reported amounts of assets and liabilities and disclosure of
contingent assets and liabilities at the date of the financial statements and
the reported amounts of additions to and deductions from the net assets
available for benefits during the reporting period. Actual results could differ
from those estimates.

BASIS OF ACCOUNTING

The accompanying financial statements of the Plan are presented on the accrual
basis of accounting.

VALUATION OF INVESTMENTS

MUTUAL FUNDS - The fair value of the participation units in mutual funds is
based on the quoted redemption value on the last business day of the year.

EMPLOYER COMMON STOCK - This investment consists of the Employer's common stock,
which is valued at the last reported sale price during the year as reported on
Nasdaq.

The fair value of individual investments that represent 5 percent or more of the
Plan's net assets available for benefits as of December 31, 1999 or 1998, are
summarized as follows:

                                             1999                 1998
                                       -----------------    -----------------

Employer common stock                          $402,361             $370,565
Baron Asset Fund                                123,858              135,108
Invesco Industrial Income Fund                  117,014               57,660
GAM International Fund                          311,356               89,675
Janus Fund                                      334,571              177,102
Neuberger& Berman Guardian Fund                 102,938              250,975
20th Century Ultra Fund                         162,727               74,918
Schwab S&P 500 Index Fund                       163,675               95,255
Schwab Retirement Money Market Fund             139,950               85,703


                                       F-5

<PAGE>

During the year ended December 31, 1999, the Plan's investments appreciated in
fair value as follows:

                                                                    Amount
                                                                  ---------

Mutual funds                                                       $186,081
Employer common stock                                                74,396
                                                                  ---------
Total realized and unrealized appreciation in value
of investments                                                     $260,477
                                                                  ---------
                                                                  ---------

3. INVESTMENT PROGRAMS

FUND OPTIONS

As of December 31, 1999 and 1998, contributions to the Plan are invested in one
or more of 11 separate investment options at the direction of each participant.
The investment options are: (1) Chas. Schwab Retirement Money Market Fund, (2)
Strong Short Term Bond Fund, (3) Founders Balanced Fund, (4) Invesco Industrial
Income Fund, (5) Schwab S&P 500 Index Fund, (6) Janus Fund, (7) 20th Century
Ultra Fund, (8) Baron Asset Fund, (9) GAM International Fund, (10) Neuberger and
Berman Guardian Fund and (11) Anika Therapeutics, Inc. common stock.

In the accompanying statements of net assets available for benefits as of
December 31, 1999 and 1998, all of the mutual funds are aggregated for
presentation purposes and the Employer stock and money market fund are shown
individually.

INVESTMENT INCOME AND EXPENSES

Each participant's account shall be allocated the investment income and expenses
of each fund based on the value of each participant's accounts in each fund, in
proportion to the total value of all accounts in each fund, taking into account
any contributions to or disbursements from the participant's account. General
expenses of the Plan not attributable to any particular fund shall be allocated
among participants' accounts in proportion to the value of each account, taking
into consideration the participant's contributions and distributions.


                                      F-6

<PAGE>

PARTICIPANT LOANS

A participant may, with the approval of the trustees, borrow from his or her
own account a minimum of $1,000 up to a maximum equal to the lesser of
$50,000 or 50 percent of the participant's vested account balance.
Participants may not have more than one loan outstanding at any time. Loans,
which are repayable biweekly over periods generally up to five years, are
collateralized by notes and by a security interest in the borrower's vested
account balance. The loans bear interest at the rate of prime plus 2 percent,
determined at the time the loan is approved.

4. FEDERAL INCOME TAX STATUS

The Plan obtained its latest determination letter on July 10, 1995, in which the
Internal Revenue Service stated that the Plan was in compliance with the
applicable sections of the Internal Revenue Code (IRC). The Plan has been
amended and restated since receiving the determination letter. However, the
Plan's management believes that the Plan is designed and is currently being
operated in compliance with the applicable requirements of the IRC.


                                       F-7

<PAGE>

5. SUPPLEMENTAL SCHEDULE

The following supplemental schedule of assets held for investment is included as
a required schedule under ERISA.

SCHEDULE I



                    Identity and Description of Issues:                Value
     ----------------------------------------------------           -----------
     Participant directed
           Chas. Schwab Retirement Money Market Fund                  $139,950

        Mutual funds -
           Strong Short Term Bond Fund                                  55,135
           Founders Balance Fund                                        31,686
           Invesco Industrial Income Fund                              117,014
           Schwab S&P 500 Index Fund                                   163,675
           Neuberger& Berman Guardian Fund                             102,938
           Janus Fund                                                  334,571
           20th Century Ultra Fund                                     162,727
           Baron Asset Fund                                            123,858
           GAM International Fund                                      311,356
                                                                    -----------
              Total mutual funds                                     1,402,960

     Employer common stock                                             402,361

     Participant loans (bearing interest at rates ranging
     between 9.75 and 10.5 percent)                                    100,232
                                                                    -----------

           Total investments                                        $2,045,503
                                                                    -----------
                                                                    -----------

                                       F-8




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