TRIMERIS INC
SC 13G/A, 1999-06-03
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549





                                  SCHEDULE 13G
                    Under the Securities Exchange Act of 1934
                               (Amendment No. 2)*




                                 Trimeris, Inc.
- --------------------------------------------------------------------------------
                                (Name of Issuer)


                         Common Stock, $0.001 par value
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    896263100
- --------------------------------------------------------------------------------
                                 (CUSIP Number)
- --------------------------------------------------------------------------------

                                  May 27, 1999
- --------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)


Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

|_|  Rule 13d-1(b)
|X|  Rule 13d-1(c)
|_|  Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).



<PAGE>


- -------------------                                         --------------------
CUSIP No. 896263100                   13G                   Page 2 of 25 pages
- -------------------                                         --------------------

- ------------- ------------------------------------------------------------------
     1        NAME OF REPORTING PERSON
              I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

              Four Partners
- ------------- ------------------------------------------------------------------
     2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                       (a)   |_|
                                                                       (b)   |_|

- ------------- ------------------------------------------------------------------
     3        SEC USE ONLY


- ------------- ------------------------------------------------------------------
     4        CITIZENSHIP OR PLACE OF ORGANIZATION

              New York
- ---------------------------------- ---------- ----------------------------------
                                       5      SOLE VOTING POWER

                                              329,700
            NUMBER OF
                                   ---------- ----------------------------------
             SHARES                    6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                          -0-
                                   ---------- ----------------------------------
              EACH                     7      SOLE DISPOSITIVE POWER
            REPORTING
             PERSON                           329,700
                                   ---------- ----------------------------------
              WITH                     8      SHARED DISPOSITIVE POWER

                                              -0-

- ---------------------------------- ---------- ----------------------------------
     9        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                       329,700
- ------------- ------------------------------------------------------------------
     10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
              CERTAIN SHARES*
                                                                             |X|
- ------------- ------------------------------------------------------------------
     11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                       2.5%
- ------------- ------------------------------------------------------------------
     12       TYPE OF REPORTING PERSON*

                       PN
- ------------- ------------------------------------------------------------------


<PAGE>


- -------------------                                         --------------------
CUSIP No. 896263100                   13G                   Page 3 of 25 pages
- -------------------                                         --------------------


- ------------- ------------------------------------------------------------------
     1        NAME OF REPORTING PERSON
              I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

              Andrew H. Tisch
- ------------- ------------------------------------------------------------------
     2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                       (a)   |_|
                                                                       (b)   |_|

- ------------- ------------------------------------------------------------------
     3        SEC USE ONLY


- ------------- ------------------------------------------------------------------
     4        CITIZENSHIP OR PLACE OF ORGANIZATION

              United States
- ---------------------------------- ---------- ----------------------------------
                                       5      SOLE VOTING POWER

                                              288,325
            NUMBER OF
                                   ---------- ----------------------------------
             SHARES                    6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                          -0-
                                   ---------- ----------------------------------
              EACH                     7      SOLE DISPOSITIVE POWER
            REPORTING
             PERSON                           288,325
                                   ---------- ----------------------------------
              WITH                     8      SHARED DISPOSITIVE POWER

                                              -0-

- ---------------------------------- ---------- ----------------------------------
     9        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                       288,325
- ------------- ------------------------------------------------------------------
     10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
              CERTAIN SHARES*
                                                                             |X|
- ------------- ------------------------------------------------------------------
     11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                       2.2%
- ------------- ------------------------------------------------------------------
     12       TYPE OF REPORTING PERSON*

                       IN
- ------------- ------------------------------------------------------------------

<PAGE>


- -------------------                                         --------------------
CUSIP No. 896263100                   13G                   Page 4 of 25 pages
- -------------------                                         --------------------


- ------------- ------------------------------------------------------------------
     1        NAME OF REPORTING PERSON
              I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

              Daniel R. Tisch
- ------------- ------------------------------------------------------------------
     2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                       (a)   |_|
                                                                       (b)   |_|

- ------------- ------------------------------------------------------------------
     3        SEC USE ONLY


- ------------- ------------------------------------------------------------------
     4        CITIZENSHIP OR PLACE OF ORGANIZATION

              United States
- ---------------------------------- ---------- ----------------------------------
                                       5      SOLE VOTING POWER

                                              288,325
            NUMBER OF
                                   ---------- ----------------------------------
             SHARES                    6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                          -0-
                                   ---------- ----------------------------------
              EACH                     7      SOLE DISPOSITIVE POWER
            REPORTING
             PERSON                           288,325
                                   ---------- ----------------------------------
              WITH                     8      SHARED DISPOSITIVE POWER

                                              -0-

- ---------------------------------- ---------- ----------------------------------
     9        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                       288,325
- ------------- ------------------------------------------------------------------
     10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
              CERTAIN SHARES*
                                                                             |X|
- ------------- ------------------------------------------------------------------
     11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                       2.2%
- ------------- ------------------------------------------------------------------
     12       TYPE OF REPORTING PERSON*

                       IN
- ------------- ------------------------------------------------------------------


<PAGE>


- -------------------                                         --------------------
CUSIP No. 896263100                   13G                   Page 5 of 25 pages
- -------------------                                         --------------------

- ------------- ------------------------------------------------------------------
     1        NAME OF REPORTING PERSON
              I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

              James S. Tisch
- ------------- ------------------------------------------------------------------
     2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                       (a)   |_|
                                                                       (b)   |_|

- ------------- ------------------------------------------------------------------
     3        SEC USE ONLY


- ------------- ------------------------------------------------------------------
     4        CITIZENSHIP OR PLACE OF ORGANIZATION

              United States
- ---------------------------------- ---------- ----------------------------------
                                       5      SOLE VOTING POWER

                                              288,325
            NUMBER OF
                                   ---------- ----------------------------------
             SHARES                    6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                          -0-
                                   ---------- ----------------------------------
              EACH                     7      SOLE DISPOSITIVE POWER
            REPORTING
             PERSON                           288,325
                                   ---------- ----------------------------------
              WITH                     8      SHARED DISPOSITIVE POWER

                                              -0-

- ---------------------------------- ---------- ----------------------------------
     9        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                       288,325
- ------------- ------------------------------------------------------------------
     10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
              CERTAIN SHARES*
                                                                             |X|
- ------------- ------------------------------------------------------------------
     11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                       2.2%
- ------------- ------------------------------------------------------------------
     12       TYPE OF REPORTING PERSON*

                       IN
- ------------- ------------------------------------------------------------------


<PAGE>


- -------------------                                         --------------------
CUSIP No. 896263100                   13G                   Page 6 of 25 pages
- -------------------                                         --------------------

- ------------- ------------------------------------------------------------------
     1        NAME OF REPORTING PERSON
              I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

              Thomas J. Tisch
- ------------- ------------------------------------------------------------------
     2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                       (a)   |_|
                                                                       (b)   |_|

- ------------- ------------------------------------------------------------------
     3        SEC USE ONLY


- ------------- ------------------------------------------------------------------
     4        CITIZENSHIP OR PLACE OF ORGANIZATION

              United States
- ---------------------------------- ---------- ----------------------------------
                                       5      SOLE VOTING POWER

                                              288,325
            NUMBER OF
                                   ---------- ----------------------------------
             SHARES                    6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                          -0-
                                   ---------- ----------------------------------
              EACH                     7      SOLE DISPOSITIVE POWER
            REPORTING
             PERSON                           288,325
                                   ---------- ----------------------------------
              WITH                     8      SHARED DISPOSITIVE POWER

                                              -0-

- ---------------------------------- ---------- ----------------------------------
     9        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                       288,325
- ------------- ------------------------------------------------------------------
     10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
              CERTAIN SHARES*
                                                                             |X|
- ------------- ------------------------------------------------------------------
     11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                       2.2%
- ------------- ------------------------------------------------------------------
     12       TYPE OF REPORTING PERSON*

                       IN
- ------------- ------------------------------------------------------------------

<PAGE>


- -------------------                                         --------------------
CUSIP No. 896263100                   13G                   Page 7 of 25 pages
- -------------------                                         --------------------

- ------------- ------------------------------------------------------------------
     1        NAME OF REPORTING PERSON
              I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

              The Andrew H. Tisch 1999 Annuity Trust IV
- ------------- ------------------------------------------------------------------
     2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                       (a)   |_|
                                                                       (b)   |_|
- ------------- ------------------------------------------------------------------
     3        SEC USE ONLY


- ------------- ------------------------------------------------------------------
     4        CITIZENSHIP OR PLACE OF ORGANIZATION

              United States
- ---------------------------------- ---------- ----------------------------------
                                       5      SOLE VOTING POWER

                                              38,325
            NUMBER OF
                                   ---------- ----------------------------------
             SHARES                    6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                          -0-
                                   ---------- ----------------------------------
              EACH                     7      SOLE DISPOSITIVE POWER
            REPORTING
             PERSON                           38,325
                                   ---------- ----------------------------------
              WITH                     8      SHARED DISPOSITIVE POWER

                                              -0-

- ---------------------------------- ---------- ----------------------------------
     9        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                       38,325
- ------------- ------------------------------------------------------------------
     10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
              CERTAIN SHARES*
                                                                             |X|
- ------------- ------------------------------------------------------------------
     11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                       0.3%
- ------------- ------------------------------------------------------------------
     12       TYPE OF REPORTING PERSON*

                       OO
- ------------- ------------------------------------------------------------------

<PAGE>


- -------------------                                         --------------------
CUSIP No. 896263100                   13G                   Page 8 of 25 pages
- -------------------                                         --------------------

- ------------- ------------------------------------------------------------------
     1        NAME OF REPORTING PERSON
              I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

              The Daniel R. Tisch 1999 Annuity Trust IV
- ------------- ------------------------------------------------------------------
     2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                       (a)   |_|
                                                                       (b)   |_|

- ------------- ------------------------------------------------------------------
     3        SEC USE ONLY


- ------------- ------------------------------------------------------------------
     4        CITIZENSHIP OR PLACE OF ORGANIZATION

              United States
- ---------------------------------- ---------- ----------------------------------
                                       5      SOLE VOTING POWER

                                              38,325
            NUMBER OF
                                   ---------- ----------------------------------
             SHARES                    6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                          -0-
                                   ---------- ----------------------------------
              EACH                     7      SOLE DISPOSITIVE POWER
            REPORTING
             PERSON                           38,325
                                   ---------- ----------------------------------
              WITH                     8      SHARED DISPOSITIVE POWER

                                              -0-

- ---------------------------------- ---------- ----------------------------------
     9        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                       38,325
- ------------- ------------------------------------------------------------------
     10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
              CERTAIN SHARES*
                                                                             |X|
- ------------- ------------------------------------------------------------------
     11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                       0.3%
- ------------- ------------------------------------------------------------------
     12       TYPE OF REPORTING PERSON*

                       OO
- ------------- ------------------------------------------------------------------


<PAGE>


- -------------------                                         --------------------
CUSIP No. 896263100                   13G                   Page 9 of 25 pages
- -------------------                                         --------------------


- ------------- ------------------------------------------------------------------
     1        NAME OF REPORTING PERSON
              I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

              The James S. Tisch 1999 Annuity Trust IV
- ------------- ------------------------------------------------------------------
     2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                       (a)   |_|
                                                                       (b)   |_|

- ------------- ------------------------------------------------------------------
     3        SEC USE ONLY


- ------------- ------------------------------------------------------------------
     4        CITIZENSHIP OR PLACE OF ORGANIZATION

              United States
- ---------------------------------- ---------- ----------------------------------
                                       5      SOLE VOTING POWER

                                              38,325
            NUMBER OF
                                   ---------- ----------------------------------
             SHARES                    6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                          -0-
                                   ---------- ----------------------------------
              EACH                     7      SOLE DISPOSITIVE POWER
            REPORTING
             PERSON                           38,325
                                   ---------- ----------------------------------
              WITH                     8      SHARED DISPOSITIVE POWER

                                              -0-

- ---------------------------------- ---------- ----------------------------------
     9        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                       38,325
- ------------- ------------------------------------------------------------------
     10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
              CERTAIN SHARES*
                                                                             |X|
- ------------- ------------------------------------------------------------------
     11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                       0.3%
- ------------- ------------------------------------------------------------------
     12       TYPE OF REPORTING PERSON*

                       OO
- ------------- ------------------------------------------------------------------

<PAGE>


- -------------------                                         --------------------
CUSIP No. 896263100                   13G                   Page 10 of 25 pages
- -------------------                                         --------------------

- ------------- ------------------------------------------------------------------
     1        NAME OF REPORTING PERSON
              I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

              The Thomas J. Tisch 1999 Annuity Trust IV
- ------------- ------------------------------------------------------------------
     2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                       (a)   |_|
                                                                       (b)   |_|

- ------------- ------------------------------------------------------------------
     3        SEC USE ONLY


- ------------- ------------------------------------------------------------------
     4        CITIZENSHIP OR PLACE OF ORGANIZATION

              United States
- ---------------------------------- ---------- ----------------------------------
                                       5      SOLE VOTING POWER

                                              38,325
            NUMBER OF
                                   ---------- ----------------------------------
             SHARES                    6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                          -0-
                                   ---------- ----------------------------------
              EACH                     7      SOLE DISPOSITIVE POWER
            REPORTING
             PERSON                           38,325
                                   ---------- ----------------------------------
              WITH                     8      SHARED DISPOSITIVE POWER

                                              -0-

- ---------------------------------- ---------- ----------------------------------
     9        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                       38,325
- ------------- ------------------------------------------------------------------
     10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
              CERTAIN SHARES*
                                                                             |X|
- ------------- ------------------------------------------------------------------
     11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                       0.3%
- ------------- ------------------------------------------------------------------
     12       TYPE OF REPORTING PERSON*

                       OO
- ------------- ------------------------------------------------------------------


<PAGE>


- -------------------                                         --------------------
CUSIP No. 896263100                   13G                   Page 11 of 25 pages
- -------------------                                         --------------------

- ------------- ------------------------------------------------------------------
     1        NAME OF REPORTING PERSON
              I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

              The Andrew H. Tisch 1999 Annuity Trust VII
- ------------- ------------------------------------------------------------------
     2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                       (a)   |_|
                                                                       (b)   |_|
- ------------- ------------------------------------------------------------------
     3        SEC USE ONLY


- ------------- ------------------------------------------------------------------
     4        CITIZENSHIP OR PLACE OF ORGANIZATION

              United States
- ---------------------------------- ---------- ----------------------------------
                                       5      SOLE VOTING POWER

                                              250,000
            NUMBER OF
                                   ---------- ----------------------------------
             SHARES                    6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                          -0-
                                   ---------- ----------------------------------
              EACH                     7      SOLE DISPOSITIVE POWER
            REPORTING
             PERSON                           250,000
                                   ---------- ----------------------------------
              WITH                     8      SHARED DISPOSITIVE POWER

                                              -0-

- ---------------------------------- ---------- ----------------------------------
     9        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                       250,000
- ------------- ------------------------------------------------------------------
     10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
              CERTAIN SHARES*
                                                                             |X|
- ------------- ------------------------------------------------------------------
     11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                       1.9%
- ------------- ------------------------------------------------------------------
     12       TYPE OF REPORTING PERSON*

                       OO
- ------------- ------------------------------------------------------------------

<PAGE>


- -------------------                                         --------------------
CUSIP No. 896263100                   13G                   Page 12 of 25 pages
- -------------------                                         --------------------

- ------------- ------------------------------------------------------------------
     1        NAME OF REPORTING PERSON
              I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

              The Daniel R. Tisch 1999 Annuity Trust VII
- ------------- ------------------------------------------------------------------
     2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                       (a)   |_|
                                                                       (b)   |_|

- ------------- ------------------------------------------------------------------
     3        SEC USE ONLY


- ------------- ------------------------------------------------------------------
     4        CITIZENSHIP OR PLACE OF ORGANIZATION

              United States
- ---------------------------------- ---------- ----------------------------------
                                       5      SOLE VOTING POWER

                                              250,000
            NUMBER OF
                                   ---------- ----------------------------------
             SHARES                    6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                          -0-
                                   ---------- ----------------------------------
              EACH                     7      SOLE DISPOSITIVE POWER
            REPORTING
             PERSON                           250,000
                                   ---------- ----------------------------------
              WITH                     8      SHARED DISPOSITIVE POWER

                                              -0-

- ---------------------------------- ---------- ----------------------------------
     9        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                       250,000
- ------------- ------------------------------------------------------------------
     10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
              CERTAIN SHARES*
                                                                             |X|
- ------------- ------------------------------------------------------------------
     11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                       1.9%
- ------------- ------------------------------------------------------------------
     12       TYPE OF REPORTING PERSON*

                       OO
- ------------- ------------------------------------------------------------------


<PAGE>


- -------------------                                         --------------------
CUSIP No. 896263100                   13G                   Page 13 of 25 pages
- -------------------                                         --------------------

- ------------- ------------------------------------------------------------------
     1        NAME OF REPORTING PERSON
              I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

              The James S. Tisch 1999 Annuity Trust VII
- ------------- ------------------------------------------------------------------
     2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                       (a)   |_|
                                                                       (b)   |_|

- ------------- ------------------------------------------------------------------
     3        SEC USE ONLY


- ------------- ------------------------------------------------------------------
     4        CITIZENSHIP OR PLACE OF ORGANIZATION

              United States
- ---------------------------------- ---------- ----------------------------------
                                       5      SOLE VOTING POWER

                                              250,000
            NUMBER OF
                                   ---------- ----------------------------------
             SHARES                    6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                          -0-
                                   ---------- ----------------------------------
              EACH                     7      SOLE DISPOSITIVE POWER
            REPORTING
             PERSON                           250,000
                                   ---------- ----------------------------------
              WITH                     8      SHARED DISPOSITIVE POWER

                                              -0-

- ---------------------------------- ---------- ----------------------------------
     9        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                       250,000
- ------------- ------------------------------------------------------------------
     10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
              CERTAIN SHARES*
                                                                             |X|
- ------------- ------------------------------------------------------------------
     11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                       1.9%
- ------------- ------------------------------------------------------------------
     12       TYPE OF REPORTING PERSON*

                       OO
- ------------- ------------------------------------------------------------------


<PAGE>


- -------------------                                         --------------------
CUSIP No. 896263100                   13G                   Page 14 of 25 pages
- -------------------                                         --------------------

- ------------- ------------------------------------------------------------------
     1        NAME OF REPORTING PERSON
              I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

              The Thomas J. Tisch 1999 Annuity Trust VII
- ------------- ------------------------------------------------------------------
     2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                       (a)   |_|
                                                                       (b)   |_|

- ------------- ------------------------------------------------------------------
     3        SEC USE ONLY


- ------------- ------------------------------------------------------------------
     4        CITIZENSHIP OR PLACE OF ORGANIZATION

              United States
- ---------------------------------- ---------- ----------------------------------
                                       5      SOLE VOTING POWER

                                              250,000
            NUMBER OF
                                   ---------- ----------------------------------
             SHARES                    6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                          -0-
                                   ---------- ----------------------------------
              EACH                     7      SOLE DISPOSITIVE POWER
            REPORTING
             PERSON                           250,000
                                   ---------- ----------------------------------
              WITH                     8      SHARED DISPOSITIVE POWER

                                              -0-

- ---------------------------------- ---------- ----------------------------------
     9        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                       250,000
- ------------- ------------------------------------------------------------------
     10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
              CERTAIN SHARES*
                                                                             |X|
- ------------- ------------------------------------------------------------------
     11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                       1.9%
- ------------- ------------------------------------------------------------------
     12       TYPE OF REPORTING PERSON*

                       OO
- ------------- ------------------------------------------------------------------


<PAGE>

                                                             Page 15 of 25 pages

Item 1.

         (a) Name of Issuer

             Trimeris, Inc. (the "Issuer")

         (b) Address of Issuer's Principal Executive Offices

             4727 University Drive
             Durham, NC  27707

Item 2.

         (a) Name of Persons Filing

         This Schedule 13G is being filed jointly by the following entities and
individuals:

         1.   Four Partners, a New York general partnership ("FP");

         2.   Andrew H. Tisch;

         3.   Daniel R. Tisch;

         4.   James S. Tisch;

         5.   Thomas J. Tisch (Andrew H. Tisch, Daniel R. Tisch, James S. Tisch
              and Thomas J. Tisch are referred to collectively as the "Messrs.
              Tisch");

         6.   The Andrew H. Tisch 1999 Annuity Trust IV ("Andrew Tisch GRAT
              IV");

         7.   The Daniel R. Tisch 1999 Annuity Trust IV ("Daniel Tisch GRAT
              IV");

         8.   The James S. Tisch 1999 Annuity Trust IV ("James Tisch GRAT IV");

         9.   The Thomas J. Tisch 1999 Annuity Trust IV ("Thomas Tisch GRAT IV";
              and collectively with Andrew Tisch GRAT IV, Daniel Tisch GRAT IV
              and James Tisch GRAT IV, the "GRATs IV");

         10.  The Andrew H. Tisch 1999 Annuity Trust VII ("Andrew Tisch GRAT
              VII");

         11.  The Daniel R. Tisch 1999 Annuity Trust VII ("Daniel Tisch GRAT
              VII");

         12.  The James S. Tisch 1999 Annuity Trust VII ("James Tisch GRAT
              VII"); and

         13.  The Thomas J. Tisch 1999 Annuity Trust VII ("Thomas Tisch GRAT
              VII"; and collectively with the GRATs IV, Andrew Tisch GRAT VII,
              Daniel Tisch GRAT VII and James Tisch GRAT VII, the "GRATs").

         The sole partners of FP are Andrew H. Tisch 1991 Trust, for which
         Andrew H. Tisch is the managing trustee, Daniel R. Tisch 1991 Trust,
         for which Daniel R. Tisch is the


<PAGE>
                                                             Page 16 of 25 pages

         managing trustee, James S. Tisch 1991 Trust, for which James S. Tisch
         is the managing trustee, and Thomas J. Tisch 1991 Trust, for which
         Thomas J. Tisch is the managing trustee. Thomas J. Tisch has been
         appointed the Manager of FP.

         Each of the GRATs is a grantor retained annuity trust in which the
         grantor holds an annuity interest and in which the remainder interest
         was created in favor of a trust or trusts for the grantor's offspring.
         Thomas J. Tisch is the grantor and Andrew H. Tisch is the trustee of
         Thomas Tisch GRAT IV. Daniel R. Tisch is the grantor and James S. Tisch
         is the trustee of Daniel Tisch GRAT IV. James S. Tisch is the grantor
         and Thomas J. Tisch is the trustee of James Tisch GRAT IV. Andrew H.
         Tisch is the grantor and Daniel R. Tisch is the trustee of Andrew Tisch
         GRAT IV. Thomas J. Tisch is the grantor and Andrew H. Tisch is the
         trustee of Thomas Tisch GRAT VII. Daniel R. Tisch is the grantor and
         James S. Tisch is the trustee of Daniel Tisch GRAT VII. James S. Tisch
         is the grantor and Thomas J. Tisch is the trustee of James Tisch GRAT
         VII. Andrew H. Tisch is the grantor and Daniel R. Tisch is the trustee
         of Andrew Tisch GRAT VII.

         Prior to the opening of business on May 27, 1999, FP transferred to
         each of Daniel Tisch GRAT VII and James Tisch GRAT VII 250,000 shares
         of common stock, $.001 par value ("Common Stock"), of the Issuer. Later
         that day, Thomas Tisch GRAT VII and Andrew Tisch GRAT VII each
         purchased 250,000 shares of Common Stock in a public offering by the
         Issuer.

         The Reporting Persons believe that the transaction on May 27, 1999 in
         which FP transferred shares of Common Stock to each of Daniel Tisch
         GRAT VII and James Tisch GRAT VII was not a "sale" for purposes of the
         Securities Act of 1933, as amended (the "Securities Act"), or the
         Securities Exchange Act of 1934, as amended (the "Exchange Act"), and
         represented only a change in the form of beneficial ownership of the
         shares of Common Stock and not an actual change in the beneficial
         ownership of such shares of Common Stock.

         Each of the Messrs. Tisch is herein reporting beneficial ownership of
         the shares of Common Stock owned by the GRATs for which he is the
         trustee. The shares of Common Stock reported herein as beneficially
         owned by each of the Messrs. Tisch do not include shares owned by FP.

         The filing of this statement is not an admission by any Reporting
         Person that such Reporting Person and any other person or persons
         constitute a "group" for purposes of Section 13(d)(3) of the Securities
         Exchange Act of 1934, as amended, or Rule 13d-5 thereunder or that any
         Reporting Person is the beneficial owner of any securities owned by any
         other person.


<PAGE>
                                                             Page 17 of 25 pages

         (b) Address of Principal Business Office or, if none, Residence

             The mailing address of FP is:

                    c/o Thomas J. Tisch
                    667 Madison Avenue
                    New York, NY  10021

              The mailing address for each of the GRATs is:

                    c/o Mr. Barry Bloom
                    655 Madison Avenue - 8th Floor
                    New York, NY  10021

              The addresses of the Messrs. Tisch are:

              Name                               Business Address
              ----                               ----------------

              Andrew H. Tisch                    667 Madison Avenue
                                                 New York, NY 10021

              Daniel R. Tisch                    c/o Mentor Partners, L.P.
                                                 499 Park Avenue
                                                 New York, NY 10022

              James S. Tisch                     667 Madison Avenue
                                                 New York, NY 10021

              Thomas J. Tisch                    667 Madison Avenue
                                                 New York, NY 10021

              (c)   Citizenship

              FP is a New York general partnership.

              The Messrs. Tisch are brothers and are United States citizens.

              (d)   Title of Class of Securities

              Common Stock, $0.001 par value

              (e)   CUSIP Number

                    896263100

Item 3.  If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b) or
         (c), check whether the person filing is a:

         (a) |_| Broker or Dealer registered under Section 15 of the Act,

         (b) |_| Bank as defined in Section 3(a)(6) of the Act,

         (c) |_| Insurance company as defined in Section 3(a)(19) of the Act,


<PAGE>
                                                             Page 18 of 25 pages


         (d) |_| Investment company registered under section 8 of the Investment
         Company Act of 1940,

         (e) |_| Investment Adviser registered under section 203 of the
         Investment Advisers Act of 1940,

         (f) |_| An employee benefit plan, Pension Fund which is subject to the
         provisions of the Employee Retirement Income Security Act of 1974 or
         Endowment Fund; see ss. 240.13d-1(b)(1)(ii)(F),

         (g) |_| A parent holding company, in accordance with ss.
         240.13d-1(b)(ii)(G) (Note: See Item 7),

         (h) |_| A savings association as defined in Section 3(b) of the Federal
         Deposit Insurance Act (12 U.S.C. 1813);

         (i) |_| A church plan that is excluded from the definition of an
         investment company under section 3(c)(14) of the Investment Company Act
         of 1940 (15 U.S.C. 80a-3);

         (j) |_| Group, in accordance with ss. 240.13d-1(b)(1)(ii)(J).

         If this statement is filed pursuant to ss. 240.13d-1(c), check this box
         |X|.


<PAGE>
                                                             Page 19 of 25 pages


Item 4.       Ownership

              (a-b) Amount Beneficially Owned and Percent of Class

FP owns 329,700 shares of Common Stock. Each GRAT IV owns 38,325 shares of
Common Stock and each GRAT VII owns 250,000 shares of Common Stock.
Collectively, FP and the GRATs own 1,483,000 shares of Common Stock, 11.2% of
the outstanding shares of Common Stock.

Set forth in the table below is the aggregate number of shares of Common Stock
beneficially owned as of the date hereof by each person or entity listed in Item
2 above, together with the percentage of outstanding shares of Common Stock
which is beneficially owned by each such person or entity.



Name of                            Amount and Nature of            % of Class
Beneficial Owner                   Beneficial Ownership          Outstanding (1)
- ----------------                   --------------------          ---------------

Four Partners                           329,700                      2.5%
Andrew H. Tisch 1991 Trust                    0                      0%
Daniel R. Tisch 1991 Trust                    0                      0%
James S. Tisch 1991 Trust                     0                      0%
Thomas J. Tisch 1991 Trust                    0                      0%
Andrew Tisch GRAT IV                     38,325                      0.3%
Daniel Tisch GRAT IV                     38,325                      0.3%
James Tisch GRAT IV                      38,325                      0.3%
Thomas Tisch GRAT IV                     38,325                      0.3%
Andrew Tisch GRAT VII                   250,000                      2.2%
Daniel Tisch GRAT VII                   250,000                      2.2%
James Tisch GRAT VII                    250,000                      2.2%
Thomas Tisch GRAT VII                   250,000                      2.2%
Andrew H. Tisch                         288,325 (2)                  1.9%
Daniel R. Tisch                         288,325 (2)                  1.9%
James S. Tisch                          288,325 (2)                  1.9%
Thomas J. Tisch                         288,325 (2)                  1.9%
                                        -------                      ----
Total                                 1,483,000                     11.2%  (1)


<PAGE>
                                                             Page 20 of 25 pages


(1)    The ownership percentages set forth in the table above are based on
       13,183,355 shares of Common Stock outstanding as of May 27, 1999, which
       information was reported in the Issuer's Prospectus dated May 27, 1999.

(2)    Each of the Messrs. Tisch is herein reporting beneficial ownership of the
       shares of Common Stock owned by the GRATs for which he is trustee.

              (c) Set forth in the table below is information with respect to
       the number of shares of Common Stock beneficially owned as of the date
       hereof by each person or entity named in Item 2 above, indicating, with
       respect to such shares of Common Stock, whether each such person has the
       sole power to vote or direct the vote or shared power to vote or direct
       the vote and sole power to dispose or direct the disposition or shared
       power to dispose or direct the disposition.

<TABLE>
<CAPTION>

                Name of                              Power to Vote or                 Power to Dispose or
           Reporting Person                           Direct the Vote                Direct the Disposition
           ----------------                          ----------------                -----------------------
                                                Sole                Shared                Sole           Shared
                                                ----                ------                ----           ------
<S>                                           <C>                   <C>                  <C>             <C>
Four Partners                                 329,700                  0                 329,700            0
Andrew H. Tisch 1991 Trust                       0                     0                    0               0
Daniel R. Tisch 1991 Trust                       0                     0                    0               0
James S. Tisch 1991 Trust                        0                     0                    0               0
Thomas J. Tisch 1991 Trust                       0                     0                    0               0
Andrew Tisch GRAT IV                           38,325                  0                 38,325             0
Daniel Tisch GRAT IV                           38,325                  0                 38,325             0
James Tisch GRAT IV                            38,325                  0                 38,325             0
Thomas Tisch GRAT IV                           38,325                  0                 38,325             0
Andrew Tisch GRAT VII                         250,000                  0                 250,000            0
Daniel Tisch GRAT VII                         250,000                  0                 250,000            0
James Tisch GRAT VII                          250,000                  0                 250,000            0
Thomas Tisch GRAT VII                         250,000                  0                 250,000            0
Andrew H. Tisch (1)(2)                        288,325                  0                 288,325            0
Daniel R. Tisch (1)(2)                        288,325                  0                 288,325            0
James S. Tisch (1)(2)                         288,325                  0                 288,325            0
Thomas J. Tisch (1)(2)                        288,325                  0                 288,325            0

</TABLE>
                                                             Page 21 of 25 pages


- --------------------

(1)    By virtue of their status as trustees of the respective GRATs, the
       Messrs. Tisch may be deemed to have power to vote or direct the vote of
       the securities owned by those GRATs and power to dispose or direct the
       disposition of the securities owned by those GRATs.

(2)    Does not include shares of Common Stock owned by FP. By virtue of their
       status as managing trustees of the trusts which are the general partners
       of FP, the Messrs. Tisch may be deemed to have indirectly shared power to
       vote or direct the vote and to dispose or direct the disposition of the
       shares owned by FP. By virtue of his status as manager of FP, Thomas J.
       Tisch may be deemed to have the power to vote or direct the vote of the
       securities owned by FP and power to dispose or direct the disposition of
       the securities owned by FP.

Item 5.       Ownership of Five Percent or Less of a Class

              Not applicable.

Item 6.       Ownership of More than Five Percent on Behalf of Another Person

              Not applicable.

Item 7.       Identification and Classification of the Subsidiary Which Acquired
              the Security Being Reported on By the Parent Holding Company

              Not applicable.

Item 8.       Identification and Classification of Members of the Group

              Not applicable.

Item 9.       Notice of Dissolution of Group

              Not applicable.

Item 10.      Certification

                    By signing below I certify that, to the best of my knowledge
              and belief, the securities referred to above were not acquired and
              are not held for the purpose of or with the effect of changing or
              influencing the control of the issuer of such securities and were
              not acquired and are not held in connection with or as a
              participant in any transaction having that purpose or effect.


<PAGE>
                                                             Page 22 of 25 pages


                                    SIGNATURE

                  After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true,
complete and correct.

June 3, 1999                       FOUR PARTNERS

                                   By    /s/ Thomas J. Tisch
                                     --------------------------------------
                                         Thomas J. Tisch, Manager


                                   /s/ Andrew H. Tisch
                                   ----------------------------------------
                                   Andrew H. Tisch


                                   /s/ Daniel R. Tisch
                                   ----------------------------------------
                                   Daniel R. Tisch


                                   /s/ James S. Tisch
                                   ----------------------------------------
                                   James S. Tisch


                                   /s/ Thomas J. Tisch
                                   ----------------------------------------
                                   Thomas J. Tisch


                                   THE ANDREW H. TISCH 1999 ANNUITY TRUST IV

                                   By    /s/ Daniel R. Tisch
                                     --------------------------------------
                                         Daniel R. Tisch, Trustee


                                   THE DANIEL R. TISCH 1999 ANNUITY TRUST IV

                                    By    /s/ James S. Tisch
                                     --------------------------------------
                                          James S. Tisch, Trustee


<PAGE>
                                                             Page 23 of 25 pages


                                    THE JAMES S. TISCH 1999 ANNUITY TRUST IV

                                     By    /s/ Thomas J. Tisch
                                     --------------------------------------
                                           Thomas J. Tisch, Trustee


                                     THE THOMAS J. TISCH 1999 ANNUITY TRUST IV

                                     By    /s/ Andrew H. Tisch
                                     --------------------------------------
                                           Andrew H. Tisch, Trustee


                                     THE ANDREW H. TISCH 1999 ANNUITY TRUST VII

                                     By    /s/ Daniel R. Tisch
                                     --------------------------------------
                                           Daniel R. Tisch, Trustee


                                     THE DANIEL R. TISCH 1999 ANNUITY TRUST VII

                                     By    /s/ James S. Tisch
                                     --------------------------------------
                                           James S. Tisch, Trustee


                                     THE JAMES S. TISCH 1999 ANNUITY TRUST VII

                                     By    /s/ Thomas J. Tisch
                                     --------------------------------------
                                           Thomas J. Tisch, Trustee


                                     THE THOMAS J. TISCH 1999 ANNUITY TRUST VII

                                     By    /s/ Andrew H. Tisch
                                     --------------------------------------
                                           Andrew H. Tisch, Trustee


<PAGE>
                                                             Page 24 of 25 pages



                                    AGREEMENT


         In accordance with Rule 13d-1(k)(1) under the Securities Exchange Act
of 1934, as amended, the undersigned hereby agree that this Schedule 13G dated
June 3, 1999 relating to the Common Stock, $0.001 par value per share, of
Trimeris, Inc., as the same may be amended from time to time hereafter, is being
filed with the Securities and Exchange Commission on behalf of each of them.

Dated:  June 3, 1999



                                   FOUR PARTNERS

                                   By    /s/ Thomas J. Tisch
                                     --------------------------------------
                                         Thomas J. Tisch, Manager


                                   /s/ Andrew H. Tisch
                                   ----------------------------------------
                                   Andrew H. Tisch


                                   /s/ Daniel R. Tisch
                                   ----------------------------------------
                                   Daniel R. Tisch


                                   /s/ James S. Tisch
                                   ----------------------------------------
                                   James S. Tisch


                                   /s/ Thomas J. Tisch
                                   ----------------------------------------
                                   Thomas J. Tisch


                                   THE ANDREW H. TISCH 1999 ANNUITY TRUST IV

                                   By    /s/ Daniel R. Tisch
                                     --------------------------------------
                                         Daniel R. Tisch, Trustee


                                   THE DANIEL R. TISCH 1999 ANNUITY TRUST IV

                                    By    /s/ James S. Tisch
                                     --------------------------------------
                                          James S. Tisch, Trustee


<PAGE>
                                                             Page 25 of 25 pages


                                    THE JAMES S. TISCH 1999 ANNUITY TRUST IV

                                     By    /s/ Thomas J. Tisch
                                     --------------------------------------
                                           Thomas J. Tisch, Trustee


                                     THE THOMAS J. TISCH 1999 ANNUITY TRUST IV

                                     By    /s/ Andrew H. Tisch
                                     --------------------------------------
                                           Andrew H. Tisch, Trustee


                                     THE ANDREW H. TISCH 1999 ANNUITY TRUST VII

                                     By    /s/ Daniel R. Tisch
                                     --------------------------------------
                                           Daniel R. Tisch, Trustee


                                     THE DANIEL R. TISCH 1999 ANNUITY TRUST VII

                                     By    /s/ James S. Tisch
                                     --------------------------------------
                                           James S. Tisch, Trustee


                                     THE JAMES S. TISCH 1999 ANNUITY TRUST VII

                                     By    /s/ Thomas J. Tisch
                                     --------------------------------------
                                           Thomas J. Tisch, Trustee


                                     THE THOMAS J. TISCH 1999 ANNUITY TRUST VII

                                     By    /s/ Andrew H. Tisch
                                     --------------------------------------
                                           Andrew H. Tisch, Trustee



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