OXIGENE INC
4, 1999-03-10
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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   FORM 4
__ Check this box if no
   longer subject to
   Section 16. Form 4
   or Form 5 obligations
   may continue. See
   Instruction 1(b).
   (Print or type Responses)
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                UNITED STATES SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                  STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

    Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934.
Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(f)
                     of the Investment Company Act of 1940.


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           OMB Approval
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   OMB Number:  3235-0287
   Expires:     September 30, 1998
   Estimated average burden
   hours per response...0.5
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<TABLE>
<CAPTION>
- --------------------------------------------------- ------------------------------------------------------ -------------------------
1.  Name and Address of        2. Issuer Name and Ticker or Trading Symbol  6. Relationship of Reporting Person(s) to Issuer
    Reporting Person*                                                                             (Check all applicable)
                                                                            X  Director                    __  10% Owner
                                                                            __  Officer (give title below)  __ Other (specify below)
SODERBERG, Per-Olof            OXiGENE, Inc. (OXGN)
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(Last)        (First)   (Middle)               3. IRS or Social        4. Statement for    7. Individual or Joint/Group Reporting
                                                  Security Number of      Month/Year                 (check applicable line)
                                                  Reporting Person                         X  Form Filed by One Reporting Person
                                                  (Voluntary)             02/99            __ Form Filed by More than One Reporting
                                                                                              Person
c/o OXiGENE, Inc.
One Copley Place, Suite 602
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                  (Street)                                             5. If Amendment,
                                                                          Date of Original
                                                                          (Month/Year)

Boston, MA 02116
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(City)         (State)       (Zip)         Table 1 -- Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
<S>                       <C>         <C>              <C>                         <C>                <C>             <C>
- ------------------------------------------ ------------- ----------------- ---------------------------------------------------------
1. Title of Security      2. Trans-   3. Transaction    4. Securities Acquired (A)  5. Amount of      6. Ownership    7. Nature of
   (Instr. 3)                action      Code (Instr.      or Disposed of (D)          Securities        Form:           Indirect
                             Date        8)                (Instr. 3, 4 and 5)         Beneficially      Direct (D)      Beneficial
                             (Month/                                                   Owned at End      or Indirect     Ownership
                             Day/                                                      of Month          (I)             (Instr. 4)
                             Year)                                                     (Instr. 3         (Instr. 4)
                                                                                        and 4
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                                         Code   V          Amount  (A) or (D)  Price
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Common Stock                 02/18/99      P               23,300     A        $7.38      118,900             D
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                                                                                            1,320             I       by spouse and
                                                                                                                      minor children
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Reminder:  Report on a separate line for each class of securities beneficially owned directly or indirectly.
*  If the form is filed by more than one reporting person, See Instruction 4(b)(v).
</TABLE>
<PAGE>

<TABLE>
FORM 4 (continued)                  Table II -- Derivative Securities Acquired, Disposed of, or Beneficially Owned
                                             (e.g., puts, calls, warrants, options, convertible securities)

<S>       <C>         <C>        <C>       <C>            <C>           <C>           <C>      <C>        <C>         <C> 


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1. Title  2. Conver-  3. Trans-  4. Trans- 5. Number of   6. Date       7. Title      8. Price 9. Number  10. Owner-  11. Nature of
   of        sion or     action     action    Derivative     Exer-         and           of       of          ship        Indirect
   Deri-     Exercise    Date       Code      Securities     cisable       Amount        Deri-    Deri-       Form        Beneficial
   vative    Price of               (Instr.   Acquired (A)   and Expi-     of            vative   vative      of Deri-    Ownership
   Secu-     Deri-       (Month/     8)       or Disposed    ration        Under-        Secu-    Secu-       vative      (Instr. 4)
   rity      vative      Day/                 of (D)         Date          Lying         rity     rities      Security:   
   (Instr.   Security    Year)                (Instr. 3,     (Month/       Securi-       (Instr.  Benefi-     Direct 
   3)                                         4, and 5)      Day/          ties           5)      cially      (D) or 
                                                             Year)         (Instr.                Owned       Indirect
                                                                           3 and 4)                at End      (I)
                                                                                                  of          (Instr.
                                                                                                  Month        4)
                                                                                                  (Instr.
                                                                                                   4)
                                    --------------------------------------------------
                                    Code V    (A)   (D)    Date    Expir- Title Amount
                                                           Exerci- ation        or
                                                           sable   Date         Number
                                                                                of
                                                                                Shares
                                   ---------------------------------------------------

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Explanation of Responses:

** Intentional misstatements or omissions of       By:  /s/ M. A. Kunst                               March 10, 1999
   facts constitute Federal Criminal                    ---------------------------------------       ------------------------------
   Violations.                                          M. A. Kunst                                   Date
   See 18 U.S.C. and 15 U.S.C. 78ff(a).                 Attorney-in-Fact, pursuant to power
                                                        of attorney filed herewith
Note:    File three copies of this Form, one
         of which must be manually signed.
         If space provided is insufficient,
         see Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless form
displays a currently valid OMB number.


Reminder:  Report on a separate line for each class of securities beneficially owned directly or indirectly.
*   If the form is filed by more than one reporting person, See Instruction 4(b)(v).
</TABLE>



                                POWER OF ATTORNEY

         Know all by these presents, that the undersigned hereby constitutes and
appoints M. Andica Kunst the undersigned's true and lawful attorney-in-fact to:

                  (1)  execute  for and on  behalf  of the  undersigned,  in the
                  undersigned's  capacity  as director  of  OXiGENE,  Inc.  (the
                  "Company"), Forms 3, 4, and 5 in accordance with Section 16(a)
                  of  the  Securities   Exchange  Act  of  1934  and  the  rules
                  thereunder;

                  (2) do and  perform  any and all acts for and on behalf of the
                  undersigned  which may be  necessary  or desirable to complete
                  and execute any such Form 3, 4, or 5 and timely file such form
                  with the United States Securities and Exchange  Commission and
                  any stock exchange or similar authority; and

                  (3) take any other action of any type whatsoever in connection
                  with   the   foregoing   which,   in  the   opinion   of  such
                  attorney-in-fact,  may be of benefit to, in the best  interest
                  of,  or  legally  required  by,  the  undersigned,   it  being
                  understood    that   the    documents    executed    by   such
                  attorney-in-fact on behalf of the undersigned pursuant to this
                  Power of Attorney shall be in such form and shall contain such
                  terms and conditions as such  attorney-in-fact  may approve in
                  such attorney-in-fact's discretion.

         The undersigned hereby grants to each such  attorney-in-fact full power
and  authority  to do and  perform  any  and  every  act  and  thing  whatsoever
requisite,  necessary, or proper to be done in the exercise of any of the rights
and  powers  herein  granted,  as  fully  to all  intents  and  purposes  as the
undersigned  might  or  could  do if  personally  present,  with  full  power of
substitution  or  revocation,  hereby  ratifying  and  confirming  all that such
attorney-in-fact,  or such attorney-in-fact's  substitute or substitutes,  shall
lawfully  do or cause to be done by virtue  of this  power of  attorney  and the
rights  and  powers  hereby  granted.  The  undersigned  acknowledges  that  the
foregoing  attorney-in-fact,  in serving in such  capacity at the request of the
undersigned,  are  not  assuming,  nor  is  the  Company  assuming,  any  of the
undersigned's  responsibilities  to comply  with  Section  16 of the  Securities
Exchange Act of 1934.

         This Power of Attorney  shall remain in full force and effect until the
undersigned is no longer  required to file Forms 3, 4, and 5 with respect to the
undersigned's  holdings of and transactions in securities issued by the Company,
unless earlier revoked by the  undersigned in a signed writing  delivered to the
foregoing attorneys-in-fact.

         IN WITNESS  WHEREOF,  the undersigned has caused this Power of Attorney
to be executed as of this 27th day of February 1999.


                                               /s/ Per-Olof Soderberg
                                             -----------------------------------
                                               Per-Olof Soderberg



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