GENEMEDICINE INC
SC 13G/A, 1997-02-14
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  Schedule 13G

                    Under the Securities Exchange Act of 1934
                               (Amendment No. 1)*

                               GeneMedicine, Inc.
       -----------------------------------------------------------------
                                (Name of Issuer)


                                  Common Stock
       -----------------------------------------------------------------
                         (Title of Class of Securities)


                                   036870 71 0
       -----------------------------------------------------------------
                                 (CUSIP Number)

Check the following box if a fee is being paid with this  statement.[  ]. (A fee
is not  required  if the filing  person:  (1) has a previous  statement  on file
reporting  beneficial  ownership  of more  than  five  percent  of the  class of
securities  described  in Item 1;  and (2) has  filed  no  amendment  subsequent
thereto reporting  beneficial  ownership of five percent or less of such class.)
(See Rule 13d-7).

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).

                         (Continued on following pages)

                                 Page 1 of 17 Pages
                         Exhibit Index Contained on Page 14


<PAGE>


<TABLE>
<S>                                                        <C>        <C>
- ---------------------------------------------------                   ----------------------------------------------------
CUSIP NO. 036870 71 0                                        13G            Page 2 of 17 Pages
- ---------------------------------------------------                   ----------------------------------------------------

- -----------------------------------------------------------------------------------------------------------------------------
1            NAME OF REPORTING PERSON
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                  Kleiner Perkins Caufield & Byers VI, L.P., a
                   California Limited Partnership ("KPCB VI")
                      94-3157816
- -----------------------------------------------------------------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                          (a)    [ ]     (b)    [X]
- -----------------------------------------------------------------------------------------------------------------------------
3            SEC USE ONLY
- ----------------------------------------------------------------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION
                California Limited Partnership
- -----------------------------------------------------------------------------------------------------------------------------
              NUMBER OF                 5         SOLE VOTING POWER
               SHARES                                                                                                 - 0 -
            BENEFICIALLY
              OWNED BY                ---------------------------------------------------------------------------------------
                EACH                    6         SHARED VOTING POWER
              REPORTING                                                                                             590,119
               PERSON                 ---------------------------------------------------------------------------------------
                WITH                    7         SOLE DISPOSITIVE POWER
                                                                                                                      - 0 -
                                      ---------------------------------------------------------------------------------------
                                        8         SHARED DISPOSITIVE POWER
                                                                                                                    590,119
- -----------------------------------------------------------------------------------------------------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON
                                                                                                                    590,119
- -----------------------------------------------------------------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES*                                                                                   [ ]
- -----------------------------------------------------------------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                                                                       4.5%
- -----------------------------------------------------------------------------------------------------------------------------
12           TYPE OF REPORTING PERSON*
                                                                                                                         PN
- -----------------------------------------------------------------------------------------------------------------------------
<FN>
                                               * SEE INSTRUCTIONS BEFORE FILLING OUT!
</FN>
</TABLE>


<PAGE>


<TABLE>
<S>                                                        <C>        <C>
- ---------------------------------------------------                   ----------------------------------------------------
CUSIP NO. 036870 71 0                                        13G            Page 3 of 17 Pages
- ---------------------------------------------------                   ----------------------------------------------------

- -----------------------------------------------------------------------------------------------------------------------------
1            NAME OF REPORTING PERSON
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                      KPCB VI Associates, L.P., a California Limited
                      Partnership ("KPCB VI Associates") 94-3158010
- -----------------------------------------------------------------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                          (a)    [ ]     (b)    [X]
- -----------------------------------------------------------------------------------------------------------------------------
3            SEC USE ONLY
- -----------------------------------------------------------------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION
                California Limited Partnership
- -----------------------------------------------------------------------------------------------------------------------------
              NUMBER OF                 5         SOLE VOTING POWER
               SHARES                                                                                                 - 0 -
            BENEFICIALLY              ---------------------------------------------------------------------------------------
              OWNED BY                  6         SHARED VOTING POWER
                EACH                              590,119  shares  are  directly
              REPORTING                           owned  by  KPCB  VI.  KPCB  VI
               PERSON                             Associates   is  the   general
                WITH                              partner  of KPCB  VI and  KPCB
                                                  VI.
                                      ---------------------------------------------------------------------------------------
                                        7         SOLE DISPOSITIVE POWER
                                                                                                                      - 0 -
                                      ---------------------------------------------------------------------------------------
                                        8         SHARED DISPOSITIVE POWER
                                                  590,119  shares  are  directly
                                                  owned  by  KPCB  VI.  KPCB  VI
                                                  Associates   is  the   general
                                                  partner  of KPCB  VI and  KPCB
                                                  VI.
- -----------------------------------------------------------------------------------------------------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON
                                                                                                                    590,119
- -----------------------------------------------------------------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES*                                                                                   [ ]
- -----------------------------------------------------------------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                                                                       4.5%
- -----------------------------------------------------------------------------------------------------------------------------
12           TYPE OF REPORTING PERSON*
                                                                                                                         PN
- -----------------------------------------------------------------------------------------------------------------------------
<FN>
                                               * SEE INSTRUCTIONS BEFORE FILLING OUT!
</FN>
</TABLE>


<PAGE>


<TABLE>
<S>                                                        <C>        <C>
- ---------------------------------------------------                   ----------------------------------------------------
CUSIP NO. 036870 71 0                                        13G            Page 4 of 17 Pages
- ---------------------------------------------------                   ----------------------------------------------------

- -----------------------------------------------------------------------------------------------------------------------------
1            NAME OF REPORTING PERSON
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                      Brook H. Byers
- -----------------------------------------------------------------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                          (a)    [ ]     (b)    [X]
- -----------------------------------------------------------------------------------------------------------------------------
3            SEC USE ONLY
- -----------------------------------------------------------------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION
                United States
- -----------------------------------------------------------------------------------------------------------------------------
              NUMBER OF                 5         SOLE VOTING POWER
               SHARES                                                                                                 1,266
            BENEFICIALLY              ---------------------------------------------------------------------------------------
              OWNED BY                  6         SHARED VOTING POWER
                EACH                              590,119  shares  are  directly
              REPORTING                           owned  by  KPCB  VI.  KPCB  VI
               PERSON                             Associates   is  the   general
                WITH                              partner  of  KPCB  VI and  Mr.
                                                  Byers is a general  partner of
                                                  KPCB VI Associates.
                                      ---------------------------------------------------------------------------------------
                                        7         SOLE DISPOSITIVE POWER
                                                                                                                      1,266
                                      ---------------------------------------------------------------------------------------
                                        8         SHARED    DISPOSITIVE    POWER
                                                  590,119  shares  are  directly
                                                  owned  by  KPCB  VI.  KPCB  VI
                                                  Associates   is  the   general
                                                  partner  of  KPCB  VI and  Mr.
                                                  Byers is a general  partner of
                                                  KPCB VI Associates.
- -----------------------------------------------------------------------------------------------------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON
                                                                                                                    591,385
- -----------------------------------------------------------------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES*                                                                                    [ ]
- -----------------------------------------------------------------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                                                                       4.5%
- -----------------------------------------------------------------------------------------------------------------------------
12           TYPE OF REPORTING PERSON*
                                                                                                                         IN
- -----------------------------------------------------------------------------------------------------------------------------
<FN>
                                               * SEE INSTRUCTIONS BEFORE FILLING OUT!
</FN>
</TABLE>


<PAGE>


<TABLE>
<S>                                                        <C>        <C>
- ---------------------------------------------------                   ----------------------------------------------------
CUSIP NO. 036870 71 0                                        13G            Page 5 of 17 Pages
- ---------------------------------------------------                   ----------------------------------------------------

- -----------------------------------------------------------------------------------------------------------------------------
1            NAME OF REPORTING PERSON
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                      Vinod Khosla
- -----------------------------------------------------------------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                          (a)    [ ]     (b)    [X]
- -----------------------------------------------------------------------------------------------------------------------------
3            SEC USE ONLY
- -----------------------------------------------------------------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION
                United States
- -----------------------------------------------------------------------------------------------------------------------------
              NUMBER OF                 5         SOLE VOTING POWER
               SHARES
            BENEFICIALLY              ---------------------------------------------------------------------------------------
              OWNED BY                  6         SHARED  VOTING  POWER  590,119    
                EACH                              shares are  directly  owned by    
              REPORTING                           KPCB VI. KPCB VI Associates is    
               PERSON                             the  general  partner  of KPCB    
                WITH                              VI.  Mr  Kholsla  is a general    
                                                  partner of KPCB VI Associates.    
                                                  In addition, the Vinod & Neeru    
                                                  Khosla Trust holds 429 shares,    
                                                  beneficial  ownership of which    
                                                  Mr. Khosla disclaims.             
                                      ---------------------------------------------------------------------------------------
                                        7         SOLE DISPOSITIVE POWER
                                                                                                                      - 0 -
                                      ---------------------------------------------------------------------------------------
                                        8         SHARED    DISPOSITIVE    POWER
                                                  590,119  shares  are  directly
                                                  owned  by  KPCB  VI.  KPCB  VI
                                                  Associates   is  the   general
                                                  partner  of  KPCB  VI and  Mr.
                                                  Khosla is a general partner of
                                                  KPCB VI Associates. Mr Kholsla
                                                  is a general  partner  of KPCB
                                                  VI  Associates.  In  addition,
                                                  the Vinod & Neeru Khosla Trust
                                                  holds 429  shares,  beneficial
                                                  ownership of which Mr.  Khosla
                                                  disclaims.
- -----------------------------------------------------------------------------------------------------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON
                                                                                                                    590,548
- -----------------------------------------------------------------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES*                                                                                   [ ]
- -----------------------------------------------------------------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                                                                       4.5%
- -----------------------------------------------------------------------------------------------------------------------------
12           TYPE OF REPORTING PERSON*
                                                                                                                         IN
- -----------------------------------------------------------------------------------------------------------------------------
<FN>
                                               * SEE INSTRUCTIONS BEFORE FILLING OUT!
</FN>
</TABLE>


<PAGE>


<TABLE>
<S>                                                        <C>        <C>
- ---------------------------------------------------                   ----------------------------------------------------
CUSIP NO. 036870 71 0                                        13G            Page 6 of 17 Pages
- ---------------------------------------------------                   ----------------------------------------------------

- -----------------------------------------------------------------------------------------------------------------------------
1            NAME OF REPORTING PERSON
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                      E. Floyd Kvamme
- -----------------------------------------------------------------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                          (a)    [ ]     (b)    [X]
- -----------------------------------------------------------------------------------------------------------------------------
3            SEC USE ONLY
- -----------------------------------------------------------------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION
                United States
- -----------------------------------------------------------------------------------------------------------------------------
              NUMBER OF                 5         SOLE VOTING POWER
               SHARES                                                                                                    633
            BENEFICIALLY              ---------------------------------------------------------------------------------------
              OWNED BY                  6         SHARED VOTING POWER
                EACH                              590,119  shares  are  directly
              REPORTING                           owned  by  KPCB  VI.  KPCB  VI
               PERSON                             Associates   is  the   general
                WITH                              partner  of  KPCB  VI and  Mr.
                                                  Kvamme is a general partner of
                                                  KPCB VI Associates.
                                      ---------------------------------------------------------------------------------------
                                        7         SOLE DISPOSITIVE POWER
                                                                                                                        633
                                      ---------------------------------------------------------------------------------------
                                        8         SHARED    DISPOSITIVE    POWER
                                                  590,119  shares  are  directly
                                                  owned  by  KPCB  VI.  KPCB  VI
                                                  Associates   is  the   general
                                                  partner  of  KPCB  VI and  Mr.
                                                  Kvamme is a general partner of
                                                  KPCB VI Associates.
- -----------------------------------------------------------------------------------------------------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON
                                                                                                                    590,752
- -----------------------------------------------------------------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES*                                                                                   [ ]
- -----------------------------------------------------------------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                                                                       4.5%
- -----------------------------------------------------------------------------------------------------------------------------
12           TYPE OF REPORTING PERSON*
                                                                                                                         IN
- -----------------------------------------------------------------------------------------------------------------------------
<FN>
                                               * SEE INSTRUCTIONS BEFORE FILLING OUT!
</FN>
</TABLE>


<PAGE>


<TABLE>
<S>                                                        <C>        <C>
- ---------------------------------------------------                   ----------------------------------------------------
CUSIP NO. 036870 71 0                                        13G            Page 7 of 17 Pages
- ---------------------------------------------------                   ----------------------------------------------------

- -----------------------------------------------------------------------------------------------------------------------------
1            NAME OF REPORTING PERSON
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                      L. John Doerr
- -----------------------------------------------------------------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                          (a)    [ ]     (b)    [X]
- -----------------------------------------------------------------------------------------------------------------------------
3            SEC USE ONLY
- -----------------------------------------------------------------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION
                United States
- -----------------------------------------------------------------------------------------------------------------------------
              NUMBER OF                 5         SOLE VOTING POWER
               SHARES                                                                                                 3,875
            BENEFICIALLY              ---------------------------------------------------------------------------------------
              OWNED BY                  6         SHARED VOTING POWER
                EACH                              590,119  shares  are  directly
              REPORTING                           owned  by  KPCB  VI.  KPCB  VI
               PERSON                             Associates   is  the   general
                WITH                              partner  of  KPCB  VI and  Mr.
                                                  Doerr is a general  partner of
                                                  KPCB VI Associates.
                                      ---------------------------------------------------------------------------------------
                                        7         SOLE DISPOSITIVE POWER
                                                                                                                      3,875
                                      ---------------------------------------------------------------------------------------
                                        8         SHARED    DISPOSITIVE    POWER
                                                  590,119  shares  are  directly
                                                  owned  by  KPCB  VI.  KPCB  VI
                                                  Associates   is  the   general
                                                  partner  of  KPCB  VI and  Mr.
                                                  Doerr is a general  partner of
                                                  KPCB VI Associates.
- -----------------------------------------------------------------------------------------------------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON
                                                                                                                    593,994
- -----------------------------------------------------------------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES*                                                                                  [ ]
- -----------------------------------------------------------------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                                                                       4.5%
- -----------------------------------------------------------------------------------------------------------------------------
12           TYPE OF REPORTING PERSON*
                                                                                                                         IN
- -----------------------------------------------------------------------------------------------------------------------------
<FN>
                                               * SEE INSTRUCTIONS BEFORE FILLING OUT!
</FN>
</TABLE>


<PAGE>


<TABLE>
<S>                                                        <C>        <C>
- ---------------------------------------------------                   ----------------------------------------------------
CUSIP NO. 036870 71 0                                        13G            Page 8 of 17 Pages
- ---------------------------------------------------                   ----------------------------------------------------

- -----------------------------------------------------------------------------------------------------------------------------
1            NAME OF REPORTING PERSON
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                      Joseph S. Lacob
- -----------------------------------------------------------------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                          (a)    [ ]     (b)    [X]
- -----------------------------------------------------------------------------------------------------------------------------
3            SEC USE ONLY
- -----------------------------------------------------------------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION
                United States
- -----------------------------------------------------------------------------------------------------------------------------
              NUMBER OF                 5         SOLE VOTING POWER
               SHARES                                                                                                   429
            BENEFICIALLY              ---------------------------------------------------------------------------------------
              OWNED BY                  6         SHARED VOTING POWER
                EACH                              590,119  shares  are  directly
              REPORTING                           owned  by  KPCB  VI.  KPCB  VI
               PERSON                             Associates   is  the   general
                WITH                              partner  of  KPCB  VI and  Mr.
                                                  Lacob is a general  partner of
                                                  KPCB VI Associates.
                                      ---------------------------------------------------------------------------------------
                                        7         SOLE DISPOSITIVE POWER
                                                                                                                        429
                                      ---------------------------------------------------------------------------------------
                                        8         SHARED    DISPOSITIVE    POWER
                                                  590,119  shares  are  directly
                                                  owned  by  KPCB  VI.  KPCB  VI
                                                  Associates   is  the   general
                                                  partner  of  KPCB  VI and  Mr.
                                                  Lacob is a general  partner of
                                                  KPCB VI Associates.
- -----------------------------------------------------------------------------------------------------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON
                                                                                                                    590,548
- -----------------------------------------------------------------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES*                                                                                   [ ]
- -----------------------------------------------------------------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                                                                       4.5%
- -----------------------------------------------------------------------------------------------------------------------------
12           TYPE OF REPORTING PERSON*
                                                                                                                         IN
- -----------------------------------------------------------------------------------------------------------------------------
<FN>
                                               * SEE INSTRUCTIONS BEFORE FILLING OUT!
</FN>
</TABLE>


<PAGE>


<TABLE>
<S>                                                        <C>       <C>
- ---------------------------------------------------                   ----------------------------------------------------
CUSIP NO. 036870 71 0                                        13G            Page 9 of 17 Pages
- ---------------------------------------------------                   ----------------------------------------------------

- -----------------------------------------------------------------------------------------------------------------------------
1            NAME OF REPORTING PERSON
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                      Bernard Lacroute
- -----------------------------------------------------------------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                          (a)    [ ]     (b)    [X]
- -----------------------------------------------------------------------------------------------------------------------------
3            SEC USE ONLY
- -----------------------------------------------------------------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION
                United States
- -----------------------------------------------------------------------------------------------------------------------------
              NUMBER OF                 5         SOLE VOTING POWER
               SHARES                                                                                                   429
            BENEFICIALLY              ---------------------------------------------------------------------------------------
              OWNED BY                  6         SHARED VOTING POWER
                EACH                              590,119  shares  are  directly
              REPORTING                           owned  by  KPCB  VI.  KPCB  VI
               PERSON                             Associates   is  the   general
                WITH                              partner  of  KPCB  VI and  Mr.
                                                  Lacroute  is a general partner
                                                  of KPCB VI Associates.
                                      ---------------------------------------------------------------------------------------
                                        7         SOLE DISPOSITIVE POWER
                                                                                                                        429
                                      ---------------------------------------------------------------------------------------
                                        8         SHARED    DISPOSITIVE    POWER
                                                  590,119  shares  are  directly
                                                  owned  by  KPCB  VI.  KPCB  VI
                                                  Associates   is  the   general
                                                  partner  of  KPCB  VI and  Mr.
                                                  Lacroute is a general  partner
                                                  of KPCB VI Associates.
- -----------------------------------------------------------------------------------------------------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON
                                                                                                                    590,548
- -----------------------------------------------------------------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES*                                                                                  [ ]
- -----------------------------------------------------------------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                                                                       4.5%
- -----------------------------------------------------------------------------------------------------------------------------
12           TYPE OF REPORTING PERSON*
                                                                                                                         IN
- -----------------------------------------------------------------------------------------------------------------------------
<FN>
                                               * SEE INSTRUCTIONS BEFORE FILLING OUT!
</FN>
</TABLE>


<PAGE>


<TABLE>
<S>                                                        <C>        <C>
- ---------------------------------------------------                   ----------------------------------------------------
CUSIP NO. 036870 71 0                                        13G            Page 10 of 17 Pages
- ---------------------------------------------------                   ----------------------------------------------------

- -----------------------------------------------------------------------------------------------------------------------------
1            NAME OF REPORTING PERSON
             SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                      James P. Lally
- -----------------------------------------------------------------------------------------------------------------------------
2            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                          (a)    [ ]     (b)    [X]
- -----------------------------------------------------------------------------------------------------------------------------
3            SEC USE ONLY
- -----------------------------------------------------------------------------------------------------------------------------
4            CITIZENSHIP OR PLACE OF ORGANIZATION
                United States
- -----------------------------------------------------------------------------------------------------------------------------
              NUMBER OF                 5         SOLE VOTING POWER
               SHARES                                                                                                   613
            BENEFICIALLY              ---------------------------------------------------------------------------------------
              OWNED BY                  6         SHARED VOTING POWER
                EACH                              590,119  shares  are  directly
              REPORTING                           owned  by  KPCB  VI.  KPCB  VI
               PERSON                             Associates   is  the   general
                WITH                              partner  of  KPCB  VI and  Mr.
                                                  Lally is a general  partner of
                                                  KPCB VI Associates.
                                      ---------------------------------------------------------------------------------------
                                        7         SOLE DISPOSITIVE POWER
                                                                                                                        613
                                      ---------------------------------------------------------------------------------------
                                        8         SHARED    DISPOSITIVE    POWER
                                                  590,119  shares  are  directly
                                                  owned  by  KPCB  VI.  KPCB  VI
                                                  Associates   is  the   general
                                                  partner  of  KPCB  VI and  Mr.
                                                  Lally is a general  partner of
                                                  KPCB VI Associates.
- -----------------------------------------------------------------------------------------------------------------------------
9            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
             REPORTING PERSON
                                                                                                                    590,732
- -----------------------------------------------------------------------------------------------------------------------------
10           CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
             EXCLUDES CERTAIN SHARES*                                                                                  [ ]
- -----------------------------------------------------------------------------------------------------------------------------
11           PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                                                                       4.5%
- -----------------------------------------------------------------------------------------------------------------------------
12           TYPE OF REPORTING PERSON*
                                                                                                                         IN
- -----------------------------------------------------------------------------------------------------------------------------
<FN>
                                               * SEE INSTRUCTIONS BEFORE FILLING OUT!
</FN>
</TABLE>


<PAGE>


                                                                   Page 11 of 17

ITEM 1(A).        NAME OF ISSUER

                  GeneMedicine, Inc.

ITEM 1(B).        ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES

                  8080 North Stadium Drive, Suite 2100
                  Houston, TX  77054

ITEM 2(A)-(C).             NAME, ADDRESS AND CITIZENSHIP OF PERSONS FILING

                  This statement is being filed by KPCB VI  Associates,  L.P., a
California Limited Partnership ("KPCB VI Associates"),  whose principal business
address  is 2750 Sand Hill  Road,  Menlo  Park,  California  94025.  The  names,
business  addresses  and  citizenships  of all the  general  partners of KPCB VI
Associates, are set forth on Exhibit B hereto.

                  KPCB VI  Associates  is general  partner  to  Kleiner  Perkins
Caufield & Byers VI, L.P., a California  limited  partnership  ("KPCB VI"). This
amended  statement  is being  filed by KPCB VI  Associates  and KPCB VI and with
respect to KPCB VI  Associates,  relates only to KPCB VI  Associates'  indirect,
beneficial  ownership  of shares  of Common  Stock of  GeneMedicine,  Inc.  held
directly by KPCB VI (the "Shares") and, with respect to each individual  general
partner, to the extent applicable, each individual general partner's interest in
the shares over which he has sole voting and dispositive control. The Shares are
held directly by KPCB VI and KPCB VI  Associates  does not directly or otherwise
hold any  Shares.  Management  of the  business  affairs of KPCB VI  Associates,
including  decisions  respecting  disposition and/or voting of the Shares, is by
majority  decision  of the  general  partners  of KPCB VI  Associates  listed on
Exhibit B hereto, each of whom disclaims beneficial ownership of the Shares.


ITEM 2(D) AND (E).  TITLE OF CLASS OF SECURITIES AND CUSIP NUMBER

                  Common Stock
                  CUSIP # 036870 71 0

ITEM 3.           Not Applicable

ITEM 4.           OWNERSHIP

                  Please  see Item 5 hereof.  Each  individual  general  partner
                  disclaims beneficial ownership of the Shares.



<PAGE>


                                                                   Page 12 of 17

ITEM 5.           OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS.

                  This amended  statement is being filed to report the fact that
                  each reporting person has ceased to be the beneficial owner of
                  more than five  percent of the Common  Stock of  GeneMedicine,
                  Inc.

ITEM 6.           OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF
                  ANOTHER PERSON.

                  Not  applicable  for any  reporting  party  because the shares
                  owned  as  of  12/31/96   do  not  exceed   five   percent  of
                  GeneMedicine,  Inc.'s  outstanding  shares.  Please see Item 5
                  hereof.

ITEM 7.           IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY
                  WHICH ACQUIRED THE SECURITY BEING REPORTED ON BY
                  THE PARENT HOLDING COMPANY.

                  Not applicable.

ITEM 8.           IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE
                  GROUP.

                  Not applicable.

ITEM 9.           NOTICE OF DISSOLUTION OF GROUP.

                  Not applicable.

ITEM 10.          CERTIFICATION.

                  Not applicable.




<PAGE>


                                                                   Page 13 of 17

                                   SIGNATURES

                  After  reasonable  inquiry and to the best of my knowledge and
belief,  I certify  that the  information  set forth in this  statement is true,
complete and correct.

Dated:  February 13, 1997
                                          KPCB VI ASSOCIATES, L.P., A CALIFORNIA
                                          LIMITED PARTNERSHIP


                                          By:
                                             -----------------------------------
                                               A General Partner



                                          KLEINER  PERKINS  CAUFIELD & BYERS VI,
                                          L.P., A CALIFORNIA LIMITED PARTNERSHIP

                                          By  KPCB  VI   Associates,   L.P.,   a
                                          California  limited  partnership,  its
                                          General Partner


                                          By:
                                             -----------------------------------
                                               A General Partner



                                          BROOK H. BYERS
                                          VINOD KHOSLA
                                          E. FLOYD KVAMME
                                          L. JOHN DOERR
                                          JOSEPH S. LACOB
                                          BERNARD LACROUTE
                                          JAMES P. LALLY


                                          By:
                                             -----------------------------------
                                               Michael S. Curry
                                               Attorney-in-Fact




<PAGE>


                                                                   Page 14 of 17

                                                   EXHIBIT INDEX


                                                                     Found on
                                                                   Sequentially
Exhibit                                                            Numbered Page
- -------                                                            -------------

Exhibit A:  Agreement of Joint Filing                                   15

Exhibit B:  List of General Partners of KPCB VI Associates              16



<PAGE>


                                                                   Page 15 of 17

                                    EXHIBIT A

                            Agreement of Joint Filing


                  The  undersigned  hereby  agree that they are  filing  jointly
pursuant to Rule 13d-1 of the Act the amended statement dated February 13, 1997,
containing  the  information  required by Schedule  13G, for the Common Stock of
GeneMedicine,  Inc.  held by  Kleiner  Perkins  Caufield  & Byers  VI,  L.P.,  a
California  limited  partnership  and, with respect to each  individual  general
partner, to the extent applicable, each individual general partner's interest in
the shares over which he has sole voting and dispositive control.

Dated:  February 13, 1997
                                          KPCB VI ASSOCIATES, L.P., A CALIFORNIA
                                          LIMITED PARTNERSHIP


                                          By:
                                             -----------------------------------
                                               A General Partner



                                          KLEINER  PERKINS  CAUFIELD & BYERS VI,
                                          L.P., A CALIFORNIA LIMITED PARTNERSHIP

                                          By  KPCB  VI   Associates,   L.P.,   a
                                          California  limited  partnership,  its
                                          General Partner


                                          By:
                                             -----------------------------------
                                               A General Partner



                                          BROOK H. BYERS
                                          VINOD KHOSLA
                                          E. FLOYD KVAMME
                                          L. JOHN DOERR
                                          JOSEPH S. LACOB
                                          BERNARD LACROUTE
                                          JAMES P. LALLY


                                          By:
                                             -----------------------------------
                                               Michael S. Curry
                                               Attorney-in-Fact



<PAGE>


                                                                   Page 16 of 17

                                    EXHIBIT B

                               General Partners of
              KPCB VI Associates, a California limited partnership


                  Set forth below,  with respect to each general partner of KPCB
VI  Associates,  is the  following:  (a)  name;  (b)  business  address  and (c)
citizenship.

1.       (a)      Brook H. Byers
         (b)      c/o Kleiner Perkins Caufield & Byers
                  2750 Sand Hill Road
                  Menlo Park, CA  94025
         (c)      United States Citizen

2.       (a)      Vinod Khosla
         (b)      c/o Kleiner Perkins Caufield & Byers
                  2750 Sand Hill Road
                  Menlo Park, CA  94025
         (c)      United States Citizen

3.       (a)      E. Floyd Kvamme
         (b)      c/o Kleiner Perkins Caufield & Byers
                  2750 Sand Hill Road
                  Menlo Park, CA  94025
         (c)      United States Citizen

4.       (a)      L. John Doerr
         (b)      c/o Kleiner Perkins Caufield & Byers
                  2750 Sand Hill Road
                  Menlo Park, CA  94025
         (c)      United States Citizen

5.       (a)      Joseph Lacob
         (b)      c/o Kleiner Perkins Caufield & Byers
                  2750 Sand Hill Road
                  Menlo Park, CA  94025
         (c)      United States Citizen

6.       (a)      Bernard Lacroute
         (b)      c/o Kleiner Perkins Caufield & Byers
                  2750 Sand Hill Road
                  Menlo Park, CA  94025
         (c)      United States Citizen


<PAGE>


                                                                   Page 17 of 17

7.       (a)      James P. Lally
         (b)      c/o Kleiner Perkins Caufield & Byers
                  2750 Sand Hill Road
                  Menlo Park, CA  94025
         (c)      United States Citizen






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