APROGENEX INC
10QSB, 1996-08-08
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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         U.S. SECURITIES AND EXCHANGE COMMISSION
                 Washington, D.C.  20549



                     Form 10-QSB



     QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF 
            THE SECURITIES EXCHANGE ACT OF 1934



     For the quarterly period ended June 30, 1996



                 Commission file number  1-12416


                    Aprogenex, Inc.
(Exact name of Small Business Issuer as specified in its charter)





       Delaware                          76-0269632
(State of incorporation)   (I.R.S. Employer Identification Number)

                     8000 El Rio Street
                   Houston, TX  77054-4104
           (Address of principal executive offices)

                      (713) 748-5114
                (Issuer's telephone number)

Check whether the issuer: (1) filed all reports required to be 
filed by Section 13 or 15(d) of the Exchange Act during the past 
12 months (or for such shorter period that the registrant was 
required to file such reports), and (2) has been subject to such 
filing requirements for the past 90 days.
                      YES: X    NO:
                               
As of August 5, 1996, there were 5,200,598 shares of Common Stock 
outstanding.

Transitional Small Business Disclosure Format (check one):
                      YES:      NO: X

            PART I - FINANCIAL INFORMATION

Item 1. Financial Statements

                  Aprogenex, Inc.
    (A Delaware Corporation in the Development Stage)
                  Balance Sheets
                   (Unaudited)

                                      December 31,      June 30,
                                          1995            1996
                                     -----------     -----------
     ASSETS
Current assets:
  Cash and cash equivalents          $ 1,301,934     $ 1,562,219
  Accounts receivable and 
  prepaid expenses                       103,412          90,335
                                     -----------     -----------
      Total current assets             1,405,346       1,652,554
Property and equipment, net              956,034         787,857
Other assets, net                         30,574         128,532
                                     -----------     -----------
                                     $ 2,391,954     $ 2,568,943
                                     ===========     ===========


     LIABILITIES AND STOCKHOLDERS' EQUITY (DEFICIT)
Current liabilities:
  Accounts payable                   $   273,361     $   159,456
  Accrued liabilities                    244,491         193,559
  Current portion of  
    capital lease obligations            176,962         174,127
                                      ----------      ----------
      Total current liabilities          694,814         527,142
Capital lease obligations,
net of current portion                   203,905         103,768
Convertible Notes Payable                   --         1,951,837
Commitments and contingencies
Stockholders' equity
  Undesignated Preferred Stock,
  10,320,000 shares authorized,
  none issued                               --              --
  Series A Convertible Preferred
  Stock, $.001 par value; 880,000
  shares authorized; 459,000 and 
  449,000 shares issued and 
  outstanding,respectively; 
  liquidation preference of $13 per
  share (aggregating to $5,967,000 
  and $5,837,000, respectively)              459             449
  Common Stock, $.001 par value; 
  20,000,000 shares authorized; 
  5,156,345 and 5,200,598 shares 
  issued and outstanding, 
  respectively                             5,156           5,201
  Additional paid-in capital          27,311,550      27,312,430
  Deficit accumulated during 
  the development stage              (26,002,816)    (27,575,770)
Warrants to purchase Common and 
Preferred Stock                          178,886         243,886
                                     -----------     -----------
      Total stockholders' 
      equity (deficit)                 1,493,235         (13,804)
                                     -----------     -----------
                                     $ 2,391,954     $ 2,568,943
                                     ===========     ===========

The accompanying notes are an integral part of these financial 
statements

                    Aprogenex, Inc.
     (A Delaware Corporation in the Development Stage)
               Statements of Operations
                        (Unaudited)
                                                       For the
                                                       Period
                                                        From
                                                      Inception
                                For the Three        (January 25,
                             Months Ended June 30,   1989)Through
                           ------------------------    June 30,
                                1995         1996        1996   
                           -----------  -----------  ------------
Revenues                   $     8,070  $    13,236  $    211,310
                           -----------  -----------  ------------
Costs and expenses:
 Research and development      959,974      520,156    16,312,036
 General and administrative    499,642      279,818    10,566,733
                           -----------  -----------  ------------
Total costs and expenses     1,459,616      799,974    26,878,769
                           -----------  -----------  ------------
Loss before interest
  and other                 (1,451,546)    (786,738)  (26,667,459)
Interest expense               (20,299)     (26,524)     (621,112)
Interest income and 
  other,net                     33,818       16,084       645,456
                           -----------  -----------  ------------
Net loss                   $(1,438,027) $  (797,178) $(26,643,115)
                           ===========  ===========  ============
Net loss per Common share      $ (.29)      $ (.15)
                           ===========  =========== 
Shares used in computing 
  net loss per Common share  5,043,340   5,200,598
                           ===========  ===========  

The accompanying notes are an integral part of these financial 
statements.

                  Aprogenex, Inc.
   (A Delaware Corporation in the Development Stage)
        Statements of Operations (Continued)
                      (Unaudited)
                                                       For the
                                                       Period
                                                        From
                                                      Inception
                                For the Six          (January 25,
                             Months Ended June 30,   1989)Through
                           ------------------------    June 30,
                                1995         1996        1996   
                           -----------  -----------  ------------
Revenues                   $     8,070  $    30,581  $    211,310
                           -----------  -----------  ------------
Costs and expenses:
 Research and development    1,813,005    1,040,853    16,312,036
 General and administrative  1,088,628      549,361    10,566,733
                           -----------  -----------  ------------
Total costs and expenses     2,901,633    1,590,214    26,878,769
                           -----------  -----------  ------------
Loss before interest
  and other                 (2,893,563)  (1,559,633)  (26,667,459)
Interest expense               (42,430)     (42,022)     (621,112)
Interest income and 
  other,net                     50,764       28,701       645,456
                           -----------  -----------  ------------
Net loss                   $(2,885,229) $(1,572,954) $(26,643,115)
                           ===========  ===========  ============
Net loss per Common share      $ (.58)      $ (.30)
                           ===========  =========== 
Shares used in computing 
  net loss per Common share  4,993,863   5,189,923
                           ===========  ===========  

The accompanying notes are an integral part of these financial 
statements.

                   Aprogenex, Inc.
    (A Delaware Corporation in the Development Stage)
               Statements of Cash Flows
                    (Unaudited)
                                                       For the
                                                       Period
                                                        From
                                                      Inception
                                For the Three        (January 25,
                             Months Ended June 30,   1989)Through
                           ------------------------    June 30,
                                1995         1996        1996   
                           -----------  -----------  ------------
Operating Activities:
Net loss                   $(1,438,027) $  (797,178) $(26,643,115)
Adjustments to reconcile 
  to net cash used by 
  operating activities 
  Depreciation and 
    amortization                76,007       88,698     1,831,280
  Interest expense on 
    Convertible Notes 
    payable  in 199               --         10,437        10,437
  Amortization of discount 
    on Convertible Notes          --          1,400         1,400
  Amortization of deferred 
    compensation related to
    certain stock options         --           --          94,300
  Non-cash portion of 
    technology acquisition         --          --       2,421,875
  Interest expense on notes 
    payable converted into 
  preferred stock                  --          --         186,154
  Issuance of common stock, 
    options, or warrants 
    for services                   --          --          48,295
  Changes in assets
    and liabilities-
    (Increase) decrease in 
    prepaid expenses, 
    receivables and other       (6,658)     (12,855)     (110,755)
  Increase (decrease) in 
    accounts payable and 
    accrued liabilities        194,703       66,350       353,015
                           -----------  -----------  ------------
Net cash used by 
  operating activities      (1,173,975)    (643,148)  (21,807,114)
Investing Activities:
Purchases of 
  marketable securities       (161,078)        --      (5,018,891)
Disposition of 
  marketable securities           --           --       5,018,891
Purchases of property 
  and equipment                (38,827)        --      (2,239,113)
Proceeds from 
  sale-leaseback agreement         --          --         982,416
Deferred organization costs        --          --          (1,788)
                           -----------  -----------  ------------
Net cash provided (used) 
  by investing activities     (199,905)        --      (1,258,485)
                           -----------  -----------  ------------
Financing Activities:
Net proceeds from sale
  of preferred stock         3,835,440         --       8,676,736
Net proceeds from sale
  of common stock              555,015         --      10,511,178
Net borrowings under 
  Convertible Notes               --      1,834,318     1,834,318
Exercise of stock options        5,859         --         110,087
Proceeds from sale of 
  warrants                      48,786       65,000       183,886
Principal payments under 
  capital lease obligations    (40,233)     (61,448)   (1,045,185)
Borrowings under notes 
  payable converted
  into preferred stock            --           --       4,363,048
Net borrowings under
  Bridge Loans                    --           --         570,000
Repayment of Bridge Loans         --           --        (570,000)
Purchase of treasury stock        --           --          (6,250)
                           -----------  -----------  ------------
Net cash provided (used)     
  by financing activities    4,404,867    1,837,870    24,627,818
                           -----------  -----------  ------------
Increase (decrease) in cash
  and cash equivalents       3,030,987    1,194,722     1,562,219
Cash and cash equivalents,
  beginning of period          450,540      367,497          --
                           -----------  -----------  ------------
Cash and cash equivalents,
  end of period            $ 3,481,527  $ 1,562,219  $  1,562,219
                           ===========  ===========  ============

The accompanying notes are an integral part of these financial 
statements.

                    Aprogenex, Inc.
     (A Delaware Corporation in the Development Stage)
            Statements of Cash Flows (Continued)
                          (Unaudited)
                                                       For the
                                                       Period
                                                        From
                                                      Inception
                                For the Six          (January 25,
                             Months Ended June 30,   1989)Through
                           ------------------------    June 30,
                                1995         1996        1996   
                           -----------  -----------  ------------
Operating Activities:
Net loss                   $(2,885,229) $(1,572,954) $(26,643,115)
Adjustments to reconcile 
  to net cash used by 
  operating activities 
  Depreciation and 
    amortization               150,885      178,652     1,831,280
  Interest expense on 
    Convertible Notes 
    payable  in 199               --         10,437        10,437
  Amortization of discount 
    on Convertible Notes          --          1,400         1,400
  Amortization of deferred 
    compensation related to
    certain stock options         --           --          94,300
  Non-cash portion of 
    technology acquisition         --          --       2,421,875
  Interest expense on notes 
    payable converted into 
  preferred stock                  --          --         186,154
  Issuance of common stock, 
    options, or warrants 
    for services                   --          --          48,295
  Changes in assets
    and liabilities-
    (Increase) decrease in 
    prepaid expenses, 
    receivables and other      (83,623)      13,077     (110,755)
  Increase (decrease) in 
    accounts payable and 
    accrued liabilities         92,326     (164,837)      353,015
                           -----------  -----------  ------------
Net cash used by 
  operating activities      (2,725,641)  (1,534,225)  (21,807,114)
Investing Activities:
Purchases of 
  marketable securities       (161,078)        --      (5,018,891)
Disposition of 
  marketable securities      1,000,000         --       5,018,891
Purchases of property 
  and equipment                (46,360)      (2,751)   (2,239,113)
Proceeds from 
  sale-leaseback agreement         --          --         982,416
Deferred organization costs        --          --          (1,788)
                           -----------  -----------  ------------
Net cash provided (used) 
  by investing activities      792,562       (2,751)   (1,258,485)
                           -----------  -----------  ------------
Financing Activities:
Net proceeds from sale
  of preferred stock         3,835,440         --       8,676,736
Net proceeds from sale
  of common stock              555,015         --      10,511,178
Net borrowings under 
  Convertible Notes               --      1,834,318     1,834,318
Exercise of stock options       43,546          915       110,087
Proceeds from sale of 
  warrants                      48,786       65,000       183,886
Principal payments under 
  capital lease obligations    (83,734)    (102,972)   (1,045,185)
Borrowings under notes 
  payable converted
  into preferred stock            --           --       4,363,048
Net borrowings under
  Bridge Loans                    --           --         570,000
Repayment of Bridge Loans         --           --        (570,000)
Purchase of treasury stock        --           --          (6,250)
                           -----------  -----------  ------------
Net cash provided (used)     
  by financing activities    4,399,053    1,797,261    24,627,818
                           -----------  -----------  ------------
Increase (decrease) in cash
  and cash equivalents       2,465,974      260,285     1,562,219
Cash and cash equivalents,
  beginning of period        1,015,553    1,301,934          --
                           -----------  -----------  ------------
Cash and cash equivalents,
  end of period            $ 3,481,527  $ 1,562,219  $  1,562,219
                           ===========  ===========  ============

The accompanying notes are an integral part of these financial 
statements.


Condensed Notes to Financial Statements

1.  Description of Business and Certain Significant Risks

Aprogenex, Inc. (Aprogenex or the Company) was incorporated as 
Molecular Analysis Incorporated on August 1, 1988, and commenced 
operations on January 25, 1989.  The Company was organized to 
research, develop, and market medical diagnostic products using 
DNA probes to detect and identify diseases and genetic disorders.  
The proprietary technology of Aprogenex includes methods of in 
situ hybridization using synthesized DNA probes.

Aprogenex is in the development stage and has only generated 
limited revenues from the sale of research-use-only products.  The 
future success of the Company is dependent upon many factors, 
including the protection of its proprietary technology, the 
ability to practice its technology without infringing patents 
issued to others, the successful identification and development of 
saleable products using this technology, obtaining regulatory 
approvals to market such products, the penetration of markets for 
these products, and obtaining funds necessary to complete these 
activities.  

The Company's technology can be utilized to develop products that 
serve various markets ranging from genetics to infectious 
diseases.  The potential customers for the Company's product 
candidates are generally laboratories throughout the world, and 
such laboratories may require a broader range of products or 
instrumentation than is available from the Company.  Additionally, 
the Company's product candidates must compete with products from 
other companies developed using similar technologies, as well as 
with products developed using other technologies.  Most 
competitors have substantially greater resources than the Company, 
which will make penetration of markets for the Company's products 
difficult.  

The Company estimates that, as of June 30, 1996, it has cash 
resources to fund its normal operations through the end of 1996.  
Accordingly, the Company will require additional funding to 
complete its product development activities or to sustain 
operations through the commercialization of such products.  The 
Company from time to time is engaged in activities to raise funds 
through the sale of equity or debt or the license of portions of 
its technology.  The ability of the Company to continue its 
activities, to realize or recover its investment in property and 
equipment, or to continue as a going concern is dependent upon its 
ability to obtain additional funding.  There can be no assurance 
that the Company will be able to obtain such funding, or the terms 
upon which any such funding may occur.

As previously disclosed in the Company's Form 10-KSB for the year 
ended December 31, 1995, as filed with the Securities and Exchange 
Commission, the opinion of Arthur Andersen LLP, the independent 
public accountants for the Company, included an explanatory fourth 
paragraph that indicated that the Company's continued operations 
is dependent upon its ability to obtain additional working capital 
to complete the research and development and other activities and 
to attain successful future operations.  


2.  Basis of Presentation

The accompanying unaudited financial statements have been prepared 
pursuant to the rules and regulations of the Securities and 
Exchange Commission (the "Commission").  Certain information and 
footnote disclosures normally included in the annual financial 
statements prepared in accordance with generally accepted 
accounting principles have been condensed or omitted pursuant to 
those rules and regulations.  This financial information should be 
read in conjunction with the Financial Statements included within 
the Company's Form 10-KSB for the year ended December 31, 1995.
In the opinion of the management of the Company, the accompanying 
financial statements reflect all adjustments (consisting only of 
normal recurring adjustments) that are necessary for a fair 
presentation of financial position and the results of operations 
for the periods presented. 


3.  Sale of Convertible Notes and Warrants

On June 12, 1996, the Company issued $2,005,000 principal amount 
of Convertible Notes due on May 29, 1998 (the "Convertible Notes") 
and warrants to acquire 130,323 shares of Common Stock (the "1996 
Warrants") for total consideration of $2,005,000.  The Convertible 
Notes bear interest at the rate of 10% per annum, based on a 365 
day year, compounded quarterly.  Interest is payable at maturity 
or upon prepayment.  The principal and accrued interest on the 
Convertible Notes are convertible into the Common Stock of the 
Company at the rate of one share of Common Stock for every $1.10 
in principal and accrued interest. 

On the twentieth business day prior to the maturity date of the 
Convertible Notes (the "Reset Date"), the conversion price will be 
adjusted to the average of the closing price of the Common Stock 
on the American Stock Exchange (or such other trading forum as may 
be applicable at that time) for the ten trading days prior to the 
Reset Date (the "Reset Conversion Price") if and only if such new 
Reset Conversion Price is lower than the then-current Conversion 
Price.  However, such price shall not be less than 50% of the 
then-Conversion Price.

The Convertible Notes contain provisions to protect the holders 
against dilution by adjusting the number of shares issuable upon 
conversion thereof.

The Company has the right to prepay principal and accrued interest 
upon twenty days notice to the holders of the Convertible Notes.  
However, the holders have the right to convert the Convertible 
Notes  into Common Stock as set forth above prior to such 
redemption.

The principal and accrued interest of the Note become immediately 
due and payable upon the insolvency of the Company, the commission 
of any act of bankruptcy by the Company, the execution by the 
Company of a general assignment for the benefit of creditors, the 
filing by or against the Company of any petition in bankruptcy or 
any petition for relief under the provisions of the federal 
bankruptcy act or any other state or federal law for the relief of 
debtors and the continuation of such petition without dismissal 
for a period of thirty (30) days or more, or the appointment of a 
receiver or trustee to take possession of the property or assets 
of the Company. 

The 1996 Warrants entitle the holders thereof to purchase Common 
Stock at $1.10 per share and are exercisable at any time, but such 
exercise must occur prior to the close of business on May 28, 
1999.  The 1996 Warrants contain provisions to protect the holders 
thereof against dilution by adjusting the price at which the 1996 
Warrants are exercisable and the number of shares issuable upon 
exercise thereof upon the occurrence of certain events.  

Commencing September 10, 1996, the holders of the May Warrants 
will have "piggyback" registration rights to require the Company 
to include the Common Stock underlying such warrants in certain 
registration statements filed by the Company.

The net proceeds from the sale of the Convertible Notes and the 
1996 warrants totaled approximately $1.8 million after deducting 
the expenses and fees related to the offering.  The Company 
expects the proceeds from the sale to fund its normal operations 
through 1996.  See Forward-Looking Statements herein.

The Company has assigned a value of approximately $.50 per share 
of Common Stock to the 1996 Warrants, or a total of $65,000.  This 
valuation was based on review of the trading history of the Common 
Stock, the non-transferable provisions of the 1996 Warrants, and 
various other factors.  The value assigned to the 1996 Warrants 
was treated as issue discount on the Convertible Notes and 
amortized as additional interest on the Convertible Notes.  Such 
amortization will increase the effective interest rate on the 
Convertible Notes to approximately 11.7%, assuming the Convertible 
Notes remain outstanding until maturity.


Item 2.  Management's Discussion and Analysis or Plan of 
Operation

Liquidity and Capital Resources

At June 30, 1996, the Company had cash resources of $1,562,000 
available to it and had net working capital of $1.1 million.

To date, the Company has financed its operations primarily through 
private placements of its equity and debt securities and its 
initial public offering in 1993. The Company has raised 
approximately $25.5 million in net proceeds through these 
transactions, including $4.5 million of such sales consummated 
through the conversion of the Company's debt securities into 
equity.  Additionally, the Company has financed $1.3 million of 
its approximately $2.6 million of capital expenditures since 
inception through equipment leases. 

The Company has expended and will continue to expend in the future 
substantial funds to continue the research and development of its 
products, conduct clinical investigations, make capital 
expenditures, and manufacture and market its products.  Its 
products are in various stages of development.  Additional amounts 
will be expended in research activities, continuing development of 
products, testing of these existing and other products in field 
trials and clinical investigations, seeking regulatory approval of 
successfully tested products, and the manufacturing and marketing 
of products approved for sale.  If regulatory approvals are 
obtained, the Company expects to expend substantial funds on 
marketing and distribution activities.  The amount and timing of 
anticipated expenditures will depend upon numerous factors both 
within and outside the Company's control.  Factors within the 
Company's control include the number of products under 
development, the timing of the commencement of clinical 
investigations and regulatory filings, and the extent of 
pre-marketing or marketing activities.  Factors generally beyond 
the control of the Company include the results of research and 
development activities, the extent of clinical investigations and 
the regulatory process to obtain FDA or other approvals of 
products and technological advances of, and products developed by, 
its competitors.  Moreover, even if the Company's activities are 
successful, the ability to generate income from the sale of 
products will be dependent upon, among other things, acceptance of 
products by customers, access to distribution channels for 
products and the Company's ability to obtain reimbursement 
approval from government and third-party payers.  The necessity 
for instrumentation to be used with the Company's products may 
also affect capital requirements.  

In addition to the foregoing, the Company's working capital 
requirements during the next 12 months may vary depending upon 
numerous additional factors, including the progress of the 
Company's research and development program, the results of 
laboratory testing, the time and cost required to seek regulatory 
approvals, the need to obtain licenses to proprietary rights held 
by others, any required adjustments to the Company's operating 
plan to respond to the competitive pressures or technological 
advances, the time of pre-marketing and marketing activities, and 
the success of the Company in developing collaborative 
arrangements with others for the development of its technology.

The Company's cash and marketable securities as of June 30, 1996, 
are expected to be used as set forth in "Plan of Operations" 
below.  The Company anticipates that its resources will be 
sufficient to fund its activities through the 1996.  The report of 
the Company's independent auditors on the financial statements for 
the year ended December 31, 1995 included an explanatory paragraph 
with respect to the need for future financing.  The Company 
expects to seek additional financing in 1996 to fund its 
operations during 1997.  The Company will seek to obtain 
additional funds through equity or debt financing, collaborative 
or other arrangements with corporate partners and others, and from 
other sources.  If additional funds are raised by issuing equity 
securities, dilution to stockholders may occur.  The Board of 
Directors of the Company is empowered, without stockholder 
approval (other than in certain cases approvals of the holders of 
the Series A Convertible Preferred Stock), to issue additional 
shares of Series A Preferred Stock or other series of preferred 
stock with dividend, liquidation, conversion, voting and other 
rights that could adversely affect the voting power or other 
rights of the holders of the Company's securities.  If debt 
securities are issued, a portion of the Company's cash flow will 
have to be dedicated to payment of principal and interest on such 
indebtedness and the Company may be subject to certain restrictive 
financial and operating restrictions in the agreements and 
instruments relating to such indebtedness.  There can be no 
assurance that there will be significant sales of the Company's 
products or that such revenues will be sufficient for operations.  
In such event, the Company would also be required to seek 
additional funds. There can be no assurance that additional 
financing, whenever required, will be available when needed or on 
terms acceptable to the Company.  If adequate funds are not 
available, the Company may be required to delay or to eliminate 
expenditures for certain of its products, to license to third 
parties the rights to commercialize additional products or 
technologies that the Company would otherwise seek to develop 
itself or if no other reasonable alternative is available, to 
cease operations.  

Additionally, depending on market conditions or future business 
opportunities, the Company may decide to issue additional equity 
or debt securities for cash or to acquire assets or technology of 
others.  The working capital of the Company may also be used to 
acquire such assets or technology, reducing the funds available 
for alternative use. 

The Company from time to time engages in discussions with 
diagnostic companies regarding collaborative arrangements for the 
development and sale of applications of the Company's technology 
which, depending upon the terms and requirements of such 
arrangements, could expand the Company's research activities.  
Such arrangements, if consummated, could significantly reduce the 
amount of capital that would be required for the development and 
commercialization of certain applications.  It is possible, 
however, that the net proceeds ultimately derived from any such 
arrangement could be less than would be the case if the Company 
undertook and completed development of such products itself. There 
can be no assurance as to the ability of the Company to consummate 
any such arrangement, or the terms or timing of any such 
arrangement.  Additionally, from time to time the Company engages 
in exploratory discussions with others regarding mergers, 
acquisitions, joint ventures, dispositions and other transactions.  
There can be no assurance, however, that any such transaction will 
be effected by the Company or on what terms.

The Company's liquidity will be reduced as amounts are expended 
for continuing activities.  While not currently anticipated, the 
Company's liquidity could also be substantially reduced if 
significant amounts are expended for additional facilities, 
equipment or to license or acquire proprietary technology owned by 
others or to legally defend its proprietary technology.


Plan of Operations

During the next 12 months, the principal focus of the Company's 
activities is currently expected to be (i) the development and 
marketing of research-use-only HIV products, (ii) the development 
of clinical HIV products for submission to regulatory authorities 
as therapeutic monitoring products, (iii) the marketing of DNA 
probe products to other companies for use in their genetics 
programs, (iv) the development of other products and enhancements 
to the Company's technology, and (v) if any of the foregoing 
development activities are successful, conducting field trials 
for, seeking any required regulatory approvals of, and the 
marketing of these products.  Such planned activities may change 
depending upon business opportunities that present themselves, the 
success of development activities, the financial position of the 
Company and other matters that may arise in the future.  As 
indicated, these planned activities reflect an increased emphasis 
on the development of HIV and other products and a reduced 
emphasis on the continued development of genetics products.

For a discussion of certain of the factors that affect the timing 
of any sales of the Company's products, see the Company's Form 10-
KSB for the year ended December 31, 1995.  

The Company expects to either renew its lease for its facilities 
in 1996 or to move to a new location.  Any move would require the 
construction of new manufacturing and laboratory facilities and 
may require the expenditure of approximately $1.0 million or more.  
Capital expenditures of other equipment are not expected to exceed 
$500,000 during the next 12 months.  However, all such 
expenditures will vary based on the success of the Company's 
efforts, its financial resources, changes in manufacturing, 
research or development programs, and other factors.  

The Company does not believe that it is likely that the sales of 
its For Research Use Only genetic testing products will provide 
sufficient commercialization to fund its operations.  The Company 
can not currently predict the success or market acceptance of its 
"For Research Use Only" HIV product.  There can be no assurance 
that the Company will ever achieve profitability or that its 
products will be marketed successfully or become commercially 
viable. There can be no assurance that the Company will not 
encounter substantial expenses related to further testing and 
development, regulatory compliance, production and marketing 
problems, and competition or defense of the Company's license and 
patent rights. 

As of August 5, 1996, the Company employed 14 full and part-time 
employees and engaged three contract personnel.  If the Company is 
successful in its development and marketing activities, the number 
of employees and temporary personnel will increase.  The number of 
such personnel will depend on the progress of the Company's 
efforts and cannot be forecast with certainty.

The foregoing plan of operation includes certain objectives of the 
Company, and there can be no assurance that these objectives will 
be achieved within the stated period, if at all.  Furthermore, 
this plan of operation is subject to change based on future events 
and circumstances, many of which are beyond the control of the 
Company.  See Forward Looking Statements below.

Results of Operations

The Company's net losses for the three month periods ended June 
30, 1995, March 31, 1996, and June 30, 1996 were $1,438,000, 
$776,000, and $797,000, respectively.  The decrease in losses from 
the 1995 period is principally the result of reduced activities in 
developing prenatal genetic testing products partially offset by 
increased research on Human Immunodeficiency Virus (HIV) 
products.  See the Company's Form 10-KSB for the year ended 
December 31, 1995 and the discussion below.  The Company expects 
to incur substantial operating losses into at least 1997 as it 
continues the activities discussed in Plan of Operations above.  
The Company expects to incur additional losses thereafter until 
such time, if ever, as there is sufficient commercialization of 
its products to offset its research and development activities.  
There can be no assurance that the Company will be able to achieve 
or sustain profitability.

Revenues for the three month periods ended June 30, 1995, March 
31, 1996, and June 30, 1996 were $8,000, $17,000 and $13,000, 
respectively.  Such amounts were obtained from Research Use Only 
sales of the Company's products.  For a discussion of the market 
potential for these products, see the Company's Form 10-KSB for 
the year ended December 31, 1995.  

Research and development expenditures have varied with the nature 
and scope of the Company's research activities.  These amounts 
include the costs of basic and product-related research, process 
development efforts, and costs associated with field trials.  
Research and development expenditures for the three month periods 
ended June 30, 1995, March 31, 1996, and June 30, 1996 were 
$960,000, $521,000 and $520,000, respectively.  The decrease from 
the second quarters of 1995 to the first and second quarter of 
1996 is principally attributable to reduced expenditures for 
development of an enrichment component to the Company's prenatal 
genetic testing product using fetal cells from maternal blood 
(GenSite).  While development efforts for the enrichment 
component of GenSite constituted a significant portion of the 
Company's resources prior to 1996, such efforts constituted a 
small portion of the Company's efforts in 1996.  During mid-1996, 
the Company ended its efforts for the development of its own 
enrichment system as well as any efforts to license the enrichment 
systems of others; both such efforts were ended in 1996 in 
conjunction with the Company's collaboration efforts with other 
companies developing enrichment systems.  

The Company expects the level of research and development 
expenditures, exclusive of acquisition costs, during the next 
twelve months to depend on its financial resources, the success of 
its development and testing activities for certain products, and 
market acceptance of its products and the need for product 
enhancements, and such expenditures may increase as a result of 
such activities.  Expenses could increase as a result of any 
additional acquisitions of intellectual property or other research 
costs.  

The cost of materials sold is currently included in research and 
development costs because such materials manufactured are 
principally used for development activities.  The costs associated 
with products sold in 1995 and 1996 were not material.

General and administrative expenses for the three month periods 
ended June 30, 1995, March 31, 1996, and June 30, 1996 were 
$500,000, $270,000 and $280,000, respectively.  The decrease from 
the second quarter of 1995 to the first and second quarters of 
1996 is principally attributable to reduced administrative, 
marketing and legal costs.  The Company's President, who resigned 
in September, 1995, was not replaced until April, 1996, reducing 
administrative expenses through March 31, 1996.  The Company 
eliminated two marketing and business development related 
positions in 1995 as a result of delays in the expected marketing 
of its prenatal genetic testing product, and instead relied upon 
part-time consulting arrangements to market its "Research Use 
Only" products in certain areas.  Additionally, legal expenses 
declined because of lower patent prosecution fees.  

The Company's selling expenses are included in selling, general 
and administrative expenses, but have not been material to date.  
The Company expects selling expenses to increase as the number of 
research-use-only products available for sale increases, as 
regulatory approvals of its products are obtained and the Company 
commences the commercialization of its products.  The Company 
currently intends to employ distributors for certain products, and 
selling expenses will vary depending upon the success of this 
strategy.

Interest expense for the three month periods ended June 30, 1995, 
March 31, 1996, and June 30, 1996 were $20,000, $15,000, and 
$27,000, respectively.  Such amounts are principally interest on 
capitalized leases, and the amounts declined from the second 
quarter of 1995 to the second quarter of 1996 as a result of the 
expiration of certain leases and principal payments on the 
remaining leases, partially offset by the $12,000 of interest 
expense on the Convertible Notes during the quarter ended June 30, 
1996.  Such amounts are payable upon maturity of the Convertible 
Notes.  See Part II  Other Information - Item 2.  Changes in 
Securities.

Interest income and other, net, for the three month periods ended 
June 30, 1995, March 31, 1996, and June 30, 1996 were $34,000, 
$13,000, and $16,000, respectively.  The decrease from the second 
quarter of 1995 is the result of lower funds available for 
investment.

Forward-Looking Statements

The statements contained in all parts of this document regarding 
future products and product developments, financial performance, 
future regulatory approvals, business strategies, market 
acceptance, business arrangements, and results and other 
statements which are not historical facts are forward-looking 
statements.  The words expect, project, estimate, predict, 
anticipate, beieves, and similar expressions are also intended 
to identify forward looking statements.  The forward looking 
statements involve risks and uncertainties, including, but not 
limited to, those relating to: the Company's products being in the 
early stage of development; uncertainty of developing markets; the 
need for additional financing and limited access to capital 
funding; the Company's limited operating history; its accumulated 
deficit and anticipated losses; government regulation (including 
that the Company's products are subject to extensive regulation 
and required government approvals, that there is no assurance of 
regulatory approvals and that failure to obtain such approvals 
will have an adverse effect; uncertainty of the type of, timing or 
receipt of FDA approval; that the Company will be subject to 
numerous international regulations and that other regulations may 
adversely affect the Company); the Company's reliance on 
distributors and collaborative partners; license patents and trade 
secrets (including the uncertainty of domestic and international 
patent protection, the possibility of patent infringement claims 
against the Company, the Company's reliance on trade secrets and 
proprietary know-how and that there is no assurance of 
confidentiality); the potential adverse effects of technological 
change and competition; potential of limited third-party 
reimbursement; use of hazardous materials; possibility of product 
liability claims; dependence on key personnel; limited 
manufacturing and marketing experience; uncertainty relating to 
health care reform measures; and other factors detailed in the 
Company's Securities and Exchange Commission filings. 



           PART II - OTHER INFORMATION


Item 2.  Changes in Securities

On June 12, 1996, Aprogenex, Inc. (the Company) completed the 
sale of $2,005,000 of convertible notes (the Convertible Notes) 
and warrants to acquire 130,323 shares of Common Stock, $.001 par 
value (the 1996 Warrants) in a private placement.  The following 
sections describe certain of the principal terms of the 
transaction and the securities.

Principal Terms of the Convertible Convertible Notes. 
  
On June 12, 1996, the Company issued $2,005,000 principal amount of 
Convertible Notes due on May 29, 1998.  

The Convertible Notes bear interest at the rate of 10% per annum, 
based on a 365 day year, compounded quarterly.  Interest is 
payable at maturity or upon prepayment.  

The Convertible Notes are convertible into Common Stock at the 
option of the holder at any time after the earlier of (i) the 
approval for listing by the American Stock Exchange (the "AMEX") 
of the Common Stock issuable upon conversion of the Convertible 
Notes, or (ii) if the Common Stock of the Company ceases to be 
listed for trading on the AMEX, on the day of such de-listing.  
However, the Convertible Notes may not be converted after the 
close of business on the fifth business day prior to either the 
scheduled maturity or any scheduled redemption.  

The Convertible Notes are convertible into Common Stock at a rate 
of one share of Common Sock for every $1.10 in principal and 
accrued interest (the "Conversion Price").  Accordingly, the 
Convertible Notes are initially convertible into a total of 
1,822,727 shares of Common Stock, but such number of shares will 
increase as a result of interest on the Convertible Notes and may 
be further adjusted by changes in the Conversion Price as set 
forth herein.  All or part of the principal amount of the 
Convertible Notes may be converted at the election of the holder, 
but accrued interest applicable to the converted principal amount 
will also be converted into Common Stock.

On the twentieth business day prior to the maturity date of the 
Convertible Notes (the Reset Date), the Conversion Price will be 
adjusted to the average of the closing price of the Common Stock 
on the AMEX (or such other trading forum as may be applicable at 
that time) for the ten trading days prior to the Reset Date (the 
Reset Conversion Price) if and only if such new Reset Conversion 
Price is lower than the then-current Conversion Price.  However, 
such price shall not be less than 50% of the then-Conversion 
Price.

The Convertible Notes contain provisions to protect the holders 
against dilution by adjusting the number of shares issuable upon 
conversion thereof.

The Company has the right to prepay principal and accrued interest 
upon twenty days notice to the holders of the Convertible Notes.  
However, the holders have the right to convert the Convertible 
Notes  into Common Stock as set forth above prior to such 
redemption.

On or prior to August 11, 1996, the Company intends to file a 
Registration Statement on Form S-3 to register the resale of 
Common Stock issuable upon conversion of the Convertible Notes.  

The principal and accrued interest of the Convertible Notes become 
immediately due and payable upon the insolvency of the Company, 
the commission of any act of bankruptcy by the Company, the 
execution by the Company of a general assignment for the benefit 
of creditors, the filing by or against the Company of any petition 
in bankruptcy or any petition for relief under the provisions of 
the federal bankruptcy act or any other state or federal law for 
the relief of debtors and the continuation of such petition 
without dismissal for a period of thirty (30) days or more, or the 
appointment of a receiver or trustee to take possession of the 
property or assets of the Company. 

Principal Terms of the 1996 Warrants.  

Warrants to acquire 
130,323 shares of Common Stock were issued in conjunction with the 
Convertible Notes, or warrants for approximately 6,500 shares for 
every $100,000 of principal.

The 1996 Warrants entitle the holders thereof to purchase Common 
Stock at $1.10 per share and are exercisable at any time after the 
earlier of (i) the approval for listing by the American Stock 
Exchange (the AMEX) of the Common Stock issuable upon exercise 
of the warrants, or (ii) if the Common Stock of the Company ceases 
to be listed for trading on the AMEX, on the day of such de-
listing, but such exercise must occur prior to the close of 
business on May 28, 1999.  The 1996 Warrants contain provisions to 
protect the holders thereof against dilution by adjusting the 
price at which the 1996 Warrants are exercisable and the number of 
shares issuable upon exercise thereof upon the occurrence of 
certain events.  Commencing September 10, 1996, the holders of the 
May Warrants will have piggyback registration rights to require 
the Company to include the Common Stock underlying such warrants 
in certain registration statements filed by the Company.

Purchases by Affiliates.  

A substantial part of the Convertible 
Notes and 1996 Warrants were purchased by existing stockholders 
and affiliates of the Company.  W.S. Farish and Company purchased 
$1,170,000 of Convertible Notes and 1996 Warrants to acquire 
76,050 shares of Common Stock.  W.S. Farish and Company was the 
beneficial owner of approximately 9.3% of the outstanding Common 
Stock prior to the purchase.  This purchase will increase the 
beneficial ownership of W.S. Farish and Company to approximately 
25.5% as of June 12, 1996.  Terry Ward is the Financial Vice 
President of W.S. Farish and Company, and is a director and 
Chairman of the Board of the Company.  Mr. Ward purchased $70,000 
of Convertible Notes and 1996 Warrants to acquire 4,550 shares of 
Common Stock.  Including the shares beneficially owned by W.S. 
Farish and Company, Mr. Ward beneficially owned 9.8% of the Common 
Stock of the Company prior to the purchase and 26.8% of the Common 
Stock after the purchase.  Mr. Ward disclaims such beneficial 
ownership of securities owned by W.S. Farish and Company.  
Additionally, Mr. W.S. Farish  and members of his family acquired 
$150,000 of the Convertible Notes and 1996 Warrants to acquire 
9,750 shares of Common Stock.  Mr. Farish is a director and 
stockholder in W.S. Farish and Company.  Further information with 
respect to the security ownership of purchasers of Convertible 
Notes and 1996 Warrants may be available through any filings of 
these parties pursuant to the Securities and Exchange Act of 1934.


Item 6.  Submission of Matters to a Vote of Security-
Holders

On July 12, 1996, the annual meeting of stockholders was held in 
Houston, Texas.  There were 5,200,598 shares of Common Stock and 
449,000 shares of Series A Convertible Preferred Stock (each of 
which is entitled to 4.26 votes) issued, outstanding and entitled 
to vote at the meeting.  Three items were acted upon by the 
stockholders.

The first action was the election of Directors of the Company.  
All of the nominees were elected in uncontested elections, and the 
votes cast for and against were as follow:
Nominees                              No. of Votes
                                 For            Withheld 
Dr. Michael E. Hogan            4,118,320        22,653
Christopher T. Kelly            4,118,320        22,653
David Leech                     4,118,320        22,653
J. Donald Payne                 4,118,320        22,653
Terry Ward                      4,118,320        22,653

The second action was the approval of the amended and restated 
Directors Stock Option Plan and the increase by 50,000 in the 
number shares of Common Stock authorized for issuance under the 
plan.  At the meeting, there were 3,681,308 votes for the approval 
of the increase, 425,315 votes against the approval of the 
increase, 34,350 votes abstained and no shares did not vote.

The final action was the approval of Arthur Andersen LLP as the 
independent public accountants for Aprogenex, Inc. for the Company 
for 1996.  At the meeting, there were 4,135,143 votes for the 
approval of Arthur Andersen LLP, 2,530 votes against, 3,300 votes 
abstained, and no shares did not vote.

Item 7.  Exhibits and Reports on Form 8-K
a.)  Exhibits

Exhibit 
Number      Document Description

4.1       Director Stock Option Plan, as Amended and Restated on 
          July 12, 1996.

4.2(a)*   Convertible Note Subscription Agreement dated as of 
          May 1, 1996 among Aprogenex, Inc. and the various 
          purchasers (Incorporated by reference from Exhibit 
          4.1(a) to the Company's Form 8-K dated as of June 12, 
          1996).

4.2(b)*   Form of Convertible Note dated as of June 12, 1996 
          (Incorporated by reference from Exhibit 4.1(b) to the 
          Company's Form 8-K dated as of June 12, 1996).

4.3*      Warrant Agreement dated as of May 1, 1996 among 
          Aprogenex, Inc. and the various warrantholders  
          (Incorporated by reference from Exhibit 4.2 to the 
          Company's Form 8-K dated as of June 12, 1996).

27        Financial Data Schedule.

* Incorporated by reference from a previous filing as indicated.

b.)  Reports on Form 8-K
A Form 8-K was filed as of April 1, 1996 regarding the appointment 
of David Leech to the Board of Directors and as Acting President 
and Chief Executive Officer.  Additionally, a Form 8-K was filed 
as of June 12, 1996 describing the sale of the Convertible Notes 
and 1996 Warrants.


                      SIGNATURES
In accordance with the requirements of the Exchange Act, the 
Company has caused this report to be signed on its behalf by the 
undersigned, thereunto duly authorized.

                                  Aprogenex, Inc.



August 8, 1996                   By:   /s/ J. Donald Payne
                                    --------------------------
                                   J. Donald Payne	
                                   Vice President - Finance and 
                                   Chief Financial Officer 
                                   (Principal Financial and 
                                   Accounting Officer)

                             Exhibit Index

Exhibit 
Number      Document Description

4.1       Director Stock Option Plan, as Amended and Restated on 
          July 12, 1996.

4.2(a)*   Convertible Note Subscription Agreement dated as of 
          May 1, 1996 among Aprogenex, Inc. and the various 
          purchasers (Incorporated by reference from Exhibit 
          4.1(a) to the Company's Form 8-K dated as of June 12, 
          1996).

4.2(b)*   Form of Convertible Note dated as of June 12, 1996 
          (Incorporated by reference from Exhibit 4.1(b) to the 
          Company's Form 8-K dated as of June 12, 1996).

4.3*      Warrant Agreement dated as of May 1, 1996 among 
          Aprogenex, Inc. and the various warrantholders  
          (Incorporated by reference from Exhibit 4.2 to the 
          Company's Form 8-K dated as of June 12, 1996).

27        Financial Data Schedule.

* Incorporated by reference from a previous filing as indicated.


                                   




                        EXHIBIT 4.1


                   APROGENEX, INC.

              DIRECTOR STOCK OPTION PLAN
         Amended and Restated as of July 12, 1996


1.  Purpose.  The purpose of this Director Stock Option Plan 
(the "Plan") of Aprogenex, Inc. (the "Company"), is to encourage 
ownership in the Company by outside directors of the Company whose 
services are considered essential to the Company's continued 
progress and thus to provide them with a further incentive to 
continue to serve as directors of the Company.  The Plan is also 
intended to assist the Company through utilization of the 
incentives provided by the Plan to attract and retain experienced 
and qualified candidates to fill vacancies in the Board which may 
occur in the future.  

2.  Administration.  The Plan will be administered by the Board 
of Directors (the "Board") of the Company.  Subject to the express 
provisions of the Plan, the Board will have complete authority to 
interpret the Plan; to prescribe, amend, and rescind rules and 
regulations relating to it; to determine the terms and provisions 
of the respective option agreements in accordance with the 
provisions of the Plan; and to make all other determinations 
necessary or advisable for the administration of the Plan.  The 
Board's determination on the matters referred to in this Section 2 
will be conclusive.

3.  Participation in the Plan.  The Directors of the Company 
who are not employees of the Company or any Parent or Subsidiary 
of the Company (within the meaning of Section 424(e) or (f) of the 
Internal Revenue Code of 1986, as amended) ("Eligible Directors") 
shall be eligible to participate in the Plan.  A director who is 
or has been an employee of the Company or any Parent or Subsidiary 
of the Company shall not be eligible to become an Eligible 
Director unless and until such director is elected to a new term 
of office as a director while no longer serving as an employee of 
the Company.

4.  Stock Subject to the Plan.  The stock subject to the Plan 
shall consist of 150,000 shares of the $0.001 par value common 
stock of the Company ("Common Stock").  Such shares may, as the 
Board shall from time to time determine, be either authorized and 
unissued shares of Common Stock or issued shares of Common Stock 
which have been reacquired by the Company.  If any option granted 
under the Plan expires or terminates for any reason without having 
been exercised in full, the shares subject to, but not delivered 
under, such option may again become available for the grant of 
other options under the Plan.

5.  Stock Options.  Each option granted under this Plan shall be 
evidenced by a written agreement in such form as the Board shall 
from time to time approve, which agreements shall comply with and 
be subject to the following terms and conditions:

A.  Option Grant Dates.  For each Eligible Director who is 
elected to the Board of Directors after the date of approval 
of the Plan, as amended and restated, by the stockholders of 
the Company (such date hereinafter referred to as the 
"Effective Date"), options shall be granted to each such 
Eligible Director on the day of his or her initial election 
or appointment to the Board of Directors (or, if such date 
falls on a non-business day, the first business day 
thereafter) (the "Grant Date").  If the election or 
appointment is subject to or conditioned upon the acceptance 
by the Eligible Director, then the Grant Date for all 
purposes herein (other than the determination of Fair Market 
Value as set forth in Section 5C herein) shall be such date 
of acceptance.  Initially, for each Eligible Director serving 
on the Effective Date, the Effective Date shall be the Grant 
Date for such Eligible Director.

B.  Number of Shares Earned.  On the Grant Date, each 
Eligible Director shall be awarded an option to purchase 
10,000 shares of Common Stock.  Such grant is a one-time 
grant and not an annual grant.

C.  Option Price per Share.  The  options granted 
hereunder shall be exercisable at a price per share equal to 
the Fair Market Value of the Common Stock on the Grant Date 
(except that for Eligible Directors whose term of service 
starts after the date of appointment or election, the date of 
such appointment or election shall be the date for 
determination of the Fair Market Value).  For purposes of 
this Plan, the "Fair Market Value" of a share on a particular 
date shall be deemed to be, (i) if the Common Stock is listed 
on a national securities exchange, the closing selling price 
per share of the Common Stock on any such national securities 
exchange on that date, as reported in The Wall Street Journal 
or, if there shall have been no such sale so reported on that 
date, on the last preceding date on which such a sale was so 
reported, or (ii) if the Common Stock is not so listed, the 
closing selling price (or, if not so reported, the mean 
between the closing bid and asked price) on that date, or, if 
there are no quotations available for such date, on the last 
preceding date on which such quotations shall be available, 
as reported by NASDAQ, or, if not reported by NASDAQ, by the 
National Quotation Bureau, Inc. 

D.  Options Nontransferable.  Each option granted under 
the Plan by its terms shall not be transferable by the 
optionee otherwise than by will, or by the laws of descent 
and distribution, and shall be exercisable during the 
lifetime of the optionee only by the optionee.  While living, 
no option or interest therein may be transferred, assigned, 
pledged, or hypothecated by the optionee, whether by 
operation of law or otherwise, or be made subject to 
execution, attachment, or similar process.

E.  Exercisability and Term of Options.  Each option 
granted under the Plan shall vest as follows: (i) options as 
to 5,000 shares shall vest and be exercisable on the first 
anniversary of the Grant Date; and (ii) options as to the 
remaining 5,000 shares shall vest and be exercisable on the 
second anniversary of the Grant Date.  If not previously 
exercised or forfeited pursuant to the provisions of Sections 
5F, 5G and 5H herein, such options shall expire on the fifth 
anniversary of the Grant Date.

F.  Termination of Status as a Director.  In the event 
of termination of an optionee's status as an Eligible 
Director (regardless of whether such termination is by 
resignation, removal, failure to nominate or reelect upon the 
end of any term or by becoming an employee of the Company) 
prior to such option or portion thereof becoming exercisable 
pursuant to the provisions of Section 5E or 5G herein, then 
such option or portion thereof which was not exercisable as 
of the date of such termination shall be forfeited.  Any 
portion of the option which was exercisable as of the date of 
such termination shall continue to be exercisable until the 
earlier of (i) the expiration of such option pursuant to 
Section 5E herein or (ii) six months after the death of such 
optionee pursuant to the provisions of section 5H herein.

G.  Disability of Optionee.  In the event of the total 
and permanent disability (as defined in Section 22(e)(3) of 
the Internal Revenue Code of 1986) of an Eligible Director, 
regardless of whether the Eligible Director continues to 
serve as a director of the Company, all of such option shall 
become fully exercisable and may be exercised at any time 
prior to the earlier of (i) the expiration of the option as 
set forth in Section 5E herein or (ii) six months after the 
death of such optionee pursuant to the provisions of section 
5H herein.  

H.  Death.  In the event of the death of an optionee during 
the term of the option who is at the time of his death an 
Eligible Director of the Company, the option shall become 
fully exercisable (regardless of the extent of the right to 
exercise that had accrued as of the date of death), and all 
of such option may be exercised at any time within six (6) 
months following the date of death, by the optionee's estate 
or by a person who acquired the right to exercise the Option 
by bequest or inheritance.  In the event of the death of an 
optionee during the term of the option who is not at the time 
of his death an Eligible Director of the Company, the option  
may be exercised at any time within six (6) months following 
the date of death, by the optionee's estate or by a person 
who acquired the right to exercise the Option by bequest or 
inheritance, but only to the extent that the right to 
exercise that had accrued as of the date of death.  However, 
in no event may an option be exercised after the expiration 
of such option pursuant to the provisions of section 5E 
herein.

I.  Exercise of Options.  Options may be exercised only by 
written notice to the Company at its corporate office 
accompanied by payment of the full consideration for the 
shares as to which they are exercised, including any federal, 
state and/or local income tax withholding amount due in 
connection with the exercise.  The purchase price, together 
with any income tax withholding amount due, is to be paid in 
full to the Company upon the exercise of the option by cash 
payment, which may take the form of a personal check payable 
to the order of the Company.

J.  Nonstatutory Options.  All options granted hereunder 
shall be non-statutory options not intended to qualify under 
Section 422 of the Internal Revenue Code of 1986, as amended 
(the "Code").

6.  Assignment.  The rights and benefits of a participant under 
this Plan may not be assigned and any attempted assignment of such 
rights and benefits shall be null and void.


7.  Limitation of Rights.  

A.  No Right to Continue as a Director.  Neither the Plan, 
nor the granting of an option nor any other action taken pursuant 
to the Plan, shall constitute or be evidence of any agreement or 
understanding, express or implied, that the Company will retain a 
Director for any period of time, or at any particular rate of 
compensation.

B.  No Stockholder's Rights for Optionees.  An optionee or 
the optionee's representative shall have no rights as a 
stockholder with respect to the shares covered by the options 
until the date of the issuance to the optionee or the optionee's 
representative of a stock certificate therefore, and no adjustment 
will be made for dividends or other rights for which the record 
date is prior to the date such certificate is issued.

8.  Changes in Present Stock.
 
A.  Corporate Acts.  The existence of outstanding options shall 
not affect in any manner the right or power of the Company or its 
stockholders to make or authorize any or all adjustments, 
recapitalizations, reorganizations or other changes in the capital 
stock of the Company or its business or any merger or 
consolidation of the Company, or any issue of bonds, debentures, 
preferred or prior preference stock (whether or not such issue is 
prior to, on a parity with or junior to the Common Stock) or the 
dissolution or liquidation of the Company, or any sale or transfer 
of all or any part of its assets or business, or any other 
corporate act or proceeding of any kind, whether or not of a 
character similar to that of the acts or proceedings enumerated 
above.  

B.  Adjustments.  In the event of any subdivision or 
consolidation of outstanding shares of Common Stock or declaration 
of a dividend payable in shares of Common Stock or capital 
reorganization or reclassification or other transaction involving 
an increase or reduction in the number of outstanding shares of 
Common Stock, the Board shall adjust proportionally (i) the number 
of shares of Common Stock reserved under this Plan and covered by 
outstanding options denominated in Common Stock; (ii) the exercise 
price in respect of such options; and (iii) the appropriate Fair 
Market Value and other price determinations for such options.  In 
the event of any consolidation or merger of the Company with 
another corporation or entity or the adoption by the Company of a 
plan of exchange affecting the Common Stock or any distribution to 
holders of Common Stock of securities or property (other than 
normal cash dividends or dividends payable in Common Stock), the 
Board shall make such adjustments as it may deem equitable, 
including adjustments to avoid fractional shares, to give proper 
effect to such event.  In the event of a corporate merger, 
consolidation, acquisition of property or stock, separation, 
reorganization or liquidation, the Board shall be authorized to 
issue or assume stock options, regardless of whether in a 
transaction to which Section 424(a) of the Code applies, by means 
of substitution of new options for previously issued options or an 
assumption of previously issued options.

9.  Effective Date, Transition for Current Directors, and 
Duration of the Plan.  

A.  Effective Date.  The Plan, as amended and restated, shall 
take effect on the date of approval of the Plan by the affirmative 
votes of the holders of a majority of the outstanding shares of 
the Company present, or represented, and entitled to vote at a 
meeting of the Company's stockholders, or by the written consent 
of the holders of a majority of the outstanding shares of the 
Company entitled to vote.  

B.  Transition Provisions.  Upon the adoption of the Plan as 
set forth herein, it is anticipated that current or previous 
Eligible Directors during 1996 would otherwise be entitled to 
compensation under the provisions of the Plan prior to its 
amendment and restatement.  For any Eligible Directors serving as 
a director as of such date of adoption, any authorized or 
anticipated grants of options for service in 1996 pursuant to the 
provisions of the Plan prior to such amendment and restatement 
shall be superseded by the provisions of this Plan as amended and 
restated.  For any Eligible Directors whose service as a director 
in 1996 terminated prior to such amendment and restatement, any 
authorized or anticipated grants of options pursuant to the 
provisions of the Plan prior to such amendment shall be made and 
governed by the provisions of this Plan prior to this amendment 
and restatement.  Any grants to Eligible Directors under the 
provisions of the Plan prior to this amendment and restatement 
shall continue to be governed by the provisions of the Plan before 
such amendment and restatement.

C.  Termination.  The Plan shall terminate when all Common Stock 
subject to the Plan is subject to an option to purchase (unless 
earlier discontinued by the Board) but such termination shall not 
affect the rights of the holder of any option outstanding on such 
date of termination.  If, on a date on which options would 
normally be granted, there is not a sufficient number of shares 
available to grant each person otherwise eligible to receive an 
option on that date an option to purchase the full number of 
shares to which he or she would normally be entitled, options 
shall be prorated among optionees according to the number of 
shares available on such date of grant.  Such optionees shall be 
deemed to have received the full amount due to them on such date 
of grant.  All options granted under the Plan are subject to and 
may not be exercised before.  

10.  Amendment of the Plan.  The Board may suspend or 
discontinue the Plan or revise or amend it in any respect 
whatsoever; provided, however, that to the extent required by Rule 
16b-3 under the Securities Exchange Act of 1934, as amended ("Rule 
16b-3"), the provisions of this Plan relating to the class of 
persons eligible to participate in this Plan and the amount, 
price, and timing of awards may not be amended more often than 
once every six months except to comport with changes in the Code, 
the Employee Retirement Income Security Act or rules promulgated 
thereunder; and provided, further, that no revision or amendment 
to the Plan shall be effective without stockholder approval to the 
extent required by Rule 16b-3.

11.  Requirements of Law.  The granting of options and the 
issuance of shares of Common Stock upon the exercise of an option 
shall be subject to all applicable laws, rules and regulations and 
to such approvals by any governmental agencies or national 
securities exchanges as may be required.

12.  Notice.  Any written notice to the Company required by any 
of the provisions of this Plan shall be addressed to the Secretary 
of the Company and shall become effective when it is received.

13.  Governing Law.  This Plan and all determinations made and 
actions taken pursuant hereto shall be governed by the law of the 
State of Delaware and construed accordingly.

APROGENEX, INC.

As approved by the Board of Directors
of the Company on May 30, 1996


/s/  J. Donald Payne
- --------------------
Secretary

As approved by the stockholders of the
Company on July 12, 1996


/s/  J. Donald Payne
- --------------------
Secretary


                                




<TABLE> <S> <C>

<ARTICLE> 5
<LEGEND>
This schedule contains summary financial information extracted from the
unaudited Balance Sheet as of June 30, 1996 and the unaudited Statement of
Operations for the six months ended June 30, 1996 and is qualified
in its entirety by reference to such financial statements.
</LEGEND>
       
<S>                             <C>
<PERIOD-TYPE>                   6-MOS
<FISCAL-YEAR-END>                          DEC-31-1996
<PERIOD-END>                               JUN-30-1996
<CASH>                                         1562219
<SECURITIES>                                         0
<RECEIVABLES>                                    90335
<ALLOWANCES>                                         0
<INVENTORY>                                          0
<CURRENT-ASSETS>                               1652554
<PP&E>                                          787857<F1>
<DEPRECIATION>                                       0
<TOTAL-ASSETS>                                 2568943
<CURRENT-LIABILITIES>                           527142
<BONDS>                                        2055605
                                0
                                        449
<COMMON>                                          5201
<OTHER-SE>                                     (19454)
<TOTAL-LIABILITY-AND-EQUITY>                   2568943
<SALES>                                          30581
<TOTAL-REVENUES>                                 30581
<CGS>                                                0
<TOTAL-COSTS>                                        0
<OTHER-EXPENSES>                                     0
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                               42022
<INCOME-PRETAX>                              (1572954)
<INCOME-TAX>                                         0
<INCOME-CONTINUING>                          (1572954)
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                 (1572954)
<EPS-PRIMARY>                                    (.30)
<EPS-DILUTED>                                    (.30)
<FN>
<F1>Net of accumulated depreciation.
</FN>
        

</TABLE>


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