AXYS PHARMECUETICALS INC
8-K, 1998-10-09
PHARMACEUTICAL PREPARATIONS
Previous: MACE SECURITY INTERNATIONAL INC, 3, 1998-10-09
Next: ABC RAIL PRODUCTS CORP, 10-K, 1998-10-09



<PAGE>   1
                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D. C. 20549

                                    FORM 8-K

                      RELATING TO ADOPTION OF A RIGHTS PLAN



                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934



        Date of Report (Date of earliest event reported): October 8, 1998



                           AXYS PHARMACEUTICALS, INC.
             (Exact name of registrant as specified in its charter)


                                    DELAWARE
                 (State or other jurisdiction of incorporation)



     0-22788                                              22-2969941
(Commission File No.)                          (IRS Employer Identification No.)



                                 180 KIMBALL WAY
                          SOUTH SAN FRANCISCO, CA 94080
              (Address of principal executive offices and zip code)



       Registrant's telephone number, including area code: (650) 829-1000



                          -----------------------------

<PAGE>   2

         Item 5.  Other Events.

         On October 8, 1998, the Board of Directors of Axys Pharmaceuticals,
Inc. (the "Company") approved the adoption of a Preferred Share Purchase Rights
Plan (the "Plan"). Terms of the Plan provide for a dividend distribution of one
preferred share purchase right (a "Right") for each outstanding share of common
stock, par value $.001 per share (the "Common Shares"), of the Company. The
dividend is payable on October 28, 1998 (the "Record Date") to the stockholders
of record on that date. Each Right entitles the registered holder to purchase
from the Company one one-hundredth of a share of Series A Junior Participating
Preferred Stock, par value $.001 per share (the "Preferred Shares"), at a price
of $35.00 per one one-hundredth of a Preferred Share (the "Purchase Price"),
subject to adjustment. Each one one-hundredth of a Preferred Share has
designations and powers, preferences and rights, and the qualifications,
limitations and restrictions which make its value approximately equal to the
value of a Common Share. The description and terms of the Rights are set forth
in a Rights Agreement (the "Rights Agreement"), dated as of October 8, 1998
entered into between the Company and ChaseMellon Shareholder Services, L.L.C.,
as rights agent (the "Rights Agent"). The following summary is qualified in its
entirety by reference to the Rights Agreement.

         Initially, the Rights will be evidenced by the stock certificates
representing the Common Shares then outstanding, and no separate Right
Certificates, as defined in the Plan, will be distributed. Until the earlier to
occur of (i) the date of a public announcement that a person, entity or group of
affiliated or associated persons have acquired beneficial ownership of 15% or
more of the outstanding Common Shares (an "Acquiring Person") or (ii) 10
business days (or such later date as may be determined by action of the Board of
Directors prior to such time as any person or entity becomes an Acquiring
Person) following the commencement of, or announcement of an intention to
commence, a tender offer or exchange offer the consummation of which would
result in any person or entity becoming an Acquiring Person (the earlier of such
dates being called the "Distribution Date"), the Rights will be evidenced, with
respect to any of the Common Share certificates outstanding as of the Record
Date, by such Common Share certificate with or without a copy of the Summary of
Rights, which is included in the Rights Agreement as Exhibit C thereof (the
"Summary of Rights").

         Until the Distribution Date, the Rights will be transferable with and
only with the Common Shares. Until the Distribution Date (or earlier redemption
or expiration of the Rights), new Common Share certificates issued after the
Record Date, upon transfer or new issuance of Common Shares, will contain a
notation incorporating the Rights Agreement by reference. Until the Distribution
Date (or earlier redemption or expiration of the Rights), the surrender or
transfer of any certificates for Common Shares outstanding as of the Record
Date, even without such notation or a copy of the Summary of Rights being
attached thereto, will also constitute the transfer of the Rights associated
with the Common Shares represented by such certificate. As soon as practicable
following the Distribution Date, separate certificates evidencing the Rights
("Right Certificates") will be mailed to holders of record of the Common Shares
as of the close of business on the Distribution Date and such separate Right
Certificates alone will evidence the Rights.



                                       1
<PAGE>   3

         The Rights are not exercisable until the Distribution Date. The Rights
will expire on October 7, 2008 (the "Final Expiration Date"), unless the Rights
are earlier redeemed or exchanged by the Company, in each case, as described
below.

         The Purchase Price payable, and the number of Preferred Shares or other
securities or other property, upon exercise of the Rights are subject to
adjustment from time to time to prevent dilution (i) in the event of a stock
dividend on, or a subdivision, combination or reclassification of, the Preferred
Shares, (ii) upon the grant to holders of the Preferred Shares of certain rights
or warrants to subscribe for or purchase Preferred Shares at a price, or
securities convertible into Preferred Shares with a conversion price, less than
the then current market price of the Preferred Shares or (iii) upon the
distribution to holders of the Preferred Shares of evidences of indebtedness or
assets (excluding regular periodic cash dividends paid out of earnings or
retained earnings or dividends payable in Preferred Shares) or of subscription
rights or warrants (other than those referred to above). The exercise of Rights
for Preferred Shares is at all times subject to the availability of a sufficient
number of authorized but unissued Preferred Shares.

         The number of outstanding Rights and the number of one one-hundredths
of a Preferred Share issuable upon exercise of each Right are also subject to
adjustment in the event of a stock split of the Common Shares or a stock
dividend on the Common Shares payable in Common Shares or subdivisions,
consolidation or combinations of the Common Shares occurring, in any case, prior
to the Distribution Date.

         Preferred Shares purchasable upon exercise of the Rights will not be
redeemable. Each Preferred Share will be entitled to a minimum preferential
quarterly dividend payment of $1.00 but will be entitled to an aggregate
dividend of 100 times the dividend declared per Common Share. In the event of
liquidation, the holders of the Preferred Shares would be entitled to a minimum
preferential liquidation payment of $100 per share, but would be entitled to
receive an aggregate payment equal to 100 times the payment made per Common
Share. Each Preferred Share will have 100 votes, voting together with the Common
Shares. Finally, in the event of any merger, consolidation or other transaction
in which Common Shares are exchanged, each Preferred Share will be entitled to
receive 100 times the amount of consideration received per Common Share. These
rights are protected by customary anti-dilution provisions. Because of the
nature of the Preferred Shares' dividend and liquidation rights, the value of
one one-hundredth of a Preferred Share should approximate the value of one
Common Share. The Preferred Shares would rank junior to any other series of the
Company's preferred stock.

         In the event that any person or group of affiliated or associated
persons becomes an Acquiring Person, proper provision shall be made so that each
holder of a Right, other than Rights beneficially owned by the Acquiring Person
and its associates and affiliates (which will thereafter be void), will for a
60-day period have the right to receive upon exercise that number of Common
Shares having a market value of two times the exercise price of the Right (or,
if such number of shares is not and cannot be authorized, the Company may issue
Preferred Shares, cash, debt, stock or a combination thereof in exchange for the
Rights). This right will terminate 60 days after the date on which the Rights
become nonredeemable (as described below), unless



                                       2
<PAGE>   4

there is an injunction or similar obstacle to exercise of the Rights, in which
event this right will terminate 60 days after the date on which the Rights again
become exercisable.

         Generally, under the Plan, an "Acquiring Person" shall not be deemed to
include (i) the Company, (ii) a subsidiary of the Company, (iii) any employee
benefit or compensation plan of the Company, or (iv) any entity holding Common
Shares for or pursuant to the terms of any such employee benefit or compensation
plan. In addition, except under limited circumstances, no person or entity shall
become an Acquiring Person as the result of the acquisition of Common Shares by
the Company which, by reducing the number of shares outstanding, increases the
proportionate number of shares beneficially owned by such person or entity to
15% or more of the Common Shares then outstanding.

         In the event that the Company is acquired in a merger or other business
combination transaction or 50% or more of its consolidated assets or earning
power are sold to an Acquiring Person, its associates or affiliates or certain
other persons in which such persons have an interest, proper provision will be
made so that each holder of a Right will thereafter have the right to receive,
upon the exercise thereof at the then current exercise price of the Right, that
number of shares of common stock of the acquiring company which at the time of
such transaction will have a market value of two times the exercise price of the
Right.

         At any time after an Acquiring Person becomes an Acquiring Person and
prior to the acquisition by such Acquiring Person of 50% or more of the
outstanding Common Shares, the Board of Directors of the Company may exchange
the Rights (other than Rights owned by such person or group which have become
void), in whole or in part, at an exchange ratio of one Common Share, or one
one-hundredth of a Preferred Share, per Right (or, at the election of the
Company, the Company may issue cash, debt, stock or a combination thereof in
exchange for the Rights), subject to adjustment.

         With certain exceptions, no adjustment in the Purchase Price will be
required until cumulative adjustments require an adjustment of at least 1% in
such Purchase Price. No fractional Preferred Shares will be issued (other than
fractions which are integral multiples of the number of one one-hundredths of a
Preferred Share issuable upon the exercise of one Right, which may, at the
election of the Company, be evidenced by depositary receipts), and in lieu
thereof, an adjustment in cash will be made based on the market price of the
Preferred Shares on the last trading day prior to the date of exercise.

         At any time prior to the earliest of (i) the day of the first public
announcement that a person has become an Acquiring Person or (ii) the Final
Expiration Date, the Board of Directors of the Company may redeem the Rights in
whole, but not in part, at a price of $.01 per Right (the "Redemption Price").
Following the expiration of the above periods, the Rights become nonredeemable.
Immediately upon any redemption of the Rights, the right to exercise the Rights
will terminate and the only right of the holders of Rights will be to receive
the Redemption Price.



                                       3
<PAGE>   5

         The terms of the Rights may be amended by the Board of Directors of the
Company without the consent of the holders of the Rights, except that from and
after such time as the rights are distributed no such amendment may adversely
affect the interest of the holders of the Rights excluding the interests of an
Acquiring Person.

         Until a Right is exercised, the holder thereof, as such, will have no
rights as a stockholder of the Company, including, without limitation, the right
to vote or to receive dividends.

         The Rights have certain anti-takeover effects. The Rights will cause
substantial dilution to a person or group that attempts to acquire the Company
on terms not approved by the Company's Board of Directors. The Rights should not
interfere with any merger or other business combination approved by the Board of
Directors since the Rights may be amended to permit such acquisition or redeemed
by the Company at $.01 per Right prior to the earliest of (i) the time that a
person or group has acquired beneficial ownership of 15% or more of the Common
Shares or (ii) the Final Expiration Date.


         Item 7.  Exhibits.

<TABLE>
<S>                        <C>
                  99.1     Press Release, dated as of October 8, 1998 entitled
                           "Axys Pharmaceuticals, Inc. Adopts Stockholder Rights
                           Plan."

                  99.2     Rights Agreement dated as of October 8, 1998, among
                           Axys Pharmaceuticals, Inc. and ChaseMellon
                           Shareholder Services, L.L.C.

                  99.3     Registrant's Certificate of Designation of Series A
                           Junior Participating Preferred Stock.

                  99.4     Form of Rights Certificate.
</TABLE>



                                       4
<PAGE>   6

                                    SIGNATURE

         Pursuant to the requirements of the Securities Exchange Act of 1934,
the registrant has duly caused this report to be signed on its behalf by the
undersigned, thereunto duly authorized.


                                        AXYS PHARMACEUTICALS, INC.


Dated:  October 8, 1998                 By: /s/ Frederick J. Ruegsegger


                                        Name: Frederick J. Ruegsegger

                                        Title: Senior Vice President & Chief 
                                               Financial Officer



                                       5
<PAGE>   7

                                INDEX TO EXHIBITS



<TABLE>
<S>                        <C>
                  99.1     Press Release, dated as of October 8, 1998 entitled
                           "Axys Pharmaceuticals, Inc. Adopts Stockholder Rights
                           Plan."

                  99.2     Rights Agreement dated as of October 8, 1998, among
                           Axys Pharmaceuticals, Inc. and ChaseMellon
                           Shareholder Services, L.L.C..

                  99.3     Registrant's Certificate of Designation of Series A
                           Junior Participating Preferred Stock.

                  99.4     Form of Rights Certificate.
</TABLE>



                                       6

<PAGE>   1
                                                                    EXHIBIT 99.1



         Contact:

         Axys Pharmaceuticals, Inc.                     Burns McClellan, Inc.
         John Walker                                    Justin Jackson (media)
         Chairman and CEO                               John Nugent (investors)
         or                                                  (212) 213-0006
         David Gennarelli
         Manager Investor Relations
         (650) 829-1000


FOR IMMEDIATE RELEASE


               AXYS PHARMACEUTICALS ADOPTS STOCKHOLDER RIGHTS PLAN

         SOUTH SAN FRANCISCO, Calif. -- October 8, 1998 -- Axys Pharmaceuticals,
Inc. (Nasdaq: AXPH) announced today that its Board of Directors approved the
adoption of a Share Purchase Rights Plan under which all stockholders of record
as of October 28, 1998 will receive rights to purchase one one-hundredth of a
share of a new series of Preferred Stock.

         The Rights Plan is designed to enable all Axys Pharmaceuticals
stockholders to realize the full value of their investment and to provide for
fair and equal treatment for all stockholders in the event that an unsolicited
attempt is made to acquire Axys Pharmaceuticals. The adoption of the Rights Plan
is intended as a means to guard against abusive takeover tactics and is not in
response to any particular proposal.

         The rights will be distributed as a non-taxable dividend and will
expire in ten years from the Record Date. The rights will be exercisable only if
a person or group acquires 15 percent or more of Axys Pharmaceuticals' Common
Stock or announces a tender offer for 15 percent or more of the Common Stock. If
a person acquires 15 percent or more of Axys Pharmaceuticals' Common Stock, all
rightsholders except that person will be entitled to acquire Axys
Pharmaceuticals' Common Stock at a discount. The effect will be to discourage
acquisitions of more than 15 percent of Axys Pharmaceuticals' Common Stock
without negotiations with the Board.



                                   -- more --
<PAGE>   2

Axys Adopts Rights Plan
Page 2



         The rights will trade with Axys Pharmaceuticals' Common Stock, unless
and until they are separated upon the occurrence of certain future events. The
rights distribution is not taxable to the stockholders. Axys Pharmaceuticals'
Board of Directors may terminate the Rights Plan at any time or redeem the
rights prior to the time a person acquires more than 15 percent of Axys
Pharmaceuticals' Common Stock. Additional details regarding the Rights Plan will
be outlined in a summary to be mailed to all stockholders following the Record
Date.

         Axys Pharmaceuticals is a leader in the integration of life science
technologies with a focus on transforming gene discoveries into drugs. The
company has research collaborations with world-class pharmaceutical companies,
covering a broad range of therapeutic areas, including respiratory,
cardiovascular, and infectious disease, as well as oncology and central nervous
system disorders.

         Except for the historical information contained herein, this press
release contains forward-looking statements that involve risks and uncertainties
which could cause Axys' actual results to differ materially from those discussed
here, including unexpected difficulties and delays in the development of new
technologies the risk that Axys' collaborations will not be successful, the risk
that Axys will not be successful in entering into new collaborations, the risk
that clinical trials will not proceed as anticipated or may not be successful,
the risk of Axys' early stage of development, Axys' reliance on the efforts of
its collaborative partners, competition, and general economic conditions that
may affect Axys' actual results and developments. Additional factors that could
cause or contribute to such differences include, but are not limited to, those
discussed in the sections entitled "Business" and "Additional Risk Factors" in
the company's SEC Reports, including the company's report on Form 10-K for the
fiscal year ended December 31, 1997.

                                      # # #

For more information on Axys Pharmaceuticals, Inc., please visit the company's
website at http://www.axyspharm.com.



<PAGE>   1
                                                                    EXHIBIT 99.2



          -----------------------------------------------------------



                           AXYS PHARMACEUTICALS, INC.



                                      AND



                    CHASEMELLON SHAREHOLDER SERVICES, L.L.C.
                                AS RIGHTS AGENT



                                RIGHTS AGREEMENT



                          DATED AS OF OCTOBER 8, 1998



          -----------------------------------------------------------


<PAGE>   2
                               TABLE OF CONTENTS

<TABLE>
<CAPTION>
                                                                                   PAGE
<S>          <C>                                                                   <C>
SECTION 1.   CERTAIN DEFINITIONS....................................................1

SECTION 2.   APPOINTMENT OF RIGHTS AGENT............................................5

SECTION 3.   ISSUE OF RIGHT CERTIFICATES............................................5

SECTION 4.   FORM OF RIGHT CERTIFICATES.............................................7

SECTION 5.   COUNTERSIGNATURE AND REGISTRATION......................................8

SECTION 6.   TRANSFER, SPLIT UP, COMBINATION AND EXCHANGE OF RIGHT CERTIFICATES; 
             MUTILATED, DESTROYED, LOST OR STOLEN RIGHT CERTIFICATES................8

SECTION 7.   EXERCISE OF RIGHTS; PURCHASE PRICE; EXPIRATION DATE OF RIGHTS..........9

SECTION 8.   CANCELLATION AND DESTRUCTION OF RIGHT CERTIFICATES....................11

SECTION 9.   AVAILABILITY OF PREFERRED SHARES......................................11

SECTION 10.  PREFERRED SHARES RECORD DATE..........................................12

SECTION 11.  ADJUSTMENT OF PURCHASE PRICE, NUMBER OF SHARES OR NUMBER OF RIGHTS....13

SECTION 12.  CERTIFICATE OF ADJUSTED PURCHASE PRICE OR NUMBER OF SHARES............22

SECTION 13.  CONSOLIDATION, MERGER OR SALE OR TRANSFER OF ASSETS OR EARNING POWER..22

SECTION 14.  FRACTIONAL RIGHTS AND FRACTIONAL SHARES...............................26

SECTION 15.  RIGHTS OF ACTION......................................................27

SECTION 16.  AGREEMENT OF RIGHT HOLDERS............................................28

SECTION 17.  RIGHT CERTIFICATE HOLDER NOT DEEMED A STOCKHOLDER.....................28

SECTION 18.  CONCERNING THE RIGHTS AGENT...........................................29

SECTION 19.  MERGER OR CONSOLIDATION OR CHANGE OF NAME OF RIGHTS AGENT.............29

SECTION 20.  DUTIES OF RIGHTS AGENT................................................30

SECTION 21.  CHANGE OF RIGHTS AGENT................................................32

SECTION 22.  ISSUANCE OF NEW RIGHT CERTIFICATES....................................33

SECTION 23.  REDEMPTION............................................................34

SECTION 24.  EXCHANGE..............................................................36

SECTION 25.  NOTICE OF CERTAIN EVENTS..............................................38

SECTION 26.  NOTICES...............................................................39

SECTION 27.  SUPPLEMENTS AND AMENDMENTS............................................39

SECTION 28.  DETERMINATION AND ACTIONS BY THE BOARD OF DIRECTORS, ETC..............40
</TABLE>


<PAGE>   3
                               TABLE OF CONTENTS
                                  (CONTINUED)


<TABLE>
<CAPTION>
                                                                                   PAGE
<S>          <C>                                                                   <C>
SECTION 29.  SUCCESSORS............................................................40

SECTION 30.  BENEFITS OF THIS AGREEMENT............................................40

SECTION 31.  SEVERABILITY..........................................................41

SECTION 32.  GOVERNING LAW.........................................................41

SECTION 33.  COUNTERPARTS..........................................................41

SECTION 34.  DESCRIPTIVE HEADINGS..................................................41

EXHIBIT A -  CERTIFICATE OF DESIGNATION

EXHIBIT B -  FORM OF RIGHT CERTIFICATE

EXHIBIT C -  SUMMARY OF RIGHTS TO PURCHASE PREFERRED SHARES
</TABLE>



                                       2

<PAGE>   4

                                RIGHTS AGREEMENT


        THIS RIGHTS AGREEMENT ("AGREEMENT"), dated as of October 8, 1998,
between AXYS PHARMACEUTICALS, INC., a Delaware corporation (the "Company"), and
CHASEMELLON SHAREHOLDER SERVICES, L.L.C. ("Rights Agent").

        The Board of Directors of the Company has authorized and declared a
dividend of one preferred share purchase right (a "Right") for each Common Share
(as such term is hereinafter defined) outstanding at the close of business on
October 28, 1998 (the "Record Date"), each Right representing the right to
purchase one one-hundredth of a Preferred Share (as such term is hereinafter
defined), upon the terms and subject to the conditions herein set forth, and has
further authorized and directed the issuance of one Right with respect to each
Common Share that shall become outstanding between the Record Date and the
earliest to occur of the Distribution Date, the Redemption Date and the Final
Expiration Date (as such terms are hereinafter defined); provided, however, that
Rights may be issued with respect to Common Shares that shall become outstanding
after the Distribution Date and prior to the earlier of the Redemption Date and
the Final Expiration Date in accordance with the provisions of Section 22
hereof.

        Accordingly, in consideration of the premises and the mutual agreements
herein set forth, the parties hereby agree as follows:

SECTION 1.     CERTAIN DEFINITIONS.  For purposes of this Agreement, the 
               following terms have the meanings indicated:

               (a)  "ACQUIRING PERSON" shall mean any Person (as such term is
                    hereinafter defined) who or which, together with all
                    Affiliates and Associates (as such terms are hereinafter
                    defined) of such Person, shall be the Beneficial Owner (as
                    such term is hereinafter defined) of 15% or more of the
                    Common Shares then outstanding. Notwithstanding the
                    foregoing, (A) the term Acquiring Person shall not include
                    (i) the Company, (ii) any Subsidiary (as such term is
                    hereinafter defined) of the Company, (iii) any employee
                    benefit or compensation plan of the Company or any
                    Subsidiary of the Company, (iv) any entity holding Common
                    Shares for or pursuant to the terms of any such employee
                    benefit or compensation plan, and (B) no Person shall become
                    an "Acquiring Person" either (x) as the result of an
                    acquisition of Common Shares by the Company which, by
                    reducing the number of shares outstanding, increases the
                    proportionate number of shares beneficially owned by such
                    Person to 15% or more of the Common Shares then outstanding;
                    provided, however, that if a Person shall become the
                    Beneficial Owner of 15% or more of the Common Shares then
                    outstanding by reason of share purchases by the Company and
                    shall, following written notice from, or public disclosure
                    by the Company of such share purchases by the Company,
                    become the Beneficial Owner of any additional Common Shares
                    without the prior consent of the Company 



                                       1
<PAGE>   5

                    and shall then Beneficially Own more than 15% of the Common
                    Shares then outstanding, then such Person shall be deemed to
                    be an "Acquiring Person," or (y) if the Board of Directors
                    determines in good faith that a Person who would otherwise
                    be an "Acquiring Person," as defined pursuant to the
                    foregoing provisions of this paragraph (a), has become such
                    inadvertently, and such Person divests, as promptly as
                    practicable (as determined in good faith by the Board of
                    Directors), but in any event within five Business Days,
                    following receipt of written notice from the Company of such
                    event, of Beneficial Ownership of a sufficient number of
                    Common Shares so that such Person would no longer be an
                    Acquiring Person, as defined pursuant to the foregoing
                    provisions of this paragraph (a), then such Person shall no
                    longer be deemed to be an "Acquiring Person" for purposes of
                    this Agreement; provided, however, that if such Person shall
                    again become the Beneficial Owner of 15% or more of the
                    Common Shares then outstanding, such Person shall be deemed
                    an "Acquiring Person," subject to the exceptions set forth
                    in this Section 1(a).

               (b)  "AFFILIATE" and "ASSOCIATE" shall have the respective
                    meanings ascribed to such terms in Rule 12b-2 of the General
                    Rules and Regulations under the Securities Exchange Act of
                    1934, as amended (the "Exchange Act"), as in effect on the
                    date of this Agreement.

               (c)  A Person shall be deemed the "BENEFICIAL OWNER" of and shall
                    be deemed to "beneficially own" any securities:

                    (i)  which such Person or any of such Person's Affiliates or
                         Associates is deemed to beneficially own, within the
                         meaning of Rule 13d-3 of the General Rules and
                         Regulations under the Exchange Act as in effect on the
                         date of this Rights Agreement;

                    (ii) which such Person or any of such Person's Affiliates or
                         Associates has (A) the right to acquire (whether such
                         right is exercisable immediately or only after the
                         passage of time) pursuant to any agreement, arrangement
                         or understanding (other than customary agreements with
                         and between underwriters and selling group members with
                         respect to a bona fide public offering of securities
                         and other than agreements between the Company and any
                         corporate partner pursuant to which the right to
                         purchase shares is conditioned upon the achievement of
                         research or development milestones) or upon the
                         exercise of conversion rights, exchange rights, rights
                         (other than these Rights), warrants or options, or
                         otherwise; provided, however, that a Person shall not
                         be deemed the Beneficial Owner of, or to beneficially
                         own, securities tendered pursuant to a tender or
                         exchange offer made by or on behalf of 



                                       2
<PAGE>   6

                         such Person or any of such Person's Affiliates or
                         Associates until such tendered securities are accepted
                         for purchase or exchange; or (B) the right to vote
                         pursuant to any agreement, arrangement or
                         understanding; provided, however, that a Person shall
                         not be deemed the Beneficial Owner of, or to
                         beneficially own, any security if the agreement,
                         arrangement or understanding to vote such security (1)
                         arises solely from a revocable proxy or consent given
                         to such Person in response to a public proxy or consent
                         solicitation made pursuant to, and in accordance with,
                         the applicable rules and regulations promulgated under
                         the Exchange Act and (2) is not also then reportable on
                         Schedule 13D under the Exchange Act (or any comparable
                         or successor report); or

                   (iii) which are beneficially owned, directly or indirectly,
                         by any other Person with which such Person or any of
                         such Person's Affiliates or Associates has any
                         agreement, arrangement or understanding (other than
                         customary agreements with and between underwriters and
                         selling group members with respect to a bona fide
                         public offering of securities) for the purpose of
                         acquiring, holding, voting (except to the extent
                         contemplated by the proviso to Section 1(c)(ii)(B)
                         hereof) or disposing of any securities of the Company.

                    Notwithstanding anything in this definition of Beneficial
                    Ownership to the contrary, the phrase, "then outstanding,"
                    when used with reference to a Person's Beneficial Ownership
                    of securities of the Company, shall mean the number of such
                    securities then issued and outstanding together with the
                    number of such securities not then actually issued and
                    outstanding which such Person would be deemed to own
                    beneficially hereunder.

               (d)  "BUSINESS DAY" shall mean any day other than a Saturday, a
                    Sunday, or a day on which banking institutions in the State
                    of California are authorized or obligated by law or
                    executive order to close.

               (e)  "CLOSE OF BUSINESS" on any given date shall mean 5:00 p.m.,
                    Pacific Time, on such date; provided, however, that if such
                    date is not a Business Day it shall mean 5:00 p.m., Pacific
                    Time, on the next succeeding Business Day.

               (f)  "COMMON SHARES" shall mean the shares of common stock, par
                    value $.001 per share, of the Company; provided, however,
                    that, "Common Shares," when used in this Agreement in
                    connection with a specific reference to any Person other
                    than the Company, shall mean the capital stock (or equity
                    interest) with the greatest voting power of such other
                    Person or, if such other Person is a Subsidiary of another
                    Person, the Person or Persons which ultimately control such
                    first-mentioned Person.



                                       3
<PAGE>   7

               (g)  "DISTRIBUTION DATE" shall have the meaning set forth in
                    Section 3 hereof.

               (h)  "FINAL EXPIRATION DATE" shall have the meaning set forth in
                    Section 7(a) hereof.

               (i)  "INTERESTED STOCKHOLDER" shall mean any Acquiring Person or
                    any Affiliate or Associate of an Acquiring Person or any
                    other Person in which any such Acquiring Person, Affiliate
                    or Associate has an interest, or any other Person acting
                    directly or indirectly on behalf of or in concert with any
                    such Acquiring Person, Affiliate or Associate.

               (j)  "PERSON" shall mean any individual, firm, corporation or
                    other entity, and shall include any successor (by merger or
                    otherwise) of such entity.

               (k)  "PREFERRED SHARES" shall mean shares of Series A Junior
                    Participating Preferred Stock, par value $.001 per share, of
                    the Company having the designations and the powers,
                    preferences and rights, and the qualifications, limitations
                    and restrictions set forth in the Form of Certificate of
                    Designation attached to this Agreement as Exhibit A.

               (l)  "PURCHASE PRICE" shall have the meaning set forth in Section
                    7(b) hereof.

               (m)  "REDEMPTION DATE" shall have the meaning set forth in
                    Section 7(a) hereof.

               (n)  "SHARES ACQUISITION DATE" shall mean the first date of
                    public announcement by the Company or an Acquiring Person
                    that an Acquiring Person has become such; provided, however
                    that, if such Person is determined not to have become an
                    Acquiring Person pursuant to clause (y) of Subsection
                    1(a)(B) hereof, then no Shares Acquisition Date shall be
                    deemed to have occurred.

               (o)  "SUBSIDIARY" of any Person shall mean any corporation or
                    other entity of which a majority of the voting power of the
                    voting equity securities or equity interest is owned,
                    directly or indirectly, by such Person.

               (p)  "TRANSACTION" shall mean any merger, consolidation or sale
                    of assets described in Section 13(a) hereof or any
                    acquisition of Common Shares which would result in a Person
                    becoming an Acquiring Person or a Principal Party (as such
                    term is hereinafter defined).

               (q)  "TRANSACTION PERSON" with respect to a Transaction shall
                    mean (i) any Person who (x) is or will become an Acquiring
                    Person or a Principal Party (as such term is hereinafter
                    defined) if the Transaction were to be consummated and (y)
                    directly or indirectly proposed or nominated a director of
                    the Company which director is in office at the time of



                                       4
<PAGE>   8

                    consideration of the Transaction, or (ii) an Affiliate or
                    Associate of such a Person.

SECTION 2.     APPOINTMENT OF RIGHTS AGENT. The Company hereby appoints the 
               Rights Agent to act as agent for the Company in accordance with
               the terms and conditions hereof, and the Rights Agent hereby
               accepts such appointment. The Company may from time to time
               appoint such co-Rights Agents as it may deem necessary or
               desirable.

SECTION 3.     ISSUE OF RIGHT CERTIFICATES.

               (a)  Until the earlier of (i) the Shares Acquisition Date or (ii)
                    the tenth Business Day (or such later date as may be
                    determined by action of the Board of Directors prior to such
                    time as any Person becomes an Acquiring Person) after the
                    date of the commencement (determined in accordance with Rule
                    14d-2 under the Exchange Act) by any Person (other than the
                    Company, any Subsidiary of the Company, any employee benefit
                    plan of the Company or of any Subsidiary of the Company or
                    any entity holding Common Shares for or pursuant to the
                    terms of any such plan) of, or of the first public
                    announcement of the intention of any Person (other than the
                    Company, any Subsidiary of the Company, any employee benefit
                    plan of the Company or of any Subsidiary of the Company or
                    any entity holding Common Shares for or pursuant to the
                    terms of any such plan) to commence, a tender or exchange
                    offer (which intention to commence remains in effect for
                    five Business Days after such announcement), the
                    consummation of which would result in any Person becoming an
                    Acquiring Person (including any such date which is after the
                    date of this Agreement and prior to the issuance of the
                    Rights, the earlier of such dates being herein referred to
                    as the "Distribution Date"), (x) the Rights will be
                    evidenced by the certificates for Common Shares registered
                    in the names of the holders thereof (which certificates
                    shall also be deemed to be Right Certificates) and not by
                    separate Right Certificates, and (y) the Rights (and the
                    right to receive Right Certificates therefor) will be
                    transferable only in connection with the transfer of Common
                    Shares. As soon as practicable after the Distribution Date,
                    the Company will prepare and execute, the Rights Agent will
                    countersign, and the Company will send or cause to be sent
                    (and the Rights Agent will, if requested, send) by
                    first-class, insured, postage-prepaid mail, to each record
                    holder of Common Shares as of the Close of Business on the
                    Distribution Date, at the address of such holder shown on
                    the records of the Company, a Right Certificate, in
                    substantially the form of Exhibit B hereto (a "Right
                    Certificate"), evidencing one Right for each Common Share so
                    held, subject to the adjustment provisions of Section 11 of
                    this Rights Agreement. As of the Distribution Date, the
                    Rights will be evidenced solely by such Right Certificates.



                                       5
<PAGE>   9

               (b)  On the Record Date, or as soon as practicable thereafter,
                    the Company will send (directly or through the Rights Agent
                    or its transfer agent) a copy of a Summary of Rights to
                    Purchase Preferred Shares, in substantially the form of
                    Exhibit C hereto (the "Summary of Rights"), by first-class,
                    postage-prepaid mail, to each record holder of Common Shares
                    as of the Close of Business on the Record Date, at the
                    address of such holder shown on the records of the Company.
                    With respect to certificates for Common Shares outstanding
                    as of the Record Date, until the Distribution Date, the
                    Rights will be evidenced by such certificates registered in
                    the names of the holders thereof. Until the Distribution
                    Date (or the earlier of the Redemption Date and the Final
                    Expiration Date), the surrender for transfer of any
                    certificate for Common Shares outstanding on the Record Date
                    shall also constitute the transfer of the Rights associated
                    with the Common Shares represented thereby.

               (c)  Certificates for Common Shares which become outstanding
                    (including, without limitation, reacquired Common Shares
                    referred to in the last sentence of this paragraph (c))
                    after the Record Date but prior to the earliest of the
                    Distribution Date, the Redemption Date or the Final
                    Expiration Date shall have impressed on, printed on, written
                    on or otherwise affixed to them the following legend:

                        This certificate also evidences and entitles
                        the holder hereof to certain rights as set
                        forth in a Rights Agreement between Axys
                        Pharmaceuticals, Inc. (the "Corporation") and
                        ChaseMellon Shareholder Services, L.L.C., as
                        Rights Agent (the "Rights Agent"), dated as of
                        October 8, 1998, as amended from time to time
                        (the "Rights Agreement"), the terms of which
                        are hereby incorporated herein by reference
                        and a copy of which is on file at the
                        principal executive offices of the
                        Corporation. Under certain circumstances, as
                        set forth in the Rights Agreement, such Rights
                        will be evidenced by separate certificates and
                        will no longer be evidenced by this
                        certificate. The Corporation will mail to the
                        holder of this certificate a copy of the
                        Rights Agreement without charge after receipt
                        of a written request therefor addressed to the
                        Secretary of the Corporation. As described in
                        the Rights Agreement, Rights issued to any
                        Person who becomes an Acquiring Person or an
                        Affiliate or Associate thereof (as defined in
                        the Rights Agreement) and certain related
                        persons, whether currently held by or on
                        behalf of such Person or by any subsequent
                        holder, shall become null and void.



                                        6
<PAGE>   10

                    With respect to such certificates containing the foregoing
                    legend, until the Distribution Date, the Rights associated
                    with the Common Shares represented by such certificates
                    shall be evidenced by such certificates alone, and the
                    surrender for transfer of any such certificate shall also
                    constitute the transfer of the Rights associated with the
                    Common Shares represented thereby. In the event that the
                    Company purchases or acquires any Common Shares after the
                    Record Date but prior to the Distribution Date, any Rights
                    associated with such Common Shares shall be deemed canceled
                    and retired so that the Company shall not be entitled to
                    exercise any Rights associated with the Common Shares which
                    are no longer outstanding. Notwithstanding this Section
                    3(c), the omission of a legend shall not affect the
                    enforceability of any part of this Rights Agreement or the
                    rights of any holder of the Rights.

SECTION 4.     FORM OF RIGHT CERTIFICATES.

               (a)  The Right Certificates (and the form of election to purchase
                    Preferred Shares, the form of assignment and the form of
                    certification to be printed on the reverse thereof) shall be
                    substantially the same as Exhibit B hereto and may have such
                    marks of identification or designation and such legends,
                    summaries or endorsements printed thereon as the Company may
                    deem appropriate and as are not inconsistent with the
                    provisions of this Agreement, or as may be required to
                    comply with any applicable law or with any rule or
                    regulation made pursuant thereto or with any rule or
                    regulation of any stock exchange or quotation system on
                    which the Rights may from time to time be listed, or to
                    conform to usage. Subject to the provisions of Sections 7,
                    11 and 22 hereof, the Right Certificates shall entitle the
                    holders thereof to purchase such number of one
                    one-hundredths of a Preferred Share as shall be set forth
                    therein at the price per one one-hundredth of a Preferred
                    Share set forth therein (the "Purchase Price"), but the
                    number of such one one-hundredths of a Preferred Share and
                    the Purchase Price shall be subject to adjustment as
                    provided herein.

               (b)  Any Right Certificate issued pursuant to Section 3(a) or
                    Section 22 hereof that represents Rights which are null and
                    void pursuant to Section 11(a)(ii) hereof and any Right
                    Certificate issued pursuant to Section 6 or Section 11
                    hereof upon transfer, exchange, replacement or adjustment of
                    any other Right Certificate referred to in this sentence
                    shall contain (to the extent feasible) the following legend:

                        The Rights represented by this Right
                        Certificate are or were beneficially owned by
                        a Person who was or became an Acquiring Person
                        or an Affiliate or Associate of an Acquiring
                        Person (as such terms are defined in the
                        Rights Agreement). Accordingly, this 



                                       7
<PAGE>   11

                        Right Certificate and the Rights represented
                        hereby are null and void.

                    The provisions of Section 11(a)(ii) hereof shall be
                    operative whether or not the foregoing legend is contained
                    on any such Right Certificate.

SECTION 5.     COUNTERSIGNATURE AND REGISTRATION. The Right Certificates shall 
               be executed on behalf of the Company by its Chairman of the
               Board, its Chief Executive Officer, its President, its Vice
               Chairman of the Board, its Chief Financial Officer, or any of its
               Vice Presidents, either manually or by facsimile signature, shall
               have affixed thereto the Company's seal or a facsimile thereof,
               and shall be attested by the Secretary or an Assistant Secretary
               of the Company, either manually or by facsimile signature. The
               Right Certificates shall be manually countersigned by the Rights
               Agent and shall not be valid for any purpose unless
               countersigned. In case any officer of the Company who shall have
               signed any of the Right Certificates shall cease to be such
               officer of the Company before countersignature by the Rights
               Agent and issuance and delivery by the Company, such Right
               Certificates, nevertheless, may be countersigned by the Rights
               Agent and issued and delivered by the Company with the same force
               and effect as though the person who signed such Right
               Certificates had not ceased to be such officer of the Company;
               and any Right Certificate may be signed on behalf of the Company
               by any person who, at the actual date of the execution of such
               Right Certificate, shall be a proper officer of the Company to
               sign such Right Certificate, although at the date of the
               execution of this Agreement any such person was not such an
               officer.

               Following the Distribution Date, the Rights Agent will keep or
               cause to be kept, at its office designated for such purpose,
               books for registration and transfer of the Right Certificates
               issued hereunder. Such books shall show the names and addresses
               of the respective holders of the Right Certificates, the number
               of Rights evidenced on its face by each of the Right Certificates
               and the date of each of the Right Certificates.

SECTION 6.     TRANSFER, SPLIT UP, COMBINATION AND EXCHANGE OF RIGHT 
               CERTIFICATES; MUTILATED, DESTROYED, LOST OR STOLEN RIGHT
               CERTIFICATES. Subject to the provisions of Section 11(a)(ii),
               Section 14 and Section 24 hereof, at any time after the Close of
               Business on the Distribution Date, and at or prior to the Close
               of Business on the earlier of the Redemption Date or the Final
               Expiration Date, any Right Certificate or Right Certificates may
               be transferred, split up, combined or exchanged for another Right
               Certificate or Right Certificates, entitling the registered
               holder to purchase a like number of one one-hundredths of a
               Preferred Share as the Right Certificate or Right Certificates
               surrendered then entitled such holder to purchase. Any registered
               holder desiring to transfer, split up, combine or exchange any
               Right Certificate or Right Certificates shall make such request
               in writing delivered to the Rights Agent, and shall surrender the
               Right Certificate or Right Certificates to be transferred, split
               up, combined or exchanged at the office 



                                       8
<PAGE>   12

               of the Rights Agent designated for such purpose. Neither the
               Rights Agent nor the Company shall be obligated to take any
               action whatsoever with respect to the transfer of any such
               surrendered Right Certificate until the registered holder shall
               have completed and signed the certificate contained in the form
               of assignment on the reverse side of such Right Certificate and
               shall have provided such additional evidence of the identity of
               the Beneficial Owner (or former Beneficial Owner) or Affiliates
               or Associates thereof as the Company shall reasonably request.
               Thereupon the Rights Agent shall, subject to Section 11(a)(ii),
               Section 14 and Section 24 hereof, countersign and deliver to the
               person entitled thereto a Right Certificate or Right
               Certificates, as the case may be, as so requested. The Company
               may require payment of a sum sufficient to cover any tax or
               governmental charge that may be imposed in connection with any
               transfer, split up, combination or exchange of Right
               Certificates.

               Upon receipt by the Company and the Rights Agent of evidence
               reasonably satisfactory to them of the loss, theft, destruction
               or mutilation of a Right Certificate, and, in case of loss, theft
               or destruction, of indemnity or security reasonably satisfactory
               to them, and, at the Company's request, reimbursement to the
               Company and the Rights Agent of all reasonable expenses
               incidental thereto, and upon surrender to the Rights Agent and
               cancellation of the Right Certificate if mutilated, the Company
               will issue, execute and deliver a new Right Certificate of like
               tenor to the Rights Agent for countersignature and delivery to
               the registered holder in lieu of the Right Certificate so lost,
               stolen, destroyed or mutilated.

               Notwithstanding any other provisions hereof, the Company and the
               Rights Agent may amend this Rights Agreement to provide for
               uncertificated Rights in addition to or in place of Rights
               evidenced by Rights Certificates.

SECTION 7.     EXERCISE OF RIGHTS; PURCHASE PRICE; EXPIRATION DATE OF RIGHTS.

               (a)  The registered holder of any Right Certificate may exercise
                    the Rights evidenced thereby (except as otherwise provided
                    herein) in whole or in part at any time after the
                    Distribution Date upon surrender of the Right Certificate,
                    with the form of election to purchase on the reverse side
                    thereof duly executed, to the Rights Agent at the office of
                    the Rights Agent designated for such purpose, together with
                    payment of the Purchase Price for each one one-hundredth of
                    a Preferred Share (or such other number of shares or other
                    securities) as to which the Rights are exercised, at or
                    prior to the earliest of (i) the Close of Business on
                    October 7, 2008 (the "Final Expiration Date"), (ii) the time
                    at which the Rights are redeemed as provided in Section 23
                    hereof (the "Redemption Date"), or (iii) the time at which
                    such Rights are exchanged as provided in Section 24 hereof.

               (b)  The purchase price (the "Purchase Price") for each one
                    one-hundredth of a Preferred Share pursuant to the exercise
                    of a Right shall initially be $35.00 



                                       9
<PAGE>   13

                    and shall be subject to adjustment from time to time as
                    provided in Sections 11 and 13 hereof and shall be payable
                    in lawful money of the United States of America in
                    accordance with paragraph (c) below.

               (c)  Upon receipt of a Right Certificate representing exercisable
                    Rights, with the form of election to purchase duly executed,
                    accompanied by payment of the Purchase Price for the shares
                    to be purchased and an amount equal to any applicable
                    transfer tax required to be paid by the holder of such Right
                    Certificate in accordance with Section 9 hereof by certified
                    check, cashier's check, bank draft or money order payable to
                    the order of the Company, the Rights Agent shall thereupon
                    promptly (i) (A) requisition from any transfer agent for the
                    Preferred Shares certificates for the number of Preferred
                    Shares to be purchased and the Company hereby irrevocably
                    authorizes its transfer agent to comply with all such
                    requests, or (B) if the Company, in its sole discretion,
                    shall have elected to deposit the Preferred Shares issuable
                    upon exercise of the Rights hereunder into a depository,
                    requisition from the depositary agent depositary receipts
                    representing such number of one one-hundredths of a
                    Preferred Share as are to be purchased (in which case
                    certificates for the Preferred Shares represented by such
                    receipts shall be deposited by the transfer agent with the
                    depositary agent) and the Company hereby directs the
                    depositary agent to comply with such request, (ii) when
                    appropriate, requisition from the Company the amount of cash
                    to be paid in lieu of issuance of fractional shares in
                    accordance with Section 14 hereof, (iii) after receipt of
                    such certificates or depositary receipts, cause the same to
                    be delivered to or upon the order of the registered holder
                    of such Right Certificate, registered in such name or names
                    as may be designated by such holder and (iv) when
                    appropriate, after receipt, deliver such cash to or upon the
                    order of the registered holder of such Right Certificate. In
                    the event that the Company is obligated to issue securities
                    of the Company other than Preferred Shares (including Common
                    Shares) of the Company pursuant to Section 11(a) hereof, the
                    Company will make all arrangements necessary so that such
                    other securities are available for distribution by the
                    Rights Agent, if and when appropriate.

                    In addition, in the case of an exercise of the Rights by a
                    holder pursuant to Section 11(a)(ii) hereof, the Rights
                    Agent shall return such Right Certificate to the registered
                    holder thereof after imprinting, stamping or otherwise
                    indicating thereon that the rights represented by such Right
                    Certificate no longer include the rights provided by Section
                    11(a)(ii) hereof, and, if fewer than all the Rights
                    represented by such Right Certificate were so exercised, the
                    Rights Agent shall indicate on the Right Certificate the
                    number of Rights represented thereby which continue to
                    include the rights provided by Section 11(a)(ii) hereof.



                                       10
<PAGE>   14

               (d)  In case the registered holder of any Right Certificate shall
                    exercise fewer than all the Rights evidenced thereby, a new
                    Right Certificate evidencing Rights equivalent to the Rights
                    remaining unexercised shall be issued by the Rights Agent to
                    the registered holder of such Right Certificate or to his
                    duly authorized assigns, subject to the provisions of
                    Section 14 hereof.

               (e)  The Company covenants and agrees that it will cause to be
                    reserved and kept available out of its authorized and
                    unissued Preferred Shares or any Preferred Shares held in
                    its treasury, the number of Preferred Shares that will be
                    sufficient to permit the exercise in full of all outstanding
                    Rights in accordance with this Section 7.

               (f)  Notwithstanding anything in this Agreement to the contrary,
                    neither the Rights Agent nor the Company shall be obligated
                    to undertake any action with respect to a registered holder
                    upon the occurrence of any purported exercise as set forth
                    in this Section 7 unless such registered holder shall have
                    (i) completed and signed the certification following the
                    form of election to purchase set forth on the reverse side
                    of the Rights Certificate surrendered for such exercise and
                    (ii) provided such additional evidence of the identity of
                    the Beneficial Owner (or former Beneficial Owner) or
                    Affiliates or Associates thereof as the Company shall
                    reasonably request.

SECTION 8.     CANCELLATION AND DESTRUCTION OF RIGHT CERTIFICATES. All Right
               Certificates surrendered for the purpose of exercise, transfer,
               split up, combination or exchange shall, if surrendered to the
               Company or to any of its agents, be delivered to the Rights Agent
               for cancellation or in canceled form, or, if delivered or
               surrendered to the Rights Agent, shall be canceled by it, and no
               Right Certificates shall be issued in lieu thereof except as
               expressly permitted by any of the provisions of this Agreement.
               The Company shall deliver to the Rights Agent for cancellation
               and retirement, and the Rights Agent shall so cancel and retire,
               any other Right Certificate purchased or acquired by the Company
               otherwise than upon the exercise thereof. The Rights Agent shall
               deliver all canceled Right Certificates to the Company, or shall,
               at the written request of the Company, destroy such canceled
               Right Certificates, and in such case shall deliver a certificate
               of destruction thereof to the Company.

SECTION 9.     AVAILABILITY OF PREFERRED SHARES. The Company covenants and 
               agrees that so long as the Preferred Shares (and, after the time
               a person becomes an Acquiring Person, Common Shares or any other
               securities) issuable upon the exercise of the Rights may be
               listed on any national securities exchange or quotation system,
               the Company shall use its best efforts to cause, from and after
               such time as the Rights become exercisable, all shares reserved
               for such issuance to be listed on such exchange or quotation
               system upon official notice of issuance upon such exercise.

               The Company covenants and agrees that it will take all such
               action as may be necessary to ensure that all Preferred Shares
               (or Common Shares and other 



                                       11
<PAGE>   15

               securities, as the case may be) delivered upon exercise of Rights
               shall, at the time of delivery of the certificates for such
               Preferred Shares (subject to payment of the Purchase Price), be
               duly and validly authorized and issued and fully paid and
               nonassessable shares or other securities.

               The Company further covenants and agrees that it will pay when
               due and payable any and all federal and state transfer taxes and
               charges which may be payable in respect of the issuance or
               delivery of the Right Certificates or of any Preferred Shares
               upon the exercise of Rights. The Company shall not, however, be
               required to pay any transfer tax which may be payable in respect
               of any transfer or delivery of Right Certificates to a person
               other than, or the issuance or delivery of certificates or
               depositary receipts for the Preferred Shares in a name other than
               that of, the registered holder of the Right Certificate
               evidencing Rights surrendered for exercise or to issue or to
               deliver any certificates or depositary receipts for Preferred
               Shares upon the exercise of any Rights until any such tax shall
               have been paid (any such tax being payable by the holder of such
               Right Certificate at the time of surrender) or until it has been
               established to the Company's reasonable satisfaction that no such
               tax is due.

               As soon as practicable after the Shares Acquisition Date, the
               Company shall use its best efforts to:

                    (i)  prepare and file a registration statement under the
                         Securities Act of 1933, as amended (the "Act"), with
                         respect to the Rights and the securities purchasable
                         upon exercise of the Rights on an appropriate form,
                         will use its best efforts to cause such registration
                         statement to become effective as soon as practicable
                         after such filing and will use its best efforts to
                         cause such registration statement to remain effective
                         (with a prospectus at all times meeting the
                         requirements of the Act) until the Final Expiration
                         Date; and

                    (ii) use its best efforts to qualify or register the Rights
                         and the securities purchasable upon exercise of the
                         Rights under the blue sky laws of such jurisdictions as
                         may be necessary or appropriate.

SECTION 10.    PREFERRED SHARES RECORD DATE. Each person in whose name any
               certificate for Preferred Shares or other securities is issued
               upon the exercise of Rights shall for all purposes be deemed to
               have become the holder of record of the Preferred Shares or other
               securities represented thereby on, and such certificate shall be
               dated, the date upon which the Right Certificate evidencing such
               Rights was duly surrendered with the forms of election and
               certification duly executed and payment of the Purchase Price
               (and any applicable transfer taxes) was made; provided, however,
               that if the date of such surrender and payment is a date upon
               which the Preferred Shares or other securities transfer books of
               the Company are closed, such person shall be deemed to have
               become the record holder of such 



                                       12
<PAGE>   16

               shares on, and such certificate shall be dated, the next
               succeeding Business Day on which the Preferred Shares or other
               securities transfer books of the Company are open. Prior to the
               exercise of the Rights evidenced thereby, the holder of a Right
               Certificate, as such, shall not be entitled to any rights of a
               holder of Preferred Shares for which the Rights shall be
               exercisable, including, without limitation, the right to vote, to
               receive dividends or other distributions or to exercise any
               preemptive rights, and shall not be entitled to receive any
               notice of any proceedings of the Company, except as provided
               herein.

SECTION 11.    ADJUSTMENT OF PURCHASE PRICE, NUMBER OF SHARES OR NUMBER OF 
               RIGHTS. The Purchase Price, the number of Preferred Shares
               covered by each Right and the number of Rights outstanding are
               subject to adjustment from time to time as provided in this
               Section 11.

               (a)

                    (i)  In the event the Company shall at any time after the
                         date of this Agreement (A) declare a dividend on the
                         Preferred Shares payable in Preferred Shares, (B)
                         subdivide the outstanding Preferred Shares, (C) combine
                         the outstanding Preferred Shares into a smaller number
                         of Preferred Shares or (D) issue any shares of its
                         capital stock in a reclassification of the Preferred
                         Shares (including any such reclassification in
                         connection with a consolidation or merger in which the
                         Company is the continuing or surviving Company), except
                         as otherwise provided in this Section 11(a), the
                         Purchase Price in effect at the time of the record date
                         for such dividend or of the effective date of such
                         subdivision, combination or reclassification, and the
                         number and kind of shares of capital stock issuable on
                         such date, shall be proportionately adjusted so that
                         the holder of any Right exercised after such time shall
                         be entitled to receive the aggregate number and kind of
                         shares of capital stock which, if such Right had been
                         exercised immediately prior to such date and at a time
                         when the Preferred Shares transfer books of the Company
                         were open, such holder would have owned upon such
                         exercise and been entitled to receive by virtue of such
                         dividend, subdivision, combination or reclassification;
                         provided, however, that in no event shall the
                         consideration to be paid upon the exercise of one Right
                         be less than the aggregate par value of the shares of
                         capital stock of the Company issuable upon exercise of
                         one Right. If an event occurs which would require an
                         adjustment under both Section 11(a)(i) and Section
                         11(a)(ii) hereof, the adjustment provided for in this
                         Section 11(a)(i) shall be in addition to, and shall be
                         made prior to any adjustment required pursuant to
                         Section 11(a)(ii) hereof.



                                       13
<PAGE>   17

                    (ii) Subject to Section 24 hereof and the provisions of the
                         next paragraph of this Section 11(a)(ii), in the event
                         any Person shall become an Acquiring Person, each
                         holder of a Right shall, for a period of 60 days after
                         the later of such time any Person becomes an Acquiring
                         Person or the effective date of an appropriate
                         registration statement under the Act pursuant to
                         Section 9 hereof (provided, however that, if at any
                         time prior to the expiration or termination of the
                         Rights there shall be a temporary restraining order, a
                         preliminary injunction, an injunction, or temporary
                         suspension by the Board of Directors, or similar
                         obstacle to exercise of the Rights (the "Injunction")
                         which prevents exercise of the Rights, a new 60-day
                         period shall commence on the date the Injunction is
                         removed), have a right to receive, upon exercise
                         thereof at a price equal to the then current Purchase
                         Price multiplied by the number of one one-hundredths of
                         a Preferred Share for which a Right is then
                         exercisable, in accordance with the terms of this
                         Agreement and in lieu of Preferred Shares, such number
                         of Common Shares as shall equal the result obtained by
                         (A) multiplying the then current Purchase Price by the
                         number of one one-hundredths of a Preferred Share for
                         which a Right is then exercisable and dividing that
                         product by (B) 50% of the then current per share market
                         price of the Common Shares (determined pursuant to
                         Section 11(d) hereof) on the date such Person became an
                         Acquiring Person; provided, however, that if the
                         transaction that would otherwise give rise to the
                         foregoing adjustment is also subject to the provisions
                         of Section 13 hereof, then only the provisions of
                         Section 13 hereof shall apply and no adjustment shall
                         be made pursuant to this Section 11(a)(ii). In the
                         event that any Person shall become an Acquiring Person
                         and the Rights shall then be outstanding, the Company
                         shall not take any action which would eliminate or
                         diminish the benefits intended to be afforded by the
                         Rights.

                         Notwithstanding anything in this Agreement to the
                         contrary, from and after the time any Person becomes an
                         Acquiring Person, any Rights beneficially owned by (i)
                         such Acquiring Person or an Associate or Affiliate of
                         such Acquiring Person, (ii) a transferee of such
                         Acquiring Person (or of any such Associate or
                         Affiliate) who becomes a transferee after the Acquiring
                         Person became such, or (iii) a transferee of such
                         Acquiring Person (or of any such Associate or
                         Affiliate) who becomes a transferee prior to or
                         concurrently with the Acquiring Person's becoming such
                         and receives such Rights pursuant to either (A) a
                         transfer (whether or not for consideration) from the
                         Acquiring Person to holders of equity interests in such
                         Acquiring Person or to any Person with 



                                       14
<PAGE>   18

                         whom the Acquiring Person has any continuing agreement,
                         arrangement or understanding regarding the transferred
                         Rights or (B) a transfer which the Board of Directors
                         of the Company has determined is part of a plan,
                         arrangement or understanding which has as a primary
                         purpose or effect the avoidance of this Section
                         11(a)(ii), shall become null and void without any
                         further action and no holder of such Rights shall have
                         any rights whatsoever with respect to such Rights,
                         whether under any provision of this Agreement or
                         otherwise. The Company shall use all reasonable efforts
                         to insure that the provisions of this Section 11(a)(ii)
                         and Section 4(b) hereof are complied with, but shall
                         have no liability to any holder of Right Certificates
                         or other Person as a result of its failure to make any
                         determinations with respect to an Acquiring Person or
                         its Affiliates, Associates or transferees hereunder. No
                         Right Certificate shall be issued at any time upon the
                         transfer of any Rights to an Acquiring Person whose
                         Rights would be void pursuant to the preceding sentence
                         or any Associate or Affiliate thereof or to any nominee
                         of such Acquiring Person, Associate or Affiliate; and
                         any Right Certificate delivered to the Rights Agent for
                         transfer to an Acquiring Person whose Rights would be
                         void pursuant to the preceding sentence shall be
                         canceled.

                   (iii) In lieu of issuing Common Shares in accordance with
                         Section 11(a)(ii) hereof, the Company may, if a
                         majority of the Board of Directors then in office
                         determines that such action is necessary or appropriate
                         and not contrary to the interests of holders of Rights,
                         elect to (and, in the event that the Board of Directors
                         has not exercised the exchange right contained in
                         Section 24(c) hereof and there are not sufficient
                         treasury shares and authorized but unissued Common
                         Shares to permit the exercise in full of the Rights in
                         accordance with the foregoing subparagraph (ii), the
                         Company shall) take all such action as may be necessary
                         to authorize, issue or pay, upon the exercise of the
                         Rights, cash (including by way of a reduction of the
                         Purchase Price), property, Common Shares, other
                         securities or any combination thereof having an
                         aggregate value equal to the value of the Common Shares
                         which otherwise would have been issuable pursuant to
                         Section 11(a)(ii) hereof, which aggregate value shall
                         be determined by a nationally recognized investment
                         banking firm selected by a majority of the Board of
                         Directors then in office. For purposes of the preceding
                         sentence, the value of the Common Shares shall be
                         determined pursuant to Section 11(d) hereof. Any such
                         election by the Board of Directors must be made within
                         60 days following the date on which the event described
                         in Section 11(a)(ii) hereof shall have 



                                       15
<PAGE>   19

                         occurred. Following the occurrence of the event
                         described in Section 11(a)(ii) hereof, a majority of
                         the Board of Directors then in office may suspend the
                         exercisability of the Rights for a period of up to 60
                         days following the date on which the event described in
                         Section 11(a)(ii) hereof shall have occurred to the
                         extent that such directors have not determined whether
                         to exercise their rights of election under this Section
                         11(a)(iii). In the event of any such suspension, the
                         Company shall issue a public announcement stating that
                         the exercisability of the Rights has been temporarily
                         suspended.

               (b)  In case the Company shall fix a record date for the issuance
                    of rights, options or warrants to all holders of Preferred
                    Shares entitling them to subscribe for or purchase Preferred
                    Shares (or shares having the same designations and the
                    powers, preferences and rights, and the qualifications,
                    limitations and restrictions as the Preferred Shares
                    ("equivalent preferred shares")) or securities convertible
                    into Preferred Shares or equivalent preferred shares at a
                    price per Preferred Share or equivalent preferred share (or
                    having a conversion price per share, if a security
                    convertible into Preferred Shares or equivalent preferred
                    shares) less than the then current per share market price of
                    the Preferred Shares (as such term is hereinafter defined)
                    on such record date, the Purchase Price to be in effect
                    after such record date shall be determined by multiplying
                    the Purchase Price in effect immediately prior to such
                    record date by a fraction, the numerator of which shall be
                    the number of Preferred Shares outstanding on such record
                    date plus the number of Preferred Shares which the aggregate
                    offering price of the total number of Preferred Shares
                    and/or equivalent preferred shares so to be offered (and/or
                    the aggregate initial conversion price of the convertible
                    securities so to be offered) would purchase at such current
                    market price and the denominator of which shall be the
                    number of Preferred Shares outstanding on such record date
                    plus the number of additional Preferred Shares and/or
                    equivalent preferred shares to be offered for subscription
                    or purchase (or into which the convertible securities so to
                    be offered are initially convertible); provided, however,
                    that in no event shall the consideration to be paid upon the
                    exercise of one Right be less than the aggregate par value
                    of the shares of capital stock of the Company issuable upon
                    exercise of one Right. In case such subscription price may
                    be paid in a consideration part or all of which shall be in
                    a form other than cash, the value of such consideration
                    shall be as determined in good faith by the Board of
                    Directors of the Company, whose determination shall be
                    described in a statement filed with the Rights Agent.
                    Preferred Shares owned by or held for the account of the
                    Company shall not be deemed outstanding for the purpose of
                    any such computation. Such adjustment shall be made
                    successively whenever such a record date is fixed; and in
                    the event that such rights, options or warrants 



                                       16
<PAGE>   20

                    are not so issued, the Purchase Price shall be adjusted to 
                    be the Purchase Price which would then be in effect if such
                    record date had not been fixed.

               (c)  In case the Company shall fix a record date for the making
                    of a distribution to all holders of the Preferred Shares
                    (including any such distribution made in connection with a
                    consolidation or merger in which the Company is the
                    continuing or surviving Company) of evidences of
                    indebtedness or assets (other than a regular quarterly cash
                    dividend or a dividend payable in Preferred Shares) or
                    subscription rights or warrants (excluding those referred to
                    in Section 11(b) hereof), the Purchase Price to be in effect
                    after such record date shall be determined by multiplying
                    the Purchase Price in effect immediately prior to such
                    record date by a fraction, the numerator of which shall be
                    the then current per share market price of the Preferred
                    Shares (as such term is hereinafter defined) on such record
                    date, less the fair market value (as determined in good
                    faith by the Board of Directors of the Company, whose
                    determination shall be described in a statement filed with
                    the Rights Agent) of the portion of the assets or evidences
                    of indebtedness so to be distributed or of such subscription
                    rights or warrants applicable to one Preferred Share and the
                    denominator of which shall be such current per share market
                    price of the Preferred Shares; provided, however, that in no
                    event shall the consideration to be paid upon the exercise
                    of one Right be less than the aggregate par value of the
                    shares of capital stock of the Company to be issued upon
                    exercise of one Right. Such adjustments shall be made
                    successively whenever such a record date is fixed; and in
                    the event that such distribution is not so made, the
                    Purchase Price shall again be adjusted to be the Purchase
                    Price which would then be in effect if such record date had
                    not been fixed.

               (d)  

                    (i)  For the purpose of any computation hereunder, the
                         "current per share market price" of any security (a
                         "Security" for the purpose of this Section 11(d)(i)) on
                         any date shall be deemed to be the average of the daily
                         closing prices per share of such Security for the 30
                         consecutive Trading Days (as such term is hereinafter
                         defined) immediately prior to such date; provided,
                         however, that in the event that the current per share
                         market price of the Security is determined during a
                         period following the announcement by the issuer of such
                         Security of (A) a dividend or distribution on such
                         Security payable in shares of such Security or
                         securities convertible into such shares, or (B) any
                         subdivision, combination or reclassification of such
                         Security or securities convertible into such shares, or
                         (C) any subdivision, combination or reclassification of
                         such Security and prior to the expiration of 30 Trading
                         Days 



                                       17
<PAGE>   21

                         after the ex-dividend date for such dividend or
                         distribution, or the record date for such subdivision,
                         combination or reclassification, then, and in each such
                         case, the current per share market price shall be
                         appropriately adjusted to reflect the current market
                         price per share equivalent of such Security. The
                         closing price for each day shall be the last sale
                         price, regular way, or, in case no such sale takes
                         place on such day, the average of the closing bid and
                         asked prices, regular way, in either case as reported
                         in the principal consolidated transaction reporting
                         system with respect to securities listed or admitted to
                         trading on the New York Stock Exchange or, if the
                         Security is not listed or admitted to trading on the
                         New York Stock Exchange, as reported in the principal
                         consolidated transaction reporting system with respect
                         to securities listed on the principal national
                         securities exchange on which the Security is listed or
                         admitted to trading or as reported on the Nasdaq
                         National Market or, if the Security is not listed or
                         admitted to trading on any national securities exchange
                         or reported on the Nasdaq National Market, the last
                         quoted price or, if not so quoted, the average of the
                         high bid and low asked prices in the over-the-counter
                         market, as reported by the National Association of
                         Securities Dealers, Inc. Automated Quotations System
                         ("Nasdaq") or such other system then in use, or, if on
                         any such date the Security is not quoted by any such
                         organization, the average of the closing bid and asked
                         prices as furnished by a professional market maker
                         making a market in the Security selected by the Board
                         of Directors of the Company or, if on any such date no
                         professional market maker is making a market in the
                         Security, the price as determined in good faith by the
                         Board of Directors. The term "Trading Day" shall mean a
                         day on which the principal national securities exchange
                         on which the Security is listed or admitted to trading
                         is open for the transaction of business or, if the
                         Security is not listed or admitted to trading on any
                         national securities exchange, a Business Day.

                    (ii) For the purpose of any computation hereunder, the
                         "current per share market price" of the Preferred
                         Shares shall be determined in accordance with the
                         method set forth in Section 11(d)(i) hereof. If the
                         Preferred Shares are not publicly traded, the "current
                         per share market price" of the Preferred Shares shall
                         be conclusively deemed to be the current per share
                         market price of the Common Shares as determined
                         pursuant to Section 11(d)(i) hereof (appropriately
                         adjusted to reflect any stock split, stock dividend or
                         similar transaction occurring after the date hereof)
                         multiplied by one hundred. If neither the Common Shares
                         nor the Preferred Shares are publicly held or so listed
                         or traded, "current per share market price" shall mean
                         the fair value per share as determined in good 



                                       18
<PAGE>   22

                         faith by the Board of Directors of the Company, whose
                         determination shall be described in a statement filed
                         with the Rights Agent.

               (e)  No adjustment in the Purchase Price shall be required unless
                    such adjustment would require an increase or decrease of at
                    least 1% in the Purchase Price; provided, however, that any
                    adjustments which by reason of this Section 11(e) are not
                    required to be made shall be carried forward and taken into
                    account in any subsequent adjustment. All calculations under
                    this Section 11 shall be made to the nearest cent or to the
                    nearest one one-hundredth of a Preferred Share or one
                    ten-thousandth of any other share or security as the case
                    may be. Notwithstanding the first sentence of this Section
                    11(e), any adjustment required by this Section 11 shall be
                    made no later than the earlier of (i) three years from the
                    date of the transaction which requires such adjustment or
                    (ii) the date of the expiration of the right to exercise any
                    Rights.

               (f)  If as a result of an adjustment made pursuant to Section
                    11(a) hereof, the holder of any Right thereafter exercised
                    shall become entitled to receive any shares of capital stock
                    of the Company other than Preferred Shares, thereafter the
                    number of such other shares so receivable upon exercise of
                    any Right shall be subject to adjustment from time to time
                    in a manner and on terms as nearly equivalent as practicable
                    to the provisions with respect to the Preferred Shares
                    contained in Sections 11(a) through 11(c) hereof, inclusive,
                    and the provisions of Sections 7, 9, 10, 13 and 14 hereof
                    with respect to the Preferred Shares shall apply on like
                    terms to any such other shares.

               (g)  All Rights originally issued by the Company subsequent to
                    any adjustment made to the Purchase Price hereunder shall
                    evidence the right to purchase, at the adjusted Purchase
                    Price, the number of one one-hundredths of a Preferred Share
                    purchasable from time to time hereunder upon exercise of the
                    Rights, all subject to further adjustment as provided
                    herein.

               (h)  Unless the Company shall have exercised its election as
                    provided in Section 11(i) hereof, upon each adjustment of
                    the Purchase Price as a result of the calculations made in
                    Section 11(b) and Section 11(c) hereof, each Right
                    outstanding immediately prior to the making of such
                    adjustment shall thereafter evidence the right to purchase,
                    at the adjusted Purchase Price, that number of one
                    one-hundredths of a Preferred Share (calculated to the
                    nearest one one-millionth of a Preferred Share) obtained by
                    (i) multiplying (x) the number of one one-hundredths of a
                    Preferred Share covered by a Right immediately prior to this
                    adjustment by (y) the Purchase Price in effect immediately
                    prior to such adjustment of the Purchase Price and (ii)
                    dividing the product so obtained by the Purchase Price in
                    effect immediately after such adjustment of the 



                                       19
<PAGE>   23

                    Purchase Price.

               (i)  The Company may elect on or after the date of any adjustment
                    of the Purchase Price to adjust the number of Rights, in
                    substitution for any adjustment in the number of one
                    one-hundredths of a Preferred Share purchasable upon the
                    exercise of a Right. Each of the Rights outstanding after
                    such adjustment of the number of Rights shall be exercisable
                    for the number of one one-hundredths of a Preferred Share
                    for which a Right was exercisable immediately prior to such
                    adjustment. Each Right held of record prior to such
                    adjustment of the number of Rights shall become that number
                    of Rights (calculated to the nearest one ten-thousandth)
                    obtained by dividing the Purchase Price in effect
                    immediately prior to adjustment of the Purchase Price by the
                    Purchase Price in effect immediately after adjustment of the
                    Purchase Price. The Company shall make a public announcement
                    of its election to adjust the number of Rights, indicating
                    the record date for the adjustment, and, if known at the
                    time, the amount of the adjustment to be made. This record
                    date may be the date on which the Purchase Price is adjusted
                    or any day thereafter, but, if the Right Certificates have
                    been issued, shall be at least 10 days later than the date
                    of the public announcement. If Right Certificates have been
                    issued, upon each adjustment of the number of Rights
                    pursuant to this Section 11(i), the Company shall, as
                    promptly as practicable, cause to be distributed to holders
                    of record of Right Certificates on such record date Right
                    Certificates evidencing, subject to Section 14 hereof, the
                    additional Rights to which such holders shall be entitled as
                    a result of such adjustment, or, at the option of the
                    Company, shall cause to be distributed to such holders of
                    record in substitution and replacement for the Right
                    Certificates held by such holders prior to the date of
                    adjustment, and upon surrender thereof, if required by the
                    Company, new Right Certificates evidencing all the Rights to
                    which such holders shall be entitled after such adjustment.
                    Right Certificates so to be distributed shall be issued,
                    executed and countersigned in the manner provided for herein
                    and shall be registered in the names of the holders of
                    record of Right Certificates on the record date specified in
                    the public announcement.

               (j)  Irrespective of any adjustment or change in the Purchase
                    Price or the number of one one-hundredths of a Preferred
                    Share issuable upon the exercise of the Rights, the Right
                    Certificates theretofore and thereafter issued may continue
                    to express the Purchase Price and the number of one
                    one-hundredths of a Preferred Share which were expressed in
                    the initial Right Certificates issued hereunder.

               (k)  Before taking any action that would cause an adjustment
                    reducing the Purchase Price below one one-hundredth of the
                    then par value, if any, of 



                                       20
<PAGE>   24

                    the Preferred Shares issuable upon exercise of the Rights, 
                    the Company shall take any corporate action which may, in 
                    the opinion of its counsel, be necessary in order that the
                    Company may validly and legally issue fully paid and
                    nonassessable Preferred Shares at such adjusted Purchase
                    Price.

               (l)  In any case in which this Section 11 shall require that an
                    adjustment in the Purchase Price be made effective as of a
                    record date for a specified event, the Company may elect to
                    defer until the occurrence of such event the issuing to the
                    holder of any Right exercised after such record date of the
                    Preferred Shares and other capital stock or securities of
                    the Company, if any, issuable upon such exercise on the
                    basis of the Purchase Price in effect prior to such
                    adjustment; provided, however, that the Company shall
                    deliver to such holder a due bill or other appropriate
                    instrument evidencing such holder's right to receive such
                    additional shares upon the occurrence of the event requiring
                    such adjustment.

               (m)  The Company covenants and agrees that, after the
                    Distribution Date, it will not, except as permitted by
                    Section 23 or Section 27 hereof, take (or permit any
                    Subsidiary to take) any action the purpose of which is to,
                    or if at the time such action is taken it is reasonably
                    foreseeable that the effect of such action is to, materially
                    diminish or eliminate the benefits intended to be afforded
                    by the Rights. Any such action taken by the Company during
                    any period after any Person becomes an Acquiring Person but
                    prior to the Distribution Date shall be null and void unless
                    such action could be taken under this Section 11(m) from and
                    after the Distribution Date.

               (n)  Anything in this Section 11 to the contrary notwithstanding,
                    the Company shall be entitled to make such reductions in the
                    Purchase Price, in addition to those adjustments expressly
                    required by this Section 11, as and to the extent that it in
                    its sole discretion shall determine to be advisable in order
                    that any consolidation or subdivision of the Preferred
                    Shares, issuance wholly for cash of any Preferred Shares at
                    less than the current market price, issuance wholly for cash
                    of Preferred Shares or securities which by their terms are
                    convertible into or exchangeable for Preferred Shares,
                    dividends on Preferred Shares payable in Preferred Shares or
                    issuance of rights, options or warrants referred to
                    hereinabove in Section 11(b), hereafter made by the Company
                    to holders of its Preferred Shares shall not be taxable to
                    such stockholders.

               (o)  In the event that at any time after the date of this
                    Agreement and prior to the Distribution Date, the Company
                    shall (i) declare or pay any dividend on the Common Shares
                    payable in Common Shares or (ii) effect a subdivision,
                    combination or consolidation of the Common Shares (by
                    reclassification or otherwise than by payment of dividends
                    in Common Shares) into a greater or lesser number of Common
                    Shares, then in any 



                                       21
<PAGE>   25

                    such case (A) the number of one one-hundredths of a
                    Preferred Share purchasable after such event upon proper
                    exercise of each Right shall be determined by multiplying
                    the number of one one-hundredths of a Preferred Share so
                    purchasable immediately prior to such event by a fraction,
                    the numerator of which is the number of Common Shares
                    outstanding immediately before such event and the
                    denominator of which is the number of Common Shares
                    outstanding immediately after such event, and (B) each
                    Common Share outstanding immediately after such event shall
                    have issued with respect to it that number of Rights which
                    each Common Share outstanding immediately prior to such
                    event had issued with respect to it. The adjustments
                    provided for in this Section 11(o) shall be made
                    successively whenever such a dividend is declared or paid or
                    such a subdivision, combination or consolidation is
                    effected.

               (p)  The exercise of Rights under Section 11(a)(ii) hereof shall
                    only result in the loss of rights under Section 11(a)(ii)
                    hereof to the extent so exercised and shall not otherwise
                    affect the rights represented by the Rights under this
                    Agreement, including the rights represented by Section 13
                    hereof.

SECTION 12.    CERTIFICATE OF ADJUSTED PURCHASE PRICE OR NUMBER OF SHARES. 
               Whenever an adjustment is made as provided in Sections 11 and 13
               hereof, the Company shall promptly (a) prepare a certificate
               setting forth such adjustment, and a brief statement of the facts
               accounting for such adjustment, (b) file with the Rights Agent
               and with each transfer agent for the Common Shares or the
               Preferred Shares a copy of such certificate and (c) mail a brief
               summary thereof to each holder of a Right Certificate in
               accordance with Section 25 hereof. The Rights Agent shall be
               fully protected in relying on any such certificate and on any
               adjustment therein contained and shall not be deemed to have
               knowledge of any adjustment unless and until it shall have
               received such certificate.

SECTION 13.    CONSOLIDATION, MERGER OR SALE OR TRANSFER OF ASSETS OR EARNING 
               POWER.

               (a)  In the event that, following the Shares Acquisition Date or,
                    if a Transaction is proposed, the Distribution Date,
                    directly or indirectly (x) the Company shall consolidate
                    with, or merge with and into, any Interested Stockholder, or
                    if in such merger or consolidation all holders of Common
                    Stock are not treated alike, any other Person, (y) any
                    Interested Person, or if in such merger or consolidation all
                    holders of Common Stock are not treated alike, any other
                    Person shall consolidate with the Company, or merge with and
                    into the Company, and the Company shall be the continuing or
                    surviving Corporation of such merger (other than, in the
                    case of either transaction described in (x) or (y), a merger
                    or consolidation which would result in all of the voting
                    power represented by the securities of the Company
                    outstanding immediately prior thereto continuing to
                    represent (either by remaining outstanding or by being
                    converted into 



                                       22
<PAGE>   26

                    securities of the surviving entity) all of the voting power
                    represented by the securities of the Company or such
                    surviving entity outstanding immediately after such merger
                    or consolidation and the holders of such securities not
                    having changed as a result of such merger or consolidation),
                    or (z) the Company shall sell, mortgage or otherwise
                    transfer (or one or more of its subsidiaries shall sell,
                    mortgage or otherwise transfer), in one or more
                    transactions, assets or earning power aggregating more than
                    50% of the assets or earning power of the Company and its
                    subsidiaries (taken as a whole) to any Interested
                    Stockholder or Stockholders, or if in such transaction all
                    holders of Common Stock are not treated alike, any other
                    Person, (other than the Company or any Subsidiary of the
                    Company in one or more transactions each of which
                    individually and the aggregate does not violate Section
                    13(d) hereof) then, and in each such case, proper provision
                    shall be made so that (i) each holder of a Right, subject to
                    Section 11(a)(ii) hereof, shall have the right to receive,
                    upon the exercise thereof at a price equal to the then
                    current Purchase Price multiplied by the number of one
                    one-hundredths of a Preferred Share for which a Right is
                    then exercisable in accordance with the terms of this
                    Agreement and in lieu of Preferred Shares, such number of
                    freely tradeable Common Shares of the Principal Party (as
                    such term is hereinafter defined), free and clear of liens,
                    rights of call or first refusal, encumbrances or other
                    adverse claims, as shall be equal to the result obtained by
                    (A) multiplying the then current Purchase Price by the
                    number of one one-hundredths of a Preferred Share for which
                    a Right is then exercisable (without taking into account any
                    adjustment previously made pursuant to Section 11(a)(ii)
                    hereof) and dividing that product by (B) 50% of the then
                    current per share market price of the Common Shares of such
                    Principal Party (determined pursuant to Section 11(d)
                    hereof) on the date of consummation of such consolidation,
                    merger, sale or transfer; (ii) such Principal Party shall
                    thereafter be liable for, and shall assume, by virtue of
                    such consolidation, merger, sale or transfer, all the
                    obligations and duties of the Company pursuant to this
                    Agreement; (iii) the term "Company" shall thereafter be
                    deemed to refer to such Principal Party, it being
                    specifically intended that the provisions of Section 11
                    hereof shall apply to such Principal Party; and (iv) such
                    Principal Party shall take such steps (including, but not
                    limited to, the reservation of a sufficient number of shares
                    of its Common Shares in accordance with Section 9 hereof) in
                    connection with such consummation as may be necessary to
                    assure that the provisions hereof shall thereafter be
                    applicable, as nearly as reasonably may be, in relation to
                    its Common Shares thereafter deliverable upon the exercise
                    of the Rights.



                                       23
<PAGE>   27

               (b)  "Principal Party" shall mean:

                    (i)  in the case of any transaction described in clause (x)
                         or (y) of the first sentence of Section 13(a) hereof,
                         the Person that is the issuer of any securities into
                         which Common Shares are converted in such merger or
                         consolidation, and if no securities are so issued, the
                         Person that is the other party to the merger or
                         consolidation (or, if applicable, the Company, if it is
                         the surviving Company); and

                    (ii) in the case of any transaction described in (z) of the
                         first sentence of Section 13(a) hereof, the Person that
                         is the party receiving the greatest portion of the
                         assets or earning power transferred pursuant to such
                         transaction or transactions;

                    provided, however, that in any case, (1) if the Common
                    Shares of such Person are not at such time and have not been
                    continuously over the preceding 12-month period registered
                    under Section 12 of the Exchange Act, and such Person is a
                    direct or indirect subsidiary or Affiliate of another Person
                    the Common Shares of which are and have been so registered,
                    "Principal Party" shall refer to such other Person; (2) if
                    such Person is a subsidiary, directly or indirectly, or
                    Affiliate of more than one Person, the Common Shares of two
                    or more of which are and have been so registered, "Principal
                    Party" shall refer to whichever of such Persons is the
                    issuer of the Common Shares having the greatest aggregate
                    market value; and (3) if such Person is owned, directly or
                    indirectly, by a joint venture formed by two or more Persons
                    that are not owned, directly or indirectly, by the same
                    Person, the rules set forth in (1) and (2) above shall apply
                    to each of the chains of ownership having an interest in
                    such joint venture as if such party were a "subsidiary" of
                    both or all of such joint venturers and the Principal
                    Parties in each such chain shall bear the obligations set
                    forth in this Section 13 in the same ratio as their direct
                    or indirect interests in such Person bear to the total of
                    such interests.

               (c)  The Company shall not consummate any such consolidation,
                    merger, sale or transfer unless the Principal Party shall
                    have a sufficient number of authorized Common Shares that
                    have not been issued or reserved for issuance to permit the
                    exercise in full of the Rights in accordance with this
                    Section 13 and unless prior thereto the Company and each
                    Principal Party and each other Person who may become a
                    Principal Party as a result of such consolidation, merger,
                    sale or transfer shall have (i) executed and delivered to
                    the Rights Agent a supplemental agreement providing for the
                    terms set forth in paragraphs (a) and (b) of this Section 13
                    and (ii) prepared, filed and had declared and remain
                    effective a registration statement under the Act on the
                    appropriate form with respect to the Rights and the
                    securities exercisable upon exercise of the Rights and
                    further 



                                       24
<PAGE>   28

                    providing that, as soon as practicable after the date of any
                    consolidation, merger, sale or transfer of assets mentioned
                    in paragraph (a) of this Section 13, the Principal Party at
                    its own expense will:

                    (i)   cause the registration statement under the Act with
                          respect to the Rights and the securities purchasable
                          upon exercise of the Rights on an appropriate form to
                          remain effective (with a prospectus at all times
                          meeting the requirements of the Act) until the Final
                          Expiration Date;

                    (ii)  use its best efforts to qualify or register the Rights
                          and the securities purchasable upon exercise of the
                          Rights under the blue sky laws of such jurisdictions
                          as may be necessary or appropriate;

                    (iii) list the Rights and the securities purchasable upon
                          exercise of the Rights on each national securities
                          exchange on which the Common Shares were listed prior
                          to the consummation of such consolidation, merger,
                          sale or transfer of assets or on the Nasdaq National
                          Market if the Common Shares were listed on the Nasdaq
                          National Market or, if the Common Shares were not
                          listed on a national securities exchange or the Nasdaq
                          National Market prior to the consummation of the
                          consolidation, merger, sale or transfer of assets, on
                          a national securities exchange or the Nasdaq National
                          Market; and

                    (iv)  deliver to holders of the Rights historical financial
                          statements for the Principal Party and each of its
                          Affiliates which comply in all material respects with
                          the requirements for registration on Form 10 under the
                          Exchange Act.

               The provisions of this Section 13 shall similarly apply to
               successive mergers or consolidations or sales or other transfers.

               (d)  After the Distribution Date, the Company covenants and
                    agrees that it shall not (i) consolidate with, (ii) merge
                    with or into, or (iii) sell or transfer to, in one or more
                    transactions, assets or earning power aggregating more than
                    50% of the assets or earning power of the Company and its
                    subsidiaries taken as a whole, any other Person (other than
                    a Subsidiary of the Company in a transaction which does not
                    violate Section 11(m) hereof), if (x) at the time of or
                    after such consolidation, merger or sale there are any
                    charter or bylaw provisions or any rights, warrants or other
                    instruments or securities outstanding, agreements in effect
                    or any other action taken which would diminish or otherwise
                    eliminate the benefits intended to be afforded by the Rights
                    or (y) prior to, simultaneously with or immediately after
                    such consolidation, merger or sale, the stockholders of the
                    Person who constitutes, or would constitute, the "Principal
                    Party" 



                                       25
<PAGE>   29

                    for purposes of Section 13(a) hereof shall have received a
                    distribution of Rights previously owned by such Person or
                    any of its Affiliates and Associates. The Company shall not
                    consummate any such consolidation, merger, sale or transfer
                    unless prior thereto the Company and such other Person shall
                    have executed and delivered to the Rights Agent a
                    supplemental agreement evidencing compliance with this
                    Section 13(d).

SECTION 14.    FRACTIONAL RIGHTS AND FRACTIONAL SHARES.

               (a)  The Company shall not be required to issue fractions of
                    Rights or to distribute Right Certificates which evidence
                    fractional Rights. In lieu of such fractional Rights, there
                    shall be paid to the registered holders of the Right
                    Certificates with regard to which such fractional Rights
                    would otherwise be issuable, an amount in cash equal to the
                    same fraction of the current market value of a whole Right.
                    For the purposes of this Section 14(a), the current market
                    value of a whole Right shall be the closing price of the
                    Rights for the Trading Day immediately prior to the date on
                    which such fractional Rights would have been otherwise
                    issuable. The closing price for any day shall be the last
                    sale price, regular way, or, in case no such sale takes
                    place on such day, the average of the closing bid and asked
                    prices, regular way, in either case as reported in the
                    principal consolidated transaction reporting system with
                    respect to securities listed or admitted to trading on the
                    New York Stock Exchange or, if the Rights are not listed or
                    admitted to trading on the New York Stock Exchange, as
                    reported in the principal consolidated transaction reporting
                    system with respect to securities listed on the principal
                    national securities exchange on which the Rights are listed
                    or admitted to trading or as reported on the Nasdaq National
                    Market or, if the Rights are not listed or admitted to
                    trading on any national securities exchange or reported on
                    the Nasdaq National Market, the last quoted price or, if not
                    so quoted, the average of the high bid and low asked prices
                    in the over-the-counter market, as reported by Nasdaq or
                    such other system then in use or, if on any such date the
                    Rights are not quoted by any such organization, the average
                    of the closing bid and asked prices as furnished by a
                    professional market maker making a market in the Rights
                    selected by the Board of Directors of the Company. If on any
                    such date no such market maker is making a market in the
                    Rights, the fair value of the Rights on such date as
                    determined in good faith by the Board of Directors of the
                    Company shall be used.

               (b)  The Company shall not be required to issue fractions of
                    Preferred Shares (other than fractions which are integral
                    multiples of one one-hundredth of a Preferred Share) upon
                    exercise of the Rights or to distribute certificates which
                    evidence fractional Preferred Shares (other than fractions
                    which are integral multiples of one one-hundredth of a
                    Preferred Share). Fractions of Preferred Shares in integral
                    multiples of one one-hundredth of a 



                                       26
<PAGE>   30

                    Preferred Share may, at the election of the Company, be
                    evidenced by depositary receipts; provided, however, that
                    holders of such depositary receipts shall have all of the
                    designations and the powers, preferences and rights, and the
                    qualifications, limitations and restrictions to which they
                    are entitled as beneficial owners of the Preferred Shares
                    represented by such depositary receipts. In lieu of
                    fractional Preferred Shares that are not integral multiples
                    of one one-hundredth of a Preferred Share, the Company shall
                    pay to the registered holders of Right Certificates at the
                    time such Rights are exercised as herein provided an amount
                    in cash equal to the same fraction of the current market
                    value of one Preferred Share. For the purposes of this
                    Section 14(b), the current market value of a Preferred Share
                    shall be the current per share market price of the Preferred
                    Shares (as determined pursuant to the second sentence of
                    Section 11(d)(i) hereof) for the Trading Day immediately
                    prior to the date of such exercise (or, if not publicly
                    traded, in accordance with Section 11(d)(ii) hereof).

               (c)  Following the occurrence of one of the transactions or
                    events specified in Section 11 hereof giving rise to the
                    right to receive Common Shares, capital stock equivalents
                    (other than Preferred Shares) or other securities upon the
                    exercise of a Right, the Company shall not be required to
                    issue fractions of Common Shares or units of such Common
                    Shares, capital stock equivalents or other securities upon
                    exercise of the Rights or to distribute certificates which
                    evidence fractional Common Shares, capital stock equivalents
                    or other securities. In lieu of fractional Common Shares,
                    capital stock equivalents or other securities, the Company
                    shall pay to the registered holders of Right Certificates at
                    the time such Rights are exercised as herein provided an
                    amount in cash equal to the same fraction of the current
                    market value of one Common Share or unit of such Common
                    Shares, capital stock equivalents or other securities. For
                    purposes of this Section 14(c), the current market value
                    shall be the current per share market price (as determined
                    pursuant to Section 11(d)(i) hereof) for the Trading Day
                    immediately prior to the date of such exercise and, if such
                    capital stock equivalent is not traded, each such capital
                    stock equivalent shall have the value of one one-hundredth
                    of a Preferred Share.

               (d)  The holder of a Right by the acceptance of the Right
                    expressly waives his right to receive any fractional Rights
                    or any fractional shares upon exercise of a Right (except as
                    provided above).

SECTION 15.    RIGHTS OF ACTION. All rights of action in respect of this 
               Agreement, excepting the rights of action given to the Rights
               Agent under Sections 18 and 20 hereof, are vested in the
               respective registered holders of the Right Certificates (and,
               prior to the Distribution Date, the registered holders of the
               Common Shares) and any registered holder of any Right Certificate
               (or, prior to the Distribution Date, of the Common Shares),
               without the consent of the Rights Agent or of the holder of any



                                       27
<PAGE>   31

               other Right Certificate (or, prior to the Distribution Date, of
               the Common Shares), may, in his own behalf and for his own
               benefit, enforce, and may institute and maintain any suit, action
               or proceeding against the Company to enforce, or otherwise act in
               respect of, his right to exercise the Rights evidenced by such
               Right Certificate in the manner provided in such Right
               Certificate and in this Agreement. Without limiting the foregoing
               or any remedies available to the holders of Rights, it is
               specifically acknowledged that the holders of Rights would not
               have an adequate remedy at law for any breach of this Agreement
               and will be entitled to specific performance of the obligations
               under, and injunctive relief against actual or threatened
               violations of the obligations of any Person subject to, this
               Agreement. Holders of Rights shall be entitled to recover the
               reasonable costs and expenses, including attorneys fees, incurred
               by them in any action to enforce the provisions of this
               Agreement.

SECTION 16.    AGREEMENT OF RIGHT HOLDERS. Every holder of a Right, by accepting
               the same, consents and agrees with the Company and the Rights
               Agent and with every other holder of a Right that:

               (a)  prior to the Distribution Date, the Rights will be
                    transferable only in connection with the transfer of the
                    Common Shares;

               (b)  after the Distribution Date, the Right Certificates are
                    transferable (subject to the provisions of this Rights
                    Agreement) only on the registry books of the Rights Agent if
                    surrendered at the principal office of the Rights Agent,
                    duly endorsed or accompanied by a proper instrument of
                    transfer; and

               (c)  the Company and the Rights Agent may deem and treat the
                    person in whose name the Right Certificate (or, prior to the
                    Distribution Date, the associated Common Shares certificate)
                    is registered as the absolute owner thereof and of the
                    Rights evidenced thereby (notwithstanding any notations of
                    ownership or writing on the Right Certificates or the
                    associated Common Shares certificate made by anyone other
                    than the Company or the Rights Agent) for all purposes
                    whatsoever, and neither the Company nor the Rights Agent
                    shall be affected by any notice to the contrary.

SECTION 17.    RIGHT CERTIFICATE HOLDER NOT DEEMED A STOCKHOLDER. No holder, as
               such, of any Right Certificate shall be entitled to vote, receive
               dividends or be deemed for any purpose the holder of the
               Preferred Shares or any other securities of the Company which may
               at any time be issuable on the exercise of the Rights represented
               thereby, nor shall anything contained herein or in any Right
               Certificate be construed to confer upon the holder of any Right
               Certificate, as such, any of the rights of a stockholder of the
               Company or any right to vote for the election of directors or
               upon any matter submitted to stockholders at any meeting thereof,
               or to give or withhold consent to any corporate action, or to
               receive notice of meetings or other actions affecting
               stockholders (except as 



                                       28
<PAGE>   32

               provided in Section 25 hereof), or to receive dividends or
               subscription rights, or otherwise, until the Right or Rights
               evidenced by such Right Certificate shall have been exercised in
               accordance with the provisions hereof.

SECTION 18.    CONCERNING THE RIGHTS AGENT. The Company agrees to pay to the 
               Rights Agent reasonable compensation for all services rendered by
               it hereunder and, from time to time, on demand of the Rights
               Agent, its reasonable expenses and counsel fees and other
               disbursements incurred in the administration and execution of
               this Agreement and the exercise and performance of its duties
               hereunder. The Company shall indemnify the Rights Agent for, and
               hold it harmless against, any loss, liability, claim or expense
               ("Loss") arising out of or in connection with its duties under
               this Agreement, including the costs and expenses of defending
               itself against any Loss, unless such Loss shall have been
               determined by a court of competent jurisdiction to be a result of
               the Rights Agent's gross negligence or intentional misconduct.
               The indemnity provided herein shall survive the expiration of the
               Rights and the termination of this Agreement.

               The Rights Agent shall be protected and shall incur no liability
               for, or in respect of any action taken, suffered or omitted by it
               in connection with, its administration of this Agreement in
               reliance upon any Right Certificate or certificate for the
               Preferred Shares or Common Shares or for other securities of the
               Company, instrument of assignment or transfer, power of attorney,
               endorsement, affidavit, letter, notice, direction, consent,
               certificate, statement, or other paper or document believed by it
               to be genuine and to be signed, executed and, where necessary,
               verified or acknowledged, by the proper person or persons, or
               otherwise upon the advice of counsel as set forth in Section 20
               hereof. In no case will the Rights Agent be liable for special,
               indirect, incidental or consequential or consequential loss or
               damage at any kind whatsoever (including but not limited to lost
               profits), even if the Rights Agent has been advised of such loss
               or damage.

SECTION 19.    MERGER OR CONSOLIDATION OR CHANGE OF NAME OF RIGHTS AGENT. Any
               corporation into which the Rights Agent or any successor Rights
               Agent may be merged or with which it may be consolidated, or any
               corporation resulting from any merger or consolidation to which
               the Rights Agent or any successor Rights Agent shall be a party,
               or any corporation succeeding to the shareholder services or
               corporate trust business of the Rights Agent or any successor
               Rights Agent, shall be the successor to the Rights Agent under
               this Agreement without the execution or filing of any paper or
               any further act on the part of any of the parties hereto,
               provided that such corporation would be eligible for appointment
               as a successor Rights Agent under the provisions of Section 21
               hereof. In case at the time such successor Rights Agent shall
               succeed to the agency created by this Agreement any of the Right
               Certificates shall have been countersigned but not delivered, any
               such successor Rights Agent may adopt the countersignature of the
               predecessor Rights Agent and deliver such Right Certificates so
               countersigned; 



                                       29
<PAGE>   33

               and in case at that time any of the Right Certificates shall not
               have been countersigned, any successor Rights Agent may
               countersign such Right Certificates either in the name of the
               predecessor Rights Agent or in the name of the successor Rights
               Agent; and in all such cases such Right Certificates shall have
               the full force provided in the Right Certificates and in this
               Agreement.

               In case at any time the name of the Rights Agent shall be changed
               and at such time any of the Right Certificates shall have been
               countersigned but not delivered, the Rights Agent may adopt the
               countersignature under its prior name and deliver Right
               Certificates so countersigned; and in case at that time any of
               the Right Certificates shall not have been countersigned, the
               Rights Agent may countersign such Right Certificates either in
               its prior name or in its changed name; and in all such cases such
               Right Certificates shall have the full force provided in the
               Right Certificates and in this Agreement.

SECTION 20.    DUTIES OF RIGHTS AGENT. The Rights Agent undertakes the duties 
               and obligations imposed by this Agreement upon the following
               terms and conditions, by all of which the Company and the holders
               of Right Certificates, by their acceptance thereof, shall be
               bound:

               (a)  The Rights Agent may consult with legal counsel of its
                    choice (who may be legal counsel for the Company), and the
                    opinion of such counsel shall be full and complete
                    authorization and protection to the Rights Agent as to any
                    action taken or omitted by it in good faith and in
                    accordance with such opinion.

               (b)  Whenever in the performance of its duties under this
                    Agreement the Rights Agent shall deem it necessary or
                    desirable that any fact or matter be proved or established
                    by the Company prior to taking or suffering any action
                    hereunder, such fact or matter (unless other evidence in
                    respect thereof be herein specifically prescribed) may be
                    deemed to be conclusively proved and established by a
                    certificate signed by any one of the Chairman of the Board,
                    the Chief Executive Officer, the President, the Chief
                    Financial Officer, any Vice President, the Treasurer or the
                    Secretary of the Company and delivered to the Rights Agent;
                    and such certificate shall be full authorization to the
                    Rights Agent for any action taken or suffered in good faith
                    by it under the provisions of this Agreement in reliance
                    upon such certificate.

               (c)  The Rights Agent shall be liable hereunder to the Company
                    and any other Person only for its own negligence, bad faith
                    or willful misconduct. In no case will the Rights Agent be
                    liable for special, indirect, incidental or consequential
                    loss or damages of any kind whatsoever (including but not
                    limited to lost profits), even if the Rights Agent has been
                    advised of the possibility of such damages. Any liability of
                    the Rights Agent will be limited to the amount of fees paid
                    by the Company hereunder.



                                       30
<PAGE>   34

               (d)  The Rights Agent shall not be liable for or by reason of any
                    of the statements of fact or recitals contained in this
                    Agreement or in the Right Certificates (except its
                    countersignature thereof) or be required to verify the same,
                    but all such statements and recitals are and shall be deemed
                    to have been made by the Company only.

               (e)  The Rights Agent shall not be under any responsibility in
                    respect of the validity of this Agreement or the execution
                    and delivery hereof (except the due execution hereof by the
                    Rights Agent) or in respect of the validity or execution of
                    any Right Certificate (except its countersignature thereof);
                    nor shall it be responsible for any breach by the Company of
                    any covenant or condition contained in this Agreement or in
                    any Right Certificate; nor shall it be responsible for any
                    change in the exercisability of the Rights (including the
                    Rights becoming void pursuant to Section 11(a)(ii) hereof)
                    or any adjustment in the terms of the Rights (including the
                    manner, method or amount thereof) provided for in Sections
                    3, 11, 13, 23 or 24 hereof, or the ascertaining of the
                    existence of facts that would require any such change or
                    adjustment (except with respect to the exercise of Rights
                    evidenced by Right Certificates after receipt of a
                    certificate pursuant to Section 12 hereof describing such
                    change or adjustment); nor shall it by any act hereunder be
                    deemed to make any representation or warranty as to the
                    authorization or reservation of any Preferred Shares to be
                    issued pursuant to this Agreement or any Right Certificate
                    or as to whether any Preferred Shares will, when issued, be
                    validly authorized and issued, fully paid and nonassessable.

               (f)  The Company agrees that it will perform, execute,
                    acknowledge and deliver or cause to be performed, executed,
                    acknowledged and delivered all such further and other acts,
                    instruments and assurances as may reasonably be required by
                    the Rights Agent for the carrying out or performing by the
                    Rights Agent of the provisions of this Agreement.

               (g)  The Rights Agent is hereby authorized and directed to accept
                    instructions with respect to the performance of its duties
                    hereunder from any one of the Chairman of the Board, the
                    Chief Executive Officer, the President, the Chief Financial
                    Officer, any Vice President, the Secretary or the Treasurer
                    of the Company, and to apply to such officers for advice or
                    instructions in connection with its duties, and it shall not
                    be liable for any action taken or suffered by it in good
                    faith in accordance with instructions of any such officer or
                    for any delay in acting while waiting for those
                    instructions. Any application by the Rights Agent for
                    written instructions from the Company may, at the option of
                    the Rights Agent, set forth in writing any action proposed
                    to be taken or omitted by the Rights Agent with respect to
                    its duties or obligations under this Agreement and the date
                    on and/or after which such action shall be taken or omitted
                    and the Rights Agent shall not 



                                       31
<PAGE>   35

                    be liable for any action taken or omitted in accordance with
                    a proposal included in any such application on or after the 
                    date specified therein (which date shall not be less than
                    three Business Days after the date indicated in such
                    application unless any such officer shall have consented in
                    writing to an earlier date) unless, prior to taking or
                    omitting any such action, the Rights Agent has received
                    written instructions in response to such application
                    specifying the action to be taken or omitted.

               (h)  The Rights Agent and any stockholder, director, officer or
                    employee of the Rights Agent may buy, sell or deal in any of
                    the Rights or other securities of the Company or become
                    pecuniarily interested in any transaction in which the
                    Company may be interested, or contract with or lend money to
                    the Company or otherwise act as fully and freely as though
                    it were not Rights Agent under this Agreement. Nothing
                    herein shall preclude the Rights Agent from acting in any
                    other capacity for the Company or for any other legal
                    entity.

               (i)  The Rights Agent may execute and exercise any of the rights
                    or powers hereby vested in it or perform any duty hereunder
                    either itself or by or through its attorneys or agents, and
                    the Rights Agent shall not be answerable or accountable for
                    any act, default, neglect or misconduct of any such
                    attorneys or agents or for any loss to the Company resulting
                    from any such act, default, neglect or misconduct, provided
                    reasonable care was exercised in the selection and continued
                    employment thereof.

               (j)  No provision of this Agreement shall require the Rights
                    Agent to expend or risk its own funds or otherwise incur any
                    financial liability in the performance of any of its duties
                    hereunder or in the exercise of its rights if there shall be
                    reasonable grounds for believing that repayment of such
                    funds or adequate indemnification against such risk or
                    liability is not reasonably assured to it.

               (k)  If, with respect to any Right Certificate surrendered to the
                    Rights Agent for exercise or transfer, the certificate
                    attached to the form of assignment or form of election to
                    purchase, as the case may be, has not been executed, the
                    Rights Agent shall not take any further action with respect
                    to such requested exercise of transfer without first
                    consulting with the Company.

SECTION 21.    CHANGE OF RIGHTS AGENT. The Rights Agent or any successor Rights
               Agent may resign and be discharged from its duties under this
               Agreement upon 30 days' notice in writing mailed to the Company
               and to each transfer agent for the Common Shares or Preferred
               Shares by registered or certified mail, and to the holders of the
               Right Certificates by first-class mail. The Company may remove
               the Rights Agent or any successor Rights Agent upon 30 days'
               notice in writing, mailed to the Rights Agent or successor Rights
               Agent, as the case may be, and to each transfer agent for the
               Common Shares or Preferred Shares by registered or



                                       32
<PAGE>   36

               certified mail, and to the holders of the Right Certificates by
               first-class mail. If the Rights Agent shall resign or be removed
               or shall otherwise become incapable of acting, the Company shall
               appoint a successor to the Rights Agent. If the Company shall
               fail to make such appointment within a period of 30 days after
               giving notice of such removal or after it has been notified in
               writing of such resignation or incapacity by the resigning or
               incapacitated Rights Agent or by the holder of a Right
               Certificate (who shall, with such notice, submit his Right
               Certificate for inspection by the Company), then the registered
               holder of any Right Certificate may apply to any court of
               competent jurisdiction for the appointment of a new Rights Agent.
               Any successor Rights Agent, whether appointed by the Company or
               by such a court, shall be either (a) a corporation business trust
               or limited liability company organized and doing business under
               the laws of the United States or of any other state of the United
               States which is authorized under such laws to exercise corporate
               trust or stock transfer powers and is subject to supervision or
               examination by federal or state authority and which has at the
               time of its appointment as Rights Agent a combined capital and
               surplus of at least $50 million or (b) a direct or indirect
               wholly owned subsidiary of such an entity or its wholly-owning
               parent. After appointment, the successor Rights Agent shall be
               vested with the same powers, rights, duties and responsibilities
               as if it had been originally named as Rights Agent without
               further act or deed; but the predecessor Rights Agent shall
               deliver and transfer to the successor Rights Agent any property
               at the time held by it hereunder, and execute and deliver any
               further assurance, conveyance, act or deed necessary for the
               purpose. Not later than the effective date of any such
               appointment the Company shall file notice thereof in writing with
               the predecessor Rights Agent and each transfer agent for the
               Common Shares or Preferred Shares, and mail a notice thereof in
               writing to the registered holders of the Right Certificates.
               Failure to give any notice provided for in this Section 21,
               however, or any defect therein, shall not affect the legality or
               validity of the resignation or removal of the Rights Agent or the
               appointment of the successor Rights Agent, as the case may be.

SECTION 22.    ISSUANCE OF NEW RIGHT CERTIFICATES. Notwithstanding any of the
               provisions of this Agreement or of the Rights to the contrary,
               the Company may, at its option, issue new Right Certificates
               evidencing Rights in such form as may be approved by its Board of
               Directors to reflect any adjustment or change in the Purchase
               Price and the number or kind or class of shares or other
               securities or property purchasable under the Right Certificates
               made in accordance with the provisions of this Agreement. In
               addition, in connection with the issuance or sale of Common
               Shares following the Distribution Date and prior to the earlier
               of the Redemption Date and the Final Expiration Date, the Company
               (a) shall with respect to Common Shares so issued or sold
               pursuant to the exercise of stock options or under any employee
               plan or arrangement in existence prior to the Distribution Date,
               or upon the exercise, conversion or exchange of securities, notes
               or debentures issued by the Company and in existence prior to the
               Distribution Date, and (b) may, in any other case, if deemed
               necessary or 



                                       33
<PAGE>   37

               appropriate by the Board of Directors of the Company, issue Right
               Certificates representing the appropriate number of Rights in
               connection with such issuance or sale; provided, however, that
               (i) the Company shall not be obligated to issue any such Right
               Certificates if, and to the extent that, the Company shall be
               advised by counsel that such issuance would create a significant
               risk of material adverse tax consequences to the Company or the
               Person to whom such Right Certificate would be issued, and (ii)
               no Right Certificate shall be issued if, and to the extent that,
               appropriate adjustment shall otherwise have been made in lieu of
               the issuance thereof.

SECTION 23.    REDEMPTION.

               (a)  The Rights may be redeemed by action of the Board of
                    Directors pursuant to Section 23(b) hereof and shall not be
                    redeemed in any other manner.

               (b)  

                    (i)  The Board of Directors of the Company may, at its
                         option, at any time prior to the earlier of such time
                         as any Person becoming an Acquiring Person or the Final
                         Expiration Date, redeem all but not less than all of
                         the then outstanding Rights at a redemption price of
                         $.01 per Right, appropriately adjusted to reflect any
                         stock split, stock dividend or similar transaction
                         occurring after the date hereof (such redemption price
                         being hereinafter referred to as the "Redemption
                         Price"), and the Company may, at its option, pay the
                         Redemption Price in Common Shares (based on the
                         "current per-share market price," as such term is
                         defined in Section 11(d) hereof, of the Common Shares
                         at the time of redemption), cash or any other form of
                         consideration deemed appropriate by the Board of
                         Directors. The redemption of the Rights by the Board of
                         Directors may be made effective at such time, on such
                         basis and subject to such conditions as the Board of
                         Directors in its sole discretion may establish.
                         Notwithstanding anything contained in this Agreement to
                         the contrary, the Rights shall not be exercisable
                         pursuant to Section 11(a)(ii) hereof prior to the
                         expiration or termination of the Company's right of
                         redemption under this Section 23(b)(i).

                    (ii) In addition, the Board of Directors of the Company may,
                         at its option, at any time after the time a Person
                         becomes an Acquiring Person and the expiration of any
                         period during which the holder of Rights may exercise
                         the rights under Section 11(a)(ii) hereof but prior to
                         any event described in clause (x), (y) or (z) of the
                         first sentence of Section 13 hereof, redeem all but not
                         less than all of the then outstanding Rights at the
                         Redemption Price (x) in connection with any merger,
                         consolidation or sale or other transfer 



                                       34
<PAGE>   38

                         (in one transaction or in a series of related
                         transactions) of assets or earning power aggregating
                         50% or more of the assets or earning power of the
                         Company and its subsidiaries (taken as a whole) in
                         which all holders of Common Shares are treated alike
                         and not involving (other than as a holder of Common
                         Shares being treated like all other such holders) an
                         Interested Stockholder or a Transaction Person or
                         (y)(A) if and for so long as the Acquiring Person is
                         not thereafter the Beneficial Owner of 15% or more of
                         the then outstanding Common Shares, and (B) at the time
                         of redemption no other Persons are Acquiring Persons.

               (c)  Immediately upon the action of the Board of Directors of the
                    Company ordering the redemption of the Rights pursuant to
                    Section 23(b) hereof, and without any further action and
                    without any notice, the right to exercise the Rights will
                    terminate and the only right thereafter of the holders of
                    Rights shall be to receive the Redemption Price. The Company
                    shall promptly give public notice of any such redemption;
                    provided, however, that the failure to give, or any defect
                    in, any such notice shall not affect the validity of such
                    redemption. Within 10 days after such action of the Board of
                    Directors ordering the redemption of the Rights pursuant to
                    Section 23(b) hereof, the Company shall mail a notice of
                    redemption to all the holders of the then outstanding Rights
                    at their last addresses as they appear upon the registry
                    books of the Rights Agent or, prior to the Distribution
                    Date, on the registry books of the transfer agent for the
                    Common Shares, provided, however, that failure to give, or
                    any defect in, any such notice shall not affect the validity
                    of such redemption. Any notice which is mailed in the manner
                    herein provided shall be deemed given, whether or not the
                    holder receives the notice. Each such notice of redemption
                    will state the method by which the payment of the Redemption
                    Price will be made. Neither the Company nor any of its
                    Affiliates or Associates may redeem, acquire or purchase for
                    value any Rights at any time in any manner other than that
                    specifically set forth in this Section 23 or in Section 24
                    hereof, and other than in connection with the purchase of
                    Common Shares prior to the Distribution Date.

               (d)  The Company may, at its option, discharge all of its
                    obligations with respect to any redemption of the Rights by
                    (i) issuing a press release announcing the manner of
                    redemption of the Rights and (ii) mailing payment of the
                    Redemption Price to the registered holders of the Rights at
                    their last addresses as they appear on the registry books of
                    the Rights Agent or, prior to the Distribution Date, on the
                    registry books of the transfer agent for the Common Shares,
                    and upon such action, all outstanding Right Certificates
                    shall be null and void without any further action by the
                    Company.



                                       35
<PAGE>   39

SECTION 24.    EXCHANGE.

               (a)  The Board of Directors of the Company may, at its option, at
                    any time after any Person becomes an Acquiring Person,
                    exchange all or part of the then outstanding and exercisable
                    Rights (which shall not include Rights that have become void
                    pursuant to the provisions of Section 11(a)(ii) hereof) for
                    Common Shares at an exchange ratio of one Common Share per
                    Right, appropriately adjusted to reflect any stock split,
                    stock dividend or similar transaction occurring after the
                    date hereof (such exchange ratio being hereinafter referred
                    to as the "Exchange Ratio"). Notwithstanding the foregoing,
                    the Board of Directors shall not be empowered to effect such
                    exchange at any time after any Person (other than the
                    Company, any Subsidiary of the Company, any employee benefit
                    plan of the Company or any such Subsidiary, or any entity
                    holding Common Shares for or pursuant to the terms of any
                    such plan), together with all Affiliates and Associates of
                    such Person, becomes the Beneficial Owner of 50% or more of
                    the Common Shares then outstanding.

               (b)  Immediately upon the action of the Board of Directors of the
                    Company ordering the exchange of any Rights pursuant to
                    Section 24(a) hereof and without any further action and
                    without any notice, the right to exercise such Rights shall
                    terminate and the only right thereafter of a holder of such
                    Rights shall be to receive that number of Common Shares
                    equal to the number of such Rights held by such holder
                    multiplied by the Exchange Ratio. The Company shall promptly
                    give public notice of any such exchange; provided, however,
                    that the failure to give, or any defect in, such notice
                    shall not affect the validity of such exchange. The Company
                    promptly shall mail a notice of any such exchange to all of
                    the holders of such Rights at their last addresses as they
                    appear upon the registry books of the Rights Agent;
                    provided, however, that the failure to give, or any defect
                    in, such notice shall not affect the validity of such
                    exchange. Any notice which is mailed in the manner herein
                    provided shall be deemed given, whether or not the holder
                    receives the notice. Each such notice of exchange will state
                    the method by which the exchange of the Common Shares for
                    Rights will be effected and, in the event of any partial
                    exchange, the number of Rights which will be exchanged. Any
                    partial exchange shall be effected pro rata based on the
                    number of Rights (other than Rights which have become void
                    pursuant to the provisions of Section 11(a)(ii) hereof) held
                    by each holder of Rights.

               (c)  In lieu of issuing Common Shares in accordance with Section
                    24(a) hereof, the Company may, if a majority of the Board of
                    Directors then in office determines that such action is
                    necessary or appropriate and not contrary to the interests
                    of the holders of Rights, elect to (and, in the event that
                    there are not sufficient treasury shares and authorized but
                    unissued 



                                       36
<PAGE>   40

                    Common Shares to permit any exchange of the Rights in
                    accordance with Section 24(a) hereof, the Company shall)
                    take all such action as may be necessary to authorize, issue
                    or pay, upon the exchange of the Rights, cash (including by
                    way of a reduction of the Purchase Price), property, Common
                    Shares, other securities or any combination thereof having
                    an aggregate value equal to the value of the Common Shares
                    which otherwise would have been issuable pursuant to Section
                    24(a) hereof, which aggregate value shall be determined by a
                    nationally recognized investment banking firm selected by a
                    majority of the Board of Directors then in office. For
                    purposes of the preceding sentence, the value of the Common
                    Shares shall be determined pursuant to Section 11(d) hereof.
                    Any election pursuant to this Section 24(c) by the Board of
                    Directors must be made within 60 days following the date on
                    which the event described in Section 11(a)(ii) hereof shall
                    have occurred. Following the occurrence on the event
                    described in Section 11(a)(ii) hereof, a majority of the
                    Board of Directors then in office may suspend the
                    exercisability of the Rights for a period of up to 60 days
                    following the date on which the event described in Section
                    11(a)(ii) hereof shall have occurred to the extent that such
                    directors have not determined whether to exercise their
                    rights of election under this Section 24(c). In the event of
                    any such suspension, the Company shall issue a public
                    announcement stating that the exercisability of the Rights
                    has been temporarily suspended.

               (d)  The Company shall not be required to issue fractions of
                    Common Shares or to distribute certificates which evidence
                    fractional Common Shares. In lieu of such fractional Common
                    Shares, the Company shall pay to the registered holders of
                    the Right Certificates with regard to which such fractional
                    Common Shares would otherwise be issuable an amount in cash
                    equal to the same fraction of the current market value of a
                    whole Common Share. For the purposes of this Section 24(d),
                    the current market value of a whole Common Share shall be
                    the closing price of a Common Share (as determined pursuant
                    to the second sentence of Section 11(d)(i) hereof) for the
                    Trading Day immediately after the date of the first public
                    announcement by the Company that an exchange is to be
                    effected pursuant to this Section 24.

               (e)  The Company shall not be required to issue fractions of
                    Preferred Shares (other than fractions which are integral
                    multiples of one one-hundredth of a Preferred Share) upon
                    exchange of the Rights or to distribute certificates which
                    evidence fractional Preferred Shares (other than fractions
                    which are integral multiples of one one-hundredth of a
                    Preferred Share). Fractions of Preferred Shares in integral
                    multiples of one one-hundredth of a Preferred Share may, at
                    the election of the Company, be evidenced by depositary
                    receipts; provided, however, that holders of such depositary
                    receipts shall have all of the designations and the powers,
                    preferences and 



                                       37
<PAGE>   41

                    rights, and the qualifications, limitations and restrictions
                    to which they are entitled as beneficial owners of the
                    Preferred Shares represented by such depositary receipts. In
                    lieu of fractional Preferred Shares that are not integral
                    multiples of one one-hundredth of a Preferred Share, the
                    Company shall pay to the registered holders of Right
                    Certificates at the time such Rights are exercised as herein
                    provided an amount in cash equal to the same fraction of the
                    current market value of one Preferred Share. For the
                    purposes of this Section 24(e), the current market value of
                    a Preferred Share shall be one hundred (100) times the
                    closing price of a Common Share (as determined pursuant to
                    the second sentence of Section 11(d)(i) hereof) for the
                    Trading Day immediately after the date of the first public
                    announcement by the Company that an exchange is to be
                    effected pursuant to this Section 24.

SECTION 25.    NOTICE OF CERTAIN EVENTS.

               (a)  In case the Company shall propose (i) to pay any dividend
                    payable in stock of any class to the holders of its
                    Preferred Shares or to make any other distribution to the
                    holders of its Preferred Shares (other than a regular
                    quarterly cash dividend), (ii) to offer to the holders of
                    its Preferred Shares rights or warrants to subscribe for or
                    to purchase any additional Preferred Shares or shares of
                    stock of any class or any other securities, rights or
                    options, (iii) to effect any reclassification of its
                    Preferred Shares (other than a reclassification involving
                    only the subdivision of outstanding Preferred Shares), (iv)
                    to effect any consolidation or merger into or with, or to
                    effect any sale or other transfer (or to permit one or more
                    of its Subsidiaries to effect any sale or other transfer),
                    in one or more transactions, of 50% or more of the assets or
                    earning power of the Company and its Subsidiaries (taken as
                    a whole), to any other Person, (v) to effect the
                    liquidation, dissolution or winding up of the Company, or
                    (vi) to declare or pay any dividend on the Common Shares
                    payable in Common Shares or to effect a subdivision,
                    combination or consolidation of the Common Shares (by
                    reclassification or otherwise than by payment of dividends
                    in Common Shares), then, in each such case, the Company
                    shall give to each holder of a Right Certificate, in
                    accordance with Section 26 hereof, a notice of such proposed
                    action, which shall specify the record date for the purpose
                    of such stock dividend, or distribution of rights or
                    warrants, or the date on which such reclassification,
                    consolidation, merger, sale, transfer, liquidation,
                    dissolution, or winding up is to take place and the date of
                    participation therein by the holders of the Common Shares
                    and/or the Preferred Shares, if any such date is to be
                    fixed, and such notice shall be so given in the case of any
                    action covered by clause (i) or (ii) above at least 10 days
                    prior to the record date for determining holders of the
                    Preferred Shares for purposes of such action, and in the
                    case of any such other action, at least 10 days prior to the
                    date 



                                       38
<PAGE>   42

                    of the taking of such proposed action or the date of
                    participation therein by the holders of the Common Shares
                    and/or the Preferred Shares, whichever shall be the earlier.

               (b)  In case the event set forth in Section 11(a)(ii) hereof
                    shall occur, then the Company shall as soon as practicable
                    thereafter give to each holder of a Right Certificate, in
                    accordance with Section 26 hereof, a notice of the
                    occurrence of such event, which notice shall describe the
                    event and the consequences of the event to holders of Rights
                    under Section 11(a)(ii) hereof.

SECTION 26.    NOTICES. Notices or demands authorized by this Agreement to be 
               given or made by the Rights Agent or by the holder of any Right
               Certificate to or on the Company shall be sufficiently given or
               made if sent by first-class mail, postage prepaid, addressed
               (until another address is filed in writing with the Rights Agent)
               as follows:

                              Axys Pharmaceuticals, Inc.
                              180 Kimball Way
                              South San Francisco, CA  94080
                              Attention:  General Counsel

               Subject to the provisions of Section 21 hereof, any notice or
               demand authorized by this Agreement to be given or made by the
               Company or by the holder of any Right Certificate to or on the
               Rights Agent shall be sufficiently given or made if sent by
               first-class mail, postage prepaid, addressed (until another
               address is filed in writing with the Company) as follows:

                              ChaseMellon Shareholder Services, L.L.C.
                              235 Montgomery Street, 23rd Floor
                              San Francisco, CA  94104
                              Attention:  Account Manager

               Notices or demands authorized by this Agreement to be given or
               made by the Company or the Rights Agent to the holder of any
               Right Certificate shall be sufficiently given or made if sent by
               first-class mail, postage prepaid, addressed to such holder at
               the address of such holder as shown on the registry books of the
               Company.

SECTION 27.    SUPPLEMENTS AND AMENDMENTS. Prior to the Distribution Date, the
               Company and the Rights Agent shall, if the Company so directs,
               supplement or amend any provision of this Agreement without the
               approval of any holders of the Rights. From and after the
               Distribution Date, the Company and the Rights Agent shall, if the
               Company so directs, from time to time supplement or amend any
               provision of this Agreement without the approval of any holders
               of Right Certificates in order to (i) cure any ambiguity, (ii)
               correct or supplement any provision contained 



                                       39
<PAGE>   43

               herein which may be defective or inconsistent with any other
               provisions herein, or (iii) change any other provisions with
               respect to the Rights which the Company may deem necessary or
               desirable; provided, however, that no such supplement or
               amendment shall be made which would adversely affect the
               interests of the holders of Rights (other than the interests of
               an Acquiring Person or its Affiliates or Associates). Any
               supplement or amendment adopted during any period after any
               Person has become an Acquiring Person but prior to the
               Distribution Date shall become null and void unless such
               supplement or amendment could have been adopted by the Company
               from and after the Distribution Date. Any such supplement or
               amendment shall be evidenced by a writing signed by the Company
               and the Rights Agent. Upon delivery of a certificate from an
               appropriate officer of the Company which states that the proposed
               supplement or amendment is in compliance with the terms of this
               Section 27, the Rights Agent shall execute such supplement or
               amendment unless the Rights Agent shall have determined in good
               faith that such supplement or amendment would adversely affect
               its interest under this Agreement. Prior to the Distribution
               Date, the interests of the holders of Rights shall be deemed
               coincident with the interests of the holders of Common Shares.

SECTION 28.    DETERMINATION AND ACTIONS BY THE BOARD OF DIRECTORS, ETC. For all
               purposes of this Agreement, any calculation of the number of
               Common Shares outstanding at any particular time, including for
               purposes of determining the particular percentage of such
               outstanding Common Shares or any other securities of which any
               Person is the Beneficial Owner, shall be made in accordance with
               the last sentence of Rule 13d-3(d)(1)(i) of the General Rules and
               Regulations under the Exchange Act as in effect on the date of
               this Agreement. The Board of Directors of the Company shall have
               the exclusive power and authority to administer this Agreement
               and to exercise all rights and powers specifically granted to the
               Board, or the Company, or as may be necessary or advisable in the
               administration of this Agreement, including without limitation,
               the right and power to (i) interpret the provisions of this
               Agreement, and (ii) make all determinations deemed necessary or
               advisable for the administration of this Agreement (including a
               determination to redeem or not redeem the Rights or to amend the
               Agreement). All such actions, calculations, interpretations and
               determinations (including, for purposes of clause (y) below, all
               omissions with respect to the foregoing) which are done or made
               by the Board in good faith, shall (x) be final, conclusive and
               binding on the Rights Agent and the holders of the Rights, and
               (y) not subject the Board to any liability to the holders of the
               Rights.

SECTION 29.    SUCCESSORS. All the covenants and provisions of this Agreement by
               or for the benefit of the Company or the Rights Agent shall bind
               and inure to the benefit of their respective successors and
               assigns hereunder.

SECTION 30.    BENEFITS OF THIS AGREEMENT. Nothing in this Agreement shall be
               construed to give to any person or corporation other than the
               Company, the Rights Agent and 



                                       40
<PAGE>   44

               the registered holders of the Right Certificates (and, prior to
               the Distribution Date, the Common Shares) any legal or equitable
               right, remedy or claim under this Agreement; but this Agreement
               shall be for the sole and exclusive benefit of the Company, the
               Rights Agent and the registered holders of the Right Certificates
               (and, prior to the Distribution Date, the Common Shares).

SECTION 31.    SEVERABILITY. If any term, provision, covenant or restriction of
               this Agreement is held by a court of competent jurisdiction or
               other authority to be invalid, void or unenforceable, the
               remainder of the terms, provisions, covenants and restrictions of
               this Agreement shall remain in full force and effect and shall in
               no way be affected, impaired or invalidated.

SECTION 32.    GOVERNING LAW. This Agreement and each Right Certificate issued
               hereunder shall be deemed to be a contract made under the laws of
               the State of Delaware and for all purposes shall be governed by
               and construed in accordance with the laws of such State
               applicable to contracts to be made and performed entirely within
               such State.

SECTION 33.    COUNTERPARTS. This Agreement may be executed in any number of
               counterparts and each of such counterparts shall for all purposes
               be deemed to be an original, and all such counterparts shall
               together constitute but one and the same instrument.

SECTION 34.    DESCRIPTIVE HEADINGS. Descriptive headings of the several
               Sections of this Agreement are inserted for convenience only and
               shall not control or affect the meaning or construction of any of
               the provisions hereof.



                                       41
<PAGE>   45

        IN WITNESS WHEREOF, parties whereto have caused this Agreement to be
duly executed, all as of the day and year first above written.

ATTEST:                                      AXYS PHARMACEUTICALS, INC.


/s/ William J. Newell                        /s/ John P. Walker
- ----------------------------------           -----------------------------------
Print Name: William J. Newell                Print Name: John P. Walker
Title:    Vice President, General            Title:    Chairman of the Board and
          Counsel and Secretary                        Chief Executive Officer


ATTEST:                                      CHASEMELLON SHAREHOLDER SERVICES,
                                             L.L.C.


By: /s/ Asa Drew                             By: /s/ Gloria Pouncil
- ----------------------------------           --------------------------------
Print Name: Asa Drew                         Print Name: Gloria Pouncil

Title: Assistant Vice President              Title: Relationship Manager



                                       42
<PAGE>   46
                           CERTIFICATE OF DESIGNATION

                                       OF

                  SERIES A JUNIOR PARTICIPATING PREFERRED STOCK

                                       OF

                           AXYS PHARMACEUTICALS, INC.

                         (Pursuant to Section 151 of the
                        Delaware General Corporation Law)

                         (EXHIBIT A TO RIGHTS AGREEMENT)


         AXYS PHARMACEUTICALS, INC., a corporation organized and existing under
the General Corporation Law of the State of Delaware (hereinafter called the
"Company"), hereby certifies that the following resolution was adopted by the
Board of Directors of the Corporation as required by Section 151 of the General
Corporation Law at a meeting duly called and held on October 8, 1998

                RESOLVED, that pursuant to the authority granted to
                and vested in the Board of Directors of the Company in
                accordance with the provisions of its Amended and
                Restated Certificate of Incorporation, the Board of
                Directors hereby creates a series of Preferred Stock,
                par value $.001 per share, of the Company and hereby
                states the designation and number of shares, and fixes
                the relative designations and the powers, preferences
                and rights, and the qualifications, limitations and
                restrictions thereof (in addition to the provisions
                set forth in the Certificate of Incorporation of the
                Company, which are applicable to the Preferred Stock
                of all classes and series), as follows:

                Series A Junior Participating Preferred Stock:

         SECTION 1. DESIGNATION AND AMOUNT. Five Hundred Thousand (500,000)
shares of Preferred Stock, $ .001 par value, are designated "Series A Junior
Participating Preferred Stock" with the designations and the powers, preferences
and rights, and the qualifications, limitations and restrictions specified
herein (the "Junior Preferred Stock"). Such number of shares may be increased or
decreased by resolution of the Board of Directors; provided, that no decrease
shall reduce the number of shares of Junior Preferred Stock to a number less
than the number of shares then outstanding plus the number of shares reserved
for issuance upon the exercise of 



                                      A-1
<PAGE>   47

outstanding options, rights or warrants or upon the conversion of any
outstanding securities issued by the Company convertible into Junior Preferred
Stock.

         SECTION 2. DIVIDENDS AND DISTRIBUTIONS.

                  (A) Subject to the rights of the holders of any shares of any
series of Preferred Stock (or any similar stock) ranking prior and superior to
the Junior Preferred Stock with respect to dividends, the holders of shares of
Junior Preferred Stock, in preference to the holders of Common Stock, par value
$.001 per share (the "Common Stock"), of the Company, and of any other junior
stock, shall be entitled to receive, when, as and if declared by the Board of
Directors out of funds legally available for the purpose, quarterly dividends
payable in cash on the first day of April, July, October and January in each
year (each such date being referred to herein as a "Quarterly Dividend Payment
Date"), commencing on the first Quarterly Dividend Payment Date after the first
issuance of a share or fraction of a share of Junior Preferred Stock, in an
amount per share (rounded to the nearest cent) equal to the greater of (a) $l.00
or (b) subject to the provision for adjustment hereinafter set forth, 100 times
the aggregate per share amount of all cash dividends, and 100 times the
aggregate per share amount (payable in kind) of all non-cash dividends or other
distributions, other than a dividend payable in shares of Common Stock or a
subdivision of the outstanding shares of Common Stock (by reclassification or
otherwise), declared on the Common Stock since the immediately preceding
Quarterly Dividend Payment Date or, with respect to the first Quarterly Dividend
Payment Date, since the first issuance of any share or fraction of a share of
Junior Preferred Stock. In the event the Company shall at any time declare or
pay any dividend on the Common Stock payable in shares of Common Stock, or
effect a subdivision or combination or consolidation of the outstanding shares
of Common Stock (by reclassification or otherwise than by payment of a dividend
in shares of Common Stock) into a greater or lesser number of shares of Common
Stock, then in each such case the amount to which holders of shares of Junior
Preferred Stock were entitled immediately prior to such event under clause (b)
of the preceding sentence shall be adjusted by multiplying such amount by a
fraction, the numerator of which is the number of shares of Common Stock
outstanding immediately after such event and the denominator of which is the
number of shares of Common Stock that were outstanding immediately prior to such
event.

                  (B) The Company shall declare a dividend or distribution on
the Junior Preferred Stock as provided in paragraph (A) of this Section
immediately after it declares a dividend or distribution on the Common Stock
(other than a dividend payable in shares of Common Stock); provided, that in the
event no dividend or distribution shall have been declared on the Common Stock
during the period between any Quarterly Dividend Payment Date and the next
subsequent Quarterly Dividend Payment Date, a dividend of $1.00 per share on the
Junior Preferred Stock shall nevertheless be payable on such subsequent
Quarterly Dividend Payment Date.

                  (C) Dividends shall begin to accrue and be cumulative on
outstanding shares of Junior Preferred Stock from the Quarterly Dividend Payment
Date next preceding the date of issue of such shares, unless the date of issue
of such shares is prior to the record date for the first Quarterly Dividend
Payment Date, in which case dividends on such shares shall begin to accrue from
the date of issue of such shares, or unless the date of issue is a Quarterly
Dividend Payment Date or is a date after the record date for the determination
of holders of shares of Junior 



                                      A-2
<PAGE>   48

Preferred Stock entitled to receive a quarterly dividend and before such
Quarterly Dividend Payment Date, in either of which events such dividends shall
begin to accrue and be cumulative from such Quarterly Dividend Payment Date.
Accrued but unpaid dividends shall not bear interest. Dividends paid on the
shares of Junior Preferred Stock in an amount less than the total amount of such
dividends at the time accrued and payable on such shares shall be allocated pro
rata on a share-by-share basis among all such shares at the time outstanding.
The Board of Directors may fix a record date for the determination of holders of
shares of Junior Preferred Stock entitled to receive payment of a dividend or
distribution declared thereon, which record date shall be not more than 60 days
prior to the date fixed for the payment thereof.

         SECTION 3. VOTING RIGHTS. The holders of shares of Junior Preferred
Stock shall have the following voting rights:

                  (A) Subject to the provision for adjustment hereinafter set
forth, each share of Junior Preferred Stock shall entitle the holder thereof to
100 votes on all matters submitted to a vote of the stockholders of the Company.
In the event the Company shall at any time declare or pay any dividend on the
Common Stock payable in shares of Common Stock, or effect a subdivision or
combination or consolidation of the outstanding shares of Common Stock (by
reclassification or otherwise than by payment of a dividend in shares of Common
Stock) into a greater or lesser number of shares of Common Stock, then in each
such case the number of votes per share to which holders of shares of Junior
Preferred Stock were entitled immediately prior to such event shall be adjusted
by multiplying such number by a fraction, the numerator of which is the number
of shares of Common Stock outstanding immediately after such event and the
denominator of which is the number of shares of Common Stock that were
outstanding immediately prior to such event.

                  (B) Except as otherwise provided herein, in any other
Certificate of Designation creating a series of Preferred Stock or any similar
stock, or by law, the holders of shares of Junior Preferred Stock and the
holders of shares of Common Stock and any other capital stock of the Company
having general voting rights shall vote together as one class on all matters
submitted to a vote of stockholders of the Company.

                  (C) Except as set forth herein, or as otherwise provided by
law, holders of Junior Preferred Stock shall have no special voting rights and
their consent shall not be required (except to the extent they are entitled to
vote with holders of Common Stock as set forth herein) for taking any corporate
action.

         SECTION 4. CERTAIN RESTRICTIONS.

                  (A) Whenever quarterly dividends or other dividends or
distributions payable on the Junior Preferred Stock as provided in Section 2 are
in arrears, thereafter and until all accrued and unpaid dividends and
distributions, whether or not declared, on shares of Junior Preferred Stock
outstanding shall have been paid in full, the Company shall not:

                           (i) declare or pay dividends, or make any other
distributions, on any shares of stock ranking junior (either as to dividends or
upon liquidation, dissolution or winding up) to the Junior Preferred Stock;



                                      A-3
<PAGE>   49

                           (ii) declare or pay dividends, or make any other
distributions, on any shares of stock ranking on a parity (either as to
dividends or upon liquidation, dissolution or winding up) with the Junior
Preferred Stock, except dividends paid ratably on the Junior Preferred Stock and
all such parity stock on which dividends are payable or in arrears in proportion
to the total amounts to which the holders of all such shares are then entitled;

                           (iii) redeem or purchase or otherwise acquire for
consideration shares of any stock ranking junior (either as to dividends or upon
liquidation, dissolution or winding up) to the Junior Preferred Stock, provided
that the Company may at any time redeem, purchase or otherwise acquire shares of
any such junior stock in exchange for shares of any stock of the Company ranking
junior (either as to dividends or upon dissolution, liquidation or winding up)
to the Junior Preferred Stock; or

                           (iv) redeem or purchase or otherwise acquire for
consideration any shares of Junior Preferred Stock, or any shares of stock
ranking on a parity (either as to dividends or upon liquidation, dissolution or
winding up) with the Junior Preferred Stock, except in accordance with a
purchase offer made in writing or by publication (as determined by the Board of
Directors) to all holders of such shares upon such terms as the Board of
Directors, after consideration of the respective annual dividend rates and other
relative rights and preferences of the respective series and classes, shall
determine in good faith will result in fair and equitable treatment among the
respective series or classes.

                  (B) The Company shall not permit any subsidiary of the Company
to purchase or otherwise acquire for consideration any shares of stock of the
Company unless the Company could, under paragraph (A) of this Section 4,
purchase or otherwise acquire such shares at such time and in such manner.

         SECTION 5. REACQUIRED SHARES. Any shares of Junior Preferred Stock
purchased or otherwise acquired by the Company in any manner whatsoever shall be
retired and cancelled promptly after the acquisition thereof. All such shares
shall upon their cancellation become authorized but unissued shares of Preferred
Stock and may be reissued as part of a new series of Preferred Stock subject to
the conditions and restrictions on issuance set forth herein, in the Amended and
Restated Certificate of Incorporation, or in any other Certificate of
Designation creating a series of Preferred Stock or any similar stock or as
otherwise required by law.

         SECTION 6. LIQUIDATION, DISSOLUTION OR WINDING UP. Upon any
liquidation, dissolution or winding up of the Company, no distribution shall be
made (1) to the holders of shares of stock ranking junior (either as to
dividends or upon liquidation, dissolution or winding up) to the Junior
Preferred Stock unless, prior thereto, the holders of shares of Junior Preferred
Stock shall have received $100 per share, plus an amount equal to accrued and
unpaid dividends and distributions thereon, whether or not declared, to the date
of such payment, provided that the holders of shares of Junior Preferred Stock
shall be entitled to receive an aggregate amount per share, subject to the
provision for adjustment hereinafter set forth, equal to 100 times the aggregate
amount to be distributed per share to holders of shares of Common Stock, or (2)
to the holders of shares of stock ranking on a parity (either as to dividends or
upon liquidation, dissolution or winding up) with the Junior Preferred Stock,
except distributions made ratably on the Junior Preferred Stock and all such
parity stock in proportion to the total amounts to which 



                                      A-4
<PAGE>   50

the holders of all such shares are entitled upon such liquidation, dissolution
or winding up. In the event the Company shall at any time declare or pay any
dividend on the Common Stock payable in shares of Common Stock, or effect a
subdivision or combination or consolidation of the outstanding shares of Common
Stock (by reclassification or otherwise than by payment of a dividend in shares
of Common Stock) into a greater or lesser number of shares of Common Stock, then
in each such case the aggregate amount to which holders of shares of Junior
Preferred Stock were entitled immediately prior to such event under the proviso
in clause (1) of the preceding sentence shall be adjusted by multiplying such
amount by a fraction the numerator of which is the number of shares of Common
Stock outstanding immediately after such event and the denominator of which is
the number of shares of Common Stock that were outstanding immediately prior to
such event.

         SECTION 7. CONSOLIDATION, MERGER, ETC. In case the Company shall enter
into any consolidation, merger, combination or other transaction in which the
shares of Common Stock are exchanged for or changed into other stock or
securities, cash and/or any other property, then in any such case each share of
Junior Preferred Stock shall at the same time be similarly exchanged or changed
into an amount per share, subject to the provision for adjustment hereinafter
set forth, equal to 100 times the aggregate amount of stock, securities, cash
and/or any other property (payable in kind), as the case may be, into which or
for which each share of Common Stock is changed or exchanged. In the event the
Company shall at any time declare or pay any dividend on the Common Stock
payable in shares of Common Stock, or effect a subdivision or combination or
consolidation of the outstanding shares of Common Stock (by reclassification or
otherwise than by payment of a dividend in shares of Common Stock) into a
greater or lesser number of shares of Common Stock, then in each such case the
amount set forth in the preceding sentence with respect to the exchange or
change of shares of Junior Preferred Stock shall be adjusted by multiplying such
amount by a fraction, the numerator of which is the number of shares of Common
Stock outstanding immediately after such event and the denominator of which is
the number of shares of Common Stock that were outstanding immediately prior to
such event.

         SECTION 8. NO REDEMPTION. The shares of Junior Preferred Stock shall
not be redeemable.

         SECTION 9. RANK. The Junior Preferred Stock shall rank, with respect to
the payment of dividends and the distribution of assets, junior to all series of
any other class of the Company's Preferred Stock.

         SECTION 10. AMENDMENT. The Amended and Restated Certificate of
Incorporation of the Company shall not be amended in any manner which would
materially alter or change the powers, preferences or special rights of the
Junior Preferred Stock so as to affect them adversely without the affirmative
vote of the holders of at least two-thirds of the outstanding shares of Junior
Preferred Stock, voting together as a single class.



                                      A-5
<PAGE>   51

         IN WITNESS WHEREOF, the undersigned have executed this certificate as
of October 8, 1998.


                                        ________________________________________
                                        John P. Walker, Chairman of the Board
                                        And Chief Executive Officer


                                        ________________________________________
                                        William J. Newell, Secretary



                                      A-6
<PAGE>   52
                            FORM OF RIGHT CERTIFICATE

                         (EXHIBIT B TO RIGHTS AGREEMENT)


CERTIFICATE NO. R-                                                  _____ RIGHTS


         NOT EXERCISABLE AFTER OCTOBER 7, 2008 OR EARLIER IF REDEMPTION OR
         EXCHANGE OCCURS. THE RIGHTS ARE SUBJECT TO REDEMPTION AT $.01 PER RIGHT
         AND TO EXCHANGE ON THE TERMS SET FORTH IN THE RIGHTS AGREEMENT.


                                RIGHT CERTIFICATE

                           AXYS PHARMACEUTICALS, INC.


         This certifies that ___________________ or registered assigns, is the
registered owner of the number of Rights set forth above, each of which entitles
the owner thereof, subject to the terms, provisions and conditions of the Rights
Agreement, dated as of October 8, 1998 (the "Rights Agreement"), between Axys
Pharmaceuticals, Inc., a Delaware corporation (the "Company"), and ChaseMellon
Shareholder Services, L.L.C. (the "Rights Agent"), to purchase from the Company
at any time after the Distribution Date (as such term is defined in the Rights
Agreement) and prior to 5:00 P.M., Pacific Time, on October 7, 2008 at the
office of the Rights Agent designated for such purpose, or at the office of its
successor as Rights Agent, one one-hundredth of a fully paid non-assessable
share of Series A Junior Participating Preferred Stock, par value $ .001 per
share (the "Preferred Shares"), of the Company, at a purchase price of $35.00
per one one-hundredth of a Preferred Share (the "Purchase Price"), upon
presentation and surrender of this Right Certificate with the Form of Election
to Purchase duly executed. The number of Rights evidenced by this Right
Certificate (and the number of one one-hundredths of a Preferred Share which may
be purchased upon exercise hereof) set forth above, and the Purchase Price set
forth above, are the number and Purchase Price as of October 8, 1998, based on
the Preferred Shares as constituted at such date.

         From and after the time any Person becomes an Acquiring Person, (as
such terms are defined in the Rights Agreement), if the Rights evidenced by this
Right Certificate are beneficially owned by (i) an Acquiring Person or an
Affiliate or Associate of any such Acquiring Person (as such terms are defined
in the Rights Agreement), (ii) a transferee of any such Acquiring Person,
Associate or Affiliate who becomes a transferee after the Acquiring Person
becomes such, or (iii) under certain circumstances specified in the Rights
Agreement, a transferee of any such Acquiring Person, Associate or Affiliate who
becomes a transferee prior to or concurrently with the Acquiring Person becoming
such, such Rights shall become null and void without any further action and no
holder hereof shall have any right with respect to such Rights from and after
the time any Person becomes an Acquiring Person.



                                      B-1
<PAGE>   53

         As provided in the Rights Agreement, the Purchase Price and the number
of one one-hundredths of a Preferred Share which may be purchased upon the
exercise of the Rights evidenced by this Right Certificate are subject to
modification and adjustment upon the happening of certain events.

         This Right Certificate is subject to all of the terms, provisions and
conditions of the Rights Agreement, as amended from time to time, which terms,
provisions and conditions are hereby incorporated herein by reference and made a
part hereof and to which Rights Agreement reference is hereby made for a full
description of the rights, limitations of rights, obligations, duties and
immunities hereunder of the Rights Agent, the Company and the holders of the
Right Certificates. Copies of the Rights Agreement are on file at the principal
executive offices of the Company and the above-mentioned offices of the Rights
Agent.

         This Right Certificate, with or without other Right Certificates, upon
surrender at the office of the Rights Agent designated for such purpose, may be
exchanged for another Right Certificate or Right Certificates of like tenor and
date evidencing Rights entitling the holder to purchase a like aggregate number
of Preferred Shares as the Rights evidenced by the Right Certificate or Right
Certificates surrendered shall have entitled such holder to purchase. If this
Right Certificate shall be exercised in part, the holder shall be entitled to
receive upon surrender hereof another Right Certificate or Right Certificates
for the number of whole Rights not exercised.

         Subject to the provisions of the Rights Agreement, the Rights evidenced
by this Certificate (i) may be redeemed by the Company at a redemption price of
$.01 per Right or (ii) may be exchanged in whole or in part for shares of the
Company's Common Stock, par value $ .001 per share, or, upon circumstances set
forth in the Rights Agreement, cash, property or other securities of the
Company, including fractions of a share of Preferred Stock.

         No fractional Preferred Shares will be issued upon the exercise of any
Right or Rights evidenced hereby (other than fractions which are integral
multiples of one one-hundredth of a Preferred Share, which may, at the election
of the Company, be evidenced by depositary receipts) but in lieu thereof a cash
payment will be made, as provided in the Rights Agreement.

         No holder of this Right Certificate shall be entitled to vote or
receive dividends or be deemed for any purpose the holder of the Preferred
Shares or of any other securities of the Company which may at any time be
issuable on the exercise hereof, nor shall anything contained in the Rights
Agreement or herein be construed to confer upon the holder hereof, as such, any
of the rights of a stockholder of the Company or any right to vote for the
election of directors or upon any matter submitted to stockholders at any
meeting thereof, or to give or withhold consent to any corporate action, or to
receive notice of meetings or other actions affecting stockholders (except as
provided in the Rights Agreement), or to receive dividends or subscription
rights, or otherwise, until the Right or Rights evidenced by this Right
Certificate shall have been exercised as provided in the Rights Agreement.

         This Right Certificate shall not be valid or obligatory for any purpose
until it shall have been countersigned by the Rights Agent.



                                      B-2
<PAGE>   54

         WITNESS the facsimile signature of the proper officers of the Company
and its corporate seal. Dated as of __________________.


ATTEST:                                      AXYS PHARMACEUTICALS, INC.


_________________________________________    By:________________________________
Secretary                                    Title:_____________________________


COUNTERSIGNED:


________________________________________
ChaseMellon Shareholder Services, L.L.C.
   as Rights Agent


By:_____________________________________

Print Name:_____________________________

Title:__________________________________



                                      B-3
<PAGE>   55

                    Form of Reverse Side of Right Certificate


                               FORM OF ASSIGNMENT


                (To be executed by the registered holder if such
               holder desires to transfer the Right Certificate.)


         FOR VALUE RECEIVED ______________________________________ hereby sells,
assigns and transfers unto

________________________________________________________________________________
                  (Please print name and address of transferee)

_____________________________________________________________________ this Right
Certificate, together with all right, title and interest therein, and does
hereby irrevocably constitute and appoint ________________________ Attorney, to
transfer the within Right Certificate on the books of the within-named Company,
with full power of substitution.


Dated:  ____________________



                                        ________________________________________
                                        Signature





             Form of Reverse Side of Right Certificate -- continued



                                      B-4
<PAGE>   56

Signature Guaranteed:

         Signatures must be guaranteed by an "eligible guarantor institution" as
defined in Rule 17Ad-15 promulgated under the Securities Exchange Act of 1934,
as amended.

- ----------------------------------------

         The undersigned hereby certifies that (1) the Rights evidenced by this
Right Certificate are not being sold, assigned or transferred by or on behalf of
a Person who is or was an Acquiring Person, an Interested Stockholder or an
Affiliate or Associate thereof (as such terms are defined in the Rights
Agreement); and (2) after due inquiry and to the best of the knowledge of the
undersigned, the undersigned did not acquire the Rights evidenced by this Right
Certificate from any Person who is or was an Acquiring Person, an Interested
Stockholder, or an Affiliate or Associate thereof.


                                        ________________________________________
                                        Signature



                                      B-5
<PAGE>   57

                          FORM OF ELECTION TO PURCHASE

                  (To be executed if holder desires to exercise
                  Rights represented by the Right Certificate.)


To ChaseMellon Shareholder Services, L.L.C.;

         The undersigned hereby irrevocably elects to exercise
___________________________ Rights represented by this Right Certificate to
purchase the Preferred Shares issuable upon the exercise of such Rights and
requests that certificates for such Preferred Shares be issued in the name of:

Please insert social security
or other identifying number: ______________


__________________________________________________________________
                (Please print name and address)

__________________________________________________________________

If such number of Rights shall not be all the Rights evidenced by this Right
Certificate, a new Right Certificate for the balance remaining of such Rights
shall be registered in the name of and delivered to:

Please insert social security
or other identifying number: ______________


__________________________________________________________________
                (Please print name and address)

__________________________________________________________________


Dated:  _________________


                                        ________________________________________
                                        Signature



             Form of Reverse Side of Right Certificate -- continued



                                      B-6
<PAGE>   58

Signature Guaranteed:

         Signatures must be guaranteed by an "eligible guarantor institution" as
defined in Rule 17Ad-15 promulgated under the Securities Exchange Act of 1934,
as amended.


- ------------------------------

         The undersigned hereby certifies that (1) the Rights evidenced by this
Right Certificate are not beneficially owned by nor are they being exercised on
behalf of an Acquiring Person, an Interested Stockholder or an Affiliate or
Associate thereof (as such terms are defined in the Rights Agreement); and (2)
after due inquiry and to the best of the knowledge of the undersigned, the
undersigned did not acquire the Rights evidenced by this Right Certificate from
any Person who is or was an Acquiring Person, an Interested Stockholder, or an
Affiliate or Associate thereof.



                                        ________________________________________
                                        Signature

- ------------------------------

                                     NOTICE

         The signature in the Form of Assignment or Form of Election to
Purchase, as the case may be, must conform to the name as written upon the face
of this Right Certificate in every particular, without alteration or enlargement
or any change whatsoever.

         In the event the certification set forth above in the Form of
Assignment or the Form of Election to Purchase, as the case may be, is not
completed, the Company and the Rights Agent will deem the beneficial owner of
the Rights evidenced by this Right Certificate to be an Acquiring Person or an
Affiliate or Associate thereof (as defined in the Rights Agreement) and such
Assignment or Election to Purchase will not be honored.



                                      B-7
<PAGE>   59
                           AXYS PHARMACEUTICALS, INC.

                          SUMMARY OF RIGHTS TO PURCHASE
                                PREFERRED SHARES

                         (EXHIBIT C TO RIGHTS AGREEMENT)


         On October 8, 1998, the Board of Directors of AXYS PHARMACEUTICALS,
INC. (the "Company") declared a dividend of one preferred share purchase right
(a "Right") for each outstanding share of common stock, par value $ .001 per
share (the "Common Shares"), of the Company. The dividend is effective as of
October 28, 1998 (the "Record Date") with respect to the stockholders of record
on that date. The Rights will also attach to new Common Shares issued after the
Record Date. Each Right entitles the registered holder to purchase from the
Company one one-hundredth of a share of Series A Junior Participating Preferred
Stock, par value $.001 per share (the "Preferred Shares"), of the Company at a
price of $35.00 per one one-hundredth of a Preferred Share (the "Purchase
Price"), subject to adjustment. Each Preferred Share is designed to be the
economic equivalent of 100 Common Shares. The description and terms of the
Rights are set forth in a Rights Agreement dated as of October 8, 1998 (the
"Rights Agreement"), between the Company and ChaseMellon Shareholder Services,
L.L.C. (the "Rights Agent").

DETACHMENT AND TRANSFER OF RIGHTS

         Initially, the Rights will be evidenced by the stock certificates
representing Common Shares then outstanding, and no separate Right Certificates
will be distributed. Until the earlier to occur of (i) a public announcement
that a person or group of affiliated or associated persons, has become an
"Acquiring Person" (as such term is defined in the Rights Agreement) or (ii) 10
business days (or such later date as the Board may determine) following the
commencement of, or announcement of an intention to make, a tender offer or
exchange offer which would result in the beneficial ownership by an Acquiring
Person of 15% or more of the outstanding Common Shares (the earlier of such
dates being called the "Distribution Date"), the Rights will be evidenced, with
respect to any of the Common Share certificates outstanding as of the Record
Date, by such Common Share certificate. In general, an "Acquiring Person" is a
person, the affiliates or associates of such person, or a group, which has
acquired beneficial ownership of 15% or more of the outstanding Common Shares.

         The Rights Agreement provides that, until the Distribution Date (or
earlier redemption or expiration of the Rights), the Rights will be transferable
with and only with the Common Shares. Until the Distribution Date (or earlier
redemption or expiration of the Rights), new Common Share certificates issued
after the Record Date upon transfer or new issuance of Common Shares will
contain a notation incorporating the Rights Agreement by reference. Until the
Distribution Date (or earlier redemption or expiration of the Rights) the
surrender or transfer of any certificates for Common Shares outstanding as of
the Record Date, even without such notation or a copy of this Summary of Rights
being attached thereto, will also constitute the transfer of the Rights
associated with the Common Shares represented by such certificate. As soon as
practicable following the Distribution Date, separate certificates evidencing
the Rights ("Right 



                                      C-1
<PAGE>   60

Certificates") will be mailed to holders of record of the Common Shares as of
the close of business on the Distribution Date and such separate Right
Certificates alone will evidence the Rights.

EXERCISABILITY OF RIGHTS

         The Rights are not exercisable until the Distribution Date. The Rights
will expire on October 7, 2008 (the "Final Expiration Date"), unless the Final
Expiration Date is extended or unless the Rights are earlier redeemed or
exchanged by the Company, in each case as described below. Until a Right is
exercised, the holder thereof, as such, will have no rights as a stockholder of
the Company, including, without limitation, the right to vote or to receive
dividends.

         The Purchase Price payable, and the number of Preferred Shares or other
securities or property issuable or payable, upon exercise of the Rights are
subject to adjustment from time to time to prevent dilution. The number of
outstanding Rights and the number of one one-hundredths of a Preferred Share
issuable upon exercise of each Right are also subject to adjustment in the event
of a stock split of the Common Shares or a stock dividend on the Common Shares
payable in Common Shares, or subdivisions, consolidations or combinations of the
Common Shares occurring, in any such case, prior to the Distribution Date. With
certain exceptions, no adjustment in the Purchase Price will be required until
cumulative adjustments require an adjustment of at least 1% in such Purchase
Price. No fractional Preferred Shares will be issued (other than fractions which
are integral multiples of one one-hundredth of a Preferred Share, which may, at
the election of the Company, be evidenced by depositary receipts) and in lieu
thereof, an adjustment in cash will be made based on the market price of the
Preferred Shares on the last trading day prior to the date of exercise.

TERMS OF PREFERRED SHARES

         Preferred Shares purchasable upon exercise of the Rights will not be
redeemable. Each Preferred Share will be entitled to a minimum preferential
quarterly dividend payment of $l per share but will be entitled to an aggregate
dividend of 100 times the dividend declared per Common Share. In the event of
liquidation, the holders of the Preferred Shares will be entitled to a minimum
preferential liquidation payment of $100 per share but will be entitled to an
aggregate payment of 100 times the payment made per Common Share. Each Preferred
Share will have 100 votes, voting together with the Common Shares. Finally, in
the event of any merger, consolidation or other transaction in which Common
Shares are exchanged, each Preferred Share will be entitled to receive 100 times
the amount received per Common Share. These rights are protected by customary
anti-dilution provisions. Because of the nature of the Preferred Shares'
dividend, liquidation and voting rights, the value of the one one-hundredth
interest in a Preferred Share purchasable upon exercise of each Right should
approximate the value of one Common Share. The Preferred Shares would rank
junior to any other series of the Company's preferred stock.



                                      C-2
<PAGE>   61

TRIGGER OF FLIP-IN AND FLIP-OVER RIGHTS

         In the event that any person or group of affiliated or associated
persons becomes an Acquiring Person, proper provision shall be made so that each
holder of a Right, other than Rights beneficially owned by the Acquiring Person
or any affiliate or associate thereof (which will thereafter be void), will
thereafter have the right to receive upon exercise, that number of Common Shares
having a market value of two times the exercise price of the Right. This right
will commence on the date of public announcement that a person has become an
Acquiring Person (or the effective date of a registration statement relating to
distribution of the rights, if later) and terminate 60 days later (subject to
adjustment in the event exercise of the rights is enjoined).

         In the event that the Company is acquired in a merger or other business
combination transaction or 50% or more of its consolidated assets or earning
power are sold to an Acquiring Person, its affiliates or associates or certain
other persons in which such persons have an interest, proper provision will be
made so that each such holder of a Right will thereafter have the right to
receive, upon the exercise thereof at the then current exercise price of the
Right, that number of shares of common stock of the acquiring company which at
the time of such transaction will have a market value of two times the exercise
price of the Right.

REDEMPTION AND EXCHANGE OF RIGHTS

         At any time prior to the earliest of (i) the close of business on the
day of the first public announcement that a person has become an Acquiring
Person, or (ii) the Final Expiration Date, the Board of Directors of the Company
may redeem the Rights in whole, but not in part, at a price of $.01 per Right
(the "Redemption Price"). In general, the redemption of the Rights may be made
effective at such time on such basis with such conditions as the Board of
Directors in its sole discretion may establish. Immediately upon any redemption
of the Rights, the right to exercise the Rights will terminate and the only
right of the holders of Rights will be to receive the Redemption Price.

         At any time after any Person becomes an Acquiring Person and prior to
the acquisition by such person or group of 50% or more of the outstanding Common
Shares, the Board of Directors of the Company may exchange the Rights (other
than Rights owned by such person or group which will have become void), in whole
or in part, at an exchange ratio of one Common Share, or, under circumstances
set forth in the Rights Agreement, cash, property or other securities of the
Company, including fractions of a Preferred Share (or of a share of a class or
series of the Company's preferred stock having equivalent designations and the
powers, preferences and rights, and the qualifications, limitations and
restrictions), per Right (with value equal to such Common Shares).

AMENDMENT OF RIGHTS

         The terms of the Rights generally may be amended by the Board of
Directors of the Company without the consent of the holders of the Rights,
except that from and after such time as the Rights are distributed no such
amendment may adversely affect the interests of the holders of the Rights
(excluding the interest of any Acquiring Person).



                                      C-3
<PAGE>   62

ADDITIONAL INFORMATION

         A copy of the Rights Agreement has been filed with the Securities and
Exchange Commission as an Exhibit to a Current Report on Form 8-K dated October
___, 1998. A copy of the Rights Agreement is available from the Company by
writing to: Axys Pharmaceuticals, Inc., 180 Kimball Way, South San Francisco, CA
94080, Attn: Chief Executive Officer. This summary description of the Rights is
not intended to be complete and is qualified in its entirety by reference to the
Rights Agreement, which is hereby incorporated herein by reference.



                                      C-4

<PAGE>   1
                                                                    EXHIBIT 99.3



                           CERTIFICATE OF DESIGNATION

                                       OF

                  SERIES A JUNIOR PARTICIPATING PREFERRED STOCK

                                       OF

                           AXYS PHARMACEUTICALS, INC.

                         (Pursuant to Section 151 of the
                        Delaware General Corporation Law)



         AXYS PHARMACEUTICALS, INC., a corporation organized and existing under
the General Corporation Law of the State of Delaware (hereinafter called the
"Company"), hereby certifies that the following resolution was adopted by the
Board of Directors of the Corporation as required by Section 151 of the General
Corporation Law at a meeting duly called and held on October 8, 1998

                RESOLVED, that pursuant to the authority granted to
                and vested in the Board of Directors of the Company in
                accordance with the provisions of its Amended and
                Restated Certificate of Incorporation, the Board of
                Directors hereby creates a series of Preferred Stock,
                par value $.001 per share, of the Company and hereby
                states the designation and number of shares, and fixes
                the relative designations and the powers, preferences
                and rights, and the qualifications, limitations and
                restrictions thereof (in addition to the provisions
                set forth in the Certificate of Incorporation of the
                Company, which are applicable to the Preferred Stock
                of all classes and series), as follows:

                Series A Junior Participating Preferred Stock:

         SECTION 1. DESIGNATION AND AMOUNT. Five Hundred Thousand (500,000)
shares of Preferred Stock, $ .001 par value, are designated "Series A Junior
Participating Preferred Stock" with the designations and the powers, preferences
and rights, and the qualifications, limitations and restrictions specified
herein (the "Junior Preferred Stock"). Such number of shares may be increased or
decreased by resolution of the Board of Directors; provided, that no decrease
shall reduce the number of shares of Junior Preferred Stock to a number less
than the number of shares then outstanding plus the number of shares reserved
for issuance upon the exercise of 



                                        1
<PAGE>   2

outstanding options, rights or warrants or upon the conversion of any
outstanding securities issued by the Company convertible into Junior Preferred
Stock.

         SECTION 2. DIVIDENDS AND DISTRIBUTIONS.

                  (A) Subject to the rights of the holders of any shares of any
series of Preferred Stock (or any similar stock) ranking prior and superior to
the Junior Preferred Stock with respect to dividends, the holders of shares of
Junior Preferred Stock, in preference to the holders of Common Stock, par value
$.001 per share (the "Common Stock"), of the Company, and of any other junior
stock, shall be entitled to receive, when, as and if declared by the Board of
Directors out of funds legally available for the purpose, quarterly dividends
payable in cash on the first day of April, July, October and January in each
year (each such date being referred to herein as a "Quarterly Dividend Payment
Date"), commencing on the first Quarterly Dividend Payment Date after the first
issuance of a share or fraction of a share of Junior Preferred Stock, in an
amount per share (rounded to the nearest cent) equal to the greater of (a) $l.00
or (b) subject to the provision for adjustment hereinafter set forth, 100 times
the aggregate per share amount of all cash dividends, and 100 times the
aggregate per share amount (payable in kind) of all non-cash dividends or other
distributions, other than a dividend payable in shares of Common Stock or a
subdivision of the outstanding shares of Common Stock (by reclassification or
otherwise), declared on the Common Stock since the immediately preceding
Quarterly Dividend Payment Date or, with respect to the first Quarterly Dividend
Payment Date, since the first issuance of any share or fraction of a share of
Junior Preferred Stock. In the event the Company shall at any time declare or
pay any dividend on the Common Stock payable in shares of Common Stock, or
effect a subdivision or combination or consolidation of the outstanding shares
of Common Stock (by reclassification or otherwise than by payment of a dividend
in shares of Common Stock) into a greater or lesser number of shares of Common
Stock, then in each such case the amount to which holders of shares of Junior
Preferred Stock were entitled immediately prior to such event under clause (b)
of the preceding sentence shall be adjusted by multiplying such amount by a
fraction, the numerator of which is the number of shares of Common Stock
outstanding immediately after such event and the denominator of which is the
number of shares of Common Stock that were outstanding immediately prior to such
event.

                  (B) The Company shall declare a dividend or distribution on
the Junior Preferred Stock as provided in paragraph (A) of this Section
immediately after it declares a dividend or distribution on the Common Stock
(other than a dividend payable in shares of Common Stock); provided, that in the
event no dividend or distribution shall have been declared on the Common Stock
during the period between any Quarterly Dividend Payment Date and the next
subsequent Quarterly Dividend Payment Date, a dividend of $1.00 per share on the
Junior Preferred Stock shall nevertheless be payable on such subsequent
Quarterly Dividend Payment Date.

                  (C) Dividends shall begin to accrue and be cumulative on
outstanding shares of Junior Preferred Stock from the Quarterly Dividend Payment
Date next preceding the date of issue of such shares, unless the date of issue
of such shares is prior to the record date for the first Quarterly Dividend
Payment Date, in which case dividends on such shares shall begin to accrue from
the date of issue of such shares, or unless the date of issue is a Quarterly
Dividend Payment Date or is a date after the record date for the determination
of holders of shares of Junior 



                                        2
<PAGE>   3

Preferred Stock entitled to receive a quarterly dividend and before such
Quarterly Dividend Payment Date, in either of which events such dividends shall
begin to accrue and be cumulative from such Quarterly Dividend Payment Date.
Accrued but unpaid dividends shall not bear interest. Dividends paid on the
shares of Junior Preferred Stock in an amount less than the total amount of such
dividends at the time accrued and payable on such shares shall be allocated pro
rata on a share-by-share basis among all such shares at the time outstanding.
The Board of Directors may fix a record date for the determination of holders of
shares of Junior Preferred Stock entitled to receive payment of a dividend or
distribution declared thereon, which record date shall be not more than 60 days
prior to the date fixed for the payment thereof.

         SECTION 3. VOTING RIGHTS. The holders of shares of Junior Preferred
Stock shall have the following voting rights:

                  (A) Subject to the provision for adjustment hereinafter set
forth, each share of Junior Preferred Stock shall entitle the holder thereof to
100 votes on all matters submitted to a vote of the stockholders of the Company.
In the event the Company shall at any time declare or pay any dividend on the
Common Stock payable in shares of Common Stock, or effect a subdivision or
combination or consolidation of the outstanding shares of Common Stock (by
reclassification or otherwise than by payment of a dividend in shares of Common
Stock) into a greater or lesser number of shares of Common Stock, then in each
such case the number of votes per share to which holders of shares of Junior
Preferred Stock were entitled immediately prior to such event shall be adjusted
by multiplying such number by a fraction, the numerator of which is the number
of shares of Common Stock outstanding immediately after such event and the
denominator of which is the number of shares of Common Stock that were
outstanding immediately prior to such event.

                  (B) Except as otherwise provided herein, in any other
Certificate of Designation creating a series of Preferred Stock or any similar
stock, or by law, the holders of shares of Junior Preferred Stock and the
holders of shares of Common Stock and any other capital stock of the Company
having general voting rights shall vote together as one class on all matters
submitted to a vote of stockholders of the Company.

                  (C) Except as set forth herein, or as otherwise provided by
law, holders of Junior Preferred Stock shall have no special voting rights and
their consent shall not be required (except to the extent they are entitled to
vote with holders of Common Stock as set forth herein) for taking any corporate
action.

         SECTION 4. CERTAIN RESTRICTIONS.

                  (A) Whenever quarterly dividends or other dividends or
distributions payable on the Junior Preferred Stock as provided in Section 2 are
in arrears, thereafter and until all accrued and unpaid dividends and
distributions, whether or not declared, on shares of Junior Preferred Stock
outstanding shall have been paid in full, the Company shall not:

                           (i) declare or pay dividends, or make any other
distributions, on any shares of stock ranking junior (either as to dividends or
upon liquidation, dissolution or winding up) to the Junior Preferred Stock;



                                        3
<PAGE>   4

                           (ii) declare or pay dividends, or make any other
distributions, on any shares of stock ranking on a parity (either as to
dividends or upon liquidation, dissolution or winding up) with the Junior
Preferred Stock, except dividends paid ratably on the Junior Preferred Stock and
all such parity stock on which dividends are payable or in arrears in proportion
to the total amounts to which the holders of all such shares are then entitled;

                           (iii) redeem or purchase or otherwise acquire for
consideration shares of any stock ranking junior (either as to dividends or upon
liquidation, dissolution or winding up) to the Junior Preferred Stock, provided
that the Company may at any time redeem, purchase or otherwise acquire shares of
any such junior stock in exchange for shares of any stock of the Company ranking
junior (either as to dividends or upon dissolution, liquidation or winding up)
to the Junior Preferred Stock; or

                           (iv) redeem or purchase or otherwise acquire for
consideration any shares of Junior Preferred Stock, or any shares of stock
ranking on a parity (either as to dividends or upon liquidation, dissolution or
winding up) with the Junior Preferred Stock, except in accordance with a
purchase offer made in writing or by publication (as determined by the Board of
Directors) to all holders of such shares upon such terms as the Board of
Directors, after consideration of the respective annual dividend rates and other
relative rights and preferences of the respective series and classes, shall
determine in good faith will result in fair and equitable treatment among the
respective series or classes.

                  (B) The Company shall not permit any subsidiary of the Company
to purchase or otherwise acquire for consideration any shares of stock of the
Company unless the Company could, under paragraph (A) of this Section 4,
purchase or otherwise acquire such shares at such time and in such manner.

         SECTION 5. REACQUIRED SHARES. Any shares of Junior Preferred Stock
purchased or otherwise acquired by the Company in any manner whatsoever shall be
retired and cancelled promptly after the acquisition thereof. All such shares
shall upon their cancellation become authorized but unissued shares of Preferred
Stock and may be reissued as part of a new series of Preferred Stock subject to
the conditions and restrictions on issuance set forth herein, in the Amended and
Restated Certificate of Incorporation, or in any other Certificate of
Designation creating a series of Preferred Stock or any similar stock or as
otherwise required by law.

         SECTION 6. LIQUIDATION, DISSOLUTION OR WINDING UP. Upon any
liquidation, dissolution or winding up of the Company, no distribution shall be
made (1) to the holders of shares of stock ranking junior (either as to
dividends or upon liquidation, dissolution or winding up) to the Junior
Preferred Stock unless, prior thereto, the holders of shares of Junior Preferred
Stock shall have received $100 per share, plus an amount equal to accrued and
unpaid dividends and distributions thereon, whether or not declared, to the date
of such payment, provided that the holders of shares of Junior Preferred Stock
shall be entitled to receive an aggregate amount per share, subject to the
provision for adjustment hereinafter set forth, equal to 100 times the aggregate
amount to be distributed per share to holders of shares of Common Stock, or (2)
to the holders of shares of stock ranking on a parity (either as to dividends or
upon liquidation, dissolution or winding up) with the Junior Preferred Stock,
except distributions made ratably on the Junior Preferred Stock and all such
parity stock in proportion to the total amounts to which 



                                        4
<PAGE>   5

the holders of all such shares are entitled upon such liquidation, dissolution
or winding up. In the event the Company shall at any time declare or pay any
dividend on the Common Stock payable in shares of Common Stock, or effect a
subdivision or combination or consolidation of the outstanding shares of Common
Stock (by reclassification or otherwise than by payment of a dividend in shares
of Common Stock) into a greater or lesser number of shares of Common Stock, then
in each such case the aggregate amount to which holders of shares of Junior
Preferred Stock were entitled immediately prior to such event under the proviso
in clause (1) of the preceding sentence shall be adjusted by multiplying such
amount by a fraction the numerator of which is the number of shares of Common
Stock outstanding immediately after such event and the denominator of which is
the number of shares of Common Stock that were outstanding immediately prior to
such event.

         SECTION 7. CONSOLIDATION, MERGER, ETC. In case the Company shall enter
into any consolidation, merger, combination or other transaction in which the
shares of Common Stock are exchanged for or changed into other stock or
securities, cash and/or any other property, then in any such case each share of
Junior Preferred Stock shall at the same time be similarly exchanged or changed
into an amount per share, subject to the provision for adjustment hereinafter
set forth, equal to 100 times the aggregate amount of stock, securities, cash
and/or any other property (payable in kind), as the case may be, into which or
for which each share of Common Stock is changed or exchanged. In the event the
Company shall at any time declare or pay any dividend on the Common Stock
payable in shares of Common Stock, or effect a subdivision or combination or
consolidation of the outstanding shares of Common Stock (by reclassification or
otherwise than by payment of a dividend in shares of Common Stock) into a
greater or lesser number of shares of Common Stock, then in each such case the
amount set forth in the preceding sentence with respect to the exchange or
change of shares of Junior Preferred Stock shall be adjusted by multiplying such
amount by a fraction, the numerator of which is the number of shares of Common
Stock outstanding immediately after such event and the denominator of which is
the number of shares of Common Stock that were outstanding immediately prior to
such event.

         SECTION 8. NO REDEMPTION. The shares of Junior Preferred Stock shall
not be redeemable.

         SECTION 9. RANK. The Junior Preferred Stock shall rank, with respect to
the payment of dividends and the distribution of assets, junior to all series of
any other class of the Company's Preferred Stock.

         SECTION 10. AMENDMENT. The Amended and Restated Certificate of
Incorporation of the Company shall not be amended in any manner which would
materially alter or change the powers, preferences or special rights of the
Junior Preferred Stock so as to affect them adversely without the affirmative
vote of the holders of at least two-thirds of the outstanding shares of Junior
Preferred Stock, voting together as a single class.



                                       5
<PAGE>   6

         IN WITNESS WHEREOF, the undersigned have executed this certificate as
of October 8, 1998.


                                        /s/ John P. Walker
                                        ---------------------------------------
                                        John P. Walker, Chairman of the Board
                                        And Chief Executive Officer


                                        /s/ William J. Newell
                                        ---------------------------------------
                                        William J. Newell, Secretary



                                        6

<PAGE>   1
                                                                    EXHIBIT 99.4



                            FORM OF RIGHT CERTIFICATE



CERTIFICATE NO. R-                                                  _____ RIGHTS


         NOT EXERCISABLE AFTER OCTOBER 7, 2008 OR EARLIER IF REDEMPTION OR
         EXCHANGE OCCURS. THE RIGHTS ARE SUBJECT TO REDEMPTION AT $.01 PER RIGHT
         AND TO EXCHANGE ON THE TERMS SET FORTH IN THE RIGHTS AGREEMENT.


                                RIGHT CERTIFICATE

                           AXYS PHARMACEUTICALS, INC.


         This certifies that ___________________ or registered assigns, is the
registered owner of the number of Rights set forth above, each of which entitles
the owner thereof, subject to the terms, provisions and conditions of the Rights
Agreement, dated as of October 8, 1998 (the "Rights Agreement"), between Axys
Pharmaceuticals, Inc., a Delaware corporation (the "Company"), and ChaseMellon
Shareholder Services, L.L.C. (the "Rights Agent"), to purchase from the Company
at any time after the Distribution Date (as such term is defined in the Rights
Agreement) and prior to 5:00 P.M., Pacific Time, on October 7, 2008 at the
office of the Rights Agent designated for such purpose, or at the office of its
successor as Rights Agent, one one-hundredth of a fully paid non-assessable
share of Series A Junior Participating Preferred Stock, par value $ .001 per
share (the "Preferred Shares"), of the Company, at a purchase price of $35.00
per one one-hundredth of a Preferred Share (the "Purchase Price"), upon
presentation and surrender of this Right Certificate with the Form of Election
to Purchase duly executed. The number of Rights evidenced by this Right
Certificate (and the number of one one-hundredths of a Preferred Share which may
be purchased upon exercise hereof) set forth above, and the Purchase Price set
forth above, are the number and Purchase Price as of October 8, 1998, based on
the Preferred Shares as constituted at such date.

         From and after the time any Person becomes an Acquiring Person, (as
such terms are defined in the Rights Agreement), if the Rights evidenced by this
Right Certificate are beneficially owned by (i) an Acquiring Person or an
Affiliate or Associate of any such Acquiring Person (as such terms are defined
in the Rights Agreement), (ii) a transferee of any such Acquiring Person,
Associate or Affiliate who becomes a transferee after the Acquiring Person
becomes such, or (iii) under certain circumstances specified in the Rights
Agreement, a transferee of any such Acquiring Person, Associate or Affiliate who
becomes a transferee prior to or concurrently with the Acquiring Person becoming
such, such Rights shall become null and void without any further action and no
holder hereof shall have any right with respect to such Rights from and after
the time any Person becomes an Acquiring Person.



                                        1
<PAGE>   2

         As provided in the Rights Agreement, the Purchase Price and the number
of one one-hundredths of a Preferred Share which may be purchased upon the
exercise of the Rights evidenced by this Right Certificate are subject to
modification and adjustment upon the happening of certain events.

         This Right Certificate is subject to all of the terms, provisions and
conditions of the Rights Agreement, as amended from time to time, which terms,
provisions and conditions are hereby incorporated herein by reference and made a
part hereof and to which Rights Agreement reference is hereby made for a full
description of the rights, limitations of rights, obligations, duties and
immunities hereunder of the Rights Agent, the Company and the holders of the
Right Certificates. Copies of the Rights Agreement are on file at the principal
executive offices of the Company and the above-mentioned offices of the Rights
Agent.

         This Right Certificate, with or without other Right Certificates, upon
surrender at the office of the Rights Agent designated for such purpose, may be
exchanged for another Right Certificate or Right Certificates of like tenor and
date evidencing Rights entitling the holder to purchase a like aggregate number
of Preferred Shares as the Rights evidenced by the Right Certificate or Right
Certificates surrendered shall have entitled such holder to purchase. If this
Right Certificate shall be exercised in part, the holder shall be entitled to
receive upon surrender hereof another Right Certificate or Right Certificates
for the number of whole Rights not exercised.

         Subject to the provisions of the Rights Agreement, the Rights evidenced
by this Certificate (i) may be redeemed by the Company at a redemption price of
$.01 per Right or (ii) may be exchanged in whole or in part for shares of the
Company's Common Stock, par value $ .001 per share, or, upon circumstances set
forth in the Rights Agreement, cash, property or other securities of the
Company, including fractions of a share of Preferred Stock.

         No fractional Preferred Shares will be issued upon the exercise of any
Right or Rights evidenced hereby (other than fractions which are integral
multiples of one one-hundredth of a Preferred Share, which may, at the election
of the Company, be evidenced by depositary receipts) but in lieu thereof a cash
payment will be made, as provided in the Rights Agreement.

         No holder of this Right Certificate shall be entitled to vote or
receive dividends or be deemed for any purpose the holder of the Preferred
Shares or of any other securities of the Company which may at any time be
issuable on the exercise hereof, nor shall anything contained in the Rights
Agreement or herein be construed to confer upon the holder hereof, as such, any
of the rights of a stockholder of the Company or any right to vote for the
election of directors or upon any matter submitted to stockholders at any
meeting thereof, or to give or withhold consent to any corporate action, or to
receive notice of meetings or other actions affecting stockholders (except as
provided in the Rights Agreement), or to receive dividends or subscription
rights, or otherwise, until the Right or Rights evidenced by this Right
Certificate shall have been exercised as provided in the Rights Agreement.

         This Right Certificate shall not be valid or obligatory for any purpose
until it shall have been countersigned by the Rights Agent.



                                       2
<PAGE>   3

         WITNESS the facsimile signature of the proper officers of the Company
and its corporate seal. Dated as of __________________.


ATTEST:                                      AXYS PHARMACEUTICALS, INC.


_________________________________________    By:________________________________
Secretary                                    Title:_____________________________


COUNTERSIGNED:


________________________________________
ChaseMellon Shareholder Services, L.L.C.
   as Rights Agent


By:_____________________________________

Print Name:_____________________________

Title:__________________________________



                                        3
<PAGE>   4

                    Form of Reverse Side of Right Certificate


                               FORM OF ASSIGNMENT


                (To be executed by the registered holder if such
               holder desires to transfer the Right Certificate.)


         FOR VALUE RECEIVED ______________________________________ hereby sells,
assigns and transfers unto

________________________________________________________________________________
                  (Please print name and address of transferee)

_____________________________________________________________________ this Right
Certificate, together with all right, title and interest therein, and does
hereby irrevocably constitute and appoint ________________________ Attorney, to
transfer the within Right Certificate on the books of the within-named Company,
with full power of substitution.


Dated:  ____________________



                                        ________________________________________
                                        Signature





             Form of Reverse Side of Right Certificate -- continued



                                        4
<PAGE>   5

Signature Guaranteed:

         Signatures must be guaranteed by an "eligible guarantor institution" as
defined in Rule 17Ad-15 promulgated under the Securities Exchange Act of 1934,
as amended.

- ----------------------------------------

         The undersigned hereby certifies that (1) the Rights evidenced by this
Right Certificate are not being sold, assigned or transferred by or on behalf of
a Person who is or was an Acquiring Person, an Interested Stockholder or an
Affiliate or Associate thereof (as such terms are defined in the Rights
Agreement); and (2) after due inquiry and to the best of the knowledge of the
undersigned, the undersigned did not acquire the Rights evidenced by this Right
Certificate from any Person who is or was an Acquiring Person, an Interested
Stockholder, or an Affiliate or Associate thereof.


                                        ________________________________________
                                        Signature



                                        5
<PAGE>   6

                          FORM OF ELECTION TO PURCHASE

                  (To be executed if holder desires to exercise
                  Rights represented by the Right Certificate.)


To ChaseMellon Shareholder Services, L.L.C.;

         The undersigned hereby irrevocably elects to exercise
___________________________ Rights represented by this Right Certificate to
purchase the Preferred Shares issuable upon the exercise of such Rights and
requests that certificates for such Preferred Shares be issued in the name of:

Please insert social security
or other identifying number: ______________


__________________________________________________________________
                (Please print name and address)

__________________________________________________________________

If such number of Rights shall not be all the Rights evidenced by this Right
Certificate, a new Right Certificate for the balance remaining of such Rights
shall be registered in the name of and delivered to:

Please insert social security
or other identifying number: ______________


__________________________________________________________________
                (Please print name and address)

__________________________________________________________________


Dated:  _________________


                                        ________________________________________
                                        Signature



             Form of Reverse Side of Right Certificate -- continued



                                        6
<PAGE>   7

Signature Guaranteed:

         Signatures must be guaranteed by an "eligible guarantor institution" as
defined in Rule 17Ad-15 promulgated under the Securities Exchange Act of 1934,
as amended.


- ------------------------------

         The undersigned hereby certifies that (1) the Rights evidenced by this
Right Certificate are not beneficially owned by nor are they being exercised on
behalf of an Acquiring Person, an Interested Stockholder or an Affiliate or
Associate thereof (as such terms are defined in the Rights Agreement); and (2)
after due inquiry and to the best of the knowledge of the undersigned, the
undersigned did not acquire the Rights evidenced by this Right Certificate from
any Person who is or was an Acquiring Person, an Interested Stockholder, or an
Affiliate or Associate thereof.



                                        ________________________________________
                                        Signature

- ------------------------------

                                     NOTICE

         The signature in the Form of Assignment or Form of Election to
Purchase, as the case may be, must conform to the name as written upon the face
of this Right Certificate in every particular, without alteration or enlargement
or any change whatsoever.

         In the event the certification set forth above in the Form of
Assignment or the Form of Election to Purchase, as the case may be, is not
completed, the Company and the Rights Agent will deem the beneficial owner of
the Rights evidenced by this Right Certificate to be an Acquiring Person or an
Affiliate or Associate thereof (as defined in the Rights Agreement) and such
Assignment or Election to Purchase will not be honored.



                                      7


© 2022 IncJournal is not affiliated with or endorsed by the U.S. Securities and Exchange Commission