APROGENEX INC
S-8, 1996-08-08
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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As filed with the Securities and Exchange Commission on August 8, 1996
                                          Registration 33-
               SECURITIES AND EXCHANGE COMMISSION
                    Washington, DC  20549
                    ---------------------
                           Form S-8
        REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933

                        Aprogenex, Inc.
     (Exact name of registrant as specified in its charter)
            Delaware                         76-0269632
(State or other jurisdiction of           (I.R.S. Employer 
 incorporation or organization)           Identification No.)
     8000 El Rio Street, 
       Houston, Texas                        77054-4104
(Address of Principal Executive Offices)     (Zip Code)
                        -------------------
                          APROGENEX, INC.
                    DIRECTOR STOCK OPTION PLAN
                     (Full title of the plan)
                        ------------------
                          J. Donald Payne
         Vice President - Finance, Chief Financial Officer
                      and Corporate Secretary
            8000 El Rio Street, Houston, Texas 77054-4104
              (Name and address of agent for service)
                           (713) 748-5114
   (Telephone number, including area code, of agent for service)
CALCULATION OF REGISTRATION FEE
==================================================================
                             Proposed    Proposed
Title of                     maximum     maximum     Amount
securities       Amount      offering    aggregate   of
to be            to be       price per   offering    registration
registered       registered  share (1)   price       fee (2)
- ------------------------------------------------------------------
Common Stock,    50,000       $1.00      $50,000      $18
 par value        shares
 $.001 per
 share
==================================================================
(1) Estimated pursuant to Rules 457(c) and (h) solely for purposes 
of computing the registration fee and based upon the average of 
the high and low sales prices reported on the American Stock 
Exchange on August 5, 1996.
(2) In accordance with Rule 429, an additional 100,000 shares of 
Common Stock, par value $.001 per share, are being carried forward 
from Registration Statement No. 33-94258.  The Registrant paid the 
filing fee of $196 associated with such shares on July 3, 1995.

Pursuant to Rule 429, the Prospectus to which this Registration 
Statement relates is a combined Prospectus that also relates to 
Registration Statement No. 33-94258 previously filed by the 
Registrant on Form S-8 on July 3, 1995.

                            PART I
       INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS
Note:  The document(s) containing the information concerning the 
Aprogenex, Inc. Director Stock Option Plan (the "Plan") required 
by Item 1 of Form S-8 under the Securities Act of 1933, as amended 
(the "Securities Act"), and the statement of availability of 
registrant information, Plan information and other information 
required by Item 2 of Form S-8 will be sent or given to 
participants as specified by Rule 428.  In accordance with Rule 
428 and the requirements of Part I of Form S-8, such documents are 
not being filed with the Securities and Exchange Commission (the 
"Commission") either as part of this Registration Statement or as 
prospectuses or prospectus supplements pursuant to Rule 424.  
Aprogenex, Inc. (the "Company" or the "Registrant") shall maintain 
a file of such documents in accordance with the provisions of Rule 
428.  Upon request, the Registrant shall furnish to the Commission 
or its staff a copy or copies of all of the documents included in 
such file.

                           PART II
       INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3.  Incorporation of Certain Documents by Reference.

The following documents, which the Company has filed with the 
Commission pursuant to the Securities Exchange Act of 1934, as 
amended (the "Exchange Act") (File No. 1-12416), are incorporated 
in this Registration Statement by reference and shall be deemed to 
be a part hereof:

(a)  The Company's Annual Report on Form 10-KSB for the year ended 
December 31, 1995;

(b)  The description of the Common Stock contained in the 
Company's Registration Statement on Form 8-A dated September 20, 
1993;

(c)  The Company's Quarterly Report on Form 10-QSB for the quarter 
ended March 31, 1996;

(d)  The Company's Quarterly Report on Form 10-QSB for the quarter 
ended June 30, 1996;

(e)  The Company's Current Reports on Form 8-K dated April 1, 1996 
and June 12, 1996; and

(f)  The Company's Proxy Statement dated as of June 7, 1996, 
relating to the annual meeting of stockholders held on July 
12,1996, as adjourned from June 24, 1996.

All documents filed by the Company with the Commission pursuant to 
sections 13(a), 13(c), 14 and 15(d) of the Exchange Act subsequent 
to the date of this Registration Statement and prior to the filing 
of a post-effective amendment of this Registration Statement which 
indicates that all securities offered hereby have been sold, or 
which deregisters all securities then remaining unsold, shall be 
deemed to be incorporated in this Registration Statement by 
reference and to be a part hereof from the date of filing of such 
documents.

Any statement contained in this Registration Statement, in an 
amendment hereto or in a document incorporated by reference herein 
shall be deemed to be modified or superseded for purposes of the 
Registration Statement to the extent that a statement contained 
herein or in any subsequently filed supplement to this 
Registration Statement or in any document that also is 
incorporated by reference herein modifies or supersedes such 
statement.  Any statement so modified or superseded shall not be 
deemed, except as so modified or superseded, to constitute a part 
of the Registration Statement.

Item 4.  Description of Securities.

Not applicable.

Item 5.  Interests of Named Experts and Counsel.

Not applicable.

Item 6.  Indemnification of Directors and Officers.

The Restated Certificate of Incorporation, as amended, of the 
Company limits the personal liability of directors of the Company 
to the Company or its stockholders for monetary damages for breach 
of fiduciary duty as a director to the fullest extent permitted by 
Delaware law.  Specifically, directors of the Company will not be 
personally liable for monetary damages for breach of a directors' 
fiduciary duty as a director, except for liability (i) for any 
breach of the director's duty of loyalty to the Company or its 
stockholders, (ii) for acts or omissions not in good faith or 
which involve intentional misconduct or a knowing violation of 
law, (iii) under Section 174 of the Delaware General Corporation 
Law, which relates to unlawful payments of dividends or unlawful 
stock repurchases or redemptions or (iv) for any transaction from 
which the director derived an improper personal benefit.  The 
Delaware General Corporation Law does not eliminate a directors' 
duty of care and has no effect on the availability of equitable 
remedies such as injunction or rescission based upon a director's 
breach of the duty of care.

Section 145 of the Delaware General Corporation Law permits a 
Delaware corporation to indemnify any persons who are, or are 
threatened to be made, parties to any threatened, pending or 
completed legal action, suit or proceeding, whether civil, 
criminal, administrative or investigative (other than an action by 
or in the right of such corporation), by reason of the fact that 
such person is or was a director, officer, employee or agent of 
such corporation, or is or was serving at the request of such 
corporation as a director, officer, employee or agent of another 
corporation or enterprise.  The indemnity may include expenses 
(including attorneys' fees), judgments, fines and amounts paid in 
settlement actually and reasonably incurred by such person in 
connection with such action, suit or proceeding, provided that 
such officer or director acted in good faith and in a manner he 
reasonably believed to be in or not opposed to the corporation's 
best interests, or, for criminal proceedings, had no reasonable 
cause to believe his conduct was illegal.  A Delaware corporation 
may indemnify officers and directors in an action by or in the 
right of the corporation under the same conditions, except that no 
indemnification is permitted without judicial approval if the 
officer or director is adjudged to be liable to the corporation in 
the performance of his duty.  Where an officer or director is 
successful on the merits or otherwise in the defense of any action 
referred to above, the corporation must indemnify him against the 
expenses which such officer or director actually and reasonably 
incurred.

The Company's Bylaws provide for the indemnification of its 
executive officers and directors, and the advancement to them of 
expenses in connection with proceedings and claims, to the fullest 
extent permitted by the Delaware General Corporation Law.  The 
Bylaws include related provisions meant to facilitate the 
indemnitees' receipt of such benefits.  These provisions cover, 
among other things  (i) specification of the method of determining 
entitlement to indemnification and the selection of independent 
counsel that will in some cases make such determination, (ii) 
specification of certain time periods by which certain payments or 
determinations must be made and actions must be taken and (iii) 
the establishment of certain presumptions in favor of an 
indemnitee.  The benefits of certain of these provisions are 
available to an indemnitee only if there has been a change in 
control (as defined).

The Company has obtained directors' and officers' liability 
insurance.  The policy covers certain claims of up to $1 million 
per occurrence and $1 million in the aggregate.

Item 7.  Exemption from Registration Claimed.

Not applicable.

Item 8.  Exhibits.

Exhibits incorporated by reference to a prior filing are 
designated by an asterisk (*).

Exhibit
Number	Description

4.1*      Amended and Restated Certificate of Incorporation of the 
          Company.  (Incorporated by reference from Exhibit 3.1 to 
          the Company's Registration Statement on Form SB-2, Reg. 
          No. 33-66586-FW, declared effective October 15, 1993).

4.2*      Certificate of Amendment of Amended and Restated 
          Certificate of Incorporation of Aprogenex, Inc. 
          effective as of  June 10, 1994 (Incorporated by 
          reference from Exhibit 3.1 to the Company's Form 10-QSB 
          for the quarterly period ended June 30, 1994).

4.3*      Certificate of Designations of Series A Convertible 
          Preferred Stock effective May 26, 1995 (Incorporated by
          reference from Exhibit 4.4 to the Company's Registration 
          Statement on Form S3, Reg No. 33-95014, filed July 26, 
          1995).

4.4*      Bylaws of the Company (Incorporated by reference from 
          Exhibit 4-3 to the Company's Registration Statement on 
          Form S-3, Reg. No. 33-90514, filed on July 26, 1995).

4.5*      Form of Certificate of Common Stock.  (Incorporated by
          reference from Exhibit 4.1 to the Company's Registration
          Statement on Form SB-2, Reg. No. 33-66586-FW, declared 
          effective October 15, 1993.)

4.6*      Convertible Note Subscription Agreement dated as of 
          May 1, 1996 among Aprogenex, Inc. and the various
          purchasers (Incorporated by reference from Exhibit
          4.1(a) to the Company's Form 8-K dated as of June 12,
          1996).

4.7*      Form of Convertible Note dated as of June 12, 1996
          (Incorporated by reference from Exhibit 4.1(b) to the 
          Company's Form 8-K dated as of June 12, 1996).

4.8*      Director Stock Option Plan, as in effect prior to 
          July 12, 1996 (Incorporated by reference from Exhibit
          4.6 to the Company's Registration Statement on Form S-8,
          Reg. No. 33-94258, filed on July 3, 1995).

4.9       Director Stock Option Plan, as Amended and Restated on 
          July 12, 1996.

5         Opinion of Baker and Botts, L.L.P.

23.1      Consent of Baker and Botts, L.L.P. (included in 
          Exhibit 5).

23.2      Consent of Arthur Andersen LLP.
- -------------

Item 9.  Undertakings.

(a)  The Company hereby undertakes:

(1)  To file, during any period in which it offers or sells 
securities, a post-effective amendment to this Registration 
Statement:
     (i)  To include any prospectus required by Section 10(a)(3) 
of the Securities Act;
     (ii)  To reflect in the prospectus any facts or events which, 
individually or together, represent a fundamental change in the 
information set forth in the Registration Statement;
(iii)  To include any additional or changed material information 
with respect to the plan of distribution;

provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) of 
this Item do not apply if the information required to be included 
in a post-effective amendment by those paragraphs is incorporated 
by reference in the Registration Statement from periodic reports 
filed as a small business issuer under the Exchange Act.

(2)  For purposes of determining any liability under the 
Securities Act, it will treat each filing of a post-effective 
amendment to this Registration Statement as a new registration 
statement of the securities offered therein, and the offering of 
such securities at that time shall be deemed to be the initial 
bona fide offering thereof.

(3)  To file a post-effective amendment to remove from 
registration any of the securities that remain unsold at the end 
of the offering.

(b)  Insofar as indemnification for liabilities arising under the 
Securities Act may be permitted to directors, officers and 
controlling persons of the Company pursuant to the foregoing 
provision, or otherwise, the Company has been advised that in the 
opinion of the Commission such indemnification is against public 
policy as expressed in the Securities Act and is, therefore, 
unenforceable.  In the event that a claim for indemnification 
against such liabilities (other than the payment by the Company of 
expenses incurred or paid by a director, officer or controlling 
person of the Company in the successful defense of any action, 
suit or proceeding) is asserted by such director, officer or 
controlling person in connection with the securities being 
registered, the Company will, unless in the opinion of its counsel 
the matter has been settled by controlling precedent, submit to a 
court of appropriate jurisdiction the question whether such 
indemnification by it is against public policy as expressed in the 
Securities Act and will be governed by the final adjudication of 
such issue.


                          SIGNATURES

Pursuant to the requirements of the Securities Act of 1933, the 
Registrant certifies that it has reasonable grounds to believe 
that it meets all of the requirements for filing on Form S-8 and 
has duly caused this Registration Statement to be signed on its 
behalf by the undersigned, thereunto duly authorized, in the City 
of Houston, the State of Texas, on August 8, 1996.

                               Aprogenex, Inc.


                           By: /s/ J. Donald Payne
                              ----------------------------
                              J. Donald Payne
                              Vice President-Finance

Pursuant to the requirements of the Securities Act of 1933, this 
Registration Statement has been signed by the following persons in 
the capacities indicated and on the date indicated.

DATED:  August 8, 1996     BY: /s/ David Leech	
                              ----------------------------
                              David Leech
                              President, Chief Executive Officer
                              and Director (Principal Executive 
                              Officer and Director)

DATED:  August 8, 1996     BY: /s/ Michael Hogan
                              ----------------------------
                              Michael Hogan
                              Director

DATED:  August 8, 1996     BY: /s/ Christopher Kelly
                              ----------------------------
                              Christopher Kelly
                              Director 

DATED:  August 8, 1996     BY: /s/ Terry Ward
                              ----------------------------
                              Terry Ward
                              Director 

DATED:  August 8, 1996     BY: / s/ J. Donald Payne
                              ----------------------------
                              J. Donald Payne
                              Vice President - Finance, 
                              Chief Financial Officer and 
                              Corporate Secretary and Director 
                              (Principal Financial and Accounting
                              Officer) 


                        EXHIBIT INDEX


Exhibits incorporated by reference to a prior filing are 
designated by an asterisk (*).

Exhibit
Number     Description

4.1*     Amended and Restated Certificate of Incorporation of the 
         Company.  (Incorporated by reference from Exhibit 3.1 to 
         the Company's Registration Statement on Form SB-2, 
         Reg. No. 33-66586-FW, declared effective October 15,
         1993).

4.2*     Certificate of Amendment of Amended and Restated 
         Certificate of Incorporation of Aprogenex, Inc. effective 
         as of  June 10, 1994 (Incorporated by reference from 
         Exhibit 3.1 to the Company's Form 10-QSB for the 
         quarterly period ended June 30, 1994).

4.3*     Certificate of Designations of Series A Convertible 
         Preferred Stock effective May 26, 1995 (Incorporated by 
         reference from Exhibit 4.4 to the Company's Registration
         Statement on Form S3, Reg No. 33-95014, filed July 26, 
         1995).

4.4*     Bylaws of the Company (Incorporated by reference from 
         Exhibit 4-3 to the Company's Registration Statement on 
         Form S-3, Reg. No. 33-90514, filed on July 26, 1995).

4.5*     Form of Certificate of Common Stock.  (Incorporated by 
         reference from Exhibit 4.1 to the Company's Registration 
         Statement on Form SB-2, Reg. No. 33-66586-FW, declared 
         effective October 15, 1993.)

4.6*     Convertible Note Subscription Agreement dated as of 
         May 1, 1996 among Aprogenex, Inc. and the various 
         purchasers (Incorporated by reference from Exhibit 4.1(a)
         to the Company's Form 8-K dated as of June 12, 1996).

4.7*     Form of Convertible Note dated as of June 12, 1996 
         (Incorporated by reference from Exhibit 4.1(b) to the 
         Company's Form 8-K dated as of June 12, 1996).

4.8*     Director Stock Option Plan, as in effect prior to 
         July 12, 1996 (Incorporated by reference from Exhibit 
         4.6 to the Company's Registration Statement on Form S-8,
         Reg. No. 33-94258, filed on July 3, 1995).

4.9      Director Stock Option Plan, as Amended and Restated on 
         July 12, 1996.

5        Opinion of Baker and Botts, L.L.P.

23.1     Consent of Baker and Botts, L.L.P. (included in 
         Exhibit 5).

23.2     Consent of Arthur Andersen LLP.


 




                        EXHIBIT 4.9


                      APROGENEX, INC.

              DIRECTOR STOCK OPTION PLAN
         Amended and Restated as of July 12, 1996


1.  Purpose.  The purpose of this Director Stock Option Plan 
(the "Plan") of Aprogenex, Inc. (the "Company"), is to encourage 
ownership in the Company by outside directors of the Company whose 
services are considered essential to the Company's continued 
progress and thus to provide them with a further incentive to 
continue to serve as directors of the Company.  The Plan is also 
intended to assist the Company through utilization of the 
incentives provided by the Plan to attract and retain experienced 
and qualified candidates to fill vacancies in the Board which may 
occur in the future.  

2.  Administration.  The Plan will be administered by the Board 
of Directors (the "Board") of the Company.  Subject to the express 
provisions of the Plan, the Board will have complete authority to 
interpret the Plan; to prescribe, amend, and rescind rules and 
regulations relating to it; to determine the terms and provisions 
of the respective option agreements in accordance with the 
provisions of the Plan; and to make all other determinations 
necessary or advisable for the administration of the Plan.  The 
Board's determination on the matters referred to in this Section 2 
will be conclusive.

3.  Participation in the Plan.  The Directors of the Company 
who are not employees of the Company or any Parent or Subsidiary 
of the Company (within the meaning of Section 424(e) or (f) of the 
Internal Revenue Code of 1986, as amended) ("Eligible Directors") 
shall be eligible to participate in the Plan.  A director who is 
or has been an employee of the Company or any Parent or Subsidiary 
of the Company shall not be eligible to become an Eligible 
Director unless and until such director is elected to a new term 
of office as a director while no longer serving as an employee of 
the Company.

4.  Stock Subject to the Plan.  The stock subject to the Plan 
shall consist of 150,000 shares of the $0.001 par value common 
stock of the Company ("Common Stock").  Such shares may, as the 
Board shall from time to time determine, be either authorized and 
unissued shares of Common Stock or issued shares of Common Stock 
which have been reacquired by the Company.  If any option granted 
under the Plan expires or terminates for any reason without having 
been exercised in full, the shares subject to, but not delivered 
under, such option may again become available for the grant of 
other options under the Plan.

5.  Stock Options.  Each option granted under this Plan shall be 
evidenced by a written agreement in such form as the Board shall 
from time to time approve, which agreements shall comply with and 
be subject to the following terms and conditions:

A.  Option Grant Dates.  For each Eligible Director who is 
elected to the Board of Directors after the date of approval 
of the Plan, as amended and restated, by the stockholders of 
the Company (such date hereinafter referred to as the 
"Effective Date"), options shall be granted to each such 
Eligible Director on the day of his or her initial election 
or appointment to the Board of Directors (or, if such date 
falls on a non-business day, the first business day 
thereafter) (the "Grant Date").  If the election or 
appointment is subject to or conditioned upon the acceptance 
by the Eligible Director, then the Grant Date for all 
purposes herein (other than the determination of Fair Market 
Value as set forth in Section 5C herein) shall be such date 
of acceptance.  Initially, for each Eligible Director serving 
on the Effective Date, the Effective Date shall be the Grant 
Date for such Eligible Director.

B.  Number of Shares Earned.  On the Grant Date, each 
Eligible Director shall be awarded an option to purchase 
10,000 shares of Common Stock.  Such grant is a one-time 
grant and not an annual grant.

C.  Option Price per Share.  The  options granted 
hereunder shall be exercisable at a price per share equal to 
the Fair Market Value of the Common Stock on the Grant Date 
(except that for Eligible Directors whose term of service 
starts after the date of appointment or election, the date of 
such appointment or election shall be the date for 
determination of the Fair Market Value).  For purposes of 
this Plan, the "Fair Market Value" of a share on a particular 
date shall be deemed to be, (i) if the Common Stock is listed 
on a national securities exchange, the closing selling price 
per share of the Common Stock on any such national securities 
exchange on that date, as reported in The Wall Street Journal 
or, if there shall have been no such sale so reported on that 
date, on the last preceding date on which such a sale was so 
reported, or (ii) if the Common Stock is not so listed, the 
closing selling price (or, if not so reported, the mean 
between the closing bid and asked price) on that date, or, if 
there are no quotations available for such date, on the last 
preceding date on which such quotations shall be available, 
as reported by NASDAQ, or, if not reported by NASDAQ, by the 
National Quotation Bureau, Inc. 

D.  Options Nontransferable.  Each option granted under 
the Plan by its terms shall not be transferable by the 
optionee otherwise than by will, or by the laws of descent 
and distribution, and shall be exercisable during the 
lifetime of the optionee only by the optionee.  While living, 
no option or interest therein may be transferred, assigned, 
pledged, or hypothecated by the optionee, whether by 
operation of law or otherwise, or be made subject to 
execution, attachment, or similar process.

E.  Exercisability and Term of Options.  Each option 
granted under the Plan shall vest as follows: (i) options as 
to 5,000 shares shall vest and be exercisable on the first 
anniversary of the Grant Date; and (ii) options as to the 
remaining 5,000 shares shall vest and be exercisable on the 
second anniversary of the Grant Date.  If not previously 
exercised or forfeited pursuant to the provisions of Sections 
5F, 5G and 5H herein, such options shall expire on the fifth 
anniversary of the Grant Date.

F.  Termination of Status as a Director.  In the event 
of termination of an optionee's status as an Eligible 
Director (regardless of whether such termination is by 
resignation, removal, failure to nominate or reelect upon the 
end of any term or by becoming an employee of the Company) 
prior to such option or portion thereof becoming exercisable 
pursuant to the provisions of Section 5E or 5G herein, then 
such option or portion thereof which was not exercisable as 
of the date of such termination shall be forfeited.  Any 
portion of the option which was exercisable as of the date of 
such termination shall continue to be exercisable until the 
earlier of (i) the expiration of such option pursuant to 
Section 5E herein or (ii) six months after the death of such 
optionee pursuant to the provisions of section 5H herein.

G.  Disability of Optionee.  In the event of the total 
and permanent disability (as defined in Section 22(e)(3) of 
the Internal Revenue Code of 1986) of an Eligible Director, 
regardless of whether the Eligible Director continues to 
serve as a director of the Company, all of such option shall 
become fully exercisable and may be exercised at any time 
prior to the earlier of (i) the expiration of the option as 
set forth in Section 5E herein or (ii) six months after the 
death of such optionee pursuant to the provisions of section 
5H herein.  

H.  Death.  In the event of the death of an optionee during 
the term of the option who is at the time of his death an 
Eligible Director of the Company, the option shall become 
fully exercisable (regardless of the extent of the right to 
exercise that had accrued as of the date of death), and all 
of such option may be exercised at any time within six (6) 
months following the date of death, by the optionee's estate 
or by a person who acquired the right to exercise the Option 
by bequest or inheritance.  In the event of the death of an 
optionee during the term of the option who is not at the time 
of his death an Eligible Director of the Company, the option  
may be exercised at any time within six (6) months following 
the date of death, by the optionee's estate or by a person 
who acquired the right to exercise the Option by bequest or 
inheritance, but only to the extent that the right to 
exercise that had accrued as of the date of death.  However, 
in no event may an option be exercised after the expiration 
of such option pursuant to the provisions of section 5E 
herein.

I.  Exercise of Options.  Options may be exercised only by 
written notice to the Company at its corporate office 
accompanied by payment of the full consideration for the 
shares as to which they are exercised, including any federal, 
state and/or local income tax withholding amount due in 
connection with the exercise.  The purchase price, together 
with any income tax withholding amount due, is to be paid in 
full to the Company upon the exercise of the option by cash 
payment, which may take the form of a personal check payable 
to the order of the Company.

J.  Nonstatutory Options.  All options granted hereunder 
shall be non-statutory options not intended to qualify under 
Section 422 of the Internal Revenue Code of 1986, as amended 
(the "Code").

6.  Assignment.  The rights and benefits of a participant under 
this Plan may not be assigned and any attempted assignment of such 
rights and benefits shall be null and void.


7.  Limitation of Rights.  

A.  No Right to Continue as a Director.  Neither the Plan, 
nor the granting of an option nor any other action taken pursuant 
to the Plan, shall constitute or be evidence of any agreement or 
understanding, express or implied, that the Company will retain a 
Director for any period of time, or at any particular rate of 
compensation.

B.  No Stockholder's Rights for Optionees.  An optionee or 
the optionee's representative shall have no rights as a 
stockholder with respect to the shares covered by the options 
until the date of the issuance to the optionee or the optionee's 
representative of a stock certificate therefore, and no adjustment 
will be made for dividends or other rights for which the record 
date is prior to the date such certificate is issued.

8.  Changes in Present Stock.
 
A.  Corporate Acts.  The existence of outstanding options shall 
not affect in any manner the right or power of the Company or its 
stockholders to make or authorize any or all adjustments, 
recapitalizations, reorganizations or other changes in the capital 
stock of the Company or its business or any merger or 
consolidation of the Company, or any issue of bonds, debentures, 
preferred or prior preference stock (whether or not such issue is 
prior to, on a parity with or junior to the Common Stock) or the 
dissolution or liquidation of the Company, or any sale or transfer 
of all or any part of its assets or business, or any other 
corporate act or proceeding of any kind, whether or not of a 
character similar to that of the acts or proceedings enumerated 
above.  

B.  Adjustments.  In the event of any subdivision or 
consolidation of outstanding shares of Common Stock or declaration 
of a dividend payable in shares of Common Stock or capital 
reorganization or reclassification or other transaction involving 
an increase or reduction in the number of outstanding shares of 
Common Stock, the Board shall adjust proportionally (i) the number 
of shares of Common Stock reserved under this Plan and covered by 
outstanding options denominated in Common Stock; (ii) the exercise 
price in respect of such options; and (iii) the appropriate Fair 
Market Value and other price determinations for such options.  In 
the event of any consolidation or merger of the Company with 
another corporation or entity or the adoption by the Company of a 
plan of exchange affecting the Common Stock or any distribution to 
holders of Common Stock of securities or property (other than 
normal cash dividends or dividends payable in Common Stock), the 
Board shall make such adjustments as it may deem equitable, 
including adjustments to avoid fractional shares, to give proper 
effect to such event.  In the event of a corporate merger, 
consolidation, acquisition of property or stock, separation, 
reorganization or liquidation, the Board shall be authorized to 
issue or assume stock options, regardless of whether in a 
transaction to which Section 424(a) of the Code applies, by means 
of substitution of new options for previously issued options or an 
assumption of previously issued options.

9.  Effective Date, Transition for Current Directors, and 
Duration of the Plan.  

A.  Effective Date.  The Plan, as amended and restated, shall 
take effect on the date of approval of the Plan by the affirmative 
votes of the holders of a majority of the outstanding shares of 
the Company present, or represented, and entitled to vote at a 
meeting of the Company's stockholders, or by the written consent 
of the holders of a majority of the outstanding shares of the 
Company entitled to vote.  

B.  Transition Provisions.  Upon the adoption of the Plan as 
set forth herein, it is anticipated that current or previous 
Eligible Directors during 1996 would otherwise be entitled to 
compensation under the provisions of the Plan prior to its 
amendment and restatement.  For any Eligible Directors serving as 
a director as of such date of adoption, any authorized or 
anticipated grants of options for service in 1996 pursuant to the 
provisions of the Plan prior to such amendment and restatement 
shall be superseded by the provisions of this Plan as amended and 
restated.  For any Eligible Directors whose service as a director 
in 1996 terminated prior to such amendment and restatement, any 
authorized or anticipated grants of options pursuant to the 
provisions of the Plan prior to such amendment shall be made and 
governed by the provisions of this Plan prior to this amendment 
and restatement.  Any grants to Eligible Directors under the 
provisions of the Plan prior to this amendment and restatement 
shall continue to be governed by the provisions of the Plan before 
such amendment and restatement.

C.  Termination.  The Plan shall terminate when all Common Stock 
subject to the Plan is subject to an option to purchase (unless 
earlier discontinued by the Board) but such termination shall not 
affect the rights of the holder of any option outstanding on such 
date of termination.  If, on a date on which options would 
normally be granted, there is not a sufficient number of shares 
available to grant each person otherwise eligible to receive an 
option on that date an option to purchase the full number of 
shares to which he or she would normally be entitled, options 
shall be prorated among optionees according to the number of 
shares available on such date of grant.  Such optionees shall be 
deemed to have received the full amount due to them on such date 
of grant.  All options granted under the Plan are subject to and 
may not be exercised before.  

10.  Amendment of the Plan.  The Board may suspend or 
discontinue the Plan or revise or amend it in any respect 
whatsoever; provided, however, that to the extent required by Rule 
16b-3 under the Securities Exchange Act of 1934, as amended ("Rule 
16b-3"), the provisions of this Plan relating to the class of 
persons eligible to participate in this Plan and the amount, 
price, and timing of awards may not be amended more often than 
once every six months except to comport with changes in the Code, 
the Employee Retirement Income Security Act or rules promulgated 
thereunder; and provided, further, that no revision or amendment 
to the Plan shall be effective without stockholder approval to the 
extent required by Rule 16b-3.

11.  Requirements of Law.  The granting of options and the 
issuance of shares of Common Stock upon the exercise of an option 
shall be subject to all applicable laws, rules and regulations and 
to such approvals by any governmental agencies or national 
securities exchanges as may be required.

12.  Notice.  Any written notice to the Company required by any 
of the provisions of this Plan shall be addressed to the Secretary 
of the Company and shall become effective when it is received.

13.  Governing Law.  This Plan and all determinations made and 
actions taken pursuant hereto shall be governed by the law of the 
State of Delaware and construed accordingly.

APROGENEX, INC.

As approved by the Board of Directors
of the Company on May 30, 1996


/s/  J. Donald Payne
- --------------------
Secretary

As approved by the stockholders of the
Company on July 12, 1996


/s/  J. Donald Payne
- --------------------
Secretary


                                




BAKER & BOTTS
L.L.P.
ONE SHELL PLAZA
910 LOUISIANA
HOUSTON, TEXAS 77002-4995


G-54,581                                          August 8, 1996




Aprogenex, Inc.
8000 El Rio Street
Houston, Texas  77054-4104


Gentlemen:

As set forth in the Registration Statement on Form S-8 (the 
"Registration Statement") to be filed by Aprogenex, Inc., a 
Delaware corporation (the "Company"), with the Securities and 
Exchange Commission under the Securities Act of 1933, as amended 
(the "Securities Act"), relating to 50,000 shares (the "Shares") 
of common stock, par value $.001 per share, of the Company, 
subject to issuance pursuant to the terms of the Aprogenex, Inc. 
Director Stock Option Plan (the "Plan"), certain legal matters in 
connection with the Shares are being passed upon for the Company 
by us.  At your request, this opinion is being furnished to you 
for filing as Exhibit 5 to the Registration Statement.

In our capacity as your counsel in the connection referred to 
above, we have familiarized ourselves with the Company's Amended 
and Restated Certificate of Incorporation and Bylaws, each as 
amended to date, and have examined the originals, or copies 
certified or otherwise identified, of corporate records of the 
Company, including minute books of the Company as furnished to us 
by the Company, certificates of public officials and of 
representatives of the Company, statutes and other instruments and 
documents as a basis for the opinions hereinafter expressed.  In 
giving such opinions, we have relied upon certificates of officers 
of the Company with respect to the accuracy of the material 
factual matters contained in such certificates.

We have assumed that all signatures on all documents examined by 
us are genuine, that all documents submitted to us as originals 
are authentic, that all documents submitted to us as copies are 
true and correct copies of the originals thereof and that all 
information submitted to us was accurate and complete.

On the basis of the foregoing, and subject to the assumptions, 
limitations and qualifications hereinafter set forth, we are of 
the opinion that upon the issuance of and payment for the Shares 
in accordance with the terms and provisions of the Plan, the 
Shares will be duly authorized, validly issued, fully paid and 
nonassessable.


Aprogenex, Inc.                 -2-                August 8, 1996




The opinions set forth above are limited to the laws of Texas and 
Delaware and the applicable federal laws of the United States.

We hereby consent to the filing of this opinion as an exhibit to 
the Registration Statement.


                                  Very truly yours,



                                  /s/ Baker & Botts, L.L.P.


GJO; MLW



                       EXHIBIT 23.2



CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS

As independent public accountant, we hereby consent to the 
incorporation by reference in this Form S-8 Registration Statement 
of our report dated February 2, 1996, included in Aprogenex, 
Inc.'s Form 10-KSB for the year ended December 31, 1995, and to 
all references to our firm included in this registration 
statement.




/s/ ARTHUR ANDERSEN LLP
- --------------------------
Houston, Texas
August 8, 1996


 





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