TRIMERIS INC
3, 1999-06-03
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                UNITED STATES SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                     FORM 3

             INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

     Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934,
       Section 17(a) of the Public Utility Holding Company Act of 1935 or
               Section 30(f) of the Investment Company Act of 1940

(Print or Type Responses)

1.    Name and Address of Reporting Person:

                    Four Partners
                    c/o Thomas J. Tisch
                    667 Madison Avenue
                    New York, NY 10021

2.    Date of Event Requiring Statement (Month/Day/Year)

                  5/27/1999

3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4. Issuer Name and Ticker or Trading Symbol:

                  Trimeris, Inc. (TRMS)

5. Relationship of Reporting Persons(s) to Issuer:

                  ___ Director
                  ___ Officer (give title below)
                  _X_ 10% Owner
                  ___ Other (specify below)

                  ------------------------

6.    If Amendment, Date of Original (Month/Day/Year)



7.    Individual or Joint/Group Filing (Check Applicable Line)

<PAGE>

                                                              Page 2 of 31 pages


           ____  Form filed by One Reporting Person
           __X_  Form filed by More than One Reporting Person

             Table I - Non-Derivative Securities Beneficially Owned

1.    Title of Security

                  Common  Stock, $.001 par value

2.    Amount of Securities Beneficially Owned

                  329,700

3.    Ownership Form:  Direct (D) or Indirect (I)

                  D

4.    Nature of Indirect Beneficial Ownership

                  (See explanation)

          Table II - Derivative Securities Beneficially Owned (e.g., puts,
calls, warrants, options, convertible securities)

1.    Title of Derivative Security



2.    Date Exercisable and Expiration Date (Month/Day/Year)

                  Date Exercisable



                  Expiration Date



3.    Title and Amount of Securities Underlying Derivative Security

                  Title



                  Amount or Number of Shares

<PAGE>
                                                              Page 3 of 31 pages

4.    Conversion or Exercise Price of Derivative Security



5.    Ownership Form of Derivative Security:  Direct (D) or Indirect (I)



6.    Nature of Indirect Beneficial Ownership

      Explanation of Responses:

         This Form 3 is being filed jointly by the following individuals and
entities:

         1.  Four Partners, a New York general partnership ("FP");

         2.  Thomas J. Tisch;

         3.  Daniel R. Tisch;

         4.  James S. Tisch;

         5.  Andrew H. Tisch (Thomas J. Tisch, Daniel R. Tisch, James S. Tisch
             and Andrew H. Tisch are referred to collectively as the "Messrs.
             Tisch");

         6.  The Thomas J. Tisch 1999 Annuity Trust IV ("Thomas Tisch GRAT IV");

         7.  The Daniel R. Tisch 1999 Annuity Trust IV ("Daniel Tisch GRAT IV");

         8.  The James S. Tisch 1999 Annuity Trust IV ("James Tisch GRAT IV");

         9.  The Andrew H. Tisch 1999 Annuity Trust IV ("Andrew Tisch GRAT IV";
             and collectively with Thomas Tisch GRAT IV, Daniel Tisch GRAT IV
             and James Tisch GRAT IV, the "GRATs IV").

         10. The Thomas J. Tisch 1999 Annuity Trust VII ("Thomas Tisch GRAT
             VII");

         11. The Daniel R. Tisch 1999 Annuity Trust VII ("Daniel Tisch GRAT
             VII");

         12. The James S. Tisch 1999 Annuity Trust VII ("James Tisch GRAT VII");
             and


<PAGE>
                                                              Page 4 of 31 pages


         13. The Andrew H. Tisch 1999 Annuity Trust VII ("Andrew Tisch GRAT
             VII"; and collectively with the GRATs IV, Thomas Tisch GRAT VII,
             Daniel Tisch GRAT VII and James Tisch GRAT VII, the "GRATs").

         FP, the Messrs. Tisch and the GRATs are referred to herein individually
as a "Reporting Person" and collectively as the "Reporting Persons."

         The sole partners of FP are Andrew H. Tisch 1991 Trust, for which
Andrew H. Tisch is the managing trustee, Daniel R. Tisch 1991 Trust, for which
Daniel R. Tisch is the managing trustee, James S. Tisch 1991 Trust, for which
James S. Tisch is the managing trustee, and Thomas J. Tisch 1991 Trust, for
which Thomas J. Tisch is the managing trustee. Thomas J. Tisch has been
appointed the Manager of FP.

         Each of the GRATs is a grantor retained annuity Trust in which the
grantor holds an annuity interest and in which the remainder interest was
created in favor of a trust or trusts for the grantor's offspring. Thomas J.
Tisch is the grantor and Andrew H. Tisch is the trustee of Thomas Tisch GRAT IV.
Daniel R. Tisch is the grantor and James S. Tisch is the trustee of Daniel Tisch
GRAT IV. James S. Tisch is the grantor and Thomas J. Tisch is the trustee of
James Tisch GRAT IV. Andrew H. Tisch is the grantor and Daniel R. Tisch is the
trustee of Andrew Tisch GRAT IV. Thomas J. Tisch is the grantor and Andrew H.
Tisch is the trustee of Thomas Tisch GRAT VII. Daniel R. Tisch is the grantor
and James S. Tisch is the trustee of Daniel Tisch GRAT VII. James S. Tisch is
the grantor and Thomas J. Tisch is the trustee of James Tisch GRAT VII. Andrew
H. Tisch is the grantor and Daniel R. Tisch is the trustee of Andrew Tisch GRAT
VII.

         Prior to the opening of business on May 27, 1999, FP transferred to
each of Daniel Tisch GRAT VII and James Tisch GRAT VII 250,000 shares of common
stock, $.001 par value ("Common Stock"), of Trimeris, Inc. (the "Issuer"). Later
that day, Thomas Tisch GRAT VII and Andrew Tisch GRAT VII each purchased 250,000
shares of Common Stock in a public offering by the Issuer.

         The Reporting Persons believe that the transaction on May 27, 1999 in
which FP transferred shares of Common Stock to each of Daniel Tisch GRAT VII and
James Tisch GRAT VII was not a "sale" for purposes of the Securities Act of
1933, as amended (the "Securities Act"), or the Securities Exchange Act of 1934,
as amended (the "Exchange Act"), and represented only a change in the form of
beneficial ownership of the shares of Common Stock and not an actual change in
the beneficial ownership of such shares of Common Stock.

         Each of the Messrs. Tisch is herein reporting indirect beneficial
ownership of the shares of Common Stock owned by the GRATs for which he is the
grantor. The shares of Common Stock reported herein as beneficially owned by
each of the Messrs. Tisch do not include shares owned by FP.

<PAGE>
                                                              Page 5 of 31 pages

         The filing of this statement is not an admission by any Reporting
Person that such Reporting Person and any other person or persons constitute a
"group" for purposes of Section 13(d)(3) of the Securities Exchange Act of 1934,
as amended, or Rule 13d-5 thereunder or that any Reporting Person is the
beneficial owner of any securities owned by any other person.



         [Signatures follow all attachments]



<PAGE>
                                                              Page 6 of 31 pages


                      Attachment To Form 3 of Four Partners
                       in Respect of Trimeris, Inc. (TRMS)
                  Date of Event Requiring Statement: 5/27/1999

Joint Filer Information

1.    Name and Address of Reporting Person:

                  Thomas J. Tisch
                  667 Madison Avenue
                  New York, NY  10021

2.    Date of Event Requiring Statement (Month/Day/Year)

                  5/27/1999

3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4. Issuer Name and Ticker or Trading Symbol:

                  Trimeris, Inc. (TRMS)

5. Relationship of Reporting Persons(s) to Issuer:

                  ___ Director
                  ___ Officer (give title below)
                  _X_ 10% Owner
                  ___ Other (specify below)

                  ------------------------

6.    If Amendment, Date of Original (Month/Day/Year)



7.    Individual or Joint/Group Filing (Check Applicable Line)

                  ___ Form filed by One Reporting Person
                  _X_ Form filed by More than One Reporting Person


<PAGE>
                                                              Page 7 of 31 pages


             Table I - Non-Derivative Securities Beneficially Owned

1.    Title of Security

                  Common  Stock, $.001 par value

2.    Amount of Securities Beneficially Owned

                  288,325

3.    Ownership Form:  Direct (D) or Indirect (I)

                  I

4.    Nature of Indirect Beneficial Ownership

                  (See explanation to Form 3 of Four Partners)

        Table II - Derivative Securities Beneficially Owned (e.g., puts,
               calls, warrants, options, convertible securities)

1.    Title of Derivative Security

2.    Date Exercisable and Expiration Date (Month/Day/Year)

                  Date Exercisable

                  Expiration Date

3.    Title and Amount of Securities Underlying Derivative Security

                  Title

                  Amount or Number of Shares

4.    Conversion or Exercise Price of Derivative Security

5.    Ownership Form of Derivative Security:  Direct (D) or Indirect (I)

6.    Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]



<PAGE>
                                                              Page 8 of 31 pages


                      Attachment To Form 3 of Four Partners
                       in Respect of Trimeris, Inc. (TRMS)
                  Date of Event Requiring Statement: 5/27/1999

Joint Filer Information

1.    Name and Address of Reporting Person:

                  Daniel R. Tisch
                  c/o Mentor Partners, LP
                  499 Park Avenue
                  New York, NY  10022

2.    Date of Event Requiring Statement (Month/Day/Year)

                  5/27/1999

3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4. Issuer Name and Ticker or Trading Symbol:

                  Trimeris, Inc. (TRMS)

5. Relationship of Reporting Persons(s) to Issuer:

                  ___ Director
                  ___ Officer (give title below)
                  _X_ 10% Owner
                  ___ Other (specify below)

                  ------------------------

6.    If Amendment, Date of Original (Month/Day/Year)



7.    Individual or Joint/Group Filing (Check Applicable Line)

                  ___ Form filed by One Reporting Person
                  _X_ Form filed by More than One Reporting Person


<PAGE>
                                                              Page 9 of 31 pages


             Table I - Non-Derivative Securities Beneficially Owned

1.    Title of Security

                  Common  Stock, $.001 par value

2.    Amount of Securities Beneficially Owned

                  288,325

3.    Ownership Form:  Direct (D) or Indirect (I)

                  I

4.    Nature of Indirect Beneficial Ownership

                  (See explanation to Form 3 of Four Partners)

        Table II - Derivative Securities Beneficially Owned (e.g., puts,
               calls, warrants, options, convertible securities)

1.    Title of Derivative Security

2.    Date Exercisable and Expiration Date (Month/Day/Year)

                  Date Exercisable

                  Expiration Date

3.    Title and Amount of Securities Underlying Derivative Security

                  Title

                  Amount or Number of Shares

4.    Conversion or Exercise Price of Derivative Security

5.    Ownership Form of Derivative Security:  Direct (D) or Indirect (I)

6.    Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]



<PAGE>
                                                             Page 10 of 31 pages


                      Attachment To Form 3 of Four Partners
                       in Respect of Trimeris, Inc. (TRMS)
                  Date of Event Requiring Statement: 5/27/1999

Joint Filer Information

1.    Name and Address of Reporting Person:

                  James S. Tisch
                  667 Madison Avenue
                  New York, NY  10021

2.    Date of Event Requiring Statement (Month/Day/Year)

                  5/27/1999

3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4. Issuer Name and Ticker or Trading Symbol:

                  Trimeris, Inc. (TRMS)

5. Relationship of Reporting Persons(s) to Issuer:

                  ___ Director
                  ___ Officer (give title below)
                  _X_ 10% Owner
                  ___ Other (specify below)

                  -----------------------------

6.    If Amendment, Date of Original (Month/Day/Year)



7.    Individual or Joint/Group Filing (Check Applicable Line)

                  ___ Form filed by One Reporting Person
                  _X_ Form filed by More than One Reporting Person


<PAGE>
                                                             Page 11 of 31 pages


             Table I - Non-Derivative Securities Beneficially Owned

1.    Title of Security

                  Common  Stock, $.001 par value

2.    Amount of Securities Beneficially Owned

                  288,325

3.    Ownership Form:  Direct (D) or Indirect (I)

                  I

4.    Nature of Indirect Beneficial Ownership

      (See explanation to Form 3 of Four Partners)

        Table II - Derivative Securities Beneficially Owned (e.g., puts,
               calls, warrants, options, convertible securities)

1.    Title of Derivative Security

2.    Date Exercisable and Expiration Date (Month/Day/Year)

                  Date Exercisable

                  Expiration Date

3.    Title and Amount of Securities Underlying Derivative Security

                  Title

                  Amount or Number of Shares

4.    Conversion or Exercise Price of Derivative Security

5.    Ownership Form of Derivative Security:  Direct (D) or Indirect (I)

6.    Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]



<PAGE>
                                                             Page 12 of 31 pages


                      Attachment To Form 3 of Four Partners
                       in Respect of Trimeris, Inc. (TRMS)
                  Date of Event Requiring Statement: 5/27/1999

Joint Filer Information

1.    Name and Address of Reporting Person:

                  Andrew H. Tisch
                  667 Madison Avenue
                  New York, NY  10021

2.    Date of Event Requiring Statement (Month/Day/Year)

                  5/27/1999

3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4. Issuer Name and Ticker or Trading Symbol:

                  Trimeris, Inc. (TRMS)

5. Relationship of Reporting Persons(s) to Issuer:

                  ___ Director
                  ___ Officer (give title below)
                  _X_ 10% Owner
                  ___ Other (specify below)

                  --------------------

6.    If Amendment, Date of Original (Month/Day/Year)



7.    Individual or Joint/Group Filing (Check Applicable Line)

                  ___ Form filed by One Reporting Person
                  _X_ Form filed by More than One Reporting Person


<PAGE>
                                                             Page 13 of 31 pages


             Table I - Non-Derivative Securities Beneficially Owned

1.    Title of Security

                  Common  Stock, $.001 par value

2.    Amount of Securities Beneficially Owned

                  288,325

3.    Ownership Form:  Direct (D) or Indirect (I)

                  I

4.    Nature of Indirect Beneficial Ownership

                  (See explanation to Form 3 of Four Partners)

        Table II - Derivative Securities Beneficially Owned (e.g., puts,
               calls, warrants, options, convertible securities)

1.    Title of Derivative Security

2.    Date Exercisable and Expiration Date (Month/Day/Year)

                  Date Exercisable

                  Expiration Date

3.    Title and Amount of Securities Underlying Derivative Security

                  Title

                  Amount or Number of Shares

4.    Conversion or Exercise Price of Derivative Security

5.    Ownership Form of Derivative Security:  Direct (D) or Indirect (I)

6.    Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]



<PAGE>
                                                             Page 14 of 31 pages


                      Attachment To Form 3 of Four Partners
                       in Respect of Trimeris, Inc. (TRMS)
                  Date of Event Requiring Statement: 5/27/1999

Joint Filer Information

1.    Name and Address of Reporting Person:

                    The Thomas J. Tisch 1999 Annuity Trust IV
                    c/o Mr. Barry Bloom
                    665 Madison Avenue
                    New York, NY  10021

2.    Date of Event Requiring Statement (Month/Day/Year)

                  5/27/1999

3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4. Issuer Name and Ticker or Trading Symbol:

                  Trimeris, Inc. (TRMS)

5. Relationship of Reporting Persons(s) to Issuer:

                  ___ Director
                  ___ Officer (give title below)
                  _X_ 10% Owner
                  ___ Other (specify below)

                  --------------------

6.    If Amendment, Date of Original (Month/Day/Year)



7.    Individual or Joint/Group Filing (Check Applicable Line)

                  ___ Form filed by One Reporting Person
                  _X_ Form filed by More than One Reporting Person


<PAGE>
                                                             Page 15 of 31 pages


             Table I - Non-Derivative Securities Beneficially Owned

1.    Title of Security

                  Common  Stock, $.001 par value

2.    Amount of Securities Beneficially Owned

                  38,325

3.    Ownership Form:  Direct (D) or Indirect (I)

                  D

4.    Nature of Indirect Beneficial Ownership



        Table II - Derivative Securities Beneficially Owned (e.g., puts,
               calls, warrants, options, convertible securities)

1.    Title of Derivative Security

2.    Date Exercisable and Expiration Date (Month/Day/Year)

                  Date Exercisable

                  Expiration Date

3.    Title and Amount of Securities Underlying Derivative Security

                  Title

                  Amount or Number of Shares

4.    Conversion or Exercise Price of Derivative Security

5.    Ownership Form of Derivative Security:  Direct (D) or Indirect (I)

6.    Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]



<PAGE>
                                                             Page 16 of 31 pages


                      Attachment To Form 3 of Four Partners
                       in Respect of Trimeris, Inc. (TRMS)
                  Date of Event Requiring Statement: 5/27/1999

Joint Filer Information

1.    Name and Address of Reporting Person:

                  The Daniel R. Tisch 1999 Annuity Trust IV
                  c/o Mr. Barry Bloom
                  665 Madison Avenue
                  New York, NY  10021

2.    Date of Event Requiring Statement (Month/Day/Year)

                  5/27/1999

3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4. Issuer Name and Ticker or Trading Symbol:

                  Trimeris, Inc. (TRMS)

5. Relationship of Reporting Persons(s) to Issuer:

                  ___ Director
                  ___ Officer (give title below)
                  _X_ 10% Owner
                  ___ Other (specify below)

                  --------------------

6.    If Amendment, Date of Original (Month/Day/Year)



7.    Individual or Joint/Group Filing (Check Applicable Line)

                  ___ Form filed by One Reporting Person
                  _X_ Form filed by More than One Reporting Person


<PAGE>
                                                             Page 17 of 31 pages


             Table I - Non-Derivative Securities Beneficially Owned

1.    Title of Security

                  Common  Stock, $.001 par value

2.    Amount of Securities Beneficially Owned

                  38,325

3.    Ownership Form:  Direct (D) or Indirect (I)

                  D

4.    Nature of Indirect Beneficial Ownership



        Table II - Derivative Securities Beneficially Owned (e.g., puts,
               calls, warrants, options, convertible securities)

1.    Title of Derivative Security

2.    Date Exercisable and Expiration Date (Month/Day/Year)

                  Date Exercisable

                  Expiration Date

3.    Title and Amount of Securities Underlying Derivative Security

                  Title

                  Amount or Number of Shares

4.    Conversion or Exercise Price of Derivative Security

5.    Ownership Form of Derivative Security:  Direct (D) or Indirect (I)

6.    Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]



<PAGE>
                                                             Page 18 of 31 pages


                      Attachment To Form 3 of Four Partners
                       in Respect of Trimeris, Inc. (TRMS)
                  Date of Event Requiring Statement: 5/27/1999

Joint Filer Information

1.    Name and Address of Reporting Person:

                  The James S. Tisch 1999 Annuity Trust IV
                  c/o Thomas J. Tisch
                  665 Madison Avenue
                  New York, NY  10021

2.    Date of Event Requiring Statement (Month/Day/Year)

                  5/27/1999

3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4. Issuer Name and Ticker or Trading Symbol:

                  Trimeris, Inc. (TRMS)

5. Relationship of Reporting Persons(s) to Issuer:

                  ___ Director
                  ___ Officer (give title below)
                  _X_ 10% Owner
                  ___ Other (specify below)

                  --------------------

6.    If Amendment, Date of Original (Month/Day/Year)



7.    Individual or Joint/Group Filing (Check Applicable Line)

                  ___ Form filed by One Reporting Person
                  _X_ Form filed by More than One Reporting Person


<PAGE>
                                                             Page 19 of 31 pages


             Table I - Non-Derivative Securities Beneficially Owned

1.    Title of Security

                  Common  Stock, $.001 par value

2.    Amount of Securities Beneficially Owned

                  38,325

3.    Ownership Form:  Direct (D) or Indirect (I)

                  D

4.    Nature of Indirect Beneficial Ownership



        Table II - Derivative Securities Beneficially Owned (e.g., puts,
               calls, warrants, options, convertible securities)

1.    Title of Derivative Security

2.    Date Exercisable and Expiration Date (Month/Day/Year)

                  Date Exercisable

                  Expiration Date

3.    Title and Amount of Securities Underlying Derivative Security

                  Title

                  Amount or Number of Shares

4.    Conversion or Exercise Price of Derivative Security

5.    Ownership Form of Derivative Security:  Direct (D) or Indirect (I)

6.    Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]



<PAGE>
                                                             Page 20 of 31 pages


                      Attachment To Form 3 of Four Partners
                       in Respect of Trimeris, Inc. (TRMS)
                  Date of Event Requiring Statement: 5/27/1999

Joint Filer Information

1.    Name and Address of Reporting Person:

                  The Andrew H. Tisch 1999 Annuity Trust IV
                  c/o Mr. Barry Bloom
                  665 Madison Avenue
                  New York, NY  10021

2.    Date of Event Requiring Statement (Month/Day/Year)

                  5/27/1999

3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4. Issuer Name and Ticker or Trading Symbol:

                  Trimeris, Inc. (TRMS)

5. Relationship of Reporting Persons(s) to Issuer:

                  ___ Director
                  ___ Officer (give title below)
                  _X_ 10% Owner
                  ___ Other (specify below)

                  --------------------

6.    If Amendment, Date of Original (Month/Day/Year)



7.    Individual or Joint/Group Filing (Check Applicable Line)

                  ___ Form filed by One Reporting Person
                  _X_ Form filed by More than One Reporting Person


<PAGE>
                                                             Page 21 of 31 pages


             Table I - Non-Derivative Securities Beneficially Owned

1.    Title of Security

                  Common  Stock, $.001 par value

2.    Amount of Securities Beneficially Owned

                  38,325

3.    Ownership Form:  Direct (D) or Indirect (I)

                  D

4.    Nature of Indirect Beneficial Ownership



        Table II - Derivative Securities Beneficially Owned (e.g., puts,
               calls, warrants, options, convertible securities)

1.    Title of Derivative Security

2.    Date Exercisable and Expiration Date (Month/Day/Year)

                  Date Exercisable

                  Expiration Date

3.    Title and Amount of Securities Underlying Derivative Security

                  Title

                  Amount or Number of Shares

4.    Conversion or Exercise Price of Derivative Security

5.    Ownership Form of Derivative Security:  Direct (D) or Indirect (I)

6.    Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]



<PAGE>
                                                             Page 22 of 31 pages


                      Attachment To Form 3 of Four Partners
                       in Respect of Trimeris, Inc. (TRMS)
                  Date of Event Requiring Statement: 5/27/1999

Joint Filer Information

1.    Name and Address of Reporting Person:

                    The Thomas J. Tisch 1999 Annuity Trust VII
                    c/o Mr. Barry Bloom
                    665 Madison Avenue
                    New York, NY  10021

2.    Date of Event Requiring Statement (Month/Day/Year)

                  5/27/1999

3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4. Issuer Name and Ticker or Trading Symbol:

                  Trimeris, Inc. (TRMS)

5. Relationship of Reporting Persons(s) to Issuer:

                  ___ Director
                  ___ Officer (give title below)
                  _X_ 10% Owner
                  ___ Other (specify below)

                  --------------------

6.    If Amendment, Date of Original (Month/Day/Year)



7.    Individual or Joint/Group Filing (Check Applicable Line)

                  ___ Form filed by One Reporting Person
                  _X_ Form filed by More than One Reporting Person


<PAGE>
                                                             Page 23 of 31 pages


             Table I - Non-Derivative Securities Beneficially Owned

1.    Title of Security

                  Common  Stock, $.001 par value

2.    Amount of Securities Beneficially Owned

                  250,000

3.    Ownership Form:  Direct (D) or Indirect (I)

                  D

4.    Nature of Indirect Beneficial Ownership



        Table II - Derivative Securities Beneficially Owned (e.g., puts,
               calls, warrants, options, convertible securities)

1.    Title of Derivative Security

2.    Date Exercisable and Expiration Date (Month/Day/Year)

                  Date Exercisable

                  Expiration Date

3.    Title and Amount of Securities Underlying Derivative Security

                  Title

                  Amount or Number of Shares

4.    Conversion or Exercise Price of Derivative Security

5.    Ownership Form of Derivative Security:  Direct (D) or Indirect (I)

6.    Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]



<PAGE>
                                                             Page 24 of 31 pages


                      Attachment To Form 3 of Four Partners
                       in Respect of Trimeris, Inc. (TRMS)
                  Date of Event Requiring Statement: 5/27/1999

Joint Filer Information

1.    Name and Address of Reporting Person:

                  The Daniel R. Tisch 1999 Annuity Trust VII
                  c/o Mr. Barry Bloom
                  665 Madison Avenue
                  New York, NY  10021

2.    Date of Event Requiring Statement (Month/Day/Year)

                  5/27/1999

3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4. Issuer Name and Ticker or Trading Symbol:

                  Trimeris, Inc. (TRMS)

5. Relationship of Reporting Persons(s) to Issuer:

                  ___ Director
                  ___ Officer (give title below)
                  _X_ 10% Owner
                  ___ Other (specify below)

                  --------------------

6.    If Amendment, Date of Original (Month/Day/Year)



7.    Individual or Joint/Group Filing (Check Applicable Line)

                  ___ Form filed by One Reporting Person
                  _X_ Form filed by More than One Reporting Person


<PAGE>
                                                             Page 25 of 31 pages


             Table I - Non-Derivative Securities Beneficially Owned

1.    Title of Security

                  Common  Stock, $.001 par value

2.    Amount of Securities Beneficially Owned

                  250,000

3.    Ownership Form:  Direct (D) or Indirect (I)

                  D

4.    Nature of Indirect Beneficial Ownership



        Table II - Derivative Securities Beneficially Owned (e.g., puts,
               calls, warrants, options, convertible securities)

1.    Title of Derivative Security

2.    Date Exercisable and Expiration Date (Month/Day/Year)

                  Date Exercisable

                  Expiration Date

3.    Title and Amount of Securities Underlying Derivative Security

                  Title

                  Amount or Number of Shares

4.    Conversion or Exercise Price of Derivative Security

5.    Ownership Form of Derivative Security:  Direct (D) or Indirect (I)

6.    Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]



<PAGE>
                                                             Page 26 of 31 pages


                      Attachment To Form 3 of Four Partners
                       in Respect of Trimeris, Inc. (TRMS)
                  Date of Event Requiring Statement: 5/27/1999

Joint Filer Information

1.    Name and Address of Reporting Person:

                  The James S. Tisch 1999 Annuity Trust VII
                  c/o Thomas J. Tisch
                  665 Madison Avenue
                  New York, NY  10021

2.    Date of Event Requiring Statement (Month/Day/Year)

                  5/27/1999

3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4. Issuer Name and Ticker or Trading Symbol:

                  Trimeris, Inc. (TRMS)

5. Relationship of Reporting Persons(s) to Issuer:

                  ___ Director
                  ___ Officer (give title below)
                  _X_ 10% Owner
                  ___ Other (specify below)

                  --------------------

6.    If Amendment, Date of Original (Month/Day/Year)



7.    Individual or Joint/Group Filing (Check Applicable Line)

                  ___ Form filed by One Reporting Person
                  _X_ Form filed by More than One Reporting Person


<PAGE>
                                                             Page 27 of 31 pages


             Table I - Non-Derivative Securities Beneficially Owned

1.    Title of Security

                  Common  Stock, $.001 par value

2.    Amount of Securities Beneficially Owned

                  250,000

3.    Ownership Form:  Direct (D) or Indirect (I)

                  D

4.    Nature of Indirect Beneficial Ownership



        Table II - Derivative Securities Beneficially Owned (e.g., puts,
               calls, warrants, options, convertible securities)

1.    Title of Derivative Security

2.    Date Exercisable and Expiration Date (Month/Day/Year)

                  Date Exercisable

                  Expiration Date

3.    Title and Amount of Securities Underlying Derivative Security

                  Title

                  Amount or Number of Shares

4.    Conversion or Exercise Price of Derivative Security

5.    Ownership Form of Derivative Security:  Direct (D) or Indirect (I)

6.    Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]



<PAGE>
                                                             Page 28 of 31 pages


                      Attachment To Form 3 of Four Partners
                       in Respect of Trimeris, Inc. (TRMS)
                  Date of Event Requiring Statement: 5/27/1999

Joint Filer Information

1.    Name and Address of Reporting Person:

                  The Andrew H. Tisch 1999 Annuity Trust VII
                  c/o Mr. Barry Bloom
                  665 Madison Avenue
                  New York, NY  10021

2.    Date of Event Requiring Statement (Month/Day/Year)

                  5/27/1999

3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4. Issuer Name and Ticker or Trading Symbol:

                  Trimeris, Inc. (TRMS)

5. Relationship of Reporting Persons(s) to Issuer:

                  ___ Director
                  ___ Officer (give title below)
                  _X_ 10% Owner
                  ___ Other (specify below)

                  --------------------

6.    If Amendment, Date of Original (Month/Day/Year)



7.    Individual or Joint/Group Filing (Check Applicable Line)

                  ___ Form filed by One Reporting Person
                  _X_ Form filed by More than One Reporting Person


<PAGE>
                                                             Page 29 of 31 pages


             Table I - Non-Derivative Securities Beneficially Owned

1.    Title of Security

                  Common  Stock, $.001 par value

2.    Amount of Securities Beneficially Owned

                  250,000

3.    Ownership Form:  Direct (D) or Indirect (I)

                  D

4.    Nature of Indirect Beneficial Ownership



        Table II - Derivative Securities Beneficially Owned (e.g., puts,
               calls, warrants, options, convertible securities)

1.    Title of Derivative Security

2.    Date Exercisable and Expiration Date (Month/Day/Year)

                  Date Exercisable

                  Expiration Date

3.    Title and Amount of Securities Underlying Derivative Security

                  Title

                  Amount or Number of Shares

4.    Conversion or Exercise Price of Derivative Security

5.    Ownership Form of Derivative Security:  Direct (D) or Indirect (I)

6.    Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]



<PAGE>
                                                             Page 30 of 31 pages


                                    SIGNATURE



              Witness, the signatures of the undersigned this 3rd day of
June, 1999.

                                    FOUR PARTNERS

                                    By    /s/ Thomas J. Tisch
                                      ------------------------------
                                          Thomas J. Tisch, Manager


                                    /s/ Andrew H. Tisch
                                    --------------------------------
                                    Andrew H. Tisch


                                    /s/ Daniel R. Tisch
                                    --------------------------------
                                    Daniel R. Tisch


                                    /s/ James S. Tisch
                                    --------------------------------
                                    James S. Tisch


                                    /s/ Thomas J. Tisch
                                    --------------------------------
                                    Thomas J. Tisch


                                    THE ANDREW H. TISCH 1999 ANNUITY TRUST IV

                                    By    /s/ Daniel R. Tisch
                                      ------------------------------
                                          Daniel R. Tisch, Trustee


                                    THE DANIEL R. TISCH 1999 ANNUITY TRUST IV

                                    By    /s/ James S. Tisch
                                      ------------------------------
                                          James S. Tisch, Trustee


<PAGE>
                                                             Page 31 of 31 pages


                                    THE JAMES S. TISCH 1999 ANNUITY TRUST IV


                                    By    /s/ Thomas J. Tisch
                                      ------------------------------
                                          Thomas J. Tisch, Trustee


                                    THE THOMAS J. TISCH 1999 ANNUITY TRUST IV

                                    By    /s/ Andrew H. Tisch
                                      ------------------------------
                                           Andrew H. Tisch, Trustee


                                    THE ANDREW H. TISCH 1999 ANNUITY TRUST VII

                                    By    /s/ Daniel R. Tisch
                                      ------------------------------
                                          Daniel R. Tisch, Trustee


                                    THE DANIEL R. TISCH 1999 ANNUITY TRUST VII

                                    By    /s/ James S. Tisch
                                      ------------------------------
                                          James S. Tisch, Trustee


                                    THE JAMES S. TISCH 1999 ANNUITY TRUST VII

                                    By    /s/ Thomas J. Tisch
                                      ------------------------------
                                          Thomas J. Tisch, Trustee


                                    THE THOMAS J. TISCH 1999 ANNUITY TRUST VII

                                    By    /s/ Andrew H. Tisch
                                      ------------------------------
                                          Andrew H. Tisch, Trustee



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