INTEGRA LIFESCIENCES HOLDINGS CORP
SC 13D/A, 2000-04-05
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D
                                 (Rule 13d-101)

             INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
            TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO
                                  RULE 13d-2(a)

                               (Amendment No. 1)*

                    INTEGRA LIFESCIENCES HOLDINGS CORPORATION
                    (F/K/A INTEGRA LIFESCIENCES CORPORATION)
                     _______________________________________
                                (Name of Issuer)

                     Common Stock, Par Value $0.01 Per Share
                     _______________________________________
                         (Title of Class of Securities)

                                    457985208
                                 ______________
                                 (CUSIP Number)

                              Stephen M. Vine, Esq.
                    Akin, Gump, Strauss, Hauer & Feld, L.L.P.
                               590 Madison Avenue
                            New York, New York 10022
                                 (212) 872-1000
                 _______________________________________________
                  (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                                 March 29, 2000
                      _____________________________________
                      (Date of Event which Requires Filing
                               of this Statement)

If the filing person has previously filed a statement on Schedule 13G to report
the  acquisition  that is the subject of this  Schedule  13D, and is filing this
schedule  because of Rule  13d-1(e),  13d-1(f) or 13d-1(g),  check the following
box.[ ]

Note.  Schedules  filed in paper format shall include a signed original and five
copies of the  schedule,  including  all  exhibits.  See Rule 13d-7(b) for other
parties to whom copies are to be sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 or  otherwise  subject to the  liabilities  of that  section of the Act but
shall be subject to all other provisions of the Act (however, see the Notes).


                         Continued on following page(s)
                               Page 1 of 90 Pages
                             Exhibit Index: Page 18



<PAGE>


                                                              Page 2 of 90 Pages


                                  SCHEDULE 13D

CUSIP No. 457985208



1        Name of Reporting Person
         S.S. or I.R.S. Identification No. of Above Persons

                  QUANTUM INDUSTRIAL PARTNERS LDC

2        Check the Appropriate Box If a Member of a Group*
                                     a. [ ]
                                     b. [X]


3        SEC Use Only

4        Source of Funds*


                  WC


5        Check Box If Disclosure of Legal Proceedings IS Required Pursuant to
         Items 2(d) or 2(e)   [ ]

6        Citizenship or Place of Organization
                  Cayman Islands

                             7               Sole Voting Power
                                                  2,955,000
     Number of
  Shares
Beneficially                 8               Shared Voting Power
  Owned By                                        0
    Each
     Reporting               9               Sole Dispositive Power
    Person                                        2,955,000
    With
                             10              Shared Dispositive Power
                                                  0


11       Aggregate Amount Beneficially Owned by Each Reporting Person

                                            2,955,000

12       Check Box If the Aggregate Amount in Row (11) Excludes Certain Shares*

                                                     [X]

13       Percent of Class Represented By Amount in Row (11)

                                     15.34%

14       Type of Reporting Person*

                  OO; IV


                     * SEE INSTRUCTIONS BEFORE FILLING OUT!





<PAGE>


                                                              Page 3 of 90 Pages


                                  SCHEDULE 13D

CUSIP No. 457985208




1        Name of Reporting Person
         S.S. or I.R.S. Identification No. of Above Persons

                  QIH MANAGEMENT INVESTOR, L.P.

2        Check the Appropriate Box If a Member of a Group*
                                      a. [ ]
                                      b. [X]


3        SEC Use Only

4        Source of Funds*


                  AF


5        Check Box If Disclosure of Legal Proceedings Is Required Pursuant to
         Items 2(d) or 2(e)   [ ]

6        Citizenship or Place of Organization

                  Delaware

                             7               Sole Voting Power
                                                    2,955,000
Number of
  Shares
Beneficially                 8               Shared Voting Power
  Owned By                                          0
    Each
       Reporting             9               Sole Dispositive Power
    Person                                          2,955,000
    With
                             10              Shared Dispositive Power
                                                    0


11       Aggregate Amount Beneficially Owned by Each Reporting Person

                                               2,955,000

12       Check Box If the Aggregate Amount in Row (11) Excludes Certain Shares*

                                                     [X]

13       Percent of Class Represented By Amount in Row (11)

                                                      15.34%

14       Type of Reporting Person*

                  PN; IA


                     * SEE INSTRUCTIONS BEFORE FILLING OUT!





<PAGE>


                                                              Page 4 of 90 Pages


                                  SCHEDULE 13D

CUSIP No. 457985208



1        Name of Reporting Person
         S.S. or I.R.S. Identification No. of Above Persons

                  QIH MANAGEMENT, INC.

2        Check the Appropriate Box If a Member of a Group*
                                     a. [ ]
                                     b. [X]


3        SEC Use Only

4        Source of Funds*


                  AF


5        Check Box If Disclosure of Legal Proceedings IS Required Pursuant to
         Items 2(d) or 2(e)   [ ]

6        Citizenship or Place of Organization

                  Delaware

                             7               Sole Voting Power
                                                    2,955,000
Number of
  Shares
Beneficially                 8               Shared Voting Power
  Owned By                                          0
    Each
Reporting                    9               Sole Dispositive Power
    Person                                          2,955,000
    With
                             10              Shared Dispositive Power
                                                    0


11       Aggregate Amount Beneficially Owned by Each Reporting Person

                                               2,955,000

12       Check Box If the Aggregate Amount in Row (11) Excludes Certain Shares*

                                                     [X]

13       Percent of Class Represented By Amount in Row (11)

                                                      15.34%

14       Type of Reporting Person*

                  CO


                     * SEE INSTRUCTIONS BEFORE FILLING OUT!





<PAGE>


                                                              Page 5 of 90 Pages

                                  SCHEDULE 13D

CUSIP No. 457985208



1        Name of Reporting Person
         S.S. or I.R.S. Identification No. of Above Persons

                  SOROS FUND MANAGEMENT LLC

2        Check the Appropriate Box If a Member of a Group*
                                     a. [ ]
                                     b. [X]


3        SEC Use Only

4        Source of Funds*

                  AF

5        Check Box If Disclosure of Legal Proceedings IS Required Pursuant to
         Items 2(d) or 2(e)   [ ]

6        Citizenship or Place of Organization

                  Delaware

                             7               Sole Voting Power
                                                    2,955,000
Number of
  Shares
       Beneficially          8               Shared Voting Power
  Owned By                                          0
    Each
       Reporting             9               Sole Dispositive Power
    Person                                          2,955,000
    With
                             10              Shared Dispositive Power
                                                    0


11       Aggregate Amount Beneficially Owned by Each Reporting Person

                                                     2,955,000

12       Check Box If the Aggregate Amount in Row (11) Excludes Certain Shares*

                                                     [X]

13       Percent of Class Represented By Amount in Row (11)

                                                      15.34%

14       Type of Reporting Person*

                  OO; IA


                     * SEE INSTRUCTIONS BEFORE FILLING OUT!






<PAGE>


                                                              Page 6 of 90 Pages

                                  SCHEDULE 13D

CUSIP No. 457985208



1        Name of Reporting Person
         S.S. or I.R.S. Identification No. of Above Persons

                  GEORGE SOROS (in the capacity described herein)

2        Check the Appropriate Box If a Member of a Group*
                                      a. [ ]
                                      b. [X]


3        SEC Use Only

4        Source of Funds*


                  AF


5        Check Box If Disclosure of Legal Proceedings IS Required Pursuant to
         Items 2(d) or 2(e)   [ ]

6        Citizenship or Place of Organization

                  United States

                             7               Sole Voting Power
                                                    0
Number of
  Shares
Beneficially                 8               Shared Voting Power
  Owned By                                          3,757,800
    Each
Reporting                    9               Sole Dispositive Power
    Person                                          0
    With
                             10              Shared Dispositive Power
                                                    3,757,800


11       Aggregate Amount Beneficially Owned by Each Reporting Person

                                               3,757,800

12       Check Box If the Aggregate Amount in Row (11) Excludes Certain Shares*

                                                     [  ]

13       Percent of Class Represented By Amount in Row (11)

                                                      18.72%

14       Type of Reporting Person*

                  IA


                     * SEE INSTRUCTIONS BEFORE FILLING OUT!






<PAGE>


                                                              Page 7 of 90 Pages

                                  SCHEDULE 13D

CUSIP No. 457985208



1        Name of Reporting Person
         S.S. or I.R.S. Identification No. of Above Persons

                  STANLEY F. DRUCKENMILLER (in the capacity described herein)

2        Check the Appropriate Box If a Member of a Group*
                                      a. [ ]
                                      b. [X]


3        SEC Use Only

4        Source of Funds*

                  AF

5        Check Box If Disclosure of Legal Proceedings IS Required Pursuant to
         Items 2(d) or 2(e)   [ ]

6        Citizenship or Place of Organization


                  United States
f
                             7               Sole Voting Power
                                                    0
Number of
  Shares
Beneficially                 8               Shared Voting Power
  Owned By                                          2,955,000
    Each
Reporting                    9               Sole Dispositive Power
    Person                                          0
    With
                             10              Shared Dispositive Power
                                                    2,955,000


11       Aggregate Amount Beneficially Owned by Each Reporting Person

                                               2,955,000

12       Check Box If the Aggregate Amount in Row (11) Excludes Certain Shares*

                                                     [X]

13       Percent of Class Represented By Amount in Row (11)

                                                      15.34%

14       Type of Reporting Person*

                  IA


                     * SEE INSTRUCTIONS BEFORE FILLING OUT!





<PAGE>


                                                              Page 8 of 90 Pages





                  This  Amendment  No. 1 to  Schedule  13D  relates to shares of
Common Stock, $0.01 par value per share (the "Shares"),  of Integra LifeSciences
Holdings  Corporation  (the "Issuer") (f/k/a Integra  LifeSciences Corporation).
This  Amendment No. 1  supplementally  amends the initial  statement on Schedule
13D,  dated  April 8, 1999 (the  "Initial  Statement"),  filed by the  Reporting
Persons.  This Amendment No. 1 is being filed by the Reporting Persons to report
that  as a  result  of the  recent  acquisition  of  securities  of the  Issuer,
convertible into Shares, the number of Shares of which the Reporting Persons may
be deemed to be the beneficial  owners of has increased by more than one percent
of the total  outstanding  Shares of the Issuer.  Capitalized terms used but not
defined  herein  shall  have  the  meanings  ascribed  to  them  in the  Initial
Statement. The Initial Statement is supplementally amended as follows.

Item 2.           Identity and Background.

                  This  Statement  is  being  filed  on  behalf  of  each of the
following persons (collectively, the "Reporting Persons"):


         i)       Quantum Industrial Partners LDC ("QIP");

         ii)      QIH Management Investor, L.P. ("QIHMI");

         iii)     QIH Management, Inc. ("QIH Management");

         iv)      Soros Fund Management LLC ("SFM LLC");

         v)       Mr. George Soros ("Mr. Soros"); and

         vi)      Mr. Stanley F. Druckenmiller ("Mr. Druckenmiller").


                  This Statement  relates to the Shares held for the accounts of
QIP and SFM Domestic Investments LLC ("SFM Domestic Investments").


                              The Reporting Persons

QIP, QIHMI and QIH Management
- -----------------------------

                  Updated information  concerning the identity and background of
the  directors  and  officers  of  QIP  is set  forth  in  Annex  A  hereto  and
incorporated by reference in response to this Item 2.

SFM LLC, Mr. Soros and Mr. Druckenmiller
- ----------------------------------------

                  The  business  of SFM  LLC is  managed  through  a  Management
Committee (the "Management Committee") comprised of Mr. Soros, Mr. Druckenmiller
and Mr. Duncan P. Hennes. SFM LLC, a Delaware limited liability company, has its


<PAGE>


                                                              Page 9 of 90 Pages


principal  office at 888 Seventh Avenue,  33rd Floor,  New York, New York 10106.
Its  principal  business is to serve,  pursuant to  contract,  as the  principal
investment manager to several foreign investment  companies (the "SFM Clients").
Mr.  Soros,  as  Chairman of SFM LLC,  has the ability to direct the  investment
decisions  of SFM LLC and as such may be  deemed to have  investment  discretion
over the securities held for the accounts of the SFM Clients. Mr. Druckenmiller,
as Lead  Portfolio  Manager of SFM LLC, has the ability to direct the investment
decisions  of SFM LLC and as such may be  deemed to have  investment  discretion
over the securities held for the accounts of the SFM Clients. Set forth in Annex
B hereto and  incorporated by reference in response to this Item 2 and elsewhere
in this Schedule 13D as applicable,  is a list of the Managing  Directors of SFM
LLC.

Item 3.           Source and Amount of Funds or Other Consideration.

                  QIP expended  approximately  $4,869,900 of its working capital
to purchase  the  securities  reported  herein as being  acquired in the last 60
days. SFM Domestic  Investments expended  approximately  $530,100 of its working
capital to purchase the securities reported herein as being acquired in the last
60 days.

Item 5.           Interest in Securities of the Issuer.

                  (a)      (i)      Each of QIP, QIHMI, QIH Management,  SFM LLC
and Mr. Druckenmiller may be deemed the beneficial owner of the 2,955,000 Shares
(approximately  15.34% of the total number of Shares which would be  outstanding
assuming the  exercise  and  conversion  of all of the  securities  held for the
account of QIP).  This  number  includes  (A)  1,963,350  Shares  issuable  upon
conversion of 75,000 Series B Preferred  Shares held for the account of QIP; (B)
541,100 Shares issuable upon conversion of 48,699 Series C Preferred  Shares (as
defined  herein)  held for the account of QIP; and (C) 450,550  Shares  issuable
upon exercise of 450,550 warrants held for the account of QIP.



<PAGE>

                                                             Page 10 of 90 Pages



                           (ii)     Mr. Soros may be deemed the beneficial owner
of 3,757,800  Shares  (approximately  18.72% of the total number of Shares which
would  be  outstanding  assuming  the  exercise  and  conversion  of  all of the
securities  held for the  accounts of QIP and SFM  Domestic  Investments).  This
number includes (A) 1,963,350 Shares issuable upon conversion of 75,000 Series B
Preferred  Shares held for the account of QIP; (B) 541,100 Shares  issuable upon
conversion of 48,699 Series C Preferred  Shares held for the account of QIP; (C)
450,550 Shares  issuable upon exercise of 450,550  warrants held for the account
of QIP; (D) 654,450 Shares issuable upon conversion of 25,000 Series B Preferred
Shares  held for the  account of SFM  Domestic  Investments;  (E) 58,900  Shares
issuable upon conversion of 5,301 Series C Preferred Shares held for the account
of SFM Domestic  Investments;  and (F) 89,450  Shares  issuable upon exercise of
89,450 warrants held for the account of SFM Domestic Investments.

                  (b)       (i)     Each of QIP,  QIHMI,  QIH Management and SFM
LLC (by  virtue of the QIP  contract)  may be  deemed to have the sole  power to
direct the voting and  disposition of the 2,955,000  Shares held for the account
of QIP  (assuming  the  conversion  of all Series B Preferred  Shares,  Series C
Preferred Shares and the exercise of all warrants held for the account of QIP).

                            (ii)    Mr. Soros and Mr. Druckenmiller, as a result
of their  positions  with SFM LLC,  may be  deemed to have the  shared  power to
direct the voting and disposition of the 2,955,000  Shares held for the  account
of QIP  (assuming  the  conversion  of all Series B Preferred  Shares,  Series C
Preferred Shares and the exercise of all warrants held for the account of QIP).

                            (iii)   Mr.  Soros  in his  capacity  as a  managing
member of SFM  Domestic  Investments  may be  deemed  to have the sole  power to
direct the voting and  disposition of the 802,800 Shares held for the account of
SFM Domestic  Investments  (assuming  the  conversion  of all Series B Preferred
Shares,  Series C Preferred Shares and the exercise of all warrants held for the
account of SFM Domestic Investments).

                  (c)       Except  for  the  transactions  listed  on  Annex  C
hereto,  which were effected in privately  negotiated  transactions,  there have
been no transactions  effected with respect to the Shares since February 3, 2000
(60 days prior to the date hereof) by any of the Reporting Persons.

                  (d)       (i)     The shareholders of QIP,  including  Quantum
Industrial  Holdings,  Ltd., a British  Virgin  Islands  international  business
company,  have the right to  participate  in the receipt of dividends  from,  or
proceeds  from the sale  of,  the  securities  held  for the  account  of QIP in
accordance with their ownership interests in QIP.


<PAGE>

                                                             Page 11 of 90 Pages


                            (ii)    Certain members of SFM Domestic  Investments
have the right to participate in the receipt of dividends from, or proceeds from
the sale of, the securities held for the account of SFM Domestic Investments.

                           (e)      Not applicable.

Item 6.           Contracts, Arrangements, Understandings or Relationships with
                  Respect to Securities of the Issuer.

                  On March 29, 2000, QIP and SFM Domestic  Investments  closed a
transaction contemplated in the Series C Convertible Preferred Stock and Warrant
Purchase  Agreement dated February 16, 2000 (the "Series C Agreement")  with the
Issuer (a copy of which is attached hereto as Exhibit J and incorporated  herein
by  reference  in response to this Item 6) pursuant to which they  purchased  an
aggregate of 54,000 shares of Series C Convertible  Preferred  Stock  ("Series C
Preferred Shares") and warrants to purchase, subject to the terms and conditions
thereof, an aggregate of 300,000 Shares.

                  On March 29, 2000,  each of QIP and SFM  Domestic  Investments
entered  into  an  Amended  and  Restated  Registration  Rights  Agreement  (the
"Registration  Rights  Agreement")  with the Issuer (a copy of which is attached
hereto as Exhibit K and  incorporated  herein by  reference  in response to this
Item 6)  pursuant  to which the Issuer has agreed to grant  registration  rights
with respect to certain securities.

                  Pursuant to Section 3 of the  Registration  Rights  Agreement,
QIP and SFM Domestic  Investments  were granted certain rights relating to their
ability to demand  that the Issuer  register  under the  Securities  Act of 1933
unregistered securities of the Issuer held by QIP or SFM Domestic Investments.

                  Pursuant to Section 4 of the  Registration  Rights  Agreement,
QIP and SFM Domestic  Investments were granted certain  piggy-back  registration
rights,  which,  if  exercised,  entitle  QIP and SFM  Domestic  Investments  to
participate in registered offerings by the Issuer.

                  Pursuant to Section 5 of the  Registration  Rights  Agreement,
each of QIP and SFM Domestic Investments may be required to enter into a lock-up
agreement  under  certain  circumstances,  provided  that  entering into such an
agreement will not violate  applicable law or contravene  QIP's and SFM Domestic
Investments' fiduciary duties.

                  Pursuant to Section 6 of the  Registration  Rights  Agreement,
each  of QIP and SFM  Domestic  Investments  will  be  required  to  discontinue
disposition of the Issuer's  securities  upon  receiving  notice from the Issuer
that the Issuer's  prospectus contains an untrue statement of a material fact or
omits to state a material fact required to be stated therein.

                  The foregoing description of the Registration Rights Agreement
does not purport to be complete and is qualified in its entirety by reference to
the Registration  Rights Agreement  (attached as Exhibit K to this Amendment No.
1), which is incorporated herein by reference.

<PAGE>


                                                             Page 12 of 90 Pages


                           Except as described above,  the Reporting  Persons do
not have any  contracts,  arrangements,  understandings  or  relationships  with
respect to any securities of the Issuer.

Item 7.           Material to be Filed as Exhibits.

                  G.       Power  of  Attorney, dated  as of  January  27, 2000,
granted by Mr. Soros in favor of Mr. Michael C. Neus and Mr. Richard D. Holahan,
Jr.

                  H.       Power  of  Attorney, dated  as of  January  27, 2000,
granted by Mr.  Druckenmiller in favor of Mr. Michael C. Neus and Mr. Richard D.
Holahan, Jr.

                  I.       Power of  Attorney,  dated as of  January  24,  2000,
granted by QIP in favor of Mr. Michael Neus and Mr. Richard D. Holahan, Jr.

                  J.       Series C  Convertible  Preferred  Stock  and  Warrant
Purchase  Agreement, dated  February  16,  2000, among the  Issuer,  QIP and SFM
Domestic Investments.

                  K.       Amended and Restated Registration  Rights  Agreement,
dated March 29, 2000, and all amendments thereto, executed by the Issuer for the
benefit of QIP and SFM Domestic Investments.





<PAGE>


                                                             Page 13 of 90 Pages




                                   SIGNATURES


                  After  reasonable  inquiry and to the best of my knowledge and
belief,  the  undersigned  certifies  that  the  information  set  forth in this
Statement is true, complete and correct.


Date: April 3, 2000

                                   QUANTUM INDUSTRIAL PARTNERS LDC


                                   By:      /S/ MICHAEL C. NEUS
                                            _________________________________
                                            Michael C. Neus
                                            Attorney-in-Fact

                                   QIH MANAGEMENT INVESTOR, L.P.

                                   By:      QIH Management, Inc.,
                                            its General Partner

                                            By:    /S/ MICHAEL C. NEUS
                                                   __________________________
                                                   Michael C. Neus
                                                   Vice President

                                   QIH MANAGEMENT, INC.


                                   By:    /S/ MICHAEL C. NEUS
                                          ________________________________
                                          Michael C. Neus
                                          Vice President

                                   SOROS FUND MANAGEMENT LLC


                                   By:    /S/ MICHAEL C. NEUS
                                          _________________________________
                                          Michael C. Neus
                                          Deputy General Counsel

                                   GEORGE SOROS


                                   By:      /S/ MICHAEL C. NEUS
                                            __________________________________
                                            Michael C. Neus
                                            Attorney-in-Fact





<PAGE>


                                                             Page 14 of 90 Pages


                                   STANLEY F. DRUCKENMILLER


                                   By:      /S/ MICHAEL C. NEUS
                                            __________________________________
                                            Michael C. Neus
                                            Attorney-in-Fact




<PAGE>


                                                             Page 15 of 90 Pages


                                                      ANNEX A

                       Directors and Officers of Quantum Industrial Partners LDC


<TABLE>
<CAPTION>
<S>                                           <C>                                        <C>

Name/Title/Citizenship                        Principal Occupation                       Business Address
- ----------------------                        --------------------                       -----------------
Curacao Corporation Company N.V.              Managing Director of Netherlands Antilles  Kaya Flamboyan 9
Managing Director                             corporations                               Willemstad
(Netherlands Antilles)                                                                   Curacao,
                                                                                         Netherlands Antilles

Inter Caribbean Services Limited Secretary    Administrative services                    Citco Building
(British Virgin Islands)                                                                 Wickhams Cay
                                                                                         Road Town
                                                                                         Tortola
                                                                                         British Virgin Islands

                                   Directors and Officers of QIH Management, Inc.


Duncan P. Hennes                          Chief Executive Officer of SFM LLC       888 Seventh Avenue
Director and President                                                             33rd Floor
(United States)                                                                    New York, NY 10106

Michael C. Neus                           Deputy General Counsel of SFM LLC        888 Seventh Avenue
Director and Vice President                                                        33rd Floor
(United States)                                                                    New York, NY 10106

Peter Streinger                           Chief Financial Officer of SFM LLC       888 Seventh Avenue
Director and Treasurer                                                             33rd Floor
(United States)                                                                    New York, New York 10106

Richard D. Holahan, Jr.                   Assistant General Counsel of SFM LLC     888 Seventh Avenue
Secretary                                                                          33rd Floor
(United States)                                                                    New York, New York 10106


</TABLE>

                  To the best of the Reporting Persons' knowledge /1/:

                          (a)  None of the above persons hold any Shares. /1/

                          (b)  None of the  above  persons  has  any  contracts,
arrangements, understandings or relationships with respect to the Shares. /1/


- ----------
/1/ Certain persons may have an interest in SFM Domestic Investments.





<PAGE>


                                                             Page 16 of 90 Pages



                                     ANNEX B



                  The  following  is a list of all of the  persons  (other  than
Stanley Druckenmiller) who serve as Managing Directors of SFM LLC. /1/

Scott K. H. Bessent
Walter Burlock
L. Kevin Dann
Duncan P. Hennes
Ron Hiram
Michael Karsh
Sheldon Kasowitz
David N. Kowitz
Carson Levit
Alexander C. McAree
Steven Okin
Michael Pendy
Frank Sica

                  Each of the  above-listed  persons is a United States  citizen
whose  principal  occupation  is serving as Managing  Director of SFM LLC or its
affiliates,  and each has a business  address c/o Soros Fund Management LLC, 888
Seventh Avenue, 33rd Floor, New York, New York 10106.

                  To the best of the Reporting Persons' knowledge:

                         (a)  None of the above persons hold any Shares./1/

                         (b)  None  of the  above  persons  has  any  contracts,
arrangements, understandings or relationships with respect to the Shares. /1/

- --------------------------------

/1/  Certain persons may have an interest in SFM Domestic Investments.





<PAGE>


                                                             Page 17 of 90 Pages



                                                      ANNEX C

                                     RECENT TRANSACTIONS IN THE SECURITIES OF
                                     INTEGRA LIFESCIENCES HOLDINGS CORPORATION

<TABLE>
<CAPTION>
<S>                                  <C>                <C>                    <C>                       <C>
                                       Date of           Nature of               Number of
For the amount of                    Transaction        Transaction              Securities              Price
- -----------------                    -----------        -----------            ---------------           -----
QIP                                    3/29/00           PURCHASE                 48,699 /1/              /3/
                                                                                  270,550 /2/

SFM Domestic Investments               3/29/00           PURCHASE                 5,301 /1/               /4/
                                                                                  29,450 /2/


- -------------------------------------

/1/  Shares of Series C Preferred Stock.
/2/  Warrants.
/3/  Total consideration of $4,869,900 was paid for the securities purchased by QIP.
/4/  Total consideration of $530,100 was paid for the securities purchased by SFM Domestic Investments.


</TABLE>



<PAGE>


                                                             Page 18 of 90 Pages



                                                   EXHIBIT INDEX

                                                                        Page No.
                                                                        --------


G.       Power of Attorney, dated as of January 27, 2000, granted
         by Mr. George Soros in favor of Mr. Michae1 C.  Neus and
         Mr. Richard D. Holahan, Jr..............................             19

H.       Power of Attorney, dated as of January 27, 2000, granted
         by Mr. Stanley F.  Druckenmiller in favor of Mr. Michael
         C. Neus and Mr. Richard D. Holahan, Jr..................             20

I.       Power of Attorney, dated as of January 24, 2000, granted
         by  Quantum  Industrial  Partners  LDC in  favor  of Mr.
         Michael C. Neus and Mr. Richard D. Holahan, Jr..........             21

J.       Series  C  Convertible   Preferred   Stock  and  Warrant
         Purchase  Agreement,  dated  February 16,  2000,  by and
         among Integra LifeSciences Holdings Corporation, Quantum
         Industrial Partners LDC and SFM Domestic Investments LLC             22

K.       Amended  and  Restated  Registration  Rights  Agreement,
         dated March 29, 2000, by and among Integra  LifeSciences
         Holdings  Corporation,  Quantum Industrial  Partners LDC
         and SFM Domestic Investments LLC........................             65
















                                                             Page 19 of 90 Pages



                                    EXHIBIT G

                                POWER OF ATTORNEY


KNOW ALL MEN BY THESE PRESENTS,  that I, GEORGE SOROS,  hereby make,  constitute
and  appoint  each of  MICHAEL  C.  NEUS and  RICHARD  D.  HOLAHAN,  JR.  acting
individually,  as my agent and  attorney-in-fact for the purpose of executing in
my name,  (a) in my personal  capacity  or (b) in my  capacity  as Chairman  of,
member of or in other  capacities with Soros Fund Management LLC ("SFM LLC") and
each of its  affiliates  or entities  advised by me or SFM LLC,  all  documents,
certificates,  instruments,  statements, filings and agreements ("documents") to
be filed with or delivered to any foreign or domestic governmental or regulatory
body or  required or  requested  by any other  person or entity  pursuant to any
legal  or  regulatory  requirement  relating  to  the  acquisition,   ownership,
management or  disposition  of securities  or other  investments,  and any other
documents  relating  or  ancillary  thereto,  including  but not limited to, all
documents  relating to filings with the United  States  Securities  and Exchange
Commission  (the "SEC") pursuant to the Securities Act of 1933 or the Securities
Exchange  Act of 1934 (the  "Act")  and the rules  and  regulations  promulgated
thereunder, including: (1) all documents relating to the beneficial ownership of
securities  required  to be filed  with the SEC  pursuant  to  Section  13(d) or
Section 16(a) of the Act  including,  without  limitation:  (a) any  acquisition
statements on Schedule 13D or Schedule 13G and any amendments  thereto,  (b) any
joint  filing  agreements  pursuant  to  Rule  13d-1(k),  and  (c)  any  initial
statements of, or statements of changes in,  beneficial  ownership of securities
on Form 3,  Form 4 or Form 5 and (2)  any  information  statements  on Form  13F
required to be filed with the SEC pursuant to Section 13(f) of the Act.

All past acts of the attorney-in-fact in furtherance of the foregoing are hereby
ratified and confirmed.

This power of attorney shall be valid from the date hereof until revoked by me.

IN  WITNESS  WHEREOF,  I have  executed  this  instrument  as of the 27th day of
January, 2000.

                                                     /s/ George Soros
                                                     -------------------
                                                     GEORGE SOROS







                                                             Page 20 of 90 Pages



                                    EXHIBIT H

                                POWER OF ATTORNEY


KNOW ALL MEN BY THESE PRESENTS,  that I, STANLEY F. DRUCKENMILLER,  hereby make,
constitute  and  appoint  each of MICHAEL C. NEUS and  RICHARD D.  HOLAHAN,  JR.
acting  individually,  as my  agent  and  attorney-in-fact  for the  purpose  of
executing in my name, (a) in my personal  capacity or (b) in my capacity as Lead
Portfolio  Manager  of,  member  of or  in  other  capacities  with  Soros  Fund
Management LLC ("SFM LLC") and each of its affiliates or entities  advised by me
or SFM LLC, all documents,  certificates,  instruments,  statements, filings and
agreements  ("documents")  to be  filed  with or  delivered  to any  foreign  or
domestic  governmental  or regulatory body or required or requested by any other
person or entity pursuant to any legal or regulatory requirement relating to the
acquisition,  ownership,  management  or  disposition  of  securities  or  other
investments,  and any other documents relating or ancillary  thereto,  including
but not limited to, all  documents  relating to filings  with the United  States
Securities and Exchange Commission (the "SEC") pursuant to the Securities Act of
1933 or the  Securities  Exchange  Act of 1934  (the  "Act")  and the  rules and
regulations promulgated thereunder, including: (1) all documents relating to the
beneficial ownership of securities required to be filed with the SEC pursuant to
Section 13(d) or Section 16(a) of the Act including, without limitation: (a) any
acquisition  statements  on  Schedule  13D or  Schedule  13G and any  amendments
thereto, (b) any joint filing agreements pursuant to Rule 13d-1(k),  and (c) any
initial  statements  of, or  statements of changes in,  beneficial  ownership of
securities  on Form 3, Form 4 or Form 5 and (2) any  information  statements  on
Form 13F required to be filed with the SEC pursuant to Section 13(f) of the Act.
All past acts of the attorney-in-fact in furtherance of the foregoing are hereby
ratified and confirmed.

This power of attorney shall be valid from the date hereof until revoked by me.

IN  WITNESS  WHEREOF,  I have  executed  this  instrument  as of the 27th day of
January, 2000.




                                            /s/ Stanley F. Druckenmiller
                                            ------------------------------
                                            STANLEY F. DRUCKENMILLER








                                                             Page 21 of 90 Pages


                                    EXHIBIT I

                         QUANTUM INDUSTRIAL PARTNERS LDC
                                POWER OF ATTORNEY


KNOW ALL MEN BY THESE PRESENT,  that the undersigned QUANTUM INDUSTRIAL PARTNERS
LDC (the "Company"), an exempted limited duration company existing and operating
under the laws of the Cayman Islands does, pursuant to a duly adopted resolution
of its Managing Director, hereby designate, constitute and appoint:

                   MICHAEL C. NEUS AND RICHARD D. HOLAHAN, JR.

acting,  singly and not  jointly,  as its true and lawful  agent and attorney in
fact for the purpose of  executing  in its name,  all  documents,  certificates,
instruments,  statements,  filings and agreements ("documents") to be filed with
or  delivered  to any foreign or domestic  governmental  or  regulatory  body or
required or  requested  by any other  person or entity  pursuant to any legal or
regulatory  requirement  relating to the acquisition,  ownership,  management or
disposition of securities or other investments, and any other documents relating
or ancillary  thereto,  including but not limited to, all documents  relating to
filings with the United States  Securities and Exchange  Commission  (the "SEC")
pursuant to the Securities  Act of 1933 or the  Securities  Exchange Act of 1934
(the "Act") and the rules and regulations promulgated thereunder, including: (1)
all documents relating to the beneficial  ownership of securities required to be
filed  with  the SEC  pursuant  to  Section  13(d) or  Section  16(a) of the Act
including, without limitation: (a) any acquisition statements on Schedule 13D or
Schedule  13G and  any  amendments  thereto,  (b) any  joint  filing  agreements
pursuant to Rule 13d-1(k),  and (c) any initial  statements of, or statements of
changes in,  beneficial  ownership of securities on Form 3, Form 4 or Form 5 and
(2) any  information  statements  on Form 13F  required to be filed with the SEC
pursuant to Section 13(f) of the Act.

Each  attorney-in-fact  is hereby  authorized and empowered to perform all other
acts and deeds, which he or she in his or her sole discretion deems necessary or
appropriate  to carry out to the fullest  extent the terms and the intent of the
foregoing.  All  prior  acts  of each  attorney-in-fact  in  furtherance  of the
foregoing are hereby ratified and confirmed.

IN WITNESS  WHEREOF,  the Company has caused this  document to be executed  this
24th day of January, 2000.

                                      QUANTUM INDUSTRIAL PARTNERS LDC


                                      /s/ Curacao Corporation Company N.V.
                                      -----------------------------------------
                                      Curacao Corporation Company N.V.
                                      Managing Director








                                                             Page 22 of 90 Pages



                                                                  EXECUTION COPY




- --------------------------------------------------------------------------------








                      SERIES C CONVERTIBLE PREFERRED STOCK
                         AND WARRANT PURCHASE AGREEMENT


                                      among


                   INTEGRA LIFESCIENCES HOLDINGS CORPORATION,



                        QUANTUM INDUSTRIAL PARTNERS LDC,


                                       and


                          SFM DOMESTIC INVESTMENTS LLC





                  --------------------------------------------


                            Dated: February 16, 2000

                  --------------------------------------------










- --------------------------------------------------------------------------------









<PAGE>

                                                             Page 23 of 90 Pages



                                             TABLE OF CONTENTS


<TABLE>
<CAPTION>

                                                                                                      Page
<S>                   <C>                                                                             <C>

SECTION I.            PURCHASE AND SALE OF SERIES C PREFERRED STOCK
                      AND WARRANTS.......................................................................7
           1.1        Purchase and Sale of Series C Preferred Stock and Warrants.........................7
           1.2        Certificate of Designation.........................................................7
           1.3        Closing............................................................................7

SECTION II.           REPRESENTATIONS AND WARRANTIES OF THE
                      COMPANY............................................................................7
           2.1        Corporate Existence and Power......................................................7
           2.2        Corporate Authorization; No Contravention..........................................8
           2.3        Governmental Authorization; Third Party Consents...................................8
           2.4        Binding Effect.....................................................................9
           2.5        Litigation.........................................................................9
           2.6        Compliance with Laws...............................................................9
           2.7        Capitalization....................................................................10
           2.8        No Default or Breach..............................................................10
           2.9        Taxes.............................................................................10
           2.10       Financial Statements..............................................................11
           2.11       No Material Adverse Change; Ordinary Course of Business...........................11
           2.12       SEC Documents.....................................................................12
           2.13       Investment Company................................................................12
           2.14       Private Offering..................................................................12
           2.15       Employee Benefit Plans............................................................12
           2.16       Title to Assets...................................................................12
           2.17       Intellectual Property.............................................................13
           2.18       Trade Relations...................................................................13
           2.19       Contracts and Other Agreements....................................................14
           2.20       Liabilities.......................................................................14
           2.21       Broker's, Finder's or Similar Fees................................................14
           2.22       Disclosure; Agreement and Other Documents.........................................14

SECTION III.          REPRESENTATIONS AND WARRANTIES
                      OF THE PURCHASERS                         ........................................15
           3.1        Existence and Power...............................................................15
           3.2        Authorization; No Contravention...................................................15
           3.3        Governmental Authorization; Third Party Consents..................................15
           3.4        Binding Effect....................................................................15
           3.5        Purchase for Own Account..........................................................15
           3.6        Accreditation; Sophistication; Other Securities Laws Matters......................16
           3.7        Broker's, Finder's or Similar Fees................................................16






                                                    i

<PAGE>


                                                             Page 24 of 90 Pages



                                                                                                      Page

SECTION IV.           CONDITIONS TO THE OBLIGATION
                      OF THE PURCHASERS TO CLOSE........................................................17
           4.1        Representations and Warranties....................................................17
           4.2        Compliance with this Agreement....................................................17
           4.3        Secretary's Certificate...........................................................17
           4.4        Officers' Certificate.............................................................17
           4.5        Documents.........................................................................17
           4.6        Filing of Certificate of Designation..............................................18
           4.7        Amended and Restated Rights Agreement.............................................18
           4.8        Opinion of Counsel................................................................18
           4.9        Approval of Counsel to the Purchasers.............................................18
           4.10       Purchased Shares..................................................................18
           4.11       Warrants..........................................................................18
           4.12       Consents and Approvals............................................................18
           4.13       No Litigation.....................................................................19
           4.14       No Material Judgment or Order.....................................................19
           4.15       No Material Adverse Change........................................................19
           4.16       Hart-Scott-Rodino.................................................................19
           4.17       Schedules.........................................................................19
           4.18       No Change in Capitalization.......................................................19

SECTION V.            CONDITIONS TO THE OBLIGATION
                      OF THE COMPANY TO CLOSE...........................................................19
           5.1        Representations and Warranties....................................................20
           5.2        Compliance with this Agreement....................................................20
           5.3        Amended and Restated Rights Agreement.............................................20
           5.4        Consents and Approvals............................................................20
           5.5        Payment of Purchase Price.........................................................20
           5.6        No Material Judgment or Order.....................................................20
           5.7        Hart-Scott-Rodino.................................................................20
           5.8        Consent of Purchasers.............................................................21

SECTION VI.           INDEMNIFICATION...................................................................21
           6.1        Indemnification...................................................................21
           6.2        Notification......................................................................21
           6.3        Amended and Restated Rights Agreement.............................................22

SECTION VII.          AFFIRMATIVE COVENANTS.............................................................23
           7.1        Preservation of Existence.........................................................23
           7.2        Delivery of 1999 Audited Financial Statements.....................................23
           7.3        Financial Statements and Other Information........................................24
           7.4        Reservation of Shares.............................................................25
           7.5        Registration and Listing..........................................................25
           7.6        Tax Matters.......................................................................25





                                                    ii

<PAGE>


                                                             Page 25 of 90 Pages



                                                                                                      Page

           7.7        Further Assurances................................................................26
           7.8        Delivery of Schedules.............................................................26

SECTION VIII.         TERMINATION OF AGREEMENT..........................................................26
           8.1        Termination.......................................................................26
           8.2        Survival..........................................................................27

SECTION IX.           MISCELLANEOUS.....................................................................27
           9.1        Survival of Representations and Warranties........................................27
           9.2        Notices...........................................................................27
           9.3        Successors and Assigns............................................................29
           9.4        Amendment and Waiver..............................................................29
           9.5        Counterparts......................................................................30
           9.6        Headings..........................................................................30
           9.7        GOVERNING LAW.....................................................................30
           9.8        Severability......................................................................30
           9.9        Rules of Construction.............................................................30
           9.10       Entire Agreement..................................................................30
           9.11       Fees..............................................................................30
           9.12       Publicity; Confidentiality........................................................31
           9.13       Further Assurances................................................................31
           9.14       Schedules.........................................................................31
</TABLE>







                                                   iii

<PAGE>


                                                             Page 26 of 90 Pages

EXHIBITS

A                     Form of Warrant
B                     Certificate of Designation
C                     Amended and Restated Registration Rights Agreement
D                     Form of Drinker Biddle & Shanley Opinion


SCHEDULES

1                     Purchased Shares and Warrants and Purchase Price
2.5                   Litigation
2.7                   Capitalization
2.8                   No Default or Breach
2.9                   Tax Agreements or Arrangements
2.11                  No Material Adverse Change; Ordinary Course of Business
2.16                  Title to Assets
2.17(a)               Intellectual Property
2.17(b)               Infringements of Integra
2.17(c)               Intellectual Property Litigation
2.18                  Trade Relations
2.19                  Contracts and other Agreements






                                       iv

<PAGE>


                                                             Page 27 of 90 Pages








                      SERIES C CONVERTIBLE PREFERRED STOCK
                         AND WARRANT PURCHASE AGREEMENT


                  THIS SERIES C CONVERTIBLE PREFERRED STOCK AND WARRANT PURCHASE
AGREEMENT  (this  "Agreement")  is made as of  February  16,  2000 by and  among
Integra LifeSciences Holdings Corporation,  a Delaware corporation  ("Integra"),
and the several purchasers listed on Schedule 1 hereto (the "Purchasers").

                  WHEREAS,  Integra  has agreed to issue and sell to each of the
Purchasers,  and each of the Purchasers has agreed to purchase from Integra, for
the  aggregate  purchase  price  set forth  opposite  such  Purchaser's  name on
Schedule 1 hereto,  (i) the  aggregate  number of shares of Series C Convertible
Preferred  Stock,  par value $.01 per share, of Integra (the "Series C Preferred
Stock") set forth opposite such Purchaser's name on Schedule 1 hereto,  and (ii)
a warrant ("Warrant") to purchase,  subject to the terms and conditions thereof,
the  aggregate  number of shares of Common Stock,  par value $.01 per share,  of
Integra  (the  "Common  Stock")  set forth  opposite  such  Purchaser's  name on
Schedule 1 hereto, at an exercise price of $9.00 per share, containing terms and
conditions set forth in the form of warrant attached hereto as Exhibit A.

                  NOW,  THEREFORE,  in  consideration  of the  mutual  terms and
conditions  herein  contained,  and for good  and  valuable  consideration,  the
receipt of which is hereby  acknowledged,  the parties  hereto,  intending to be
legally bound, hereby agree as follows:


                                   DEFINITIONS

                  For all purposes of this Agreement, unless otherwise expressly
provided,  (a) the terms defined in this  Definitions  section have the meanings
assigned to them herein and include the plural as well as the singular,  (b) all
accounting terms not otherwise  defined herein have the meanings  assigned under
generally  accepted  accounting   principles  in  the  United  States,  (c)  all
references in this Agreement to designated "Sections" and other subdivisions are
to the designated Sections and other subdivisions of the body of this Agreement,
(d) pronouns of either gender or neuter shall include, as appropriate, the other
pronoun forms,  and (e) the words "herein,"  "hereof" and other words of similar
import  refer to this  Agreement as a whole and not to any  particular  Article,
Section or other subdivision.



<PAGE>



                                                             Page 28 of 90 Pages


                  As used in this  Agreement,  the following  definitions  shall
apply:

                  "Action" means any action, complaint, petition, investigation,
suit or other  proceeding,  whether civil or criminal,  in law or in equity,  or
before any arbitrator or Governmental Entity.

                  "Affiliate"  shall mean any Person who is an  "affiliate"  (as
defined in Rule 12b-2 of the General  Rules and  Regulations  under the Exchange
Act) of, and any Person  controlling,  controlled  by, or under  common  control
with, any Purchaser. For the purposes of this Agreement,  "control" includes the
ability to have investment  discretion through contractual means or by operation
of law.

                  "Agreement"  means this  Agreement as the same may be amended,
supplemented or modified in accordance with the terms hereof.

                  "Amended and Restated Registration Rights Agreement" means the
Amended and Restated  Registration  Rights  Agreement  substantially in the form
attached hereto as Exhibit C.

                  "Board of Directors" means the Board of Directors of Integra.

                  "Business"  means the  business of Integra and shall be deemed
to include any of the following incidents of such business:  income, operations,
condition (financial or other), assets, properties and liabilities.

                  "Business Day" means any day other than a Saturday,  Sunday or
other day on which  commercial  banks in the State of New York are authorized or
required by law or executive order to close.

                  "By-laws"  means the amended and restated  by-laws of Integra,
as the same may have been amended and as in effect on the Closing Date.

                  "Certificate   of   Designation"   means  the  Certificate  of
Designation with respect to the Series C Preferred Stock adopted by the Board of
Directors  and filed with the  Secretary of State of the State of Delaware on or
before the Closing Date substantially in the form attached hereto as Exhibit B.

                  "Certificate of Incorporation"  means the Amended and Restated
Certificate of Incorporation of Integra,  as the same has been amended and as in
effect on the Closing Date.



<PAGE>


                                                             Page 29 of 90 Pages


                  "Closing"  has the  meaning  set forth in Section  1.3 of this
Agreement.

                  "Closing Date" means the date specified in Section 1.3 of this
Agreement.

                  "Code" means the Internal Revenue Code of 1986, as amended, or
any successor statute thereto.

                  "Commission"  means the Securities and Exchange  Commission or
any similar agency then having jurisdiction to enforce the Securities Act.

                  "Common  Stock"  means the  Common  Stock,  par value $.01 per
share,  of Integra and any other  capital stock of Integra into which such stock
is reclassified or reconstituted.

                  "Condition of Integra" means the assets, business, properties,
operations or financial  condition of Integra and the  Subsidiaries,  taken as a
whole.

                  "Contract" means any agreement, arrangement, bond, commitment,
franchise,  indemnity,  indenture,  instrument, lease, license or understanding,
whether or not in writing.

                  "Contractual   Obligations"   means  as  to  any  Person,  any
provision  of  any  security   issued  by  such  Person  or  of  any  agreement,
undertaking, contract, indenture, mortgage, deed of trust or other instrument to
which such Person is a party or by which it or any of its property is bound.

                  "Delivery  Date"  shall have the  meaning set forth in Section
2.6 of this Agreement.

                  "Encumbrance" means any claim, charge, easement,  encumbrance,
lease,  covenant,  security interest,  lien, option,  pledge,  rights of others,
restriction  (whether on voting,  sale,  transfer,  disposition  or  otherwise),
whether imposed by agreement,  understanding,  law, equity or otherwise,  except
for any restrictions on transfer  generally  arising under any applicable United
States federal or state securities law.



<PAGE>


                                                             Page 30 of 90 Pages


                  "Environmental  Laws"  means  federal,  state and local  laws,
principles of common law,  regulations  and codes,  as well as orders,  decrees,
judgments or injunctions  issued,  promulgated,  approved or entered  thereunder
relating  to  pollution,  protection  of the  environment  or public  health and
safety.

                  "ERISA" means the Employee  Retirement  Income Security Act of
1974, as amended (or any successor statute thereto).

                  "Exchange Act" means the  Securities  Exchange Act of 1934, as
amended (or any successor statute thereto), and the rules and regulations of the
Commission promulgated thereunder.

                  "Financial  Statements"  has the  meaning set forth in Section
2.10 of this Agreement.

                  "GAAP"  means  generally  accepted  United  States  accounting
principles in effect from time to time.

                  "Governmental  Authority"  means the  government of any state,
city,  locality or other political  subdivision  thereof,  any entity exercising
executive,  legislative,  judicial, regulatory or administrative functions of or
pertaining  to  government,  and  any  corporation  or  other  entity  owned  or
controlled,  through  stock or capital  ownership  or  otherwise,  by any of the
foregoing.

                  "Governmental  Entity"  means any  government  or any  agency,
bureau, board, commission,  court, department,  official, political subdivision,
tribunal  or other  instrumentality  of any  government  of or within the United
States, whether federal, state or local.

                  "HSR  Act"   shall   mean  the   Hart-Scott-Rodino   Antitrust
Improvements Act of 1976, as amended, and the rules and regulations  promulgated
thereunder.

                  "Indemnified  Party" has the  meaning set forth in Section 6.1
of this Agreement.

                  "Integra"  has the meaning  set forth in the  recitals to this
Agreement.




<PAGE>


                                                             Page 31 of 90 Pages


                  "Intellectual  Property"  has the meaning set forth in Section
2.17 of this Agreement.

                  "IP  Licenses"  has the meaning  set forth in Section  2.17 of
this Agreement.

                  "Law"  means any  constitutional  provision,  statute or other
law, rule,  regulation,  or  interpretation  of any Governmental  Entity and any
Order.

                  "Letter"  shall have the  meaning  set forth in Section 7.6 of
this Agreement.

                  "Liabilities"  has the  meaning  set forth in Section  2.20 of
this Agreement.

                  "Lien"   means   any   mortgage,   deed  of   trust,   pledge,
hypothecation, assignment, encumbrance, lien (statutory or other) or preference,
priority,  right or other security  interest or preferential  arrangement of any
kind  or  nature  whatsoever  (excluding  preferred  stock  and  equity  related
preferences) including,  without limitation,  those created by, arising under or
evidenced  by any  conditional  sale or other  title  retention  agreement,  the
interest of a lessor under a capital lease  obligation,  or any financing  lease
having substantially the same economic effect as any of the foregoing.

                  "NASDAQ"  means the  Nasdaq  National  Market of the  National
Association of Securities Dealers, Inc. Automated Quotation System.

                  "Order"  means  any  decree,  injunction,   judgement,  order,
ruling, assessment or writ of any Governmental Entity.

                  "Permits"  has the  meaning  set forth in Section  2.6 of this
Agreement.

                  "Person" means any individual, firm, corporation, partnership,
limited liability company,  trust,  incorporated or unincorporated  association,
joint venture,  joint stock company,  Governmental  Authority or other entity of
any kind,  and shall  include any  successor  (by merger or  otherwise)  of such
entity.

                  "Purchased Shares" has the meaning set forth in Section 1.1 of
this Agreement.




<PAGE>


                                                             Page 32 of 90 Pages


                  "Purchasers" has the meaning set forth in the recitals to this
Agreement.

                  "Requirements of Law" means as to any Person, any law, treaty,
rule,  regulation,  right,  privilege,  qualification,  license or  franchise or
determination of an arbitrator or a court or other  Governmental  Authority or a
stock  exchange,  in each case  applicable or binding upon such Person or any of
its  property  or to which  such  Person or any of its  property  is  subject or
pertaining to any or all of the transactions contemplated or referred to herein.

                  "SEC" means the  Securities  and  Exchange  Commission  or any
successor entity.

                  "SEC  Documents"  means  all  registration  statements,  proxy
statements,  reports and other  documents  required to be filed by Integra under
the  Securities  Act or the Exchange  Act, and all  amendments  and  supplements
thereto, filed by Integra with the Commission since December 31, 1998.

                  "Securities"  means the Purchased Shares, the shares of Common
Stock  issuable  upon  conversion  of the Purchased  Shares,  the Warrants,  the
Warrant Shares and the Additional Preferred Shares.

                  "Securities  Act" means the Securities Act of 1933, as amended
(or any  successor  statute  thereto),  and the  rules  and  regulations  of the
Commission promulgated thereunder.

                  "Series B Preferred Stock" shall have the meaning set forth in
Section 5.8 of this Agreement.

                  "Series C  Preferred  Stock" has the  meaning set forth in the
recitals to this Agreement.

                  "Subsidiary"  means, as of the relevant date of determination,
with respect to any Person,  a corporation  or other entity of which 50% or more
of the voting power of the outstanding  voting equity  securities or 50% or more
of the outstanding economic equity interest is held, directly or indirectly,  by
such Person. Unless otherwise qualified,  or the context otherwise requires, all
references to a "Subsidiary" or to  "Subsidiaries" in this Agreement shall refer



<PAGE>


                                                             Page 33 of 90 Pages


to a Subsidiary or Subsidiaries of Integra.

                  "Tax" or "Taxes"  means any  federal,  state,  county,  local,
foreign  and  other  taxes  (including,  without  limitation,  income,  profits,
premium, estimated, excise, sales, use, occupancy, gross receipts, franchise, ad
valorem, severance, capital levy, production, transfer, withholding, employment,
unemployment  compensation,  payroll and property taxes, import duties and other
governmental  charges and  assessments),  whether or not measured in whole or in
part by net income, and including  deficiencies,  interest,  additions to tax or
interest,  and penalties with respect thereto, and including expenses associated
with contesting any proposed adjustments related to any of the foregoing.

                  "Tax Returns"  shall have the meaning set forth in Section 2.9
of this Agreement.

                  "Transaction  Documents" means  collectively,  this Agreement,
the  Warrant,  the  Certificate  of  Designation  and the Amended  and  Restated
Registration Rights Agreement.

                  "Treasury  Regulations"  shall have the  meaning  set forth in
Section 2.9 of this Agreement.

                  "USRPHC"  shall have the  meaning  set forth in Section 2.9 of
this Agreement.

                  "Warrant  Shares"  has the meaning set forth in Section 1.1 of
this Agreement.

                  "Warrant"  has the meaning  set forth in the  recitals to this
Agreement.


SECTION I.        PURCHASE AND SALE OF SERIES C
                  PREFERRED STOCK AND WARRANTS

                  1.1  Purchase  and  Sale  of  Series  C  Preferred  Stock  and
Warrants.  Subject to the terms and conditions herein set forth,  Integra agrees
to issue and sell to each of the Purchasers,  and each of the Purchasers  agrees
that it will purchase from Integra,  for the aggregate  purchase price set forth



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                                                             Page 34 of 90 Pages


opposite such  Purchaser's  name on Schedule 1 hereto,  on the Closing Date, (i)
the aggregate  number of shares of Series C Preferred  Stock set forth  opposite
such  Purchaser's  name on  Schedule  1 hereto  (all of the  shares  of Series C
Preferred  Stock being  purchased  pursuant  hereto being  referred to herein as
"Purchased  Shares"),  and (ii) a Warrant to purchase  the  aggregate  number of
shares of Common Stock set forth  opposite such  Purchaser's  name on Schedule 1
hereto (all of the shares of Common Stock issuable upon exercise of the Warrants
being  purchased  pursuant  hereto  being  referred  to herein  as the  "Warrant
Shares").

                  1.2 Certificate of Designation. The Purchased Shares will have
the  rights,   preferences,   privileges  and  restrictions  set  forth  in  the
Certificate of Designation of Series C Preferred Stock to Integra's  Certificate
of   Incorporation   attached   hereto  as  Exhibit  B  (the   "Certificate   of
Designation"),  which shall be filed by Integra  with the  Secretary of State of
the State of Delaware prior to the Closing (as
hereinafter defined).

                  1.3  Closing.  Unless  this  Agreement  shall have  terminated
pursuant  to  Section  VIII and  subject  to the  satisfaction  or waiver of the
conditions  set forth in Sections IV and V (except for Sections  4.10,  4.11 and
5.5,  which  shall  occur   simultaneously  with  the  Closing  (as  hereinafter
defined)),  the closing of the purchase and issuance of the Purchased Shares and
the Warrants  (the  "Closing")  shall take place at the offices of Paul,  Weiss,
Rifkind, Wharton & Garrison, at 10:00 a.m., local time, on March 17, 2000, or at
such time and on such date that Integra and the  Purchasers may agree in writing
(the  "Closing  Date").  On the  Closing  Date,  Integra  shall  deliver  to the
Purchasers (a) stock certificates  representing the Purchased Shares and (b) the
Warrants,  against  delivery  by the  Purchasers  to  Integra  of the  aggregate
purchase price therefor by wire transfer of immediately available funds.

SECTION II.        REPRESENTATIONS AND WARRANTIES OF THE COMPANY

                  Integra represents and warrants to the Purchasers as follows:

                  2.1  Corporate  Existence  and Power.  Each of Integra and its
Subsidiaries (a) is a corporation or limited liability company duly incorporated
and  organized,  validly  existing  and in good  standing  under the laws of the
jurisdiction of its incorporation;  (b) has all requisite  corporate (or limited
liability company) power and authority to own and operate its property, to lease
the  property it  operates as lessee and to conduct the  business in which it is



<PAGE>


                                                             Page 35 of 90 Pages


currently engaged as described in the SEC Documents;  (c) is duly qualified as a
foreign  corporation  or other entity,  licensed and in good standing  under the
laws of each jurisdiction in which its ownership, lease or operation of property
or the conduct of its business requires such qualification, except to the extent
that the failure to do so or be so would not have a material  adverse  effect on
the  Condition  of  Integra;  and (d) has the  requisite  corporate  (or limited
liability  company)  power and  authority  to  execute,  deliver and perform its
obligations under this Agreement and each of the other Transaction Documents.

                  2.2 Corporate Authorization; No Contravention.  The execution,
delivery  and  performance  by Integra of this  Agreement  and each of the other
Transaction  Documents  and the  transactions  contemplated  hereby and thereby,
including, without limitation, the sale, issuance and delivery of the Securities
(a) are within  Integra's  corporate  power and have been duly authorized by all
necessary  corporate  action of Integra;  (b) do not contravene the terms of the
Certificate of  Incorporation  or By-laws,  or any  organizational  or governing
documents,  or any amendment thereof,  of the Subsidiaries;  (c) do not violate,
conflict with or result in any breach or contravention of or the creation of any
Lien  under,  any  material  Contractual  Obligation  of  Integra  or any of its
Subsidiaries,  or any  Requirement  of Law  applicable  to Integra or any of its
Subsidiaries;  and (d) do not violate any  judgment,  injunction,  writ,  award,
decree  or order of any  nature  (collectively,  "Orders")  of any  Governmental
Authority against,  or binding upon,  Integra or any of the Subsidiaries  except
for those Orders the violation of which would not have a material adverse effect
on the  Condition  of  Integra.  Neither  Integra  nor  any of its  Subsidiaries
previously  entered into any agreement  which is currently in effect or by which
Integra  is  currently  bound,  granting  any  rights  to any  Person  which are
inconsistent with the rights to be granted by Integra in this Agreement and each
of the other Transaction Documents.

                  2.3 Governmental  Authorization;  Third Party Consents.  Other
than (a) the filing and approval of an application  for the listing on NASDAQ of
the shares of Common Stock issuable upon conversion of the Purchased  Shares and
the exercise of the Warrants,  (b) the filing of the Certificate of Designation,
(c) those  required  pursuant to the applicable  state  securities or "blue sky"
laws, with respect to the offer and sale of the Securities,  (d) with respect to
the  performance  by Integra of the Amended  and  Restated  Registration  Rights
Agreement,  the  registration of the  Registrable  Securities (as defined in the
Amended and Restated  Registration  Rights  Agreement)  covered thereby with the
Commission and the registration or qualification of such Registrable  Securities
and other filings  pursuant to applicable  state  securities or "blue sky" laws,



<PAGE>


                                                              Page 36 of 90Pages


and  (e)  any  filings  required  under  the  HSR  Act,  no  approval,  consent,
compliance,  exemption,  authorization,  or other  action  by, or notice  to, or
filing with, any Governmental Authority or any other Person, including,  without
limitation, any approval or authorization of Integra's stockholders, any further
approval of the Board of Directors or any approval of NASDAQ,  and no lapse of a
waiting  period  under a  Requirement  of  Law,  is  necessary  or  required  in
connection  with the  execution,  delivery or  performance  (including,  without
limitation,  the sale,  issuance and delivery of the  Securities)  by Integra of
this Agreement,  each of the other  Transaction  Documents and the  transactions
contemplated hereby or thereby.

                  2.4  Binding  Effect.  This  Agreement  and each of the  other
Transaction  Documents  have been duly  executed  and  delivered  by Integra and
constitute the legal,  valid and  binding  obligations  of Integra,  enforceable
against Integra in accordance with their terms,  except as enforceability may be
limited  by  applicable  bankruptcy,  insolvency,   reorganization,   fraudulent
conveyance or transfer, moratorium or  similar laws affecting the enforcement of
creditors'  rights  generally and by general  principles  of equity  relating to
enforceability  (regardless  of whether  considered in a proceeding at law or in
equity).

                  2.5 Litigation.  Except as set forth in the SEC Documents, the
Financial Statements  (including the draft notes thereto) or Schedule 2.5, there
are  no  actions,   suits,   proceedings,   claims,   complaints,   disputes  or
investigations  pending or  threatened,  at law, in equity,  in  arbitration  or
before any Governmental Authority against Integra or any of its Subsidiaries and
with respect to which Integra or any of its  Subsidiaries  is responsible by way
of indemnity or  otherwise,  which would,  if adversely  determined,  (a) have a
material  adverse  effect on the  Condition  of Integra,  or (b) have an adverse
effect on the ability of Integra to perform its obligations under this Agreement
and each of the other  Transaction  Documents.  No Order has been  issued by any
court or other Governmental Authority against Integra or any of its Subsidiaries
purporting to enjoin or restrain the execution,  delivery or performance of this
Agreement or any of the other Transaction Documents.

                  2.6      Compliance with Laws.

                           (a)      Each of  Integra  and its Subsidiaries is in
compliance with all  Requirements  of Law in all respects,  except to the extent
that the  failure  to  comply  with  such  Requirements  of Law would not have a
material adverse effect on the Condition of Integra.



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                                                             Page 37 of 90 Pages


                           (b)      (i) Each of Integra and its Subsidiaries has
all  licenses,  permits,  orders  or  approvals  of any  Governmental  Authority
(collectively,  "Permits")  that are material to or necessary for the conduct of
the business of Integra in the manner described in the SEC Documents,  except to
the  extent  that the  failure  to have such  Permits  would not have a material
adverse effect on the Condition of Integra;  (ii) such Permits are in full force
and effect;  and (iii) no violations are or have been recorded in respect of any
Permit.

                           (c)      The property, assets  and operations at  any
time owned or leased by Integra have been in compliance in all material respects
with all applicable  Environmental Laws, while so owned or leased, except to the
extent that the failure to comply with such  Environmental Laws would not have a
material adverse effect on the Condition of Integra.

                  2.7      Capitalization.

                           (a)       The authorized capital stock  of Integra at
the close of business on February 16, 2000 consisted of (x) 60,000,000 shares of
Common Stock,  of which  16,285,790  shares are issued and  outstanding  and (y)
15,000,000  shares of preferred  stock,  par value $.01 per share,  of which (i)
2,000,000  shares have been  designated as Series A Preferred Stock and of which
500,000  shares are issued and  outstanding  and (ii)  120,000  shares have been
designated as Series B Preferred  Stock and of which  100,000  shares are issued
and  outstanding.  Integra has reserved an aggregate of 600,000 shares of Common
Stock for issuance upon conversion of the Purchased Shares and 300,000 shares of
Common Stock for issuance upon exercise of the Warrants.  Except as set forth in
Schedule 2.7,  there are no options,  warrants,  conversion  privileges or other
rights presently outstanding to purchase or otherwise acquire any authorized but
unissued or unauthorized shares or treasury shares of Integra's capital stock.

                           (b)     The Purchased Shares are duly authorized and,
when issued and sold to the Purchasers after payment  therefor,  will be validly
issued,  fully paid and  nonassessable  by Integra.  The shares of Common  Stock
issuable  upon  conversion  of the  Purchased  Shares  and the  exercise  of the
Warrants are duly  authorized and, when issued in compliance with the provisions
of  this  Agreement,  the  Certificate  of  Incorporation,  the  Certificate  of
Designation  (in the case of the shares of Common Stock issuable upon conversion
of the  Purchased  Shares) and the Warrants (in the case of the Warrant  Shares)
will be validly issued,  fully paid and nonassessable by Integra. The issued and
outstanding  shares of Common  Stock are all duly  authorized,  validly  issued,



<PAGE>


                                                             Page 38 of 90 Pages


fully paid and nonassessable by Integra,  and were issued in compliance with the
registration  and   qualification   requirements  of  all  applicable  federal
securities laws.

                  2.8 No Default or Breach. Except as set forth in Schedule 2.8,
neither Integra nor any of its  Subsidiaries  has received notice of, and is not
in, default under or with respect to any, Contractual Obligation in any respect,
which,  individually  or together with all such defaults,  could have a material
adverse effect on the Condition of Integra, or which could materially  adversely
affect the ability of Integra to perform its obligations under this Agreement or
any of the other Transaction Documents.

                  2.9      Taxes.

                  (a) Each of Integra and its  Subsidiaries has timely filed all
income, franchise and other material tax returns,  reports, forms and other such
documents  ("Tax  Returns")  required  to be filed  by them  and  have  paid and
discharged  all Taxes as shown on such Tax Returns  other than payments that are
being  contested in good faith by  appropriate  proceedings  and with respect to
which  adequate  reserves  have been set aside.  Such Tax  Returns  are true and
correct in all material respects.  Each of Integra and its Subsidiaries has paid
or caused to be paid,  or has  established  reserves  that are  adequate  in all
material   respects,   all  Tax  liabilities   applicable  to  Integra  and  its
Subsidiaries, respectively, for all fiscal years that have not been examined and
reported on by the taxing authorities (or closed by applicable statutes).  As to
each of Integra and its Subsidiaries (i) no additional Federal or other material
Tax assessment, Federal or other material Tax deficiency or claim for additional
Federal or other material  Taxes  (including  interest  thereon and penalties in
connection  therewith) has been heretofore  proposed or threatened by any taxing
authority,  (ii) no audit is in progress  and no  extension  of time is in force
with respect to any date on which any Federal or other material Tax Return is to
be filed and no waiver or  agreement  is in force for the  extension of time for
the  assessment  or payment of any Federal or other  material  Tax, and (iii) no
waivers of the statute of limitation or extension of time within which to assess
any Federal or other material Tax have been granted.

                  (b) There are no liens for  Federal  or other  material  Taxes
(other than for Federal or other  material  Taxes not yet due and payable)  upon
the assets of Integra or any of its Subsidiaries.



<PAGE>


                                                             Page 39 of 90 Pages


                  (c) Other than as between Integra and any of its Subsidiaries,
neither Integra nor any of its  Subsidiaries  (i) is a party to or bound by (nor
will Integra or any of its Subsidiaries, prior to the Closing, become a party to
or bound by) any Tax  indemnity,  Tax  sharing or Tax  allocation  agreement  or
arrangement  (other  than  those  arrangements  or  agreements  entered  into in
connection with the purchase or sale of a company or business listed on Schedule
2.9 hereto);  or (ii) is liable for the Taxes of any other corporation  pursuant
to Section 1.1502-6 or 1.1502-78 of the treasury  regulations  promulgated under
the Internal Revenue Code of 1986, as amended (the "Treasury  Regulations"),  or
any similar provision of state, local or foreign law.

                  (d)  Integra is not a "United  States  real  property  holding
corporation"  (a "USRPHC")  as that term is defined in Section  897(c)(2) of the
Code and the Treasury  Regulations  promulgated  thereunder,  and Integra has no
plan or intention of becoming a USRPHC.

                  2.10 Financial Statements. Integra has heretofore delivered to
the Purchasers true and correct copies of its unaudited  consolidated  financial
statements  (balance  sheet  and  statements  of  operations,   cash  flows  and
shareholders'  equity) for the nine months  ended and as at  September  30, 1999
(the "Financial  Statements").  The Financial  Statements comply in all material
respects  with the  requirements  of the Exchange Act and have been  prepared in
accordance  with GAAP applied on a consistent  basis.  The Financial  Statements
fairly present the consolidated financial condition,  operating results and cash
flows of Integra as of September  30, 1999 and for the nine months then ended in
accordance with GAAP.

                  2.11 No Material Adverse Change;  Ordinary Course of Business.
Except  as set  forth  in  Schedule  2.11  hereto  or the  SEC  Documents  or as
previously disclosed to the Purchasers in writing, (i) since September 30, 1999,
there has not been any  material  adverse  change in the  Condition  of  Integra
(other than the incurrence of operating losses  consistent with historic results
of Integra) and (ii) since  September 30, 1999,  neither  Integra nor any of its
Subsidiaries  has  participated in any transaction or acted outside the ordinary
course of business.

                  2.12     SEC Documents.

                           (a)      Integra has filed all SEC Documents required
to be filed by it since  December  31,  1998  under  the  Securities  Act or the


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                                                             Page 40 of 90 Pages


Exchange Act, and all amendments thereto.

                           (b)      As of  its  filing date,  each  SEC Document
(including  all exhibits and  schedules  thereto and documents  incorporated  by
reference therein), in each case as amended, referred to in subsection (a) above
(i) complied in all material  respects with the applicable  requirements  of the
Exchange Act and (ii) did not contain any untrue statement of a material fact or
omit to state any material fact necessary in order to make the  statements  made
therein,  in  light  of the  circumstances  under  which  they  were  made,  not
misleading.  Integra  is not aware of any issues  raised  by, or  correspondence
(other than routine filing packages and cover letters) with, the Commission with
respect to any of the SEC Documents.

                  2.13     Investment  Company.  Integra  is not an  "investment
company" within the meaning of the Investment Company Act of 1940, as amended.

                  2.14     Private Offering.  No form of general solicitation or
general  advertising  was used by Integra or its  representatives  in connection
with the offer or sale of the Purchased Shares or the Warrants.  No registration
of the  Purchased  Shares or the  Warrants,  pursuant to the  provisions  of the
Securities  Act or any state  securities  or "blue sky" laws, is required on the
date  hereof  or on the  Closing  Date by the  offer,  sale or  issuance  of the
Securities.  Integra  hereby  agrees  that  neither it nor anyone  acting on its
behalf,  will offer to sell the  Purchased  Shares or the  Warrants or any other
security  so as to  require  the  registration  of the  Purchased  Shares or the
Warrants,  pursuant  to the  provisions  of  the  Securities  Act  or any  state
securities or "blue sky" laws, unless such securities are so registered.

                  2.15     Employee  Benefit Plans.  All employee  benefit plans
(as defined in Section 3(3) of ERISA) or  arrangements  of Integra or any of the
Subsidiaries are in substantial  compliance with all applicable  Requirements of
Law.  The  execution  and  delivery  of this  Agreement  and  each of the  other
Transaction  Documents,  the purchase and sale of the Purchased Shares hereunder
and the  consummation of the transactions  contemplated  hereby and thereby will
not result in any  prohibited  transaction  within the meaning of Section 406 of
ERISA or  Section  4975 of the Code,  assuming  that  none of the  consideration
received by Integra pursuant to this Agreement is derived from the assets of any
employee benefit plan.



<PAGE>


                                                             Page 41 of 90 Pages


                  2.16     Title to  Assets.  Except  as set  forth in  Schedule
2.16,  each of  Integra  and  its  Subsidiaries  has  good  title  to all of its
properties  and assets used in the business  described in the SEC  Documents and
reflected as owned on the  Financial  Statements or so described in any Schedule
hereto,  in each  case  free  and  clear  of any  Lien,  except  for  (a)  Liens
specifically  described on the notes to the Financial  Statements  and (b) Liens
not material to the Condition of Integra.

                  2.17     Intellectual Property.

                           (a)     Schedule 2.17(a) sets forth all United States
and  foreign  patents  and  patent  applications,  trademark  and  service  mark
registrations  and  applications,  and copyright  registrations and applications
owned or licensed by Integra and all material licenses,  sublicenses,  and other
agreements or permissions  ("IP Licenses")  under which Integra is a licensor or
licensee or otherwise is authorized to use or practice any Intellectual Property
(as defined below).

                           (b)     Except  as set  forth  in  Schedule  2.17(b),
Integra  owns or  otherwise  has the right to use,  and will  continue to own or
otherwise  have the right to use  immediately  following  the Closing,  free and
clear of any and all  Encumbrances,  all United  States and foreign  patents and
patent applications,  trademark and service mark registrations and applications,
copyright registrations and applications, trade secrets, know-how, software, and
other technology and proprietary rights (collectively,  "Intellectual Property")
used in the operation of its business as described in the SEC Documents.

                           (c)     Except as set forth on Schedule  2.17(c),  to
the best of Integra's knowledge,  Integra's use or licensing of the Intellectual
Property used in the operation of its business as described in the SEC Documents
does not infringe or otherwise  violate any Intellectual  Property rights of any
third party.  Except as set forth on Schedule 2.17(c),  no litigation is pending
and no  claim  has been  made in  writing  against  Integra  or,  to the best of
Integra's  knowledge,  is threatened  contesting the right of Integra to sell or
license to third  parties or use the  Intellectual  Property  presently  sold or
licensed to third parties or used by Integra.

                           (d)     Integra has taken all reasonable  precautions
to protect the secrecy, confidentiality,  and value of its trade secrets and the
proprietary  nature and value of its know-how,  patents,  and other  technology.


<PAGE>


                                                             Page 42 of 90 Pages


Each  employee  and  third  party  who has  contributed  to the  development  of
Intellectual  Property on behalf of Integra has signed an agreement with Integra
stating that such employee or third party (i) shall maintain the confidentiality
of Integra's trade secrets and other confidential information,  and (ii) assigns
to Integra  all rights  that such  employee  or third  party  might have in such
Intellectual  Property,  except where the terms of particular agreements provide
otherwise.  To the  knowledge  of Integra,  no such  employee or third party has
materially breached any such agreement.

                  2.18 Trade  Relations.  Except as set forth in Schedule  2.18,
there exists no actual or threatened termination, cancellation or limitation of,
or any adverse  modification or change in, the business  relationship of Integra
or any of its  Subsidiaries  with, any customer or any group of customers  whose
purchases  are  individually  or in the  aggregate  material to the  business of
Integra or any of its  Subsidiaries,  or with any material  supplier,  and there
exists  no  present  condition  or state  of fact or  circumstances  that  would
materially  adversely  affect the  Condition of Integra or prevent  Integra from
conducting its business after the consummation of the transactions  contemplated
by this Agreement and each of the other Transaction Documents,  in substantially
the same  manner in which  such  business  has  heretofore  been  conducted  and
described in the SEC Documents.

                  2.19 Contracts and Other  Agreements.  All of the  Contractual
Obligations of Integra and any of its Subsidiaries  that are currently in effect
and are required to be described in the SEC Documents or to be filed as exhibits
thereto are (a) described in the SEC Documents or filed as exhibits  thereto and
(b) valid, subsisting,  in full force and effect and binding upon Integra or its
Subsidiaries,  as the case may be, and, to the  knowledge of Integra,  the other
parties  thereto,  in  accordance  with  their  terms.  Except as set forth   on
Schedule  2.19,  Integra  has  paid in  full or  accrued  all  material  amounts
currently  due  thereunder  and has satisfied in full or provided for all of its
currently matured liabilities and obligations thereunder,  and is not in default
under any of them.  Except as set forth on Schedule  2.19,  to the  knowledge of
Integra, no other party to any such Contractual  Obligation is in breach thereof
or in default  thereunder nor does any condition exist that with notice or lapse
of time or both will  constitute a breach thereof or default  thereunder by such
other party, except for such breaches or defaults that would not have a material
adverse effect on the Condition of Integra.

                  2.20  Liabilities.  As at September 30, 1999,  neither Integra


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                                                             Page 43 of 90 Pages


nor any of its Subsidiaries  had any direct or indirect  obligation or liability
required by GAAP to be set forth on its  financial  statements  or the footnotes
thereto  (the  "Liabilities")  that were not fully and  adequately  reflected or
reserved against in the Financial Statements.

                  2.21   Broker's,  Finder's  or  Similar  Fees.  There  are  no
brokerage  commissions,  finder's fees or similar fees or commissions payable by
Integra in connection  with the  transactions  contemplated  hereby based on any
agreement,  arrangement or understanding with Integra or any of its Subsidiaries
or any action taken by any such entity.

                  2.22   Disclosure;   Agreement  and  Other   Documents.   This
Agreement,  each of the other Transaction Documents and each of the certificates
furnished to the Purchasers by Integra in connection  with the purchase and sale
of the Purchased Shares and the Warrants at or prior to the Closing,  taken as a
whole, do not contain any untrue statement of a material fact or omit to state a
material  fact  necessary in order to make the  statements  contained  herein or
therein,  in  the  light of the circumstances  under  which they were made,  not
misleading.

SECTION III.      REPRESENTATIONS AND WARRANTIES
                  OF THE PURCHASERS

                  Each  of  the  Purchasers   hereby   represents  and  warrants
(severally as to itself and not jointly) to Integra as follows:

                  3.1 Existence and Power.  Such Purchaser that is an entity (a)
is duly organized and validly existing under the laws of the jurisdiction of its
formation and (b) has the requisite power and authority to execute,  deliver and
perform its obligations  under this Agreement and each of the other  Transaction
Documents to which it is a party.

                  3.2 Authorization;  No Contravention.  The execution, delivery
and  performance  by such  Purchaser  of this  Agreement  and each of the  other
Transaction  Documents to which it is a party and the transactions  contemplated
hereby and thereby, including, without limitation, the purchase of the Purchased
Shares and the Warrants,  (a) have been duly authorized by all necessary action,
(b) do not contravene the terms of such Purchaser's organizational documents, or
any amendment  thereof,  and (c) do not violate,  conflict with or result in any
breach or  contravention  of or the creation of any Lien under,  any Contractual



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                                                             Page 44 of 90 Pages


Obligation  of such  Purchaser,  or any  Requirement  of Law  applicable to such
Purchaser.

                  3.3 Governmental  Authorization;  Third Party Consents.  Other
than any filings required under the HSR Act, no approval,  consent,  compliance,
exemption,  authorization, or other action by, or notice to, or filing with, any
Govern mental  Authority or any other Person,  and no lapse of a waiting  period
under a  Requirement  of Law, is  necessary or required in  connection  with the
execution, delivery  or performance (including, without limitation, the purchase
of the  Purchased  Shares and the  Warrants) by, or  enforcement  against,  such
Purchaser of this Agreement, each of the other Transaction Documents to which it
is a party and the transactions contemplated hereby or thereby.

                  3.4  Binding  Effect.  This  Agreement  and each of the  other
Transaction  Documents  to which  it is a party  have  been  duly  executed  and
delivered  by such  Purchaser  and  constitute  the  legal,  valid  and  binding
obligations of such  Purchaser,  enforceable  against it in accordance  with its
terms,  except  as  enforceability  may be  limited  by  applicable  bankruptcy,
insolvency,  reorganization,  fraudulent  conveyance or transfer,  moratorium or
similar laws  affecting the  enforcement  of creditors'  rights  generally or by
equitable   principles   relating  to  enforceability   (regardless  of  whether
considered in a proceeding at law or in equity).

                  3.5  Purchase for Own Account.  The  Purchased  Shares and the
Warrants to be acquired by such  Purchaser  pursuant to this Agreement are being
or will be acquired for its own account and with no intention of distributing or
reselling  such  Purchased  Shares or any part thereof in any  transaction  that
would be in violation of the  securities  laws of the United States  of America,
or  any state,  without prejudice,  however,  to the rights of such Purchaser at
all  times to sell or  otherwise  dispose  of all or any part of such  Purchased
Shares  or  Warrants  under  an  effective   registration  statement  under  the
Securities Act, or under an exemption from such registration available under the
Securities   Act,  and  subject,  nevertheless,  to   the  disposition  of  such
Purchaser's  property  being at all times within its control.  If such Purchaser
should in the future decide to dispose of any of the Securities,  such Purchaser
understands  and agrees that it may do so only in compliance with the Securities
Act and  applicable  state  securities  laws, as then in effect.  Such Purchaser
agrees  to  the  imprinting,  so  long  as  required  by  law,  of a  legend  on
certificates representing the Securities substantially to the following effect:




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                                                             Page 45 of 90 Pages


         "THE  SECURITIES   REPRESENTED  BY  THIS   CERTIFICATE  HAVE  NOT  BEEN
         REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE "ACT"), OR
         THE  SECURITIES  LAWS OF ANY  STATE  AND  MAY NOT BE SOLD OR  OTHERWISE
         DISPOSED OF EXCEPT  PURSUANT  TO AN  EFFECTIVE  REGISTRATION  STATEMENT
         UNDER THE ACT AND  APPLICABLE  STATE  SECURITIES LAWS OR PURSUANT TO AN
         APPLICABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE ACT."

         "THE SECURITIES REPRESENTED BY THIS CERTIFICATE MAY
         BE ENTITLED TO THE BENEFITS OF A REGISTRATION RIGHTS
         AGREEMENT AMONG INTEGRA LIFESCIENCES HOLDINGS
         CORPORATION AND THE ORIGINAL PURCHASERS OF THE
         PREFERRED STOCK REPRESENTED HEREBY.  TRANSFEREES
         OF SUCH SECURITIES SHOULD REVIEW SUCH AGREEMENT
         TO DETERMINE THEIR RIGHTS."

                  3.6  Accreditation;   Sophistication;  Other  Securities  Laws
Matters.  Each Purchaser (a) is an "accredited  investor"  within the meaning of
Rule 501 under the Securities  Act; (b) has sufficient  knowledge and experience
in investing  in  companies  similar to Integra so as to be able to evaluate the
risks and merits of its  investment in Integra and is able  financially  to bear
the risks thereof;  (c) has had an opportunity  to discuss  Integra's  business,
management  and  financial  affairs  with  Integra's  management;  and  (d) is a
resident  of the  jurisdiction  listed next to its name on Schedule 1 hereto for
purposes of state "blue sky" securities law purposes.

                  3.7 Broker's, Finder's or Similar Fees. There are no brokerage
commissions,  finder's  fees or  similar  fees  or  commissions  payable  by the
Purchasers  or any of them,  in connection  with the  transactions  contemplated
hereby based on any agreement,  arrangement or understanding with such Purchaser
or any action taken by such Purchaser.

SECTION IV.       CONDITIONS TO THE OBLIGATION
                  OF THE PURCHASERS TO CLOSE

                  The  obligation  of the  Purchasers  to purchase the Purchased
Shares and the Warrants,  to pay the purchase  price therefor at the Closing and
to perform any  obligations  hereunder  shall be subject to the  satisfaction as
determined  by, or waiver by, the  Purchasers of the following  conditions on or



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                                                             Page 46 of 90 Pages


before the Closing Date.

                  4.1  Representations  and Warranties.  The representations and
warranties  of Integra  contained in Section II hereof shall be true and correct
in all  material  respects at and on the Closing  Date as if made at and on such
date, except to the extent that any representation and warranty expressly speaks
as of an earlier  date, in which case such  representation  and warranty is true
and correct as of such date and except for any activities or transactions  which
may have  taken  place  after the date  hereof  which are  contemplated  by this
Agreement.

                  4.2  Compliance  with  this  Agreement.   Integra  shall  have
performed and complied in all material  respects with all of its  agreements and
conditions  set forth herein that are required to be performed or complied  with
by Integra on or before the Closing Date.

                  4.3  Secretary's   Certificate.   The  Purchasers  shall  have
received a certificate from Integra,  in form and substance  satisfactory to the
Purchasers,  dated the Closing  Date and signed by a secretary  or an  assistant
secretary of Integra, certifying (a) that the attached copies of the Certificate
of  Incorporation,  the By-laws and  resolutions  of the Board of  Directors  of
Integra approving this Agreement,  each of the other  Transaction  Documents and
the transactions  contemplated  hereby and thereby,  are all true,  complete and
correct and remain  unamended  and in full force and  effect,  and (b) as to the
incumbency  and specimen  signature of each  officer of Integra  executing  this
Agreement,  each of the  other  Transaction  Documents  and any  other  document
delivered in connection herewith on behalf of Integra.

                  4.4 Officers' Certificate.  The Purchasers shall have received
a  certificate  from  Integra,  in  form  and  substance   satisfactory  to  the
Purchasers,  dated the  Closing  Date and signed by  Integra's  chief  executive
officer  and  its  treasurer,   certifying  that  (a)  the  representations  and
warranties of Integra contained in Section II hereof are true and correct in all
material respects on the Closing Date and (b) Integra has performed and complied
with in all material  respects all of the agreements and conditions set forth or
contemplated  herein that are  required  to be  performed  or  complied  with by
Integra on or before the Closing Date.

                  4.5  Documents.  The  Purchasers  shall  have  received  true,
complete and correct copies of such documents as they may reasonably  request in


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                                                             Page 47 of 90 Pages


connection  with or relating to the issue and sale of the  Purchased  Shares and
the  transactions  contemplated  hereby,  all in form and  substance  reasonably
satisfactory to the Purchasers.

                  4.6 Filing of Certificate of  Designation.  The Certificate of
Designation shall have been duly filed by Integra with the Secretary of State of
the State of Delaware in  accordance  with the  General  Corporation  Law of the
State of Delaware.

                  4.7  Amended  and  Restated   Registration  Rights  Agreement.
Integra  shall  have duly  executed  and  delivered  the  Amended  and  Restated
Registration  Rights  Agreement,  substantially  in the form attached  hereto as
Exhibit C.

                  4.8 Opinion of Counsel.  The Purchasers shall have received an
opinion  of  counsel  to  Integra,  dated  the  Closing  Date,  relating  to the
transactions  contemplated  hereby or referred to herein,  substantially  in the
form attached hereto as Exhibit D.

                  4.9  Approval  of Counsel to the  Purchasers.  All actions and
proceedings  hereunder  and all  documents  required to be  delivered by Integra
hereunder  or  in  connection  with  the   consummation   of  the   transactions
contemplated  hereby, and all other related matters,  shall have been acceptable
to Paul, Weiss, Rifkind, Wharton & Garrison, counsel to the Purchasers, in their
reasonable judgment as to their form and substance.

                  4.10 Purchased Shares. Integra shall have delivered to each of
the Purchasers stock  certificates in definitive form representing the number of
Purchased  Shares set forth opposite such  Purchaser's name on Schedule 1 hereto
and registered in the name of such Purchaser.

                  4.11 Warrants.  Integra shall have duly executed and delivered
to the Purchasers the Warrants,  each  substantially in the form attached hereto
as Exhibit A.

                  4.12  Consents  and  Approvals.   All  consents,   exemptions,
authorizations,  or other actions by, or notices to, or filings with (other than
the  filings  referenced  in  Section  2.3(a)  and  (d)  hereof),   Governmental
Authorities  and other  Persons in respect of all  Requirements  of Law and with
respect to those  Contractual  Obligations  of Integra  which are  necessary  or



<PAGE>


                                                             Page 48 of 90 Pages


required in connection with the execution,  delivery or performance  (including,
without limitation,  the issuance of the Purchased Shares, the Warrants,  shares
of Common  Stock  issuable  upon  conversion  of the  Purchased  Shares  and the
exercise of the Warrants) by, or enforcement against,  Integra of this Agreement
and each of the other  Transaction  Documents shall have been obtained and be in
full force and effect, and each of the Purchasers shall have been furnished with
appropriate evidence thereof.

                  4.13 No  Litigation.  No action,  suit,  proceeding,  claim or
dispute  shall  have been  brought or  otherwise  arisen at law,  in equity,  in
arbitration or before any Governmental  Authority  against Integra or any of its
Subsidiaries which would, if adversely  determined,  (a) have a material adverse
effect on the Condition of Integra or (b) have a material  adverse effect on the
ability of Integra to perform its obligations under this Agreement or any of the
other Transaction Documents.

                  4.14 No Material Judgment or Order.  There shall not be on the
Closing Date any Order of a court of competent jurisdiction or any ruling of any
Governmental  Authority or any condition  imposed under any  Requirement  of Law
which would, in the judgment of the Purchasers, (a) prohibit or restrict (i) the
purchase of the Purchased  Shares or (ii) the  consummation of the  transactions
contemplated  by this  Agreement,  (b) subject the  Purchasers to any penalty or
other  onerous  condition  under or  pursuant to any  Requirement  of Law if the
Purchased Shares were to be purchased hereunder or (c) restrict the operation of
the  business of Integra or any of the  Subsidiaries  as  conducted  on the date
hereof in a manner that would have a material adverse effect on the Condition of
Integra.

                  4.15 No Material Adverse Change.  Since the date hereof, there
shall have been no material  adverse  change in the Condition of Integra  (other
than operating losses consistent with the historic results of Integra).

                  4.16 Hart-Scott-Rodino. Any Person required in connection with
the  transactions  contemplated  under this Agreement to file a notification and
report  form in  compliance  with the HSR Act shall have filed such form and the
waiting period specified in the HSR Act, including any extensions thereof, shall
have expired or been terminated.

                  4.17 Schedules.  The Purchasers  shall have received copies of
Integra's  Schedules  to  this  Agreement  in  form  and  substance   reasonably



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                                                             Page 49 of 90 Pages


satisfactory to the Purchasers.

                  4.18 No Change in  Capitalization.  There  shall  have been no
change in the authorized, issued and outstanding capital stock of Integra in the
interval  between  the date hereof and the  Closing  Date,  except for shares of
Common Stock  issued upon the  exercise of warrants or options,  or purchased by
Integra pursuant to its current share repurchase program.

SECTION V.        CONDITIONS TO THE OBLIGATION
                  OF THE COMPANY TO CLOSE

                  The  obligations  of Integra  to issue and sell the  Purchased
Shares and to perform its other obligations  hereunder,  shall be subject to the
satisfaction as determined by, or waiver by, Integra of the following conditions
on or before the Closing Date:

                  5.1  Representations  and Warranties.  The representations and
warranties of the  Purchasers  contained in Section III hereof shall be true and
correct on at and on the Closing Date as if made at and on such date,  except to
the  extent  that any  representation  and  warranty  expressly  speaks as of an
earlier date, in which case such representation and warranty is true and correct
as of such date and except for any  activities  or  transactions  which may have
taken place after the date hereof which are contemplated by this Agreement.

                  5.2 Compliance with this Agreement.  The Purchasers shall have
performed and complied in all material respects with all of their agreements and
conditions  set forth herein that are required to be performed or complied  with
by the Purchasers on or before the Closing Date.

                  5.3 Amended and Restated  Registration  Rights Agreement.  The
Purchasers  shall have duly  executed  and  delivered  the Amended and  Restated
Registration  Rights  Agreement,  substantially  in the form attached  hereto as
Exhibit C.

                  5.4  Consents  and   Approvals.   All  consents,   exemptions,
authorizations,   or  other   actions  by,  or  notices  to,  or  filings  with,
Governmental Authorities and other Persons in respect of all Requirements of Law
and with respect to those  Contractual  Obligations of the Purchasers  which are
necessary or required in connection with the execution,  delivery or performance
(including,  without  limitation,  the  purchase of the  Purchased  Shares,  the


<PAGE>


                                                             Page 50 of 90 Pages


Warrants,  and the  shares of  Common  Stock  issuable  upon  conversion  of the
Purchased  Shares and the exercise of the Warrants) by, or enforcement  against,
the Purchasers of this  Agreement  shall have been obtained and be in full force
and effect,  and Integra shall have been  furnished  with  appropriate  evidence
thereof.

                  5.5     Payment of Purchase Price. Integra shall have received
the aggregate purchase price for the Purchased Shares and the Warrants.

                  5.6     No Material  Judgment or Order.  There shall not be on
the Closing Date any Order of a court of competent jurisdiction or any ruling of
any Governmental Authority or any condition imposed under any Requirement of Law
which would,  in the judgment of Integra,  (a) prohibit or restrict (i) the sale
of the  Purchased  Shares  or the  Warrants  or  (ii)  the  consummation  of the
transactions  contemplated  by this  Agreement  or (b)  subject  Integra  to any
penalty or other onerous  condition  under or pursuant to any Requirement of Law
if the Purchased Shares were to be sold hereunder.

                  5.7     Hart-Scott-Rodino.  Any Person  required in connection
with the transactions  contemplated  under this Agreement to file a notification
and report  form in  compliance  with the HSR Act shall have filed such form and
the waiting period specified in the HSR Act,  including any extensions  thereof,
shall have expired or been terminated.

                  5.8     Consent of Purchasers.  Each of the  Purchasers,  as a
holder of Series B Convertible  Preferred  Stock of Integra,  par value $.01 per
share (the "Series B Preferred Stock"), shall have consented to (a) the issuance
of the Series C Preferred  Stock,  and (b) an  amendment to the  Certificate  of
Designation,  Preferences  and Rights of the Series B Preferred  Stock  amending
certain  terms of the Series B Preferred  Stock,  the form and substance of such
amendment to be reasonably satisfactory to the Purchasers and Integra.

SECTION VI.       INDEMNIFICATION

                  6.1     Indemnification.  Except as otherwise provided in this
Section VI,  Integra  agrees to indemnify,  defend and hold harmless each of the
Purchasers  and their  Affiliates  and  their  respective  officers,  directors,
agents,  employees,  subsidiaries,  members,  partners and  controlling  persons
(each, an "Indemnified  Party") to the fullest extent  permitted by law from and
against any and all Losses (as hereinafter  defined) resulting from, arising out
of or  relating  to any  breach of any  representation,  warranty,  covenant  or
agreement  by  Integra in this  Agreement  or the other  Transaction  Documents,



<PAGE>


                                                             Page 51 of 90 Pages


including,  without limitation,  Losses arising out of or relating to any legal,
administrative or other actions  (including actions brought by the Purchasers or
Integra or any equity  holders of Integra or derivative  actions  brought by any
Person claiming  through or in Integra's  name),  proceedings or  investigations
(whether formal or informal),  or written threats thereof,  based upon, relating
to or arising out of this Agreement,  each of the other  Transaction  Documents,
the transactions  contemplated  hereby and thereby,  or any Indemnified  Party's
role  therein  or in  transactions  contemplated  hereby or  thereby;  provided,
however,  that the  Integra  shall not be liable  under this  Section  6.1 to an
Indemnified  Party to the extent that it is finally  judicially  determined that
such Losses  resulted  primarily  from the material  breach by such  Indemnified
Party of any  representation,  warranty,  covenant  or other  agreement  of such
Indemnified Party contained in this Agreement;  and provided,  further,  that if
and to the extent that such  indemnification  is  unenforceable  for any reason,
then Integra shall make the maximum contribution to the payment and satisfaction
of such Losses which shall be permissible  under applicable  laws.  Losses means
all losses,  claims  (including any claim by a third party),  damages,  expenses
(including reasonable fees,  disbursements and other charges of counsel incurred
by the Indemnified Party in any action between Integra and the Indemnified Party
or between  the  Indemnified  Party and any third party or  otherwise)  or other
liabilities;  provided,  however,  that  Losses  shall  include  only (a) direct
out-of-pocket  payments of judgments and settlements,  costs and expenses of the
Indemnified Parties and (b) diminution in value of the Purchased Shares directly
attributable to a breach of any representation,  warranty, covenant or agreement
by Integra in this Agreement or the other Transaction Documents.

                  6.2 Notification. Each Indemnified Party under this Section VI
will,  promptly after the receipt of notice of the  commencement  of any action,
investigation,  claim or other  proceeding  against  such  Indemnified  Party in
respect of which  indemnity  may be sought from  Integra  under this Section VI,
notify  Integra in writing of the  commencement  thereof.  The  omission  of any
Indemnified  Party to so notify  Integra of any such  action  shall not  relieve
Integra from any liability which Integra may have to such Indemnified  Party (a)
other than pursuant to this Section VI or (b) under this Section VI unless,  and
only to the extent  that,  such  omission  results in  Integra's  forfeiture  of
substantive  rights  or  defenses.  In case  any  such  action,  claim  or other
proceeding  shall be brought against any  Indemnified  Party and it shall notify
Integra of the  commencement  thereof,  Integra  shall be entitled to assume the
defense  thereof  at  its  own  expense,   with  counsel  satisfactory  to  such
Indemnified  Party  in its  reasonable  judgment;  provided,  however,  that any



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                                                             Page 52 of 90 Pages


Indemnified  Party  may,  at  its  own  expense,   retain  separate  counsel  to
participate in such defense at its own expense.  Notwithstanding  the foregoing,
in any action,  claim or proceeding in which both Integra,  on the one hand, and
an  Indemnified  Party,  on the other  hand,  are, or are  reasonably  likely to
become, a party,  such Indemnified Party shall have the right to employ separate
counsel at the expense of Integra and to control its own defense of such action,
claim or proceeding if, in the reasonable opinion of counsel to such Indemnified
Party, a conflict or potential conflict exists between Integra, on the one hand,
and such  Indemnified  Party,  on the other hand,  that would make such separate
representation  advisable;  provided,  however, that Integra shall not be liable
for the fees and expenses of more than one counsel to all  Indemnified  Parties.
Integra  agrees  that it will not,  without  the prior  written  consent  of the
Purchasers,  settle,  compromise  or consent to the entry of any judgment in any
pending or  threatened  claim,  action or  proceeding  relating  to the  matters
contemplated  hereby (if any  Indemnified  Party is a party  thereto or has been
actually  threatened  to be  made  a  party  thereto)  unless  such  settlement,
compromise or consent  includes  an unconditional release of  the Purchasers and
each other Indemnified Party from all liability arising or that may arise out of
such  claim,   action  or  proceeding  and  imposes  no  obligations  upon  such
Indemnified Party.  Integra shall not be liable for any settlement of any claim,
action or proceeding  effected against an Indemnified  Party without its written
consent,  which consent shall not be unreasonably  withheld. The rights accorded
to  each  Indemnified  Party  hereunder  shall  be the  sole  rights  that  such
Indemnified  Party may have at common law, by separate  agreement or  otherwise;
provided,  however,  that  notwithstanding  the  foregoing  or  anything  to the
contrary contained in this Agreement,  nothing in this Section VI shall restrict
or limit  any  rights  that any  Indemnified  Party  may have to seek  equitable
relief.

                  6.3  Amended  and  Restated   Registration  Rights  Agreement.
Notwithstanding  anything  to the  contrary  contained  in this  Section VI, the
indemnification  and  contribution   provisions  of  the  Amended  and  Restated
Registration  Rights  Agreement  shall  govern  any claim  made with  respect to
registration statements filed pursuant thereto or sales made thereunder.

SECTION VII.      AFFIRMATIVE COVENANTS

                  Integra hereby  covenants and agrees with the Purchasers  with
respect  to this  Section  VII that so long as any shares of  Purchased  Shares,
shares of Common Stock issuable upon the conversion thereof, the Warrants or the
Warrant Shares are outstanding,  except to the extent that a particular  section
of this Section VII provides for an earlier termination, as follows:




<PAGE>


                                                             Page 53 of 90 Pages


                  7.1 Preservation of Existence.  From the date hereof until the
Closing  Date,  Integra  shall,  and  shall  use its best  efforts  to cause its
Subsidiaries to:

                           (a)      preserve  and  maintain  in full  force  and
effect its  existence and good standing  under the laws of its  jurisdiction  of
formation or organization;

                           (b)      take all  reasonable  action to preserve and
maintain   in  full   force  and  effect  all   material   rights,   privileges,
qualifications,  applications,  estimates,  licenses and franchises necessary in
the normal conduct of its business;

                           (c)      use its  reasonable  efforts to preserve its
business organization;

                           (d)      conduct  its  business  in  accordance  with
sound  business  practices and keep its useful and necessary  properties in good
working order and condition (normal wear and tear excepted);

                           (e)      comply with all Requirements of Law and with
the directions of any Governmental Authority having jurisdiction over Integra or
any of the Subsidiaries or their  respective  business or property except to the
extent that the failure to comply with any  Requirements of Law would not have a
material adverse effect on the Condition of Integra; and

                           (f)      file or cause to be filed in a timely manner
all reports,  applications,  estimates  and licenses that shall be required by a
Governmental  Authority  and that,  if not timely  filed,  would have a material
adverse effect on the Condition of Integra.

                  7.2      Delivery  of  1999  Audited   Financial   Statements.
Integra shall deliver to the  Purchasers as soon as available a true and correct
copy  of its  audited  consolidated  financial  statements  (balance  sheet  and
statement of operations,  cash flows and shareholders equity,  together with the
notes thereto) for the fiscal year ended and as at December 31, 1999.

                  7.3      Financial  Statements and Other Information.  Integra
shall  deliver to the  Purchasers,  in form and  substance  satisfactory  to the
Purchasers:






<PAGE>


                                                             Page 54 of 90 Pages

                           (a)      as soon as  available,  but not  later  than
ninety (90) days after the end of each  fiscal  year of  Integra,  a copy of the
audited consolidated balance sheet of Integra and its Subsidiaries as of the end
of such year and the related  statements of  operations  and cash flows for such
fiscal year,  setting forth in each case in comparative form the figures for the
previous year, all in reasonable detail and accompanied by a management  summary
and analysis of the operations of Integra and its  Subsidiaries  for such fiscal
year and by the opinion of a nationally recognized  independent certified public
accounting  firm  which  report  shall  state  without  qualification  that such
consolidated  financial  statements present fairly the financial condition as of
such date and results of operations and cash flows for the periods  indicated in
conformity with GAAP applied on a consistent basis; provided,  however, that the
delivery to each of the Purchasers of a copy of Integra's  Annual Report on Form
10-K for each fiscal year shall satisfy the requirements of this Section 7.3(a);

                           (b)      commencing  with the fiscal period ending on
March 31, 2000, as soon as available, but in any event not later than forty-five
(45) days  after  the end of each of the first  three  fiscal  quarters  of each
fiscal  year,  the  unaudited  consolidated  balance  sheet of  Integra  and its
Subsidiaries,  and the related  statements of operations and cash flows for such
quarter  and for the period  commencing  on the first day of the fiscal year and
ending on the last day of such quarter,  all certified by an appropriate officer
of Integra as  presenting  fairly the  financial  condition  as of such date and
results of  operations  and cash flows for the periods  indicated in  conformity
with GAAP  applied  on a  consistent  basis,  subject to normal  year-end  audit
adjustments and the absence of footnotes  required by GAAP;  provided,  however,
that the delivery to each of the  Purchasers  of a copy of  Integra's  Quarterly
Report on Form 10-Q for each fiscal  quarter shall satisfy the  requirements  of
this Section 7.3(b);

                           (c)      at  any  time  when  it is  not  subject  to
Section  13 or 15(d) of the  Exchange  Act,  upon  request,  to the  Purchasers,
information  of the type  that  would  satisfy  the  requirement  of  subsection
(d)(4)(i) of Rule 144A (or any similar successor provision) under the Securities
Act; and

                           (d)      except as  otherwise  provided  in  Sections
7.3(a) and (b),  promptly after the same are filed,  copies of all  registration
statements,  proxy statements,  reports and other documents required to be filed
by Integra  under the  Securities  Act or the Exchange  Act, and all  amendments
thereto.

                  7.4 Reservation of Shares.  Integra shall at all times reserve



<PAGE>


                                                             Page 55 of 90 Pages


and keep available out of its authorized shares of Common Stock,  solely for the
purpose  of issue or  delivery  upon  conversion  of the  Purchased  Shares,  as
provided in the Certificate of Designation and the Certificate of Incorporation,
and the exercise of the Warrants,  the number of shares of Common Stock that may
be issuable or deliverable upon such conversion or exercise. Integra shall issue
such shares of Common Stock in accordance with the terms of this Agreement,  the
Certificate of Incorporation, the Certificate of Designation (in the case of the
shares of Common Stock issuable upon conversion of the Purchased Shares) and the
Warrants (in the case of the Warrant Shares),  as the case may be, and otherwise
comply with the terms hereof and thereof.

                  7.5  Registration  and Listing.  If any shares of Common Stock
required to be reserved for purposes of conversion of the Purchased  Shares,  as
provided in the Certificate of Designation,  or the exercise of the Warrants, as
provided  in  the  Warrants,  require  registration  with  or  approval  of  any
Governmental Authority under any Federal or state or other applicable law before
such  shares of Common  Stock may be issued  or  delivered  upon  conversion  or
exercise, Integra will in good faith and as expeditiously as possible cause such
shares of Common Stock to be duly  registered  or approved,  as the case may be,
unless such  registration  or approval is required solely because of a breach of
the Purchasers'  representation  contained in Section 3.5. So long as the shares
of Common  Stock are quoted on the NASDAQ or listed on any  national  securities
exchange,  Integra  will,  if permitted by the rules of such system or exchange,
quote or list and keep  quoted  or  listed  on such  system  or  exchange,  upon
official notice of issuance,  all shares of Common Stock issuable or deliverable
upon conversion of the Preferred Shares and exercise of the Warrants.

                  7.6 Tax Matters. In the event that a Purchaser desires to sell
or dispose of any of the  Preferred  Stock,  Common Stock or Warrants,  and upon
demand by such  Purchaser,  Integra and its  Subsidiaries  shall deliver to such
Purchaser a letter (the "Letter")  which  complies with Sections  1.1445-2(c)(3)
and 1.897-2(h) of the Treasury Regulations, addressed to such Purchaser, stating
whether  Integra is, or has been, a USRPHC during the period equal to the lesser
of (i) the period  beginning  five years prior to the date of the Letter through
the  date of the  Letter  and (ii) the  period  from the date of this  Agreement
through the date of the Letter.  The Letter shall be delivered to the  Purchaser
one business day prior to the close of any sale of the Preferred  Stock,  Common
Stock or Warrants by the Purchaser  (the "Delivery  Date").  The Letter shall be
dated as of the Delivery Date and signed by a corporate  officer who must verify



<PAGE>


                                                             Page 56 of 90 Pages


under  penalties of perjury that the  statement is correct to his  knowledge and
belief pursuant to Section 1.897-2(h) of the Treasury Regulations.

                  7.7      Further Assurances.

                           (a)      Each of the parties shall  execute, prior to
and  following  the Closing,  such  documents  and other papers and perform such
further  acts as may be  reasonably  required  or  desirable  to  carry  out the
provisions   hereof  and  the  transactions   contemplated   hereby,   including
notification and report forms with respect to the  transactions  contemplated by
this Agreement  under the HSR Act. Each such party shall use its reasonable best
efforts to fulfill or obtain the  fulfillment  of the conditions to the Closing,
including  the  execution  and delivery of any  documents or other  papers,  the
execution and delivery of which are conditions precedent to the Closing.

                           (b)      The  Purchasers on the one hand and Integra
on the other shall each pay  one-half of the filing fee required to be paid with
respect to this transaction under the HSR Act.

                  7.8  Delivery  of  Schedules.   The   Purchasers  and  Integra
acknowledge  that as of the date of this Agreement  Integra has not prepared the
Schedules called for by the provisions of Section II of this Agreement.  Integra
shall  prepare and deliver to the  Purchasers  on or before the Closing Date the
completed  Schedules  and shall update and revise such  Schedules to reflect the
reasonable  comments of the Purchasers.  The Purchasers  shall have the right to
determine  whether the  information  contained in such  Schedules is  reasonably
satisfactory to the Purchasers.  If, upon reasonable  negotiation  with Integra,
the Purchasers determine that such information is not reasonably satisfactory to
the  Purchasers in any material  respect,  the  Purchasers  may  terminate  this
Agreement by giving written  notice of such  termination to Integra on or before
the Closing Date,  whereupon  this  Agreement  shall become null and void and no
party shall have any further  liability  to any other  party  hereunder.  If the
Purchasers approve the Schedules, the Purchasers and Integra shall sign a letter
identifying  the  Schedules  and  confirming  their  mutual   understanding  and
agreement  that such Schedules are the Schedules  called for by this  Agreement,
whereupon  the  Schedules  shall be  deemed to be part of this  Agreement  as if
prepared and delivered to, and accepted by, the Purchasers on the date hereof.

SECTION VIII.     TERMINATION OF AGREEMENT

                  8.1 Termination. This Agreement may be terminated prior to the



<PAGE>


                                                             Page 57 of 90 Pages


Closing as follows:

                           (a)      at any time on or prior to the Closing Date,
by mutual written consent of Integra and the Purchasers; or

                           (b)      at the election of Integra or the Purchasers
by written  notice to the other  parties  hereto after 5:00 p.m.,  New York City
time on March 31, 2000, if the transactions contemplated by this Agreement shall
not have been consummated  pursuant hereto,  unless such date is extended by the
mutual written consent of Integra and the Purchasers; or

                           (c)      at the election of Integra,  if  any  one or
more of the conditions to its obligation to close set forth in Section V has not
been  satisfied  or  waived  and the  Closing  shall  not have  occurred  on the
scheduled Closing Date; or

                           (d)      at  the  election of the Purchasers pursuant
to Section  7.8 or if any one or more of the  conditions  to its  obligation  to
close set forth in Section IV has not been  satisfied  or waived and the Closing
shall not have occurred on the scheduled Closing Date; or

                           (e)      at  the election  of Integra,  if  there has
been a material breach of any representation, warranty, covenant or agreement on
the part of the  Purchasers  contained in this  Agreement,  which breach has not
been cured within ten (10)  Business  Days of notice to the  Purchasers  of such
breach; or

                           (f)      at the election of  the Purchasers, if there
has  been  a  material  breach  of any  representation,  warranty,  covenant  or
agreement on the part of Integra  contained in this Agreement,  which breach has
not been cured within ten (10) Business Days notice to Integra of such breach.

If this  Agreement  so  terminates,  it shall  become  null and void and have no
further force or effect, except as provided in Section 8.2.

                  8.2  Survival.   If  this  Agreement  is  terminated  and  the
transactions  contemplated  hereby are not consummated as described above,  this
Agreement  shall  become  void and of no  further  force and  effect;  provided,
however, that (i) none of the parties hereto shall have any liability in respect
of a termination  of this Agreement  pursuant to Section 7.8,  Section 8.1(a) or
Section  8.1(b) and (ii) nothing  shall relieve any party from any liability for



<PAGE>


                                                             Page 58 of 90 Pages


actual  damages  resulting  from a  termination  of this  Agreement  pursuant to
Section 8.1(e) or 8.1(f); and provided further,  that none of the parties hereto
shall  have  any  liability  for   speculative,   indirect,   unforeseeable   or
consequential damages resulting from a termination of this Agreement pursuant to
Section VIII.

SECTION IX.       MISCELLANEOUS

                  9.1 Survival of Representations and Warranties. Except for the
representations  and warranties in Section  2.7(c) (which shall survive  without
limitation), all of the representations and warranties made herein shall survive
the execution  and delivery of this  Agreement for a period ending 60 days after
the delivery by Integra to the Purchasers of its audited consolidated  financial
statements   (balance  sheet  and  statement  of  operations,   cash  flows  and
shareholders' equity,  together with the notes hereto) for the fiscal year ended
and as at December 31, 2000.

                  9.2  Notices.  All notices,  demands and other  communications
provided  for or  permitted  hereunder  shall be made in writing and shall be by
registered or certified first-class mail, return receipt requested,  telecopier,
courier service, overnight mail or personal delivery:


                        (i)     if to Quantum Industrial Partners LDC:

                                Quantum Industrial Partners LDC
                                Kaya Flamboyan 9,
                                Villemstad
                                Curacao
                                Netherlands-Antilles

                                with a copy to:

                                Soros Fund Management LLC
                                888 Seventh Avenue
                                New York, NY 10106
                                Telecopy:      (212) 664-0544
                                Attention:     Michael Neus, Esq.

                                and a copy to:

                                Paul, Weiss, Rifkind, Wharton & Garrison



<PAGE>


                                                             Page 59 of 90 Pages


                                1285 Avenue of the Americas
                                New York, New York 10019-6064
                                Telecopy:      (212) 757-3990
                                Attention:     Richard S. Borisoff, Esq.

                       (ii)     If to SFM Domestic Investments LLC:

                                Soros Fund Management LLC
                                888 Seventh Avenue
                                New York, NY 10106
                                Telecopy:      (212) 664-0544
                                Attention:     Michael Neus, Esq.

                                with a copy to:

                                Paul, Weiss, Rifkind, Wharton & Garrison
                                1285 Avenue of the Americas
                                New York, New York 10019-6064
                                Telecopy:      (212) 757-3990
                                Attention:     Richard S. Borisoff, Esq.

                       (iii)    if to Integra:

                                Integra LifeSciences Holdings Corporation
                                105 Morgan Lane
                                Plainsboro, NJ 08536
                                Telecopy:      (609) 799-3297
                                Attention:     Stuart M. Essig,
                                               President and CEO

                                with a copy to:

                                Drinker Biddle & Shanley LLP
                                105 College Road East
                                Princeton, NJ 08542-0627
                                Telecopy:      (609) 799-7000
                                Attention:     John E. Stoddard III, Esq.

                  All such  notices and  communications  shall be deemed to have
been duly given when delivered by hand, if personally delivered;  when delivered


<PAGE>


                                                             Page 60 of 90 Pages


by courier or overnight  mail,  if delivered by  commercial  courier  service or
overnight  mail;  five (5)  Business  Days after  being  deposited  in the mail,
postage prepaid,  if mailed; and when receipt is mechanically  acknowledged,  if
telecopied.

                  9.3 Successors and Assigns.  This Agreement shall inure to the
benefit of and be  binding  upon the  successors  and  permitted  assigns of the
parties hereto.  Subject to applicable  securities  laws, each of the Purchasers
may assign any of its rights  under  this  Agreement  to any of its  Affiliates.
Integra may not assign any of its rights  under this  Agreement  and each of the
other  Transaction  Documents,  except to a  successor-in-interest  to  Integra,
without  the  written  consent of all of the  Purchasers.  Except as provided in
Section VI no Person  other than the  parties  hereto and their  successors  and
permitted  assigns is intended to be a beneficiary of this Agreement and each of
the other Transaction Documents.

                  9.4      Amendment and Waiver.

                           (a)      No failure or delay on  the part  of Integra
or the  Purchasers  in exercising  any right,  power or remedy  hereunder  shall
operate as a waiver  thereof,  nor shall any single or partial  exercise  of any
such right,  power or remedy preclude any other or further  exercise  thereof or
the exercise of any other right, power or remedy.

                           (b)      Any amendment, supplement or modification of
or to any  provision  of this  Agreement,  any waiver of any  provision  of this
Agreement,  and any consent to any departure by Integra or the  Purchasers  from
the terms of any provision of this Agreement,  shall be effective (i) only if it
is made or given in writing and signed by Integra and the  Purchasers,  and (ii)
only in the specific  instance  and for the  specific  purpose for which made or
given. Except where notice is specifically required by this Agreement, no notice
to or  demand on  Integra  in any case  shall  entitle  Integra  to any other or
further notice or demand in similar or other circumstances.

                  9.5 Counterparts. This Agreement may be executed in any number
of  counterparts  and by the parties  hereto in separate  counterparts,  each of
which when so executed  shall be deemed to be an original and all of which taken
together shall constitute one and the same agreement.

                  9.6  Headings.   The  headings  in  this   Agreement  are  for
convenience  of  reference  only and  shall not limit or  otherwise  affect  the


<PAGE>


                                                             Page 61 of 90 Pages


meaning hereof.

                  9.7  GOVERNING  LAW. THIS  AGREEMENT  SHALL BE GOVERNED BY AND
CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW JERSEY, WITHOUT REGARD
TO THE PRINCIPLES OF CONFLICTS OF LAW THEREOF.

                  9.8  Severability.  If any  one  or  more  of  the  provisions
contained  herein,  or the  application  thereof  in any  circumstance,  is held
invalid,  illegal or unenforceable in any respect for any reason,  the validity,
legality and  enforceability of any such provision in every other respect and of
the remaining  provisions  hereof shall not be in any way  impaired,  unless the
provisions held invalid, illegal or unenforceable shall substantially impair the
benefits of the remaining provisions hereof.

                  9.9  Rules  of  Construction.  Unless  the  context  otherwise
requires, "or" is not exclusive, and references to sections or subsections refer
to sections or subsections of this Agreement.

                  9.10  Entire  Agreement.  This  Agreement,  together  with the
exhibits and schedules hereto, and the other Transaction  Documents are intended
by the par ties as a final  expression  of their  agreement and intended to be a
complete and  exclusive  statement of the  agreement  and  understanding  of the
parties  hereto in respect of the subject matter  contained  herein and therein.
There are no  restrictions,  promises,  warranties or  undertakings,  other than
those set forth or referred to herein or therein.

                  9.11 Fees.  Upon the  Closing,  Integra  shall  reimburse  the
Purchasers for their reasonable  out-of-pocket  expenses  (including  attorney's
fees,   disbursements  and  other  charges)  incurred  in  connection  with  the
transactions  contemplated by this Agreement;  provided,  however,  that Integra
shall  not  be  obligated  to  reimburse  the   Purchasers  for  any  reasonable
out-of-pocket expenses in excess of $40,000 in the aggregate.

                  9.12     Publicity; Confidentiality.

                           (a)      Except as may be required by  applicable law
or the rules of any  securities  exchange  or  market on which  shares of Common
Stock are traded,  none of the parties hereto shall issue a publicity release or
public announcement or otherwise make any disclosure  concerning this Agreement,
the transactions  contemplated hereby or the business  and financial  affairs of


<PAGE>


                                                             Page 62 of 90 Pages


Integra, without prior approval by the other parties hereto; provided,  however,
that nothing in this  Agreement  shall  restrict any Purchaser  from  disclosing
information (i) that is already publicly available,  (ii) that was known to such
Purchaser on a non-confidential  basis prior to its disclosure by Integra, (iii)
that may be required or appropriate in response to any summons or subpoena or in
connection with any litigation, provided that such Purchaser will use reasonable
efforts to notify Integra in advance of such  disclosure so as to permit Integra
to seek a  protective  order or  otherwise  contest  such  disclosure,  and such
Purchaser will use reasonable  efforts to cooperate,  at the expense of Integra,
with Integra in pursuing any such protective order, (iv) to the extent that such
Purchaser  reasonably believes it appropriate in order to protect its investment
in the Purchased  Shares in order to comply with any  Requirement of Law, (v) to
such Purchaser's officers,  directors,  agents,  employees,  members,  partners,
controlling  persons,  auditors or  counsel,  (vi) to Persons who are parties to
similar  confidentiality  agreements or (vii) to the  prospective  transferee in
connection  with any  contemplated  transfer  of any of the  Securities.  If any
announcement  is  required  by law or the rules of any  securities  exchange  or
market  on which  shares  of  Common  Stock  are  traded to be made by any party
hereto,  prior to making such  announcement  such party will  deliver a draft of
such  announcement  to the  other  parties  and  shall  give the  other  parties
reasonable opportunity to comment thereon.

                           (b)      The Purchasers shall have the opportunity to
review and modify any provision of any publicly  release or public  announcement
or document  which is to be released to the public or filed with the SEC,  which
provision mentions Soros Fund Management LLC or any of its Affiliates,  prior to
the release of such  document to the public or the filing of such  document with
the SEC.

                  9.13 Further  Assurances.  Each of the parties  shall  execute
such  documents and perform such further acts  (including,  without  limitation,
obtaining  any  consents,  exemptions,  authorizations  or other  actions by, or
giving any notices to, or making any filings with, any Governmental Authority or
any other Person) as may be reasonably  required or desirable to carry out or to
perform the provisions of this Agreement.

                  9.14 Schedules.  Anything  disclosed on any schedule  attached
hereto shall be deemed disclosed on all schedules attached hereto.



<PAGE>


                                                             Page 63 of 90 Pages

                  IN WITNESS  WHEREOF,  the  parties  hereto  have  caused  this
Agreement to be executed and  delivered by their  respective  officers  hereunto
duly authorized on the date first above written.


                             INTEGRA LIFESCIENCES HOLDINGS
                             CORPORATION


                             By:
                                              ----------------------------------
                                   Name:      Stuart M. Essig
                                   Title:     President and Chief Executive
                                              Officer


                             QUANTUM INDUSTRIAL PARTNERS LDC


                             By:
                                              ----------------------------------
                                              Name:
                                              By:


                             SFM DOMESTIC INVESTMENTS LLC


                             By:
                                              ----------------------------------

                                              Name:
                                              By:

<PAGE>



                                                             Page 64 of 90 Pages
<TABLE>
<CAPTION>



                             PURCHASED SHARES AND WARRANTS AND PURCHASE PRICE




                                                       Shares of            Warrants Purchased       Purchase Price
                                                  Series C-Preferred         From the Company
                                                 Stock Purchased From
                  Purchaser                           the Company

<S>                                              <C>                        <C>                      <C>

Quantum Industrial Partners LDC                         48,699                   270,550             $4,869,900.00
(principal place of business: Curacao)
SFM Domestic Investments LLC                             5,301                    29,450               $530,100.00
(principal place of business: New York)
                                               -------------------------------------------------------------------------------------

     TOTAL                                              54,000                   300,000             $5,400,000.00

</TABLE>










                                                             Page 65 of 90 Pages





                                                                  EXECUTION COPY









                              AMENDED AND RESTATED
                          REGISTRATION RIGHTS AGREEMENT


                                      among


                   INTEGRA LIFESCIENCES HOLDINGS CORPORATION,


                        QUANTUM INDUSTRIAL PARTNERS LDC,


                                       and


                          SFM DOMESTIC INVESTMENTS LLC







              -----------------------------------------------------

                              Dated: March 29, 2000

              -----------------------------------------------------

















<PAGE>






                                                             Page 66 of 90 Pages





                                TABLE OF CONTENTS

<TABLE>
<CAPTION>

                                                                                                      Page

<S>      <C>                                                                                             <C>

1.       Definitions.....................................................................................1

2.       General; Securities Subject to this Agreement...................................................4
         (a)      Grant of Rights........................................................................4
         (b)      Registrable Securities.................................................................4
         (c)      Holders of Registrable Securities......................................................4

3.       Demand Registration.............................................................................4
         (a)      Request for Demand Registration........................................................4
         (b)      Effective Demand Registration..........................................................5
         (c)      Expenses...............................................................................5
         (d)      Underwriting Procedures................................................................5
         (e)      Selection of Underwriters..............................................................6

4.       Piggy-Back Registration.........................................................................6
         (a)      Piggy-Back Rights......................................................................6
         (b)      Expenses...............................................................................7

5.       Holdback Agreements.............................................................................7
         (a)      Restrictions on Public Sale by Designated Holders......................................7
         (b)      Restrictions on Public Sale by the Company.............................................8

6.       Registration Procedures.........................................................................8
         (a)      Obligations of the Company.............................................................8
         (b)      Obligations of Each Designated Holder of Registrable Securities.......................11
         (c)      Notice to Discontinue.................................................................12
         (d)      Registration Expenses.................................................................13

7.       Indemnification; Contribution..................................................................13
         (a)      Indemnification by the Company........................................................13
         (b)      Indemnification by Designated Holders.................................................14
         (c)      Conduct of Indemnification Proceedings................................................14
         (d)      Contribution..........................................................................15

8.       Rule 144.......................................................................................16

9.       Miscellaneous..................................................................................16
         (a)      Recapitalizations, Exchanges, etc.....................................................16
         (b)      No Inconsistent Agreements............................................................16
         (c)      Remedies..............................................................................16
         (d)      Amendments and Waivers................................................................16



                                        i


<PAGE>




                                                             Page 67 of 90 Pages

                                                                                                      Page
         (e)      Notices...............................................................................17
         (f)      Successors and Assigns; Third Party Beneficiaries.....................................18
         (g)      Counterparts..........................................................................18
         (h)      Headings..............................................................................19
         (i)      GOVERNING LAW.........................................................................19
         (j)      Severability..........................................................................19
         (k)      Entire Agreement......................................................................19
         (l)      Further Assurances....................................................................19



</TABLE>

                                       ii















<PAGE>




                                                             Page 68 of 90 Pages


               AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT


                  AMENDED AND  RESTATED  REGISTRATION  RIGHTS  AGREEMENT,  dated
March  29,  2000  (this  "Agreement"),   among  INTEGRA  LIFESCIENCES   HOLDINGS
CORPORATION, a Delaware corporation (the "Company"), QUANTUM INDUSTRIAL PARTNERS
LDC,  a Cayman  Islands  limited  duration  company  ("QIP"),  and SFM  DOMESTIC
INVESTMENTS  LLC, a Delaware  limited  liability  company ("SFM DI" and together
with QIP, the "Stockholders").

                  WHEREAS, in connection with the Series B Convertible Preferred
Stock and Warrant  Purchase  Agreement,  dated March 29, 1999, among the Company
and  the  Stockholders   (the  "Series  B  Agreement"),   the  Company  and  the
Stockholders entered into a Registration Rights Agreement,  dated March 29, 1999
(the  "Original  Agreement"),  granting the  Stockholders  certain  registration
rights; and

                  WHEREAS, in order to induce the Stockholders to enter into the
Series C  Convertible  Preferred  Stock and Warrant  Purchase  Agreement,  dated
February  16,  2000  (the  "Series C  Agreement"),  among  the  Company  and the
Stockholders,  pursuant to which the Company has agreed to issue and sell to the
Stockholders, and the Stockholders have agreed to purchase from the Company, (i)
an aggregate of 54,000 shares of Series C Convertible Preferred Stock, par value
$.01 per  share,  of the  Company  (the  Series C  Preferred  Stock"),  and (ii)
warrants  (the  "Warrants")  to  purchase,  subject to the terms and  conditions
thereof, an aggregate of 300,000 shares of Common Stock, the parties hereto have
agreed to amend and restate the Original Agreement as provided herein;

                  NOW,  THEREFORE,  in consideration of the mutual covenants and
agreements set forth herein and for good and valuable consideration, the receipt
and  adequacy  of which is hereby  acknowledged,  the  parties  hereto  agree as
follows:

                  1. Definitions.  As used in this Agreement the following terms
have the meanings indicated:

                  "Act" means the Securities Act of 1933, as amended.

                  "Affiliate"  shall mean any Person  who is an  "affiliate"  as
defined in Rule 12b-2 of the General  Rules and  Regulations  under the Exchange
Act, and any Person controlling, controlled by, or under common control with any
Stockholder. For the purposes of this Agreement,  "control" includes the ability
to have investment discretion through contractual means or by operation of law.


<PAGE>
                                                             Page 69 of 90 Pages

                  "Agreement" has the meaning set forth in the recitals to this
Agreement.

                  "Approved Underwriter" has the meaning assigned such term in
Section 3(e).

                  "Common  Stock"  means the  Common  Stock,  par value $.01 per
share,  of the Company or any other equity  securities of the Company into which
such securities are converted, reclassified, reconstituted or exchanged.

                  "Company" has the meaning set forth in the recitals to this
Agreement.

                  "Company Underwriter" has the meaning assigned such term in
Section 4(a).

                  "Demand Registration" has the meaning assigned such term in
Section 3(a).

                  "Designated  Holder" means each of the  Stockholders,  and any
transferee of any of them to whom  Registrable  Securities have been transferred
in accordance with the provisions of this Agreement,  other than a transferee to
whom such securities have been transferred pursuant to a registration  statement
under the Securities Act or Rule 144 or Regulation S under the Securities Act.

                  "Exchange Act" means the  Securities  Exchange Act of 1934, as
amended, and the rules and regulations promulgated thereunder.

                  "Existing Rightholders" means the stockholders of the Company,
if any, who have obtained registration rights pursuant to agreements existing on
the date hereof.

                  "Initiating Holders" has the meaning assigned such term in
Section 3(a).

                  "Inspector" has the meaning assigned such term in Section 6(a)
(viii).




<PAGE>
                                                             Page 70 of 90 Pages


                  "NASD"  has  the  meaning   assigned   such  term  in  Section
6(a)(xiv).

                  "Original Agreement" has the meaning assigned such term in the
recitals to this Agreement.

                  "Person" means any individual, firm, corporation, partnership,
trust,  incorporated or unincorporated  association,  joint venture, joint stock
company,  limited  liability  company,  government  (or an agency  or  political
subdivision  thereof)  or other  entity  of any  kind,  and  shall  include  any
successor (by merger or otherwise) of such entity.

                  "QIP" means Quantum Industrial Partners LDC.

                  "Records" has the meaning assigned such term in Section 6(a)
(viii).

                  "Registrable  Securities" means each of the following: (a) any
shares of Common Stock owned by the  Designated  Holders issued or issuable upon
conversion of shares of Series B Preferred Stock or shares of Series C Preferred
Stock, or upon exercise of the Series B Warrants or the Warrants, (b) any shares
of  Common  Stock  issued  or  issuable  by  the  Company  to  any or all of the
Designated  Holders  during  the time that any of such  Designated  Holders  are
holders of shares of Common Stock,  shares of Series B Preferred Stock or shares
of Series C Preferred  Stock,  (c) any other shares of Common Stock  acquired or
owned by any of the Designated Holders and (d) any shares of Common Stock issued
or issuable with respect to shares of Common Stock, shares of Series B Preferred
Stock and shares of Series C Preferred  Stock by way of stock  dividend or stock
split or in connection with a combination of shares,  recapitalization,  merger,
consolidation  or other  reorganization  or otherwise and shares of Common Stock
issuable upon conversion, exercise or exchange thereof.

                  "Registration Expenses" has the meaning set forth in Section
6(d).

                  "SEC" means the  Securities  and  Exchange  Commission  or any
similar agency then having jurisdiction to enforce the Securities Act.


<PAGE>


                                                             Page 71 of 90 Pages



                  "Securities Act" means the Securities Act of 1933, as amended,
and the rules and regulations promulgated thereunder.

                  "Series B Agreement" has the meaning set forth in the recitals
to this Agreement.

                  "Series B  Preferred  Stock"  means the  Series B  Convertible
Preferred Stock, par value $.01, of the Company.

                  "Series B Warrants"  means the warrant,  dated March 29, 1999,
issued by the  Company  to QIP to  purchase  180,000  shares  of  Common  Stock,
together with the warrant, dated March 29, 1999, issued by the Company to SFM DI
to purchase 60,000 shares of Common Stock.

                  "Series C Agreement" has the meaning assigned such term in the
recital to this Agreement.

                  "Series C Preferred  Stock" has the meaning assigned such term
in the recital to this Agreement.

                  "SFM DI" has the meaning set forth in the recitals to this
Agreement.

                  "Stockholders" means Quantum Industrial Partners LDC and
SFM Domestic Investments LLC.

                  "Warrants" has the meaning set forth in the recitals to this
Agreement.

                  2.       General; Securities Subject to this Agreement.

                           (a)      Grant of Rights.  The Company hereby grants
registration rights to the Stockholders upon the terms and conditions set forth
in this Agreement.

                           (b)      Registrable Securities.  For the purposes of
this  Agreement,  (i)  Registrable  Securities  will  cease  to  be  Registrable
Securities when a registration  statement  covering such Registrable  Securities
has  been  declared  effective  under  the  Securities  Act by the SEC and  such
Registrable  Securities  have  been  disposed  of  pursuant  to  such  effective

<PAGE>


                                                             Page 72 of 90 Pages


registration  statement and (ii) the securities of a Designated  Holder shall be
deemed  not to be  Registrable  Securities  at any  time  when  the  Company  is
registered  pursuant to Section 12 of the Exchange Act and the entire  amount of
such Designated Holder's Registrable  Securities proposed to be sold in a single
sale, in the opinion of counsel  satisfactory  to the Company and the Designated
Holder,  each in their  reasonable  judgment,  may be  distributed to the public
pursuant  to Rule 144 (or any  successor  provision  then in  effect)  under the
Securities Act.

                           (c)      Holders of Registrable Securities.  A Person
is deemed to be a holder of Registrable  Securities whenever such Person owns of
record  Registrable  Securities,  or holds an option to purchase,  or a security
convertible  into or exercisable or exchangeable  for,  Registrable  Securities,
whether or not such  acquisition  or  conversion  has actually been effected and
disregarding  any legal  restrictions  upon the exercise of such rights.  If the
Company receives conflicting instructions, notices or elections from two or more
Persons with  respect to the same  Registrable  Securities,  the Company may act
upon  the  basis of the  instructions,  notice  or  election  received  from the
registered owner of such Registrable Securities. Registrable Securities issuable
upon  exercise  of an option or upon  conversion  of another  security  shall be
deemed outstanding for the purposes of this Agreement.

                  3.       Demand Registration.

                           (a)      Request for Demand Registration. At any time

on or after the date  hereof,  the  holders of more than 50% of the  Registrable
Securities  outstanding  may  make a  written  request  for  registration  (such
Designated Holders making such request being deemed to be "Initiating  Holders")
of Registrable  Securities under the Securities Act, and under the securities or
"blue  sky" laws of a  reasonable  number of  jurisdictions  designated  by such
holder or holders (a "Demand Registration"); provided, however, that the Company
shall not be required to effect more than three Demand Registrations pursuant to
this Section 3. If at the time of any request to register Registrable Securities
pursuant to this Section 3(a),  the Company is engaged in, or has fixed plans to
engage in within  ninety  (90) days of the time of such  request,  a  registered
public  offering or is engaged in any other  activity  which,  in the good faith
determination of the Board of Directors of the Company,  would be required to be
disclosed under applicable law as a result of such request or would be adversely
affected  by the  requested  registration,  then the  Company  may at its option
direct  that such  request be delayed for a  reasonable  period not in excess of
three  (3)  months  from  the  effective  date of such  offering  or the date of

<PAGE>


                                                             Page 73 of 90 Pages



completion  of such other  activity,  as the case may be,  such right to delay a
request  to be  exercised  by the  Company  not more than  once in any  one-year
period.  In  addition,   the  Company  shall  not  be  required  to  effect  any
registration  within  three (3)  months  after the  effective  date of any other
Registration   Statement  of  the  Company.  Each  such  request  for  a  Demand
Registration by the Initiating Holders shall state the amount of the Registrable
Securities  proposed to be sold, the intended method of disposition  thereof and
the jurisdictions in which registration is desired.  Upon a request for a Demand
Registration,  the Company  shall  promptly  take such steps as are necessary or
appropriate to prepare for the registration of the Registrable  Securities to be
registered.

                           (b)      Effective Demand Registration.  The Company
shall use commercially  reasonable efforts to cause any such Demand Registration
to become  effective  not later than  forty-five  (45) days after it  receives a
request under Section 3(a) hereof and to remain  effective for the lesser of (i)
the period  during which all  Registrable  Securities  registered  in the Demand
Registration are sold and (ii) ninety (90) days; provided,  however, that if the
Initiating Holders request the Company to withdraw such  registration,  it shall
constitute a Demand  Registration unless the Initiating Holders promptly pay all
of the costs and  expenses  incurred  by the  Company  in  connection  with such
registration.

                           (c)      Expenses.  In any registration initiated as
a Demand  Registration,  the Company shall pay all Registration  Expenses (other
than  underwriting   discounts  and  commissions  and  brokerage   commissions),
including  the  reasonable  fees and  expenses  of one  counsel  selected by the
Designated  Holders  holding a  majority  of the  Registrable  Securities  being
registered in such  registration  ("Holders'  Counsel") in connection  therewith
(not to  exceed  $15,000),  whether  or not  such  Demand  Registration  becomes
effective.

                           (d)      Underwriting Procedures.  If the Initiating
Holders  holding a majority  of the  Registrable  Securities  held by all of the
Initiating Holders to which the requested Demand Registration  relates so elect,
the offering of such Registrable Securities pursuant to such Demand Registration
shall be in the form of a firm commitment underwritten offering and the managing
underwriter  or  underwriters  selected for such offering  shall be the Approved
Underwriter (as hereinafter  defined)  selected in accordance with Section 3(e).
In such event, if the Approved  Underwriter  advises the Company in writing that
in its opinion the aggregate amount of such Registrable  Securities requested to
be included in such offering is  sufficiently  large to have a material  adverse
effect on the success of such  offering,  subject to the rights of the  Existing
Rightholders,



<PAGE>

                                                             Page 74 of 90 Pages



the Company shall  include in such  registration  only the  aggregate  amount of
Registrable  Securities  that in the opinion of the Approved  Underwriter may be
sold without any such material adverse effect and shall reduce,  first as to the
Company and any stockholders who are not Designated  Holders as a group, if any,
and then as to the  Designated  Holders as a group,  pro rata  within each group
based on the number of Registrable Securities included in the request for Demand
Registration,  the  amount of  Registrable  Securities  to be  included  by each
Designated Holder in such registration.

                           (e)      Selection of Underwriters.   If  any  Demand
Registration  of  Registrable  Securities  is in  the  form  of an  underwritten
offering,   the  Initiating  Holders  holding  a  majority  of  the  Registrable
Securities  held by all such  Initiating  Holders  shall  select  and  obtain an
investment  banking  firm  of  national   reputation  to  act  as  the  managing
underwriter of the offering (the  "Approved  Underwriter");  provided,  however,
that the Approved  Underwriter  shall, in any case, be acceptable to the Company
in its reasonable judgment.

                  4.       Piggy-Back Registration.

                           (a)      Piggy-Back Rights.  If the Company proposes
to file a  registration  statement  under the  Securities Act with respect to an
offering by the Company for its own account or for the account of an  Initiating
Holder pursuant to Section 3 of any class of security (other than a registration
statement on Form S-4 or S-8 or any successor forms  thereto),  then the Company
shall give  written  notice of such  proposed  filing to each of the  Designated
Holders of Registrable  Securities (other than any Initiating Holders), and such
notice shall describe in detail the proposed  registration  and distribution and
shall offer such  Designated  Holders  (other than any  Initiating  Holders) the
opportunity to register the number of Registrable Securities as each such holder
may request.  The Company shall, and shall use commercially  reasonable  efforts
(within ten (10) days of the notice  provided for in the preceding  sentence) to
cause the  managing  underwriter  or  underwriters  of a  proposed  underwritten
offering  (the  "Company  Underwriter")  to,  permit the  Designated  Holders of
Registrable  Securities who have  requested in writing  (within ten (10) days of
the giving of the notice of the proposed  filing by the Company) to  participate
in the registration for such offering to include such Registrable  Securities in
such offering on the same terms and  conditions as the securities of the Company
included  therein.  In  connection  with any  offering  under this  Section 4(a)
involving  an  underwriting,  the  Company  shall not be required to include any
Registrable  Securities  in such  underwriting  unless (i) the  holders  thereof
accept the terms of the  underwriting



<PAGE>


                                                             Page 75 of 90 Pages



as agreed upon between the Company and the underwriters  selected by it, (ii) if
such  underwriting  has been  initiated  by the Company or  requested by another
party  that has  contractual  registration  rights,  all of the shares of Common
Stock held by the parties  making such request or entitled to include  shares of
Common  Stock  pursuant to the same rights as the  requesting  parties have been
included in such  registration  and (iii) all of the shares of Common Stock held
by Existing  Rightholders for which such registration has been requested by such
Existing Rightholders have been included in such registration,  and then only in
such quantity as will not, in the opinion of the  underwriters,  jeopardize  the
success  of the  offering  by the  Company.  If in the  opinion  of the  Company
Underwriter  the  registration  of all, or part, of the  Registrable  Securities
which the Designated  Holders have requested to be included would materially and
adversely  affect such public  offering,  then the Company  shall be required to
include in the underwriting only that number of Registrable Securities,  if any,
which the Company Underwriter  believes may be sold without causing such adverse
effect,  and the amount of securities to be offered in the underwriting shall be
allocated first, to the Company based on the number of shares it desires to sell
in the underwritten  offering for its own account; and thereafter pro rata among
the Initiating Holders and all other selling stockholders,  if any, based on the
number of shares  otherwise  proposed to be included  therein by the  Initiating
Holders  and such  other  selling  stockholders.  If the  number of  Registrable
Securities to be included in the  underwriting  in accordance with the foregoing
is less  than the  total  number  of shares  which  the  Designated  Holders  of
Registrable  Securities  have  requested  to be  included,  then the  Designated
Holders  of  Registrable   Securities  who  have  requested  registration  shall
participate in the underwriting pro rata based upon their total ownership of the
Registrable  Securities.  If any  Designated  Holder  would thus be  entitled to
include  more shares than such holder  requested  to be  registered,  the excess
shall be allocated among other requesting Designated Holders pro rata based upon
their total ownership of Registrable Securities.

                           (b)      Expenses.   The  Company  shall  bear  all
Registration  Expenses  (other than  underwriting  discounts and commissions and
brokerage  commissions),  including  the  reasonable  fees and  expenses  of the
Holders'  Counsel (not to exceed  $15,000),  in connection with any registration
pursuant to this Section 4.

                  5.       Holdback Agreements.

                           (a)      Restrictions on Public Sale by Designated
Holders.


<PAGE>

                                                             Page 76 of 90 Pages


Each Designated Holder of Registrable Securities agrees not to effect any public
sale or distribution of any Registrable  Securities  being  registered or of any
securities  convertible into or exchangeable or exercisable for such Registrable
Securities,  including  a sale  pursuant to Rule 144 under the  Securities  Act,
during  the ninety  (90) day  period  beginning  on the  effective  date of such
registration  statement  (except  as part of such  registration),  if and to the
extent  requested  by the  Company  in the  case  of a  non-underwritten  public
offering or if and to the extent  requested  by the Company  Underwriter  or the
Approved  Underwriter in the case of an underwritten public offering,  except to
the extent  that such  Designated  Holder is  prohibited  by  applicable  law or
exercise of fiduciary  duties from agreeing to withhold  Registrable  Securities
from sale or is acting in its capacity as a fiduciary or investment  adviser. If
requested by the Company  Underwriter,  each Designated  Holder will execute and
deliver a lock-up  agreement in a form  acceptable to such  Underwriter  and the
Company for purposes of its obligations  under this Section 5. Without  limiting
the scope of the term  "fiduciary,"  a  Designated  Holder shall be deemed to be
acting as a fiduciary or an investment adviser if its actions or the Registrable
Securities  proposed to be sold are subject to the  Employee  Retirement  Income
Security  Act of 1974,  as amended, or the  Investment  Company Act of 1940,  as
amended, or if such Registrable  Securities are held in a separate account under
applicable insurance law or regulation.

                           (b)      Restrictions on Public Sale by the Company.
The Company agrees not to effect any public sale or  distribution  of any of its
securities  for  its  own  account,  or  any  securities   convertible  into  or
exchangeable   or  exercisable   for  such   securities   (except   pursuant  to
registrations  on Form S-4 or S-8 or any successor  forms  thereto),  during the
period  beginning on the effective date of any Demand  Registration in which the
Designated Holders of Registrable Securities are participating and ending on the
earlier of (i) the date on which all shares of Common Stock  registered  on such
registration  statement  are sold and (ii) the date  thirty  (30) days after the
effective date of such registration statement.

                  6.       Registration Procedures.

                           (a)      Obligations   of   the   Company.   Whenever
registration of Registrable  Securities has been requested pursuant to Section 3
or 4 of this Agreement, the Company shall use commercially reasonable efforts to
effect the registration  and sale of such  Registrable  Securities in accordance
with the  intended  method of  distribution  thereof as promptly  as  reasonably
practicable,


<PAGE>


                                                             Page 77 of 90 Pages

and in  connection  with any such  request,  the Company  shall,  as promptly as
reasonably possible:

                                    (i)     use commercially reasonable  efforts
to prepare and file with the SEC a registration  statement on any form for which
the  Company  then  qualifies  or  which  counsel  for the  Company  shall  deem
appropriate  and which form shall be available for the sale of such  Registrable
Securities in accordance with the intended method of distribution  thereof,  and
use  commercially  reasonable  efforts to cause such  registration  statement to
become  effective;  provided,  however,  that (x) before  filing a  registration
statement or prospectus or any  amendments or supplements  thereto,  the Company
shall provide Holders' Counsel and any other Inspector (as hereinafter  defined)
with an adequate and  appropriate  opportunity to participate in the preparation
of such  registration  statement and each prospectus  included therein (and each
amendment or supplement thereto) to be filed with the SEC, which documents shall
be subject to the review of Holders'  Counsel,  and (y) the Company shall notify
the Holders' Counsel and each seller of Registrable Securities of any stop order
issued or  threatened  by the SEC and take all  reasonable  action  required  to
prevent the entry of such stop order or to remove it if entered;

                                    (ii)  prepare  and  file  with  the SEC such
amendments  and  supplements to such  registration  statement and the prospectus
used in  connection  therewith  as may be  necessary  to keep such  registration
statement  effective for the lesser of (x) ninety (90) days and (y) such shorter
period which will  terminate  when all  Registrable  Securities  covered by such
registration  statement  have been sold,  and comply with the  provisions of the
Securities Act with respect to the disposition of all securities covered by such
registration  statement  during  such  period in  accordance  with the  intended
methods of  disposition  by the sellers  thereof set forth in such  registration
statement;

                                    (iii)  as  soon  as   reasonably   possible,
furnish to each seller of Registrable Securities, prior to filing a registration
statement, copies of such registration statement as is proposed to be filed, and
thereafter such number of copies of such registration statement,  each amendment
and  supplement  thereto (in each case  including  all  exhibits  thereto),  the
prospectus included in such registration  statement  (including each preliminary
prospectus) and such other documents as each such seller may reasonably  request
in order to facilitate the  disposition of the Registrable  Securities  owned by
such seller;



<PAGE>


                                                             Page 78 of 90 Pages


                                    (iv) use its best  efforts  to  register  or
qualify such  Registrable  Securities  under such other securities or "blue sky"
laws  of  such  jurisdictions  as  any  seller  of  Registrable  Securities  may
reasonably  request,  and to  continue  such  qualification  in  effect  in such
jurisdiction  for  as  long  as  permissible   pursuant  to  the  laws  of  such
jurisdiction,  or for as long as any such  seller  requests or until all of such
Registrable Securities are sold, whichever is shortest, and do any and all other
acts and things  which may be  reasonably  necessary  or advisable to enable any
such  seller  to  consummate  the  disposition  in  such  jurisdictions  of  the
Registrable Securities owned by such seller; provided, however, that the Company
shall  not  be  required  to  (x)  qualify  generally  to  do  business  in  any
jurisdiction  where it would not  otherwise  be required to qualify but for this
Section 6(a)(iv), (y) subject itself to taxation in any such jurisdiction or (z)
consent to general service of process in any such jurisdiction;

                                    (v)     use  its  best efforts  to cause the
Registrable  Securities covered by such registration  statement to be registered
with or approved by such other  governmental  agencies or  authorities as may be
necessary by virtue of the business and  operations of the Company to enable the
seller or sellers of  Registrable  Securities to consummate  the  disposition of
such Registrable Securities;

                                    (vi)  notify  each  seller  of   Registrable
Securities,  at any time when a  prospectus  relating  thereto is required to be
delivered  under the Securities  Act, upon discovery that, or upon the happening
of any event as a result of which, the prospectus  included in such registration
statement  contains an untrue statement of a material fact or omits to state any
material fact required to be stated  therein or necessary to make the statements
therein not misleading in light of the circumstances under which they were made,
and the  Company  shall  promptly  prepare a  supplement  or  amendment  to such
prospectus  (except that the Company may avoid  supplementing  or amending  such
prospectus for up to 90 days when, in the good faith  determination of the Board
of Directors of the Company,  supplementing  or amending such  prospectus  would
require  disclosure under  applicable law of any material  activity in which the
Company is then  engaged,  the  disclosure of which would  adversely  affect the
Company)  and  furnish  to each  seller  a  reasonable  number  of  copies  of a
supplement  to or an amendment of such  prospectus  as may be necessary so that,
after delivery to the purchasers of such Registrable Securities, such prospectus
shall not contain an untrue  statement  of a material  fact or omit to state any
material fact required to be stated  therein or necessary to make the statements
therein not misleading


<PAGE>


                                                             Page 79 of 90 Pages


in light of the circumstances under which they were made;

                                    (vii)  enter  into  and  perform   customary
agreements  (including  an  underwriting  agreement in  customary  form with the
Approved  Underwriter or Company  Underwriter,  if any,  selected as provided in
Sections  3 or 4) and take such  other  actions as are  prudent  and  reasonably
required in order to expedite or facilitate the disposition of such  Registrable
Securities;

                                    (viii)  make available for inspection by any
seller of Registrable Securities,  any managing underwriter participating in any
disposition  pursuant to such registration  statement,  Holders' Counsel and any
attorney,  accountant or other agent retained by any such seller or any managing
underwriter  (each,  an "Inspector" and  collectively,  the  "Inspectors"),  all
financial and other records, pertinent corporate documents and properties of the
Company  and  its  subsidiaries  (collectively,   the  "Records")  as  shall  be
reasonably   necessary   to  enable  them  to  exercise   their  due   diligence
responsibility,   and  cause  the  Company's  and  its  subsidiaries'  officers,
directors and employees,  and the independent public accountants of the Company,
to  supply  all  information  reasonably  requested  by any  such  Inspector  in
connection  with  such   registration   statement.   Records  that  the  Company
determines,  in good  faith,  to be  confidential  and  which  it  notifies  the
Inspectors are confidential  shall not be disclosed by the Inspectors unless (x)
the  disclosure of such Records is necessary to avoid or correct a  misstatement
or omission in the  registration  statement,  (y) the release of such Records is
ordered  pursuant  to a  subpoena  or  other  order  from a court  of  competent
jurisdiction  or is requested by any  regulatory  body  (including  the National
Association of Insurance  Commissioners) or (z) the information in  such Records
was known to the Inspectors on a non-confidential  basis prior to its disclosure
by the Company or has been made generally  available to the public.  Each seller
of Registrable Securities agrees that it shall, upon learning that disclosure of
such Records is sought in a court of competent jurisdiction,  give notice to the
Company and allow the Company,  at the  Company's  expense,  to undertake appro-
priate action to prevent disclosure of the Records deemed confidential;

                                    (ix)    if  such  sale  is  pursuant  to  an
underwritten  offering,  use its best efforts to obtain a "cold comfort"  letter
from the Company's independent public accountants in customary form and covering
such  matters  of the type  customarily  covered  by "cold  comfort"  letters as
Holders'  Counsel or the  managing  underwriter  reasonably  request;  provided,
however, that the Company shall not be required to obtain such a letter from its
former independent public accountants;


<PAGE>


                                                             Page 80 of 90 Pages


                                    (x)     use its best efforts to furnish, at
the request of any seller of Registrable  Securities on the date such securities
are delivered to the underwriters for sale pursuant to such  registration or, if
such  securities  are not  being  sold  through  underwriters,  on the  date the
registration  statement with respect to such securities  becomes  effective,  an
opinion,  dated such date, of counsel  representing the Company for the purposes
of such registration,  addressed to the underwriters,  if any, and to the seller
making  such   request,   covering  such  legal  matters  with  respect  to  the
registration  in respect of which such opinion is being given as such seller may
reasonably request and are customarily included in such opinions;

                                    (xi)  otherwise  use  its  best  efforts  to
comply with all applicable  rules and regulations of the SEC, and make available
to its security  holders,  as soon as reasonably  practicable  but no later than
fifteen (15) months after the effective date of the registration  statement,  an
earnings  statement  covering a period of twelve (12) months beginning after the
effective date of the  registration  statement,  in a manner which satisfies the
provisions of Section 11(a) of the Securities Act and Rule 158 thereunder;

                                    (xii) cause all such Registrable  Securities
to be listed on each securities  exchange on which similar  securities issued by
the Company are then listed,  provided, that the applicable listing requirements
are satisfied;

                                    (xiii)  keep  Holders'  Counsel  advised  in
writing as to the initiation of any registration  under Section 3 or 4 hereunder
and provide  Holders'  Counsel with copies of any SEC filings made in connection
therewith;

                                    (xiv)   cooperate   with   each   seller  of
Registrable Securities and each underwriter  participating in the disposition of
such Registrable  Securities and their respective counsel in connection with any
filings required to be made with the National Association of Securities Dealers,
Inc. (the "NASD"); and

                                    (xv)    use commercially reasonable  efforts
to take all other steps necessary to effect the  registration of the Registrable
Securities contemplated hereby.



<PAGE>



                                                             Page 81 of 90 Pages

                           (b)      Obligations  of  Each  Designated  Holder of
Registrable  Securities.  Following  the  filing  of  a  registration  statement
registering  the Eligible  Securities  of any  Designated  Holder and during any
period that the registration statement is effective, each such Designated Holder
shall:

                                 (i)   not effect any stabilization transactions
or engage in any stabilization activity in connection with any securities of the
Company in  contravention  of Regulation M under the Securities  Exchange Act of
1934, as amended (the "Exchange Act");

                                 (ii)  furnish  each  broker  or dealer  through
whom such Designated Holder offers Eligible  Securities such number of copies of
the  prospectus  as the  broker  may  require  and  otherwise  comply  with  the
prospectus delivery requirements under the Securities Act;

                                 (iii) report  to  the  Company  each  month all
sales and other  dispositions  of Eligible  Securities  made by such  Designated
Holder during said month;

                                 (iv)  not, and shall  not permit any Affiliated
Purchaser  (as that term is defined in  Regulation M under the Exchange Act) to,
bid for or  purchase  for any  account  in which  such  Designated  Holder has a
beneficial  interest,  or attempt to induce any other  person to  purchase,  any
securities  of the Company in  contravention  of Regulation M under the Exchange
Act;

                                 (v)   not offer or agree  to  pay, directly  or
indirectly,  to anyone any compensation for soliciting  another to purchase,  or
for  purchasing  (other than for such  Designated  Holder's  own  account),  any
securities of the Company on a national  securities exchange in contravention of
Regulation M under the Exchange Act;

                                 (vi)  cooperate in all reasonable respects with
the Company as it fulfills its obligations under this Agreement;

                                 (vii) furnish such information  concerning such
Designated Holder and the distribution of the Eligible Securities as the Company
may from time to time request to the extent required by federal securities laws;
and

                                 (viii)  sell  Eligible  Securities  only in the


<PAGE>


                                                             Page 82 of 90 Pages


manner  described in the  Registration  Statement  or as otherwise  permitted by
federal securities laws.

                           (c)     Notice to Discontinue. Each Designated Holder
of  Registrable  Securities  agrees  that,  upon  receipt of any notice from the
Company of the happening of any event of the kind described in Section 6(a)(vi),
such Designated  Holder shall forthwith  discontinue  disposition of Registrable
Securities  pursuant to the  registration  statement  covering such  Registrable
Securities  until  such  Designated  Holder's  receipt  of  the  copies  of  the
supplemented or  amended  prospectus  contemplated by Section  6(a)(vi).  If the
Company  shall give any such notice,  the Company shall extend the period during
which such registration statement shall be maintained effective pursuant to this
Agreement  (including,  without  limitation,  the period  referred to in Section
6(a)(ii)) by the number of days during the period from and including the date of
the giving of such notice pursuant to Section 6(a)(vi) to and including the date
when the Designated Holder shall have received the copies of the supplemented or
amended  prospectus  contemplated  by and  meeting the  requirements  of Section
6(a)(vi).

                           (d)      Registration Expenses. The Company shall pay
all expenses (other than as set forth in Sections 3(c) and 4(b)) arising from or
incident to the performance of, or compliance  with, this Agreement,  including,
without limitation, (i) SEC,  stock  exchange and NASD  registration  and filing
fees, (ii) all fees and expenses  incurred in complying with securities or "blue
sky" laws (including  reasonable  fees,  charges and  disbursements  of Holders'
Counsel  in  connection  with  "blue  sky"  qualifications  of  the  Registrable
Securities), (iii) all printing, messenger and delivery expenses, (iv) the fees,
charges  and  disbursements  of counsel to the  Company  and of its  independent
public accountants and any other accounting and legal fees, charges and expenses
incurred by the Company  (including,  without  limitation,  any expenses arising
from  any  special  audits  incident  to or  required  by  any  registration  or
qualification)  and (v) any liability  insurance or other premiums for insurance
obtained in connection with any Demand  Registration or piggy-back  registration
pursuant to the terms of this Agreement, regardless of whether such registration
statement is declared effective; provided, however, that, in connection with the
registration or qualification of the Eligible  Securities under state securities
laws, nothing herein shall be deemed to require the Company to make any payments
to third  parties in order to obtain  "lock-up,"  escrow or other  extraordinary
agreements.  All of the  expenses  described  in this  Section 6 are referred to
herein as "Registration Expenses."




<PAGE>


                                                             Page 83 of 90 Pages


                  7.       Indemnification; Contribution.

                           (a)      Indemnification by the Company.  The Company
agrees to indemnify and hold harmless,  to the fullest extent  permitted by law,
each Designated Holder, its officers, directors,  trustees, partners, employees,
advisors  and agents and each  Person who  controls  (within  the meaning of the
Securities Act or the Exchange Act) such Designated  Holder from and against any
and all losses, claims, damages,  liabilities and expenses (including reasonable
costs of  investigation)  caused by any  untrue  statement  of a  material  fact
contained in any registration statement,  prospectus or notification or offering
circular (as amended or  supplemented  if the Company  shall have  furnished any
amendments or supplements thereto) or caused by any omission or alleged omission
to state therein a material  fact required to be stated  therein or necessary to
make  the  statements  therein  (in the  case of a  prospectus,  in light of the
circumstances under which they were made) not misleading,  except insofar as the
same are caused by or contained in any  information  concerning  such Designated
Holder  furnished in writing to the Company by such Designated  Holder expressly
for use therein or caused by such Designated  Holder's failure to deliver a copy
of the prospectus or any amendments or  supplements  thereto in accordance  with
the  requirements  of the  Securities  Act after the Company has furnished  such
Designated  Holder  with a copy of the same.  The  Company  shall  also  provide
customary indemnities to any underwriters of the Registrable  Securities,  their
officers, directors and employees and each Person who controls such underwriters
(within  the meaning of the  Securities  Act and the  Exchange  Act) to the same
extent as provided above with respect to the  indemnification  of the Designated
Holders of Registrable Securities.

                           (b)      Indemnification  by  Designated Holders.  In
connection  with any  registration  statement  in which a  Designated  Holder is
participating  pursuant to Section 3 or 4 hereof,  each such  Designated  Holder
shall  furnish to the Company in writing such  information  with respect to such
Designated Holder as the Company may reasonably request or as may be required by
law for use in connection with any such registration statement or prospectus and
each  Designated  Holder agrees to indemnify and hold  harmless,  to the fullest
extent  permitted by law, the Company,  any underwriter  retained by the Company
and their respective directors, officers, employees and each Person who controls
the Company or such  underwriter  (within the meaning of the  Securities Act and
the Exchange Act) to the same extent as the foregoing indemnity from the Company
to the Designated Holders, but only with respect to any such information with


<PAGE>



                                                             Page 84 of 90 Pages


respect to such  Designated  Holder  furnished in writing to the Company by such
Designated Holder expressly for use therein,  or with respect to such Designated
Holder's  failure  to  deliver a copy of the  prospectus  or any  amendments  or
supplements  thereto in accordance  with the  requirements of the Securities Act
after the Company has furnished such Designated  Holder with a copy of the same;
provided,  however,  that the total amount to be indemnified by such  Designated
Holder  pursuant  to this  Section  7(b) shall be  limited  to the net  proceeds
received by such  Designated  Holder in the  offering to which the  registration
statement or prospectus relates.

                           (c)      Conduct of Indemnification Proceedings.  Any
Person entitled to indemnification hereunder (the "Indemnified Party") agrees to
give prompt written notice to the indemnifying party (the "Indemnifying  Party")
after  the  receipt  by the  Indemnified  Party  of any  written  notice  of the
commencement of any action, suit,  proceeding or investigation or threat thereof
made in writing for which the Indemnified Party intends to claim indemnification
or contribution pursuant to this Agreement;  provided, however, that the failure
so to notify the Indemnifying  Party shall not relieve the Indemnifying Party of
any liability that it may have to the Indemnified  Party hereunder except to the
extent that the delay or failure to give such notice  materially  prejudices the
ability  of  the  Indemnifying  Party  to  defend  such  action.  If  notice  of
commencement  of any such  action  is given to the  Indemnifying  Party as above
provided, the Indemnifying Party shall be entitled to participate in and, to the
extent  it may  wish,  jointly  with  any  other  Indemnifying  Party  similarly
notified,  to assume the defense of such action at its own expense, with counsel
chosen by it and satisfactory to such Indemnified  Party. The Indemnified  Party
shall  have  the  right to  employ  separate  counsel  in any  such  action  and
participate  in the defense  thereof,  but the fees and expenses of such counsel
shall be paid by the Indemnified Party unless (i) the Indemnifying  Party agrees
to pay the same, (ii) the Indemnifying Party fails to assume the defense of such
action with counsel  satisfactory  to the  Indemnified  Party in its  reasonable
judgment or (iii) the named parties to any such action  (including any impleaded
parties)  have  been  advised  by  such  counsel  that  representation  of  such
Indemnified  Party  and the  Indemnifying  Party  by the same  counsel  would be
inappropriate under applicable standards of professional  conduct, in which case
the  Indemnifying  Party  shall not have the right to assume the defense of such
action on behalf of such  Indemnified  Party.  No  Indemnifying  Party  shall be
liable for any  settlement  entered  into  without  its written  consent,  which
consent shall not be unreasonably withheld.

                           (d)     Contribution. If the indemnification provided


<PAGE>


                                                             Page 85 of 90 Pages


for  in  this  Section  7 from  the  Indemnifying  Party  is  unavailable  to an
Indemnified  Party  hereunder  in  respect  of  any  losses,  claims,   damages,
liabilities or expenses  referred to therein,  then the  Indemnifying  Party, in
lieu of indemnifying such Indemnified Party, shall contribute to the amount paid
or  payable  by such  Indemnified  Party as a  result  of such  losses,  claims,
damages, liabilities or expenses in such proportion as is appropriate to reflect
the relative fault of the Indemnifying Party and Indemnified Party in connection
with the actions which resulted in such losses, claims, damages,  liabilities or
expenses, as well as any other relevant equitable  considerations.  The relative
faults of such  Indemnifying  Party and Indemnified Party shall be determined by
reference to, among other things, whether any action in question,  including any
untrue or alleged  untrue  statement  of a material  fact or omission or alleged
omission to state a material  fact,  has been made by, or relates to information
supplied by, such  Indemnifying  Party or  Indemnified  Party,  and the parties'
relative intent, knowledge,  access to information and opportunity to correct or
prevent  such  action.  The amount paid or payable by a party as a result of the
losses,  claims,  damages,  liabilities and expenses  referred to above shall be
deemed to include,  subject to the  limitations set forth in Sections 7(a), 7(b)
and 7(c), any  reasonable  legal or other fees,  charges or expenses  reasonably
incurred  by such party in  connection  with any  investigation  or  proceeding;
provided that the total amount to be indemnified by such Designated Holder shall
be  limited  to the net  proceeds  received  by such  Designated  Holder  in the
offering.

                  The  parties  hereto  agree  that it  would  not be  just  and
equitable if  contribution  pursuant to this Section 7(d) were determined by pro
rata allocation or by any other method of allocation which does not take account
of  the  equitable  considerations  referred  to in  the  immediately  preceding
paragraph. No person guilty of fraudulent  misrepresentation (within the meaning
of Section 11(f) of the Securities Act) shall be entitled to  contribution  from
any person.

                  8. Rule 144.

                  The Company  covenants that it shall file any reports required
to be filed by it under the  Exchange  Act;  and that it shall take such further
action  as each  Designated  Holder of  Registrable  Securities  may  reasonably
request (including providing any information  necessary to comply with Rules 144
and 144A under the Securities Act), all to the extent required from time to time
to  enable  such  Designated  Holder  to  sell  Registrable  Securities  without
registration  under the  Securities  Act within the limitation of the exemptions
provided by (a) Rule 144 under the Securities  Act, as such rules may be amended



<PAGE>



                                                             Page 86 of 90 Pages



from time to time, or (b) any similar rules or regulations  hereafter adopted by
the SEC.  The  Company  shall,  upon the  request  of any  Designated  Holder of
Registrable Securities, deliver to such Designated Holder a written statement as
to whether it has complied with such requirements.

                  9.       Miscellaneous.

                           (a)      Recapitalizations,  Exchanges,  etc.   The
provisions of this Agreement  shall apply,  to the full extent set forth herein,
with  respect to (i) the  shares of Common  Stock and (ii) to any and all equity
securities of  the Company or any successor or assign of the Company (whether by
merger,  consolidation,  sale of  assets  or  otherwise)  which may be issued in
respect of, in conversion of, in exchange for or in substitution  of, the shares
of Common Stock and shall be  appropriately  adjusted  for any stock  dividends,
splits, reverse splits,  combinations,  recapitalizations and the like occurring
after the date hereof.

                           (b)      No  Inconsistent  Agreements.  The  Company
shall not enter  into any  agreement  with  respect  to its  securities  that is
inconsistent with the rights granted to the Designated Holders in this Agreement
or grant any additional registration rights to any Person or with respect to any
securities  which are not Registrable  Securities which are prior in right to or
inconsistent with the rights granted in this Agreement.

                           (c)      Remedies. The Designated Holders,in addition
to being entitled to exercise all rights granted by law,  including  recovery of
damages,  shall be entitled to specific  performance  of their rights under this
Agreement.  The  Company  agrees  that  monetary  damages  would not be adequate
compensation for any loss incurred by reason of a breach by it of the provisions
of this  Agreement  and  hereby  agrees  to waive  in any  action  for  specific
performance the defense that a remedy at law would be adequate.

                           (d)      Amendments and Waivers.  Except as otherwise
provided herein,  the provisions of this Agreement may not be amended,  modified
or  supplemented,  and  waivers or consents to  departures  from the  provisions
hereof may not be given  unless  consented  to in writing by all of the  parties
hereto.

                           (e)      Notices.  All  notices,  demands  and  other
communications  provided for or permitted hereunder shall be made in writing and
shall be made by  registered  or  certified  first-class  mail,  return  receipt





<PAGE>



                                                             Page 87 of 90 Pages


requested, telecopier, overnight courier service or personal delivery:

                          (i) if to QIP:

                              Quantum Industrial Partners LDC
                              Kaya Flamboyan 9,
                              Villemstad
                              Curacao
                              Netherlands-Antilles

                              with a copy to:

                              Soros Fund Management LLC
                              888 Seventh Avenue
                              New York, NY 10106
                              Telecopy: (212) 664-0544
                              Attn: Michael Neus, Esq.

                              and a copy to:

                              Paul, Weiss, Rifkind, Wharton & Garrison
                              1285 Avenue of the Americas
                              New York, New York 10019-6064
                              Telecopy: (212) 757-3990
                              Attention: Richard S. Borisoff, Esq.

                              (ii) If to SFM DI:

                              Soros Fund Management LLC
                              888 Seventh Avenue
                              New York, NY 10106
                              Telecopy: (212) 664-0544
                              Attn: Michael Neus, Esq.

                              with a copy to:

                              Paul, Weiss, Rifkind, Wharton & Garrison
                              1285 Avenue of the Americas
                              New York, New York 10019-6064
                              Telecopy: (212) 757-3990
                              Attention: Richard S. Borisoff, Esq.




<PAGE>


                                                             Page 88 of 90 Pages

                        (iii) if to the Company:

                              Integra LifeSciences Holdings Corporation
                              105 Morgan Lane
                              Plainsboro, NJ 08536
                              Telecopy: (609) 799-3297
                              Attention: Stuart M. Essig,
                              President and CEO

                              with a copy to:

                              Drinker Biddle & Shanley LLP
                              105 College Road East
                              Princeton, NJ 08542-0627
                              Telecopy: (609) 799-7000
                              Attention: John E. Stoddard III, Esq.



                        (iv)  if to any other Designated  Holder, at its address
                              as it appears on the transfer books of the Company

                  All such  notices and  communications  shall be deemed to have
been duly given when delivered by hand, if personally delivered;  when delivered
by courier,  if delivered by commercial courier service;  five (5) Business Days
after being deposited in the mail, postage prepaid,  if mailed; and when receipt
is acknowledged, if telecopied.

                          (f) Successors and Assigns; Third Party Beneficiaries.
This Agreement  shall inure to the benefit of and be binding upon the successors
and assigns of each of the parties hereto. The registration rights and the other
rights of the  Designated  Holders  contained in this  Agreement  shall be, with
respect to any Registrable Security,  (i) automatically  transferred from QIP or
SFM DI,  as the case may be,  to any  Affiliate  thereof,  and (ii) in all other
cases,  transferred  by the  Designated  Holders  only with the  consent  of the
Company.  All of the obligations of the Company hereunder shall survive any such
transfer.  No Person  other than the  parties  hereto and their  successors  and
permitted  assigns is intended to be  a beneficiary of any of the rights granted
hereunder.


<PAGE>


                                                             Page 89 of 90 Pages


                           (g)      Counterparts. This Agreement may be executed
in  any  number  of   counterparts   and  by  the  parties  hereto  in  separate
counterparts,  each of which when so executed  shall be deemed to be an original
and all of which taken together shall constitute one and the same agreement.

                           (h)      Headings. The headings in this Agreement are
for  convenience of reference  only and shall not limit or otherwise  affect the
meaning hereof.

                           (i)      GOVERNING  LAW.  THIS  AGREEMENT   SHALL  BE
GOVERNED  BY AND  CONSTRUED  IN  ACCORDANCE  WITH THE  LAWS OF THE  STATE OF NEW
JERSEY, WITHOUT REGARD TO THE PRINCIPLES OF CONFLICTS OF LAW THEREOF.

                           (j)      Severability.  If  any  one or  more  of the
provisions contained herein, or the application thereof in any circumstances, is
held  invalid,  illegal or  unenforceable  in any respect  for any  reason,  the
validity,  legality  and  enforceability  of any such  provision  in every other
respect and of the remaining provisions hereof shall not be in any way impaired,
it being  intended  that all of the  rights  and  privileges  of the  Designated
Holders shall be enforceable to the fullest extent permitted by law.

                           (k)      Entire Agreement. This Agreement is intended
by the parties as a final  expression  of their  agreement  and intended to be a
complete and  exclusive  statement of the  agreement  and  understanding  of the
parties hereto in respect of the subject matter contained  herein.  There are no
restrictions,  promises, warranties or undertakings,  other than those set forth
or referred to herein and in the Series B Agreement  and the Series C Agreement.
This Agreement  supersedes all prior agreements and  understandings  between the
parties with respect to such subject matter, including the Original Agreement.

                           (l)     Further Assurances. Each of the parties shall
execute  such  documents  and perform  such  further  acts as may be  reasonably
required  or  desirable  to  carry  out or to  perform  the  provisions  of this
Agreement.






<PAGE>

                                                             Page 90 of 90 Pages


                  IN WITNESS  WHEREOF,  the undersigned  have executed,  or have
caused to be executed, this Agreement on the date first written above.


                                            INTEGRA LIFESCIENCES HOLDINGS
                                            CORPORATION



                                            By:
                                                  ------------------------------
                                                  Name:      Stuart M. Essig
                                                  Title:     President and Chief
                                                             Executive Officer


                                            QUANTUM INDUSTRIAL PARTNERS LDC



                                            By:
                                                  ------------------------------

                                                  Name:
                                                  Title:


                                            SFM DOMESTIC INVESTMENTS LLC



                                            By:
                                                 -------------------------------

                                                  Name:
                                                  Title:







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