SUPERGEN INC
S-8, 1999-09-17
PHARMACEUTICAL PREPARATIONS
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<PAGE>


  As filed with the Securities and Exchange Commission on September 17, 1999
                                                  Registration No. 333-
- -------------------------------------------------------------------------------
- -------------------------------------------------------------------------------

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                             ----------------------

                                    FORM S-8
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933
                                 SUPERGEN, INC.
             (Exact name of Registrant as specified in its charter)

              DELAWARE                                     91-1841574
  (State or other jurisdiction of                        (I.R.S. Employer
   incorporation or organization)                     Identification Number)

                           TWO ANNABEL LANE, SUITE 220
                               SAN RAMON, CA 94583
                    (Address of principal executive offices)

                             ----------------------

                             1993 STOCK OPTION PLAN

                             ----------------------

                             JOSEPH RUBINFELD, PH.D.
                             CHIEF EXECUTIVE OFFICER
                                 SUPERGEN, INC.
                           TWO ANNABEL LANE, SUITE 220
                           SAN RAMON, CALIFORNIA 94583
                                 (925) 327-0200
            (Name, address and telephone number of agent for service)

                             ----------------------

                                    COPY TO:
                               JOHN V. ROOS, ESQ.
                     WILSON SONSINI GOODRICH & ROSATI, P.C.
                               650 PAGE MILL ROAD
                           PALO ALTO, CALIFORNIA 94304

                             ----------------------

<TABLE>
<CAPTION>
- -----------------------------------------------------------------------------------------------------------------------------------
- -----------------------------------------------------------------------------------------------------------------------------------
                         CALCULATION OF REGISTRATION FEE
- -----------------------------------------------------------------------------------------------------------------------------------
- -----------------------------------------------------------------------------------------------------------------------------------
<S>                                    <C>                <C>                <C>                  <C>
                                                          Proposed Maximum     Proposed Maximum       Amount of
                                        Amount to be       Offering Price          Aggregate        Registration
Title of Securities to be Registered   Registered (1)       Per Share (2)     Offering Price (2)         Fee
- ------------------------------------   -------------      ----------------   -------------------- ----------------

Common Stock, $.001 par value            600,000            $    15.09           $9,053,472.15        $ 2,516.87
</TABLE>
- ----------
(1)  Pursuant to Rule 429 of the Securities Act of 1933, as amended (the
     "Securities Act"), the prospectus delivered to participants under the
     Registrant's 1993 Stock Option Plan, as amended (the "1993 Plan"), also
     relates to an aggregate of 3,250,000 shares previously registered under
     Form S-8 Registration Nos. 333-07295 and 333-58303.
(2)  The Proposed Maximum Offering Price Per Share was estimated in part
     pursuant to Rule 457(h) under the Securities Act, and, in part, pursuant to
     Rule 457(c) under the Securities Act. With respect to (i) 437,662 shares
     which are subject to outstanding options to purchase Common Stock under the
     1993 Plan, the Proposed Maximum Offering Price Per Share was estimated
     pursuant to Rule 457(h) under which Rule the per share price of options to
     purchase stock under an employee stock option plan may be estimated by
     reference to the exercise price of such options. The weighted average
     exercise price of the 437,662 subject to outstanding options under the 1993
     Plan to be registered is $12.433. With respect to 162,338 shares of Common
     Stock available for future grant under the 1993 Plan, the Proposed Maximum
     Offering Price Per Share was estimated pursuant to Rule 457(c) whereby the
     per share price was determined by reference to the average between the high
     and low price reported in the Nasdaq National Market on September 14, 1999,
     which average was $22.25. The number referenced above in the table entitled
     "Proposed Maximum Offering Price per Share" represents a weighted average
     of the foregoing estimates calculated in accordance with Rules 457(h) and
     457(c).

- -------------------------------------------------------------------------------
- -------------------------------------------------------------------------------


<PAGE>


                                  PART II

            INFORMATION REQUIRED IN THE REGISTRATION STATEMENT


ITEM 3.  INCORPORATION OF DOCUMENTS BY REFERENCE

         SuperGen, Inc. (the "Company") hereby incorporates by reference in
this registration statement the following documents:

         (a)    The Company's Annual Report on Form 10-K for the fiscal year
ended December 31, 1998, pursuant to Section 13 of the Securities Exchange
Act of 1934, as amended (the "Exchange Act"), and Form 10-K/A filed with the
Securities and Exchange Commission (the "Commission") on May 14, 1999.

         (b)    The Company's Quarterly Reports on Form 10-Q for the fiscal
quarters ended March 31, 1999 and June 30, 1999, filed pursuant to Section 13
of the Exchange Act.

         (c)    All other reports filed pursuant to Section 13(a) or 15(d) of
the Exchange Act since the end of the fiscal year covered by the registrant
document referred to in (a) above.

         (d)    The description of the Company's Common Stock to be offered
hereby is contained in the Company's Registration Statement on Form 8-A filed
with the Commission on January 18, 1996 pursuant to Section 12(g) of the
Exchange Act, including any amendment or report filed for the purpose of
updating such description.

         All documents subsequently filed by the Company pursuant to Sections
13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a
post-effective amendment to this registration statement which indicates that
all securities offered hereby have been sold or which deregisters all
securities remaining unsold, shall be deemed to be incorporated by reference
in this registration statement and to be a part hereof from the date of
filing of such documents.

ITEM 4.  DESCRIPTION OF SECURITIES

         Not applicable.

ITEM 5.  INTERESTS OF NAMED EXPERTS AND COUNSEL

         Not applicable.

ITEM 6.  INDEMNIFICATION OF DIRECTORS AND OFFICERS

         The Company has adopted provisions in its current Certificate of
Incorporation which (i) eliminate the personal liability of its directors to
the Company for monetary damages to the fullest extent permissible under
Delaware law; and (ii) authorize the company to indemnify its directors and
officers to the fullest extent permitted by law. Such limitation of liability
does not affect the availability of equitable remedies, such as injunctive
relief or rescission. The Company's Certificate of Incorporation also
includes a provision


                                      II-1
<PAGE>


eliminating, to the fullest extent permitted by Delaware law, the personal
liability of its directors for monetary damages for breach of fiduciary duty
as a director. In addition, the Bylaws of the Company provide that it will be
required to indemnify its officers and directors to the maximum extent and in
the manner permitted by the Delaware General Corporation Law.

         The Company has entered into separate indemnification agreements
with each of its officers, directors and key employees that contain
provisions which are in some respects broader than the specific
indemnification provisions contained in the Delaware General Corporation Law.
The indemnification agreements may require the Company, among other things,
to indemnify such officers and directors against certain liabilities that may
arise by reason of their status or service as directors or officers (other
than liabilities arising from willful misconduct of a culpable nature), to
advance their expenses incurred as a result of any proceeding against them,
as to which they could be indemnified, and to obtain director's and officer's
insurance, if available on reasonable terms. Insofar as indemnification for
liabilities arising under the Securities Act of 1933, as amended (the
"Securities Act"), may be permitted to directors, officers and controlling
persons of the Registrant pursuant to the foregoing provisions, or otherwise,
the Registrant has been advised that in the opinion of the Commission such
indemnification is against public policy as expressed in the Securities Act
and is, therefore, unenforceable.

         At present, the Company is not aware of any pending litigation
involving a director, officer, employee or agent of the Company where
indemnification will be required or permitted. The Company is not aware of
any threatened litigation or proceeding which may result in a claim for such
indemnification.

ITEM 7.  EXEMPTION FROM REGISTRATION CLAIMED

         Not applicable.

ITEM 8.  EXHIBITS

         4.1    1993 Stock Option Plan, as amended.

         4.2*   Form of Stock Option Agreement for use under the 1993 Stock
                Option Plan.

         5.1    Opinion of Wilson Sonsini Goodrich & Rosati, P.C., as to the
                legality of securities being registered.

         23.1   Consent of Ernst & Young LLP

         23.2   Consent of Arthur Andersen LLP

         23.3   Consent of Ernst & Young LLP

         23.4   Consent of Counsel (contained in Exhibit 5.1).

         24.1   Power of Attorney (see Page II-5).

- ---------


                                      II-2
<PAGE>


* Incorporated by reference to the exhibit filed with the Company's Quarterly
  Report on Form 10-Q filed with the Securities and Exchange Commission on
  August 13, 1997.

ITEM 9.  UNDERTAKINGS

         (a)    RULE 415 OFFERING  The undersigned registrant hereby undertakes:

                (1) To file, during any period in which offers or sales are
being made, a post-effective amendment to this registration statement to
include any material information with respect to the plan of distribution not
previously disclosed in the registration statement or any material change to
such information in the registration statement.

                (2) That, for the purpose of determining any liability under
the Securities Act, each such post-effective amendment shall be deemed to be
a new registration statement relating to the securities offered therein, and
the offering of such securities at that time shall be deemed to be the
initial bona fide offering thereof.

                (3) To remove from registration by means of a post-effective
amendment any of the securities being registered which remain unsold at the
termination of the offering.

         (b)    FILING INCORPORATING SUBSEQUENT EXCHANGE ACT DOCUMENTS BY
                REFERENCE

         The undersigned registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act, each filing of the
registrant's annual report pursuant to section 13(a) or section 15(d) of the
Exchange Act (and, where applicable, each filing of an employee benefit
plan's annual report pursuant to section 15(d) of the Exchange Act) that is
incorporated by reference in the registration statement shall be deemed to be
a new registration statement relating to the securities offered therein, and
the offering of such securities at that time shall be deemed to be the
initial bona fide offering thereof.

         (h)    REQUEST FOR ACCELERATION OF EFFECTIVE DATE OR FILING OF
                REGISTRATION STATEMENT ON FORM S-8

         Insofar as indemnification for liabilities arising under the
Securities Act may be permitted to directors, officers and controlling
persons of the registrant pursuant to the foregoing provisions, or otherwise,
the registrant has been advised that in the opinion of the Securities and
Exchange Commission such indemnification is against public policy as
expressed in the Act and is, therefore, unenforceable. In the event that a
claim for indemnification against such liabilities (other than the payment by
the registrant of expenses incurred or paid by a director, officer or
controlling person of the registrant in the successful defense of any action,
suit or proceeding) is asserted by such director, officer or controlling
person in connection with the securities being registered, the registrant
will, unless in the opinion of its counsel the matter has been settled by
controlling precedent, submit to a court of appropriate jurisdiction the
question whether such indemnification by it is against public policy as
expressed in the Act and will be governed by the final adjudication of such
issue.


                                      II-3
<PAGE>


                                  SIGNATURES

         Pursuant to the requirements of the Securities Act of 1933, the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this registration
statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of San Ramon, State of California, on September 17,
1999.

                       SUPERGEN, INC.

                       By: /S/ JOSEPH RUBINFELD
                           -----------------------------------------------
                           Joseph Rubinfeld, Ph.D.
                           Chief Executive Officer, President and Director


                                      II-4
<PAGE>


                             POWER OF ATTORNEY

         KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature
appears below constitutes and appoints Joseph Rubinfeld, his
attorney-in-fact, for him in any and all capacities, to sign any amendments
to this Registration Statement on Form S-8, and to file the same, with
exhibits thereto and other documents in connection therewith, with the
Securities and Exchange Commission, hereby ratifying and confirming all that
each of said attorneys-in-fact, or his substitute or substitutes, may do or
cause to be done by virtue hereof.

         Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed below by the following persons in the
capacities and on the dates indicated.

<TABLE>
<CAPTION>
               Signature                                     Title                              Date
- ----------------------------------------     --------------------------------------      ------------------
<S>                                          <C>                                         <C>
/s/ JOSEPH RUBINFELD                         Chief Executive Officer, President and      September 17, 1999
- ----------------------------------------     Director (PRINCIPAL EXECUTIVE OFFICER)
(Joseph Rubinfeld)

/s/ RONALD H. SPAIR                          Chief Financial Officer (PRINCIPAL          September 17, 1999
- ----------------------------------------     FINANCIAL AND ACCOUNTING OFFICER)
(Ronald H. Spair)

/s/ DENIS BURGER                             Director                                    September 17, 1999
- ----------------------------------------
(Denis Burger)

/s/ LAWRENCE J. ELLISON                      Director                                    September 17, 1999
- ----------------------------------------
(Lawrence J. Ellison)

/s/ JULIUS A. VIDA                           Director                                    September 17, 1999
- ----------------------------------------
(Julius A. Vida)

/s/ DANIEL ZURR                              Director                                    September 17, 1999
- ----------------------------------------
(Daniel Zurr)
</TABLE>


                                      II-5
<PAGE>


                                SUPERGEN, INC.

                      REGISTRATION STATEMENT ON FORM S-8

                                 EXHIBIT INDEX

<TABLE>
<CAPTION>
   Exhibit
    Number      Description
    ------      -----------
   <S>          <C>
     4.1        1993 Stock Option Plan.

     4.2*       Form of Stock Option Agreement for use under the 1993 Stock Option Plan.

     5.1        Opinion of Wilson Sonsini Goodrich & Rosati, P.C., as to the
                legality of securities being registered.

    23.1        Consent of Ernst & Young LLP

    23.2        Consent of Arthur Andersen LLP

    23.3        Consent of Ernst & Young LLP

    23.4        Consent of Counsel (contained in Exhibit 5.1)

    24.1        Power of Attorney (see Page II-5).
</TABLE>

- --------

* Incorporated by reference to the exhibit filed with the Company's Quarterly
  Report on form 10-Q filed with the Securities and Exchange Commission on
  August 13, 1997.


                                      II-6



<PAGE>

                                 SUPERGEN, INC.
                             1993 STOCK OPTION PLAN

                     (AS AMENDED THROUGH FEBRUARY 20, 1999)

        1.      PURPOSES OF THE PLAN. The purposes of this Stock Plan are:

                - to attract and retain the best available personnel for
                  positions of substantial responsibility,

                - to provide additional incentive to Employees, Directors and
                  Consultants, and

                - to promote the success of the Company's business.

         Options granted under the Plan may be Incentive Stock Options or
Nonstatutory Stock Options, as determined by the Administrator at the time of
grant. Stock Purchase Rights may also be granted under the Plan.

        2.      DEFINITIONS. As used herein, the following definitions shall
apply:

                (a) "ADMINISTRATOR" means the Board or any of its Committees
as shall be administering the Plan, in accordance with Section 4 of the Plan.

                (b) "APPLICABLE LAWS" means the requirements relating to the
administration of stock option plans under U.S. state corporate laws, U.S.
federal and state securities laws, the Code, any stock exchange or quotation
system on which the Common Stock is listed or quoted and the applicable laws
of any foreign country or jurisdiction where Options or Stock Purchase Rights
are, or will be, granted under the Plan.

                (c) "BOARD" means the Board of Directors of the Company.

                (d) "CODE" means the Internal Revenue Code of 1986, as amended.

                (e) "COMMITTEE" means a Committee appointed by the Board in
accordance with Section 4 of the Plan.

                (f) "COMMON STOCK" means the Common Stock of the Company.

                (g) "COMPANY" means SuperGen, Inc., a Delaware corporation.

                (h) "CONSULTANT" means any person, including an advisor,
engaged by the Company or a Parent or Subsidiary to render services and who
is compensated for such services.

                (i) "CONTINUOUS STATUS AS A DIRECTOR OR CONSULTANT" means
that the employment relationship, directorship or consulting relationship
with the Company, any Parent, or Subsidiary, is

<PAGE>

not interrupted or terminated. Continuous Status as a Director or Consultant
shall not be considered interrupted in the case of (i) any leave of absence
approved by the Company or (ii) transfers between locations of the Company or
between the Company, its Parent, any Subsidiary, or any successor. A leave of
absence approved by the Company shall include sick leave, military leave, or
any other personal leave approved by an authorized representative of the
Company. For purposes of Incentive Stock Options, no such leave may exceed
ninety days, unless reemployment upon expiration of such leave is guaranteed
by statute or contract. If reemployment upon expiration of a leave of absence
approved by the Company is not so guaranteed, on the 181st day of such leave
any Incentive Stock Option held by the Optionee shall cease to be treated as
an Incentive Stock Option and shall be treated for tax purposes as a
Nonstatutory Stock Option.

                (j) "DIRECTOR" means a member of the Board.

                (k) "DISABILITY" means total and permanent disability as
defined in Section 22(e)(3) of the Code.

                (l) "EMPLOYEE" means any person, including Officers and
Directors, employed by the Company or any Parent or Subsidiary of the
Company. Neither service as a Director nor payment of a director's fee by the
Company shall be sufficient to constitute "employment" by the Company.

                (m) "EXCHANGE ACT" means the Securities Exchange Act of 1934,
as amended.

                (n) "FAIR MARKET VALUE" means, as of any date, the value of
Common Stock determined as follows:

                        (i) If the Common Stock is listed on any established
stock exchange or a national market system, including without limitation the
Nasdaq National Market or The Nasdaq SmallCap Market of The Nasdaq Stock
Market, its Fair Market Value shall be the closing sales price for such stock
(or the closing bid, if no sales were reported) as quoted on such exchange or
system for the last market trading day prior to the time of determination, as
reported in THE WALL STREET JOURNAL or such other source as the Administrator
deems reliable;

                       (ii) If the Common Stock is regularly quoted by a
recognized securities dealer but selling prices are not reported, the Fair
Market Value of a Share of Common Stock shall be the mean between the high
bid and low asked prices for the Common Stock on the last market trading day
prior to the day of determination, as reported in The Wall Street Journal or
such other source as the Administrator deems reliable;

                      (iii) In the absence of an established market for the
Common Stock, the Fair Market Value shall be determined in good faith by the
Administrator.

                (o) "INCENTIVE STOCK OPTION" means an Option intended to
qualify as an incentive stock option within the meaning of Section 422 of the
Code and the regulations promulgated thereunder.

                                      -2-

<PAGE>

                (p) "NONSTATUTORY STOCK OPTION" means an Option not intended
to qualify as an Incentive Stock Option.

                (q) "NOTICE OF GRANT" means a written notice evidencing
certain terms and conditions of an individual Option or Stock Purchase Right
grant. The Notice of Grant is part of the Option Agreement.

                (r) "OFFICER" means a person who is an officer of the Company
within the meaning of Section 16 of the Exchange Act and the rules and
regulations promulgated thereunder.

                (s) "OPTION" means a stock option granted pursuant to the
Plan.

                (t) "OPTION AGREEMENT" means a written agreement between the
Company and an Optionee evidencing the terms and conditions of an individual
Option grant. The Option Agreement is subject to the terms and conditions of
the Plan.

                (u) "OPTION EXCHANGE PROGRAM" means a program whereby
outstanding options are surrendered in exchange for options with a lower
exercise price.

                (v) "OPTIONED STOCK" means the Common Stock subject to an
Option or Stock Purchase Right.

                (w) "OPTIONEE" means an Employee, Director or Consultant who
holds an outstanding Option or Stock Purchase Right.

                (x) "PARENT" means a "parent corporation", whether now or
hereafter existing, as defined in Section 424(e) of the Code.

                (y) "PLAN" means this SuperGen, Inc. 1993 Stock Plan.

                (z) "RESTRICTED STOCK" means shares of Common Stock acquired
pursuant to a grant of Stock Purchase Rights under Section 11 below.

               (aa) "RESTRICTED STOCK PURCHASE AGREEMENT" means a written
agreement between the Company and the Optionee evidencing the terms and
restrictions applying to stock purchased under a Stock Purchase Right. The
Restricted Stock Purchase Agreement is subject to the terms and conditions of
the Plan and the Notice of Grant.

               (bb) "RULE 16b-3" means Rule 16b-3 of the Exchange Act or any
successor to Rule 16b-3, as in effect when discretion is being exercised with
respect to the Plan.

               (cc) "SECTION 16(b)" means Section 16(b) of the Securities
Exchange Act of 1934, as amended.

               (dd) "SHARE" means a share of the Common Stock, as adjusted in
accordance with Section 13 of the Plan.

                                      -3-

<PAGE>

               (ee) "STOCK PURCHASE RIGHT" means the right to purchase Common
Stock pursuant to Section 11 of the Plan, as evidenced by a Notice of Grant.

               (ff) "SUBSIDIARY" means a "subsidiary corporation", whether
now or hereafter existing, as defined in Section 424(f) of the Code.

        3.      STOCK SUBJECT TO THE PLAN. Subject to the provisions of
Section 13 of the Plan, the maximum aggregate number of Shares which may be
optioned and sold under the Plan is 3,850,000 Shares. The Shares may be
authorized, but unissued, or reacquired Common Stock.

                 If an Option or Stock Purchase Right expires or becomes
unexercisable without having been exercised in full, or is surrendered
pursuant to an Option Exchange Program, the unpurchased Shares which were
subject thereto shall become available for future grant or sale under the
Plan (unless the Plan has terminated); provided, however, that Shares that
have actually been issued under the Plan, whether upon exercise of an Option
or Right, shall not be returned to the Plan and shall not become available
for future distribution under the Plan, except that if Shares of Restricted
Stock are repurchased by the Company at their original purchase price, such
Shares shall become available for future grant under the Plan. For purposes
of the preceding sentence, voting rights shall not be considered a benefit of
Share ownership.

        4.      ADMINISTRATION OF THE PLAN.

                (a) PROCEDURE.

                        (i) MULTIPLE ADMINISTRATIVE BODIES. The Plan may be
administered by different Committees with respect to different groups of
Service Providers.

                       (ii) SECTION 162(m). To the extent that the
Administrator determines it to be desirable to qualify Options granted
hereunder as "performance-based compensation" within the meaning of Section
162(m) of the Code, the Plan shall be administered by a Committee of two or
more "outside directors" within the meaning of Section 162(m) of the Code.

                      (iii) RULE 16b-3. To the extent desirable to qualify
transactions hereunder as exempt under Rule 16b-3, the transactions
contemplated hereunder shall be structured to satisfy the requirements for
exemption under Rule 16b-3.

                       (iv) OTHER ADMINISTRATION. Other than as provided
above, the Plan shall be administered by (A) the Board or (B) a Committee,
which committee shall be constituted to satisfy Applicable Laws.

                (b) POWERS OF THE ADMINISTRATOR. Subject to the provisions
of the Plan, and in the case of a Committee, subject to the specific duties
delegated by the Board to such Committee, the Administrator shall have the
authority, in its discretion:

                                      -4-

<PAGE>

                        (i) to determine the Fair Market Value of the Common
Stock, in accordance with Section 2(n) of the Plan;

                       (ii) to select the Employees, Directors and
Consultants to whom Options and Stock Purchase Rights may be granted
hereunder;

                      (iii) to determine whether and to what extent Options
and Stock Purchase Rights or any combination thereof, are granted hereunder;

                       (iv) to determine the number of shares of Common Stock
to be covered by each Option and Stock Purchase Right granted hereunder;

                        (v) to approve forms of agreement for use under the
Plan;

                       (vi) to determine the terms and conditions, not
inconsistent with the terms of the Plan, of any award granted hereunder. Such
terms and conditions include, but are not limited to, the exercise price, the
time or times when Options or Stock Purchase Rights may be exercised (which
may be based on performance criteria), any vesting acceleration or waiver of
forfeiture restrictions, and any restriction or limitation regarding any
Option or Stock Purchase Right or the shares of Common Stock relating
thereto, based in each case on such factors as the Administrator, in its sole
discretion, shall determine;

                      (vii) to reduce the exercise price of any Option or
Stock Purchase Right to the then current Fair Market Value if the Fair Market
Value of the Common Stock covered by such Option or Stock Purchase Right
shall have declined since the date the Option or Stock Purchase Right was
granted;

                     (viii) to construe and interpret the terms of the Plan
and awards granted pursuant to the Plan;

                       (ix) to prescribe, amend and rescind rules and
regulations relating to the Plan, including rules and regulations relating to
sub-plans established for the purpose of qualifying for preferred tax
treatment under foreign tax laws;

                        (x) to modify or amend each Option or Stock Purchase
Right (subject to Section 15(c) of the Plan), including the discretionary
authority to extend the post-termination exercisability period of Options
longer than is otherwise provided for in the Plan;

                       (xi) to authorize any person to execute on behalf of
the Company any instrument required to effect the grant of an Option or Stock
Purchase Right previously granted by the Administrator;

                      (xii) to institute an Option Exchange Program;

                                      -5-

<PAGE>

                     (xiii) to allow Optionees to satisfy withholding tax
obligations by electing to have the Company withhold from the Shares to be
issued upon exercise of an Option or Stock Purchase Right that number of
Shares having a Fair Market Value equal to the amount required to be
withheld. The Fair Market Value of the Shares to be withheld shall be
determined on the date that the amount of tax to be withheld is to be
determined. All elections by an Optionee to have Shares withheld for this
purpose shall be made in such form and under such conditions as the
Administrator may deem necessary or advisable;

                      (xiv) to make all other determinations deemed necessary
or advisable for administering the Plan.

                (c) EFFECT OF ADMINISTRATOR'S DECISION. The Administrator's
decisions, determinations and interpretations shall be final and binding on
all Optionees and any other holders of Options or Stock Purchase Rights.

        5.      ELIGIBILITY. Nonstatutory Stock Options and Stock Purchase
Rights may be granted to Employees, Directors and Consultants. Incentive
Stock Options may be granted only to Employees.

        6.      LIMITATIONS.

                (a) Each Option shall be designated in the written option
agreement as either an Incentive Stock Option or a Nonstatutory Stock Option.
However, notwithstanding such designation, to the extent that the aggregate
Fair Market Value of the Shares with respect to which Incentive Stock Options
are exercisable for the first time by the Optionee during any calendar year
(under all plans of the Company and any Parent or Subsidiary) exceeds
$100,000, such Options shall be treated as Nonstatutory Stock Options. For
purposes of this Section 6(a), Incentive Stock Options shall be taken into
account in the order in which they were granted. The Fair Market Value of the
Shares shall be determined as of the time the Option with respect to such
Shares is granted.

                (b) Neither the Plan nor any Option or Stock Purchase Right
shall confer upon an Optionee any right with respect to continuing the
Optionee's employment relationship, directorship or consulting relationship
with the Company, nor shall they interfere in any way with the Optionee's
right or the Company's right to terminate such employment relationship,
directorship or consulting relationship at any time, with or without cause.

                (c) The following limitations shall apply to grants of
Options and Stock Purchase Rights to Employees, Directors and Consultants:

                        (i) No Employee, Director or Consultant shall be
granted, in any fiscal year of the Company, Options and Stock Purchase Rights
to purchase more than 500,000 Shares.

                       (ii) In connection with his or her initial service
with the Company, an Employee, Director or Consultant may be granted Options
and Stock Purchase Rights to purchase up to an additional 200,000 Shares
which shall not count against the limit set forth in subsection (i) above.

                                      -6-

<PAGE>

                      (iii) The foregoing limitations shall be adjusted
proportionately in connection with any change in the Company's capitalization
as described in Section 13.

                       (iv) If an Option or Stock Purchase Right is cancelled
in the same fiscal year of the Company in which it was granted (other than in
connection with a transaction described in Section 13), the cancelled Option
or Stock Purchase Right will be counted against the limits set forth in
subsections (i) and (ii) above. For this purpose, if the exercise price of an
Option or Stock Purchase Right is reduced, the transaction will be treated as
a cancellation of the Option or Stock Purchase Right and the grant of a new
Option or Stock Purchase Right.

        7.      TERM OF PLAN. Subject to Section 19 of the Plan, the Plan shall
become effective upon the earlier to occur of its adoption by the Board or
its approval by the shareholders of the Company as described in Section 19 of
the Plan. It shall continue in effect for a term of ten (10) years unless
terminated earlier under Section 15 of the Plan.

        8.      TERM OF OPTION. The term of each Option shall be stated in the
Notice of Grant; provided, however, that in the case of an Incentive Stock
Option, the term shall be ten (10) years from the date of grant or such
shorter term as may be provided in the Notice of Grant. Moreover, in the case
of an Incentive Stock Option granted to an Optionee who, at the time the
Incentive Stock Option is granted, owns stock representing more than ten
percent (10%) of the voting power of all classes of stock of the Company or
any Parent or Subsidiary, the term of the Incentive Stock Option shall be
five (5) years from the date of grant or such shorter term as may be provided
in the Notice of Grant.

        9.      OPTION EXERCISE PRICE AND CONSIDERATION.

                (a) EXERCISE PRICE. The per share exercise price for the
Shares to be issued pursuant to exercise of an Option shall be determined by
the Administrator, subject to the following:

                        (i) In the case of an Incentive Stock Option

                                (A) granted to an Employee who, at the time
the Incentive Stock Option is granted, owns stock representing more than ten
percent (10%) of the voting power of all classes of stock of the Company or
any Parent or Subsidiary, the per Share exercise price shall be no less than
110% of the Fair Market Value per Share on the date of grant.

                                (B) granted to any Employee other than an
Employee described in paragraph (A) immediately above, the per Share exercise
price shall be no less than 100% of the Fair Market Value per Share on the
date of grant.

                       (ii) In the case of a Nonstatutory Stock Option, the
per Share exercise price shall be determined by the Administrator. In the
case of a Nonstatutory Stock Option intended to qualify as "performance-based
compensation" within the meaning of Section 162(m) of the Code, the per Share
exercise price shall be no less than 100% of the Fair Market Value per Share
on the date of grant.

                                      -7-

<PAGE>

                      (iii) Notwithstanding the foregoing, Options may be
granted with a per Share exercise price of less than 100% of the Fair Market
Value per Share on the date of grant pursuant to a merger or other corporate
transaction.

                (b) WAITING PERIOD AND EXERCISE DATES. At the time an Option
is granted, the Administrator shall fix the period within which the Option
may be exercised and shall determine any conditions which must be satisfied
before the Option may be exercised. In so doing, the Administrator may
specify that an Option may not be exercised until the completion of a service
period.

                (c) FORM OF CONSIDERATION. The Administrator shall determine
the acceptable form of consideration for exercising an Option, including the
method of payment. In the case of an Incentive Stock Option, the
Administrator shall determine the acceptable form of consideration at the
time of grant. Such consideration may consist entirely of:

                        (i) cash;

                       (ii) check;

                      (iii) promissory note;

                       (iv) other Shares which (A) in the case of Shares
acquired upon exercise of an option, have been owned by the Optionee for more
than six months on the date of surrender, and (B) have a Fair Market Value
on the date of surrender equal to the aggregate exercise price of the Shares
as to which said Option shall be exercised;

                        (v) delivery of a properly executed exercise notice
together with such other documentation as the Administrator and the broker,
if applicable, shall require to effect an exercise of the Option and delivery
to the Company of the sale or loan proceeds required to pay the exercise
price;

                       (vi) a reduction in the amount of any Company
liability to the Optionee, including any liability attributable to the
Optionee's participation in any Company-sponsored deferred compensation
program or arrangement;

                      (vii) any combination of the foregoing methods of
payment; or

                     (viii) such other consideration and method of payment
for the issuance of Shares to the extent permitted by Applicable Laws.

        10.     EXERCISE OF OPTION.

                (a) PROCEDURE FOR EXERCIsE; RIGHTS AS A SHAREHOLDER. Any
Option granted hereunder shall be exercisable according to the terms of the
Plan and at such times and under such conditions as determined by the
Administrator and set forth in the Option Agreement.

                                      -8-

<PAGE>

                An Option may not be exercised for a fraction of a Share.

                An Option shall be deemed exercised when the Company
receives: (i) written notice of exercise (in accordance with the Option
Agreement) from the person entitled to exercise the Option, and (ii) full
payment for the Shares with respect to which the Option is exercised. Full
payment may consist of any consideration and method of payment authorized by
the Administrator and permitted by the Option Agreement and the Plan. Shares
issued upon exercise of an Option shall be issued in the name of the Optionee
or, if requested by the Optionee, in the name of the Optionee and his or her
spouse. Until the stock certificate evidencing such Shares is issued (as
evidenced by the appropriate entry on the books of the Company or of a duly
authorized transfer agent of the Company), no right to vote or receive
dividends or any other rights as a shareholder shall exist with respect to
the Optioned Stock, notwithstanding the exercise of the Option. The Company
shall issue (or cause to be issued) such stock certificate promptly after the
Option is exercised. No adjustment will be made for a dividend or other right
for which the record date is prior to the date the stock certificate is
issued, except as provided in Section 13 of the Plan.

                Exercising an Option in any manner shall decrease the number
of Shares thereafter available, both for purposes of the Plan and for sale
under the Option, by the number of Shares as to which the Option is
exercised.

                (b) TERMINATION OF EMPLOYMENT, CONSULTING RELATIONSHIP OR
DIRECTORSHIP. Upon termination of an Optionee's Continuous Status as an
Employee, Director or Consultant, other than upon the Optionee's death or
Disability, the Optionee may exercise his or her Option, but only within such
period of time as is specified in the Notice of Grant, and only to the extent
that the Optionee was entitled to exercise it at the date of termination (but
in no event later than the expiration of the term of such Option as set forth
in the Notice of Grant). In the absence of a specified time in the Notice of
Grant, the Option shall remain exercisable for three (3) months following the
Optionee's termination. In the case of an Incentive Stock Option, such period
of time for exercise shall not exceed three (3) months from the date of
termination. If, on the date of termination, the Optionee is not entitled to
exercise the Optionee's entire Option, the Shares covered by the
unexercisable portion of the Option shall revert to the Plan. If, after
termination, the Optionee does not exercise his or her Option within the time
specified by the Administrator, the Option shall terminate, and the Shares
covered by such Option shall revert to the Plan.

                Notwithstanding the above, in the event of an Optionee's
change in status from Consultant or Director to Employee or Employee or
Director to Consultant, an Optionee's Continuous Status as a Director or
Consultant shall not automatically terminate solely as a result of such
change in status. However, in such event, an Incentive Stock Option held by
the Optionee shall cease to be treated as an Incentive Stock Option and shall
be treated for tax purposes as a Nonstatutory Stock Option three months and
one day following such change of status from an Employee to a Consultant.

(c) DISABILITY OF OPTIONEE. In the event that an Optionee's Continuous Status
as an Employee, Director or Consultant terminates as a result of the
Optionee's Disability, the Optionee may exercise his or her Option at any
time within twelve (12) months from the date of such

                                      -9-

<PAGE>

termination, but only to the extent that the Optionee was entitled to
exercise it at the date of such termination (but in no event later than the
expiration of the term of such Option as set forth in the Notice of Grant).
If, at the date of termination, the Optionee is not entitled to exercise his
or her entire Option, the Shares covered by the unexercisable portion of the
Option shall revert to the Plan. If, after termination, the Optionee does not
exercise his or her Option within the time specified herein, the Option shall
terminate, and the Shares covered by such Option shall revert to the Plan.

                (d) DEATH OF OPTIONEE. In the event of the death of an
Optionee, the Option may be exercised at any time within twelve (12) months
following the date of death (but in no event later than the expiration of the
term of such Option as set forth in the Notice of Grant), by the Optionee's
estate or by a person who acquired the right to exercise the Option by
bequest or inheritance, but only to the extent that the Optionee was entitled
to exercise the Option at the date of death. If, at the time of death, the
Optionee was not entitled to exercise his or her entire Option, the Shares
covered by the unexercisable portion of the Option shall immediately revert
to the Plan. If, after death, the Optionee's estate or a person who acquired
the right to exercise the Option by bequest or inheritance does not exercise
the Option within the time specified herein, the Option shall terminate, and
the Shares covered by such Option shall revert to the Plan.

                (e) BUYOUT PROVISIONS. The Administrator may at any time
offer to buy out for a payment in cash or Shares, an Option previously
granted based on such terms and conditions as the Administrator shall
establish and communicate to the Optionee at the time that such offer is
made.

        11.     STOCK PURCHASE RIGHTS.

                (a) RIGHTS TO PURCHASE. Stock Purchase Rights may be issued
either alone, in addition to, or in tandem with other awards granted under
the Plan and/or cash awards made outside of the Plan. After the Administrator
determines that it will offer Stock Purchase Rights under the Plan, it shall
advise the offeree in writing, by means of a Notice of Grant, of the terms,
conditions and restrictions related to the offer, including the number of
Shares that the offeree shall be entitled to purchase, the price to be paid,
and the time within which the offeree must accept such offer, which shall in
no event exceed six (6) months from the date upon which the Administrator
made the determination to grant the Stock Purchase Right. The offer shall be
accepted by execution of a Restricted Stock Purchase Agreement in the form
determined by the Administrator.

                (b) REPURCHASE OPTION. Unless the Administrator determines
otherwise, the Restricted Stock Purchase Agreement shall grant the Company a
repurchase option exercisable upon the voluntary or involuntary termination
of the purchaser's employment with the Company for any reason (including
death or Disability). The purchase price for Shares repurchased pursuant to
the Restricted Stock purchase agreement shall be the original price paid by
the purchaser and may be paid by cancellation of any indebtedness of the
purchaser to the Company. The repurchase option shall lapse at a rate
determined by the Administrator.

                (c) OTHER PROVISIONS. The Restricted Stock Purchase Agreement
shall contain such other terms, provisions and conditions not inconsistent
with the Plan as may be determined by

                                     -10-

<PAGE>

the Administrator in its sole discretion. In addition, the provisions of
Restricted Stock Purchase Agreements need not be the same with respect to
each purchaser.

                (d) RIGHTS AS A SHAREHOLDER. Once the Stock Purchase Right is
exercised, the purchaser shall have the rights equivalent to those of a
shareholder, and shall be a shareholder when his or her purchase is entered
upon the records of the duly authorized transfer agent of the Company. No
adjustment will be made for a dividend or other right for which the record
date is prior to the date the Stock Purchase Right is exercised, except as
provided in Section 13 of the Plan.

        12.     NON-TRANSFERABILITY OF OPTIONS AND STOCK PURCHASE RIGHTS.
Unless determined otherwise by the Administrator, an Option or Stock Purchase
Right may not be sold, pledged, assigned, hypothecated, transferred, or
disposed of in any manner other than by will or by the laws of descent or
distribution and may be exercised, during the lifetime of the Optionee, only
by the Optionee. If the Administrator makes an Option or Stock Purchase Right
transferable, such Option or Stock Purchase Right shall contain such
additional terms and conditions as the Administrator deems appropriate.

        13.     ADJUSTMENTS UPON CHANGES IN CAPITALIZATION, DISSOLUTION,
MERGER OR ASSET SALE.

                (a) CHANGES IN CAPITALIZATION. Subject to any required action
by the shareholders of the Company, the number of shares of Common Stock
covered by each outstanding Option and Stock Purchase Right, and the number
of shares of Common Stock which have been authorized for issuance under the
Plan but as to which no Options or Stock Purchase Rights have yet been
granted or which have been returned to the Plan upon cancellation or
expiration of an Option or Stock Purchase Right, as well as the price per
share of Common Stock covered by each such outstanding Option or Stock
Purchase Right, shall be proportionately adjusted for any increase or
decrease in the number of issued shares of Common Stock resulting from a
stock split, reverse stock split, stock dividend, combination or
reclassification of the Common Stock, or any other increase or decrease in
the number of issued shares of Common Stock effected without receipt of
consideration by the Company; provided, however, that conversion of any
convertible securities of the Company shall not be deemed to have been
"effected without receipt of consideration." Such adjustment shall be made by
the Board, whose determination in that respect shall be final, binding and
conclusive. Except as expressly provided herein, no issuance by the Company
of shares of stock of any class, or securities convertible into shares of
stock of any class, shall affect, and no adjustment by reason thereof shall
be made with respect to, the number or price of shares of Common Stock
subject to an Option or Stock Purchase Right.

                (b) DISSOLUTION OR LIQUIDATION. In the event of the proposed
dissolution or liquidation of the Company, the Administrator shall notify
each Optionee as soon as practicable prior to the effective date of such
proposed transaction. The Administrator in its discretion may provide for an
Optionee to have the right to exercise his or her Option until ten (10) days
prior to such transaction as to all of the Optioned Stock covered thereby,
including Shares as to which the Option would not otherwise be exercisable.
In addition, the Administrator may provide that any Company repurchase option
applicable to any Shares purchased upon exercise of an Option shall lapse as
to all such Shares, provided the proposed dissolution or liquidation takes
place at the time

                                     -11-

<PAGE>

and in the manner contemplated. To the extent it has not been previously
exercised, an Option will terminate immediately prior to the consummation
of such proposed action.

                (c) MERGER OR ASSET SALE. In the event of a merger of the
Company with or into another corporation, or the sale of substantially all of
the assets of the Company, each outstanding Option and Stock Purchase Right
shall be assumed or an equivalent option or right substituted by the
successor corporation or a Parent or Subsidiary of the successor corporation.
In the event that the successor corporation refuses to assume or substitute
for the Option or Stock Purchase Right, the Optionee shall have the right to
exercise the Option or Stock Purchase Right as to all of the Optioned Stock,
including Shares as to which it would not otherwise be exercisable. If an
Option or Stock Purchase Right is exercisable in lieu of assumption or
substitution in the event of a merger or sale of assets, the Administrator
shall notify the Optionee that the Option or Stock Purchase Right shall be
fully exercisable for a period of fifteen (15) days from the date of such
notice, and the Option or Stock Purchase Right shall terminate upon the
expiration of such period. For the purposes of this paragraph, the Option or
Stock Purchase Right shall be considered assumed if, following the merger or
sale of assets, the option or right confers the right to purchase or receive,
for each Share of Optioned Stock subject to the Option or Stock Purchase
Right immediately prior to the merger or sale of assets, the consideration
(whether stock, cash, or other securities or property) received in the merger
or sale of assets by holders of Common Stock for each Share held on the
effective date of the transaction (and if holders were offered a choice of
consideration, the type of consideration chosen by the holders of a majority
of the outstanding Shares); provided, however, that if such consideration
received in the merger or sale of assets was not solely common stock of the
successor corporation or its Parent, the Administrator may, with the consent
of the successor corporation, provide for the consideration to be received
upon the exercise of the Option or Stock Purchase Right, for each Share of
Optioned Stock subject to the Option or Stock Purchase Right, to be solely
common stock of the successor corporation or its Parent equal in fair market
value to the per share consideration received by holders of Common Stock in
the merger or sale of assets.

        14.     DATE OF GRANT. The date of grant of an Option or Stock
Purchase Right shall be, for all purposes, the date on which the
Administrator makes the determination granting such Option or Stock Purchase
Right, or such other later date as is determined by the Administrator. Notice
of the determination shall be provided to each Optionee within a reasonable
time after the date of such grant.

        15.     AMENDMENT AND TERMINATION OF THE PLAN.

                (a) AMENDMENT AND TERMINATION. The Board may at any time
amend, alter, suspend or terminate the Plan.

                (b) SHAREHOLDER APPROVAL. The Company shall obtain
shareholder approval of any Plan amendment to the extent necessary and
desirable to comply with Sections 162(m) or 422 of the Code (or any successor
rule or statute or other applicable law, rule or regulation, including the
requirements of any exchange or quotation system on which the Common Stock is
listed or quoted). Such shareholder approval, if required, shall be obtained
in such a manner and to such a degree as is required by the applicable law,
rule or regulation.

                                     -12-

<PAGE>

                (c) EFFECT OF AMENDMENT OR TERMINATION. No amendment,
alteration, suspension or termination of the Plan shall impair the rights of
any Optionee, unless mutually agreed otherwise between the Optionee and the
Administrator, which agreement must be in writing and signed by the Optionee
and the Company.

        16.     CONDITIONS UPON ISSUANCE OF SHARES.

                (a) LEGAL COMPLIANCE. Shares shall not be issued pursuant to
the exercise of an Option or Stock Purchase Right unless the exercise of such
Option or Stock Purchase Right and the issuance and delivery of such Shares
shall comply with all relevant provisions of law, including, without
limitation, the Securities Act of 1933, as amended, the Exchange Act, the
rules and regulations promulgated thereunder, Applicable Laws, and the
requirements of any stock exchange or quotation system upon which the Shares
may then be listed or quoted, and shall be further subject to the approval of
counsel for the Company with respect to such compliance.

                (b) INVESTMENT REPRESENTATIONS. As a condition to the
exercise of an Option or Stock Purchase Right, the Company may require the
person exercising such Option or Stock Purchase Right to represent and
warrant at the time of any such exercise that the Shares are being purchased
only for investment and without any present intention to sell or distribute
such Shares if, in the opinion of counsel for the Company, such a
representation is required.

        17.     LIABILITY OF COMPANY.

                (a) INABILITY TO OBTAIN AUTHORITY. The inability of the
Company to obtain authority from any regulatory body having jurisdiction,
which authority is deemed by the Company's counsel to be necessary to the
lawful issuance and sale of any Shares hereunder, shall relieve the Company
of any liability in respect of the failure to issue or sell such Shares as to
which such requisite authority shall not have been obtained.

                (b) GRANTS EXCEEDING ALLOTTED SHARES. If the Optioned Stock
covered by an Option or Stock Purchase Right exceeds, as of the date of
grant, the number of Shares which may be issued under the Plan without
additional shareholder approval, such Option or Stock Purchase Right shall be
void with respect to such excess Optioned Stock, unless shareholder approval
of an amendment sufficiently increasing the number of Shares subject to the
Plan is timely obtained in accordance with Section 15(b) of the Plan.

        18.     RESERVATION OF SHARES. The Company, during the term of
this Plan, will at all times reserve and keep available such number of Shares as
shall be sufficient to satisfy the requirements of the Plan.

        19.     SHAREHOLDER APPROVAL. Continuance of the Plan shall be
subject to approval by the shareholders of the Company within twelve (12)
months before or after the date the Plan is adopted. Such shareholder
approval shall be obtained in the manner and to the degree required under
applicable federal and state law.

                                     -13-

<PAGE>

                                                                   EXHIBIT 5.1


                            September 17, 1999


SuperGen, Inc.
Two Annabel Lane, Suite 220
San Ramon, CA  94583

         RE:      REGISTRATION STATEMENT ON FORM S-8

Ladies and Gentlemen:

         We have examined the Registration Statement on Form S-8 to be filed
by you with the Securities and Exchange Commission on or about September 17,
1999 (the "Registration Statement") in connection with the registration under
the Securities Act of 1933, as amended, of 600,000 shares of your Common
Stock reserved for issuance under the 1993 Stock Option Plan (the "Plan"). As
your legal counsel, we have examined the proceedings taken and are familiar
with the proceedings taken and proposed to be taken by you in connection with
the sale and issuance of such Common Stock under the Plan.

         It is our opinion that, when issued and sold in the manner referred
to in the Plan and pursuant to the agreements which accompany the Plan, the
Common Stock issued and sold thereby will be legally and validly issued,
fully paid and non-assessable.

         We consent to the use of this opinion as an exhibit to the
Registration Statement and further consent to the use of our name wherever
appearing in the Registration Statement, including any Prospectus
constituting a part thereof, and any amendments thereto.

                                   Sincerely,

                                   WILSON SONSINI GOODRICH & ROSATI
                                   Professional Corporation

                                   /s/ Wilson Sonsini Goodrich & Rosati



<PAGE>


                                                                  EXHIBIT 23.1

             CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS

We consent to the incorporation by reference in this Registration Statement
on Form S-8 pertaining to the 1993 Stock Option Plan, as Amended and
Restated, of our report dated March 25, 1999 with respect to the consolidated
financial statements of SuperGen, Inc. included in its Annual Report (Form
10-K) for the year ended December 31, 1998, filed with the Securities and
Exchange Commission.

                                        /s/ ERNST & YOUNG LLP

Palo Alto, California
September 15, 1999




<PAGE>



                                                                   EXHIBIT 23.2


                   CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS

          As independent public accountants, we hereby consent to the
incorporation by reference in this Form S-8 Registration Statement of our
report dated February 11, 1999 included in SuperGen, Inc.'s Form 8-K filed on
August 26, 1999.

                                         /s/  ARTHUR ANDERSEN LLP


Philadelphia, Pennsylvania
September 15, 1999


<PAGE>



                                                                   EXHIBIT 23.3


                       CONSENT OF INDEPENDENT AUDITORS

          We consent to the incorporation by reference in this Registration
Statement on Form S-8 pertaining to the 1993 Stock Option Plan, as Amended
and Restated, of our report dated January 31, 1996, with respect to the
financial statements of Sparta Pharmaceuticals, Inc. included in SuperGen,
Inc.'s Current Report on Form 8-K dated August 26, 1999 filed with the
Securities and Exchange Commission.

                                          /s/  ERNST & YOUNG LLP


Raleigh, North Carolina
September 15, 1999



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