MEDICALOGIC/MEDSCAPE INC
SC 13D, EX-99.E, 2001-01-17
COMPUTER PROCESSING & DATA PREPARATION
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                                                            Page 42 of 92 Pages

                        2000 SECOND AMENDED AND RESTATED
                            INVESTOR RIGHTS AGREEMENT


     THIS 2000 SECOND AMENDED AND RESTATED  INVESTOR RIGHTS AGREEMENT is made as
of the 4th day of January  2001, by and between  MedicaLogic/Medscape,  Inc., an
Oregon  corporation (the "Company"),  and the shareholders of the Company listed
on the signature pages hereof.

                                    RECITALS

     A. As of May 28, 1999, the Company entered into a 1999 Amended and Restated
Investor Rights Agreement with certain  investors (as amended and  supplemented,
the "1999  MedicaLogic  Agreement")  that, among other things,  provided certain
registration rights to holders of capital stock of the Company.

     B.  As  of  August  4,  1999,   Medscape,   Inc.,  a  Delaware  corporation
("Medscape"),  entered into an Amended and Restated Stockholders  Agreement with
certain of its  stockholders  (as amended and  supplemented,  the "1999 Medscape
Agreement") that, among other things,  provided certain  registration  rights to
holders of Medscape capital stock.

     C. As of  August 3,  1999,  Medscape  entered  into a  Registration  Rights
Agreement  (the "CBS  Agreement")  with CBS  Corporation  ("CBS") that  provided
certain  registration  rights to CBS with respect to Medscape common stock owned
by CBS.

     D. As of August 25, 1999 and September 8, 1999, the 1999 Medscape Agreement
was amended,  among other  things,  to provide  certain  registration  rights to
America Online,  Inc.  ("AOL") with respect to Medscape common stock  underlying
warrants issued to AOL by Medscape.

     E. As of February 21, 2000,  the Company,  Medscape and  Moneypenny  Merger
Corp., a Delaware  corporation,  entered into an Agreement of Reorganization and
Merger (the "Merger  Agreement") under which Medscape will become a wholly owned
subsidiary of the Company (the  "Merger") and the Company's name will be changed
to MedicaLogic/Medscape, Inc.

     F. In accordance with the Merger Agreement, as of May 19, 2000, the Company
entered into a 2000 Amended and Restated  Investor  Rights  Agreement (the "2000
Agreement") with the parties having registration rights prior to the Merger.

     G. The Company  proposes to sell and issue up to 5,933,332 shares of Series
1  Convertible  Redeemable  Preferred  Stock,  without par value (the  "Series 1
Preferred  Stock"),  and warrants to purchase up to  4,537,254  shares of common
stock,  without par value (the "Series 1 Warrant  Shares") in a closing pursuant
to the Preferred Stock and Warrant Purchase Agreement (the "Series 1 Agreement")
among the Company and certain  investors  listed on Signature Page I dated as of
December 22, 2000, as amended (the "Series 1 Purchasers").


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                                                            Page 43 of 92 Pages

     H. As a condition  of entering  into the Series 1  Agreement,  the Series 1
Purchasers  have requested that the Company extend to them  registration  rights
and other rights with  respect to the Series 1 Preferred  Stock and the Series 1
Warrant Shares.

     I. The  undersigned  shareholders  include  the  holders of more than fifty
percent (50%) of the Company's common stock subject to the 2000 Agreement on the
date hereof as required by Sections 3.7 and 1.14 of the 2000 Agreement.

                                    AGREEMENT

     In consideration of the mutual promises and covenants set forth herein, the
parties  hereto  agree to amend and  restate  the 2000  Agreement  to  eliminate
parties that are no longer subject hereto and to further provide as follows:

     1. Registration Rights. The Company covenants and agrees as follows:

     1.1 Definitions. For purposes of this Section 1:

          (a) The term "Act" means the Securities Act of 1933, as amended.

          (b) The term "Common Stock" means the common stock of the Company.

          (c) The term "Existing Registrable Securities" means all the shares of
     Common Stock of Medscape, other than Investor Registrable Securities,  that
     were  owned on the date of the  Merger by any Holder who was a party to the
     1999 Medscape Agreement.

          (d) The term  "Form S-3" means such form under the Act as in effect on
     the date hereof or any registration form under the Act subsequently adopted
     by  the  SEC  which  permits  inclusion  or  incorporation  of  substantial
     information by reference to other  documents  filed by the Company with the
     SEC.

          (e) The term  "Holder"  means any person owning or having the right to
     acquire  Registrable  Securities or any assignee thereof in accordance with
     Section 1.13 hereof.

          (f) The term "Investor Registrable Securities" means all the shares of
     Common Stock of Medscape  issued upon the  conversion  of the shares of the
     Series C Preferred Stock or Series D Preferred Stock of Medscape; excluding
     in all  cases,  however,  (i)  any  Investor  Registrable  Securities  sold
     pursuant to  registration  under the Act or (ii) any  Investor  Registrable
     Securities  sold,  subsequent  to  Medscape's  initial  public  offering of
     securities  registered under the Act,  pursuant to SEC Rule 144 (or similar
     or successor rule) promulgated under the Act.

          (g) The term  "1934 Act" shall  mean the  Securities  Exchange  Act of
     1934, as amended.

          (h) The terms "register,"  "registered," and "registration" refer to a
     registration  effected by preparing and filing a registration  statement or
     similar document in


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                                                            Page 44 of 92 Pages

     compliance with the Act and the declaration or ordering of effectiveness of
     such registration statement or document.

          (i) The term  "Registrable  Securities"  means (i) the Common Stock of
     the Company  issued upon  conversion  of the  Company's  Series A Preferred
     Stock,  Series A-1 Preferred Stock,  Series C Preferred  Stock,  Series C-1
     Preferred  Stock,  Series E Preferred  Stock,  Series E-1 Preferred  Stock,
     Series F Preferred Stock,  Series F-1 Preferred  Stock,  Series J Preferred
     Stock, and Series J-1 Preferred Stock as listed on Signature Page A hereto;
     (ii) the Common Stock of the Company purchased pursuant to the Common Stock
     Purchase  Agreement  by and among the  Company,  Mark A.  Leavitt,  Richard
     Samco,  Sequoia Capital Growth Fund, Sequoia  Technology  Partners III, New
     Enterprise  Associates VI,  Limited  Partnership  and Stanford  University,
     dated  August 3,  1994,  as listed on  Signature  Page B hereto;  (iii) the
     Common  Stock of the Company  issued in the Merger upon  conversion  of the
     Existing Registrable  Securities and Investor Registrable Securities ; (iv)
     the Common  Stock of the  Company  issued  upon  exercise  of the  Medscape
     warrants issued to AOL (the "Warrant  Shares");  (v) the Series 1 Preferred
     Stock;  (vi) the  Common  Stock of the  Company  issued  or  issuable  upon
     conversion  of the  Series 1  Preferred  Stock;  (vii) the Series 1 Warrant
     Shares;  and (viii) any Common Stock of the Company  issued as (or issuable
     upon the  conversion  or exercise of any warrant,  right or other  security
     which is issued as) a dividend or other distribution with respect to, or in
     exchange  for or in  replacement  of the shares  referenced  in (i),  (ii),
     (iii), (iv), (v), (vi) or (vii) above, excluding in all cases, however, any
     Registrable  Securities  sold by a person in a  transaction  in which  such
     person's rights under this Section 1 are not assigned or assignable and any
     Registrable  Securities  sold to the  public or sold  pursuant  to Rule 144
     promulgated under the Act.

          (j) The number of shares of "Registrable  Securities then outstanding"
     shall be (x) the  aggregate  number of shares of Common  Stock  outstanding
     which are  Registrable  Securities  plus (y) the number of shares of Common
     Stock issuable pursuant to then exercisable or convertible securities which
     are Registrable Securities.

          (k) The term "SEC" shall mean the Securities and Exchange Commission.

     1.2 Request for Registration.

          (a) If

               (i) the Company shall receive a written  request from (A) Holders
          of at least fifteen percent (15%) of the  Registrable  Securities then
          outstanding  referred to in clauses (i) and (ii) of subsection  1.1(i)
          or (B) Holders of at least  thirty  percent  (30%) of the  Registrable
          Securities  then  outstanding  held  by  the  former  holders  of  the
          Company's  Series J Preferred  Stock (a "Series J Investor")  that the
          Company  file a  registration  statement  under the Act  covering  the
          registration of the Registrable Securities then outstanding, or

               (ii) the Company shall receive a written request from (W) Holders
          of at least fifty percent  (50%) of the  Registrable  Securities  then
          outstanding held by


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<PAGE>

                                                            Page 45 of 92 Pages

          the  former  holders of  Investor  Registrable  Securities  (excluding
          Holders  described  in clause  (X),  (Y) or (Z)  hereof)  as listed on
          Signature  Page C  hereto,  (X) any  Holder  who  purchased  more than
          650,000 shares of the Series D Preferred  Stock of Medscape (a "Series
          D Holder"),  (Y) any Holder who purchased  more than 260,000 shares of
          the Series E Preferred Stock of Medscape as listed on Signature Page E
          hereto (a "Series E  Holder"),  or (Z) any  Holder of Warrant  Shares,
          that the Company file a registration statement on Form S-1 (or similar
          successor   forms)  under  the  Act  covering  the   registration   of
          Registrable  Securities  issued in exchange for  Investor  Registrable
          Securities, or

               (iii) the Company shall receive a written request from Holders of
          at  least  twenty-five  percent  (25%) of the  Registrable  Securities
          issued or issuable  upon  conversion  of the Series 1 Preferred  Stock
          that the Company file a registration  statement under the Act covering
          the Registrable Securities held by such Holders,

     then the Company shall,  within ten (10) days of the receipt thereof,  give
     written  notice of such request to all Holders in  accordance  with Section
     3.5 (the  "Notice of  Demand")  and shall,  subject to the  limitations  of
     subsection  1.2(b),  use its  reasonable  best efforts to effect as soon as
     practicable,  and in any event  within one hundred  twenty  (120) days) (or
     sixty (60) days if such  registration  under the Act is on Form S-3) of the
     receipt of such request,  the registration under the Act of all Registrable
     Securities  that the Holders  request to be  registered  within twenty (20)
     days of the receipt of the Notice of Demand,  provided that the Registrable
     Securities  requested  by the  Holders to be  registered  pursuant  to such
     request must have an  anticipated  aggregate  public  offering price of not
     less than $5,000,000.

          (b) If the  Holders  initiating  the  registration  request  hereunder
     ("Initiating  Holders")  intend to distribute  the  Registrable  Securities
     covered by their request by means of an underwriting,  they shall so advise
     the Company as a part of their request made  pursuant to subsection  1.2(a)
     and the Company  shall  include  such  information  in the  written  notice
     referred to in subsection  1.2(a).  The underwriter will be selected by the
     Initiating  Holders  and shall be  reasonably  acceptable  to the  Company,
     provided that such underwriter shall be of nationally  recognized  standing
     and shall agree to firmly  underwrite  such  offering.  In such event,  the
     right of any Holder to include Registrable  Securities in such registration
     shall be conditioned upon such Holder's  participation in such underwriting
     and  the  inclusion  of  such  Holder's   Registrable   Securities  in  the
     underwriting (unless otherwise mutually agreed by a majority in interest of
     the Initiating  Holders and such Holder) to the extent provided herein. All
     Holders proposing to distribute their securities  through such underwriting
     shall  (together  with the Company as provided in subsection  1.4(e)) enter
     into an  underwriting  agreement in customary form with the  underwriter or
     underwriters  selected  for such  underwriting.  Notwithstanding  any other
     provisions  of this  Section  1.2, if the  underwriter,  with  respect to a
     registration  requested  under  subsection  1.2(a),  advises the Initiating
     Holders in writing  that  marketing  factors  require a  limitation  of the
     number of shares to be underwritten,  then such Initiating Holders shall so
     advise all  Holders of  Registrable  Securities  which would  otherwise  be
     underwritten  pursuant  hereto,  and the  number of  shares of  Registrable
     Securities  that may be included  in the  underwriting  shall be  allocated
     among all Holders thereof, including such Initiating Holders, in proportion
     (as nearly as practicable)  to the amount of Registrable  Securities of the
     Company owned by each Holder; provided,  however, that the number of shares
     of Registrable Securities to be included in


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<PAGE>
                                                            Page 46 of 92 Pages

     such  underwriting  shall not be reduced  unless all other  securities  are
     first entirely excluded from the underwriting;  and provided, further, that
     (i)  Registrable  Securities  held by  Holders  referred  to in  subsection
     1.2(a)(ii)  shall be entirely  excluded  from the  underwriting  before any
     Registrable Securities held by Holders referred to in subsections 1.2(a)(i)
     and  1.2(a)(iii)  and  (ii)  all  Registrable  Securities  held by  Holders
     referred to in  subsection  1.2(a)(i)  shall be entirely  excluded from the
     underwriting before any Registrable  Securities held by Holders referred to
     in subsection  1.2(a)(iii)  are  excluded.  In a  registration  pursuant to
     subsection  1.2(a),  if Registrable  Securities held by a Series J Investor
     are excluded from the registration  pursuant to the previous  sentence as a
     result of election of Holders other than Series J Investors to  participate
     in the  registration,  then  that  registration  will not be deemed to be a
     registration  requested  by the  Series J  Investors  for the  purposes  of
     Section 1.2(d)(i).

          (c)  Notwithstanding  the  foregoing,  if the Company shall furnish to
     Holders requesting a registration statement pursuant to this Section 1.2, a
     certificate  signed by the Chief  Executive  Officer of the Company stating
     that in the good faith  judgment of the Board of  Directors of the Company,
     it would  materially  interfere with any material  financing,  acquisition,
     corporate  reorganization or merger or other material transaction involving
     the  Company  and it is  therefore  essential  to defer the  filing of such
     registration  statement,  the Company  shall have the right to defer taking
     action  with  respect to such  filing for a period of not more than  ninety
     (90) days after receipt of the request of the Initiating Holders; provided,
     however,  that the Company may not utilize this right more than once in any
     twelve-month period.

          (d) In addition,  the Company shall not be obligated to effect,  or to
     take any action to effect,

               (i) any registration pursuant to subsection 1.2(a)(i):

                    (A) After the Company has effected  three (3)  registrations
               pursuant to  subsection  1.2(a)(i),  two (2) of which may only be
               initiated by Series J Investors  under  subsection  1.2(a)(i)(B),
               and such  registrations  have been declared or ordered effective;
               or

                    (B) During the period starting with the date sixty (60) days
               prior to the Company's  good faith estimate of the date of filing
               of, and  ending on a date  ninety  (90) days after the  effective
               date of, a registration  subject to Section 1.3 hereof,  provided
               that  the  Company  is  actively  employing  in  good  faith  all
               reasonable efforts to cause such registration statement to become
               effective; or

               (ii) any registration pursuant to subsection 1.2(a)(ii):

                    (A) After the Company has effected  seven (7)  registrations
               pursuant to subsection  1.2(a)(ii),  two (2) of which may only be
               initiated  by a Series  D  Holder,  one (1) of which  may only be
               initiated  by a Series  E  Holder,  two (2) of which  may only be
               initiated by a Holder of Warrant Shares, and two (2) of which may
               only be initiated by Holders who are not Series D Holders, Series
               E Holders or Holders of Warrant Shares; or



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<PAGE>
                                                            Page 47 of 92 Pages

                    (B) During the period starting with the date sixty (60) days
               prior to the Company's  good faith estimate of the date of filing
               of, and  ending on a date  ninety  (90) days after the  effective
               date of, a registration  subject to Section 1.3 hereof,  provided
               that  the  Company  is  actively  employing  in  good  faith  all
               reasonable efforts to cause such registration statement to become
               effective; or

                    (C) If the Initiating  Holders  propose to dispose of shares
               of Registrable  Securities which may be immediately registered on
               Form S-3 pursuant to a request made under Section 1.12 hereof.

               (iii) any registration pursuant to subsection 1.2(a)(iii):

                    (A) After the Company has effected  three (3)  registrations
               pursuant to subsection 1.2(a)(iii); or

                    (B) During the period starting with the date sixty (60) days
               prior to the Company's  good faith estimate of the date of filing
               of, and  ending on a date  ninety  (90) days after the  effective
               date of, a registration  subject to Section 1.3 hereof,  provided
               that  the  Company  is  actively  employing  in  good  faith  all
               reasonable efforts to cause such registration statement to become
               effective

     1.3 Company  Registration.  If (but  without any  obligation  to do so) the
Company proposes to register (including for this purpose a registration effected
by the  Company for  shareholders  other than the  Holders)  any of its stock or
other  securities  under the Act in connection  with the public offering of such
securities  solely for cash (other than a  registration  relating  solely to the
sale of securities to  participants  in a Company stock plan, a registration  on
any form which does not include  substantially  the same information as would be
required to be included in a  registration  statement  covering  the sale of the
Registrable  Securities or a  registration  in which the only Common Stock being
registered is Common Stock issuable upon conversion of debt securities which are
also being registered),  the Company shall, at such time, promptly, but at least
thirty (30) days prior to filing such registration  statement,  give each Holder
written  notice  of such  registration  in  accordance  with  Section  3.5  (the
"Piggy-Back  Notice").  Upon the  written  request of each Holder  given  within
twenty (20) days after  receipt of the  Piggy-Back  Notice,  the Company  shall,
subject to the provisions of Section 1.8,  cause to be registered  under the Act
all of the  Registrable  Securities  that each such Holder has  requested  to be
registered.

     1.4 Obligations of the Company.  Whenever  required under this Section 1 to
effect the  registration  of any Registrable  Securities,  the Company shall, as
expeditiously as reasonably possible:

          (a)  Prepare  and file  with  the SEC a  registration  statement  with
     respect to such  Registrable  Securities  and use its  diligent  efforts to
     cause  such  registration  statement  to become  effective,  and,  upon the
     request  of  the  Holders  of a  majority  of  the  Registrable  Securities
     registered  thereunder,  keep such registration  statement  effective for a
     period of up to one


                                       6
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                                                            Page 48 of 92 Pages

     hundred eighty (180) days; provided,  however, that (i) such 180-day period
     shall be  extended  for a period of time  equal to the  period  the  Holder
     refrains from selling any securities  included in such  registration at the
     request of an  underwriter  of Common  Stock (or other  securities)  of the
     Company; and (ii) in the case of any registration of Registrable Securities
     on Form S-3 which are  intended  to be offered on a  continuous  or delayed
     basis,  such 180-day  period shall be extended,  if necessary,  to keep the
     registration  statement effective until all such Registrable Securities are
     sold,  provided that Rule 415, or any successor rule under the Act, permits
     an offering on a continuous  or delayed  basis;  and provided  further that
     applicable  rules  under  the  Act  governing  the  obligation  to  file  a
     post-effective  amendment  permit,  in  lieu  of  filing  a  post-effective
     amendment which (I) includes any prospectus required by Section 10(a)(3) of
     the Act or (II)  reflects  facts  or  events  representing  a  material  or
     fundamental  change  in the  information  set  forth  in  the  registration
     statement,  the  incorporation  by reference of information  required to be
     included in (I) and (II) above to be  contained in periodic  reports  filed
     pursuant  to  Section  13 or  15(d)  of the  1934  Act in the  registration
     statement.

          (b) Prepare and file with the SEC such  amendments and  supplements to
     such registration statement and the prospectus used in connection with such
     registration statement as may be necessary to comply with the provisions of
     the Act with respect to the  disposition of all securities  covered by such
     registration statement.

          (c) Furnish to the  Holders  such  numbers of copies of a  prospectus,
     including a preliminary prospectus,  in conformity with the requirements of
     the Act, and such other  documents as they may reasonably  request in order
     to facilitate the disposition of Registrable Securities owned by them.

          (d) Use its  reasonable  best  efforts to  register  and  qualify  the
     securities  covered  by  such  registration   statement  under  such  other
     securities  or Blue Sky laws of such  jurisdictions  as shall be reasonably
     requested by the Holders;  provided  that the Company shall not be required
     in connection therewith or as a condition thereto to qualify to do business
     or to file a general  consent to  service of process in any such  states or
     jurisdictions,  unless the  Company  is already  subject to service in such
     jurisdiction and except as may be required by the Act.

          (e) In the event of any underwritten  public offering,  enter into and
     perform  its  obligations  under an  underwriting  agreement,  in usual and
     customary form, with the managing underwriter of such offering. Each Holder
     participating  in such  underwriting  shall also enter into and perform its
     obligations under such an agreement.

          (f)  Notify  each  Holder of  Registrable  Securities  covered by such
     registration  statement at any time when a prospectus  relating  thereto is
     required to be delivered  under the Act of the  happening of any event as a
     result of which the prospectus included in such registration  statement, as
     then in effect, includes an untrue statement of a material fact or omits to
     state a material  fact  required to be stated  therein or necessary to make
     the  statements  therein not  misleading in the light of the  circumstances
     then existing.



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                                                            Page 49 of 92 Pages

          (g)  Cause  all  such  Registrable   Securities   registered  pursuant
     hereunder  to be  listed  on each  securities  exchange  on  which  similar
     securities issued by the Company are then listed.

          (h)  Provide  a  transfer  agent  and  registrar  for all  Registrable
     Securities  registered  pursuant  hereunder and a CUSIP number for all such
     Registrable  Securities,  in each case not later than the effective date of
     such registration.

          (i) Furnish,  at the request of any Holder requesting  registration of
     Registrable  Securities  pursuant to this  Section 1, on the date that such
     Registrable  Securities  are  delivered  to the  underwriters  for  sale in
     connection  with a  registration  pursuant  to  this  Section  1,  if  such
     securities are being sold through underwriters,  or, if such securities are
     not being  sold  through  underwriters,  on the date that the  registration
     statement  with  respect  to  such  securities  becomes  effective,  (i) an
     opinion,  dated such date, of the counsel  representing the Company for the
     purposes of such  registration,  in form and  substance  as is  customarily
     given to underwriters in an underwritten public offering,  addressed to the
     underwriters,  if  any,  and  to the  Holders  requesting  registration  of
     Registrable  Securities  and  (ii) a  letter  dated  such  date,  from  the
     independent  certified  public  accountants  of the  Company,  in form  and
     substance  as  is  customarily   given  by  independent   certified  public
     accountants to underwriters in an underwritten  public offering,  addressed
     to the underwriters,  if any, and to the Holders requesting registration of
     Registrable Securities.

     1.5  Furnish  Information.  It  shall  be  a  condition  precedent  to  the
obligations  of the Company to take any action  pursuant to this  Section 1 with
respect to the  Registrable  Securities  of any selling  Holder that such Holder
shall furnish to the Company such information  regarding itself, the Registrable
Securities held by it, and the intended method of disposition of such securities
as shall be required to effect the  registration  of such  Holder's  Registrable
Securities.

     1.6 Expenses of Demand  Registration.  All expenses other than underwriting
discounts and commissions incurred in connection with registrations,  filings or
qualifications  pursuant to Section 1.2 (which right may be assigned as provided
in Section 1.13),  including  (without  limitation)  all  registration,  filing,
qualification,  printers' and accounting fees, fees and disbursements of counsel
for the Company,  and the reasonable fees and  disbursements  of one counsel for
the selling Holders shall be borne by the Company; provided,  however, that such
counsel shall submit  reasonably  detailed  invoices for review by the Company's
General  Counsel  prior to payment;  and  provided  further,  however,  that the
Company  shall  not be  required  to pay for any  expenses  of any  registration
proceeding  begun  pursuant  to  Section  1.2 if  the  registration  request  is
subsequently  withdrawn  at the  request of the  Holders  of a  majority  of the
Registrable Securities to be registered (in which case all participating Holders
shall bear such  expenses),  unless the Initiating  Holders agree to forfeit the
applicable demand  registration right pursuant to Section 1.2; provided further,
however,  that if at the time of such withdrawal,  the Holders have learned of a
material adverse change in the condition,  business, or prospects of the Company
from that known to the Holders at the time of their  request and have  withdrawn
the request with reasonable  promptness  following  disclosure by the Company of
such material adverse change,


                                       8
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                                                            Page 50 of 92 Pages

then the Holders  shall not be required  to pay any of such  expenses  and shall
retain their rights pursuant to Section 1.2.

     1.7 Expenses of Company  Registration.  The Company  shall bear and pay all
expenses incurred in connection with any  registration,  filing or qualification
of Registrable  Securities with respect to the registrations pursuant to Section
1.3 for each Holder  (which right may be assigned as provided in Section  1.13),
including  (without   limitation)  all  registration,   filing,   qualification,
printers'  and  accounting  fees,  fees and  disbursements  of  counsel  for the
Company,  and the  reasonable  fees and  disbursements  of one  counsel  for the
selling Holders;  provided,  however,  that such counsel shall submit reasonably
detailed  invoices for review by the Company's General Counsel prior to payment;
but excluding  underwriting  discounts and  commissions  relating to Registrable
Securities.

     1.8 Underwriting Requirements. In connection with any offering involving an
underwriting of shares of the Company's  capital stock, the Company shall not be
required  under  Section 1.3 to include any of the Holders'  securities  in such
underwriting  unless  they accept the terms of the  underwriting  as agreed upon
between the Holders of a majority of the  Registrable  Securities that indicated
they  would  like  to be  included  in the  underwriting,  the  Company  and the
underwriters  selected  by it  (or by  other  persons  entitled  to  select  the
underwriters),  and then only in such quantity as the underwriters  determine in
their sole  discretion  will not  jeopardize  the success of the offering by the
Company. If the total amount of securities,  including  Registrable  Securities,
requested by shareholders to be included in such offering  exceeds the amount of
securities  sold other than by the Company  that the  underwriters  determine in
their sole discretion is compatible  with the success of the offering,  then the
Company  shall be required to include in the  offering  only that number of such
securities,  including Registrable Securities,  which the underwriters determine
in their sole  discretion  will not  jeopardize the success of the offering (the
securities so included to be apportioned pro rata among the selling shareholders
according  to the total  amount  of  securities  entitled  and  requested  to be
included therein owned by each selling  shareholder or in such other proportions
as shall  mutually be agreed to by such  selling  shareholders)  but in no event
shall (i) the  amount of  securities  of the  selling  Holders  included  in the
offering be reduced below thirty percent (30%) of the total amount of securities
included  in such  offering,  or (ii)  notwithstanding  (i) above,  Section  1.2
governs the exclusion of shares being sold by a shareholder  exercising a demand
registration   right   granted   thereunder.   For  purposes  of  the  preceding
parenthetical concerning  apportionment,  for any selling shareholder which is a
holder of Registrable Securities and which is a partnership or corporation,  the
partners,  retired partners and shareholders of such holder,  or the estates and
family members of any such partners and retired  partners and any trusts for the
benefit of any of the foregoing  persons shall be deemed to be a single "selling
shareholder,"  and  any  pro-rata   reduction  with  respect  to  such  "selling
shareholder"  shall be based  upon  the  aggregate  amount  of  shares  carrying
registration  rights  owned by all  entities  and  individuals  included in such
"selling shareholder," as defined in this sentence.

     1.9 Delay of Registration. No Holder shall have any right to obtain or seek
an injunction  restraining or otherwise  delaying any such  registration  as the
result of any controversy that might arise with respect to the interpretation or
implementation of this Section 1.



                                       9
<PAGE>
                                                            Page 51 of 92 Pages

     1.10 Indemnification.  In the event any Registrable Securities are included
in a registration statement under this Section 1:

          (a) To the extent  permitted by law, the Company  will  indemnify  and
     hold harmless each Holder, any underwriter (as defined in the Act) for such
     Holder and each person,  if any, who  controls  such Holder or  underwriter
     within the meaning of the Act or the 1934 Act, against any losses,  claims,
     damages, or liabilities (joint or several) to which they may become subject
     under the Act, the 1934 Act or other federal or state law,  insofar as such
     losses,  claims,  damages,  or liabilities (or actions in respect  thereof)
     arise out of or are based upon any of the following  statements,  omissions
     or violations  (collectively  a "Violation"):  (i) any untrue  statement or
     alleged untrue statement of a material fact contained in such  registration
     statement,   including  any  preliminary  prospectus  or  final  prospectus
     contained  therein  or any  amendments  or  supplements  thereto,  (ii) the
     omission or alleged  omission to state  therein a material fact required to
     be  stated  therein,  or  necessary  to make  the  statements  therein  not
     misleading,  or (iii) any violation or alleged  violation by the Company of
     the Act, the 1934 Act, any state  securities law, or any rule or regulation
     promulgated  under the Act,  and the Company  will pay to each such Holder,
     underwriter or controlling person, as incurred, any legal or other expenses
     reasonably  incurred by them in connection with  investigating or defending
     any such loss, claim, damage, liability, or action; provided, however, that
     the  indemnity  agreement  contained in this  subsection  1.10(a) shall not
     apply to  amounts  paid in  settlement  of any such  loss,  claim,  damage,
     liability,  or action if such settlement is effected without the consent of
     the Company (which consent shall not be unreasonably  withheld),  nor shall
     the  Company be liable in any such case for any such loss,  claim,  damage,
     liability, or action to the extent that it arises out of or is based upon a
     Violation  which  occurs in reliance  upon and in  conformity  with written
     information   furnished   expressly  for  use  in   connection   with  such
     registration by any such Holder, underwriter or controlling person.

          (b) To the extent permitted by law, each selling Holder will indemnify
     and hold harmless the Company, each of its directors,  each of its officers
     who has  signed  the  registration  statement,  each  person,  if any,  who
     controls the Company  within the meaning of the Act, any  underwriter,  any
     other Holder  selling  securities  in such  registration  statement and any
     controlling  person or any such underwriter or Holder,  against any losses,
     claims,  damages,  or  liabilities  (joint or  several) to which any of the
     foregoing persons may become subject,  under the Act, the 1934 Act or other
     federal  or  state  law,  insofar  as  such  losses,  claims,  damages,  or
     liabilities (or actions in respect  thereto) arise out of or are based upon
     any  Violation,  in each case to the extent (and only to the  extent)  that
     such  Violation  occurs in reliance  upon and in  conformity  with  written
     information  furnished by such Holder  expressly for use in connection with
     such registration; and each such Holder will pay, as incurred, any legal or
     other expenses reasonably incurred by any person intended to be indemnified
     pursuant to this subsection  1.10(b),  in connection with  investigating or
     defending  any such loss,  claim,  damage,  liability or action;  provided,
     however,  that the indemnity agreement contained in this subsection 1.10(b)
     shall not apply to amounts  paid in  settlement  of any such  loss,  claim,
     damage,  liability,  or action if such  settlement is effected  without the
     consent of the Holder,  which consent shall not be  unreasonably  withheld;
     provided,  however,  that  in no  event  shall  any  indemnity  under  this
     subsection  1.10(b)  exceed the net proceeds from the offering  received by
     such Holder.



                                       10
<PAGE>
                                                            Page 52 of 92 Pages

          (c) Promptly after receipt by an indemnified  party under this Section
     1.10  of  notice  of  the   commencement  of  any  action   (including  any
     governmental  action),  such indemnified  party will, if a claim in respect
     thereof is to be made  against any  indemnifying  party under this  Section
     1.10,   deliver  to  the  indemnifying   party  a  written  notice  of  the
     commencement  thereof  and the  indemnifying  party shall have the right to
     participate  in,  and,  to the extent the  indemnifying  party so  desires,
     jointly with any other indemnifying party similarly notified, to assume the
     defense  thereof  with  counsel  mutually   satisfactory  to  the  parties;
     provided,  however,  that an  indemnified  party  (together  with all other
     indemnified  parties  which  may be  represented  without  conflict  by one
     counsel) shall have the right to retain one separate counsel, with the fees
     and expenses to be paid by the  indemnifying  party, if  representation  of
     such indemnified  party by the counsel  retained by the indemnifying  party
     would be  inappropriate  due to actual  or  potential  differing  interests
     between  such  indemnified  party and any other party  represented  by such
     counsel in such  proceeding.  The failure to deliver  written notice to the
     indemnifying party within a reasonable time of the commencement of any such
     action, if prejudicial to its ability to defend such action,  shall relieve
     such  indemnifying  party of any liability to the  indemnified  party under
     this Section  1.10,  but the omission so to deliver  written  notice to the
     indemnifying party will not relieve it of any liability that it may have to
     any indemnified party otherwise than under this Section 1.10.

          (d) If the  indemnification  provided for in this Section 1.10 is held
     by a court of competent  jurisdiction  to be  unavailable to an indemnified
     party  with  respect  to any loss,  liability,  claim,  damage,  or expense
     referred to herein,  then the  indemnifying  party, in lieu of indemnifying
     such indemnified  party  hereunder,  shall contribute to the amount paid or
     payable  by such  indemnified  party as a result of such  loss,  liability,
     claim,  damage,  or expense in such proportion as is appropriate to reflect
     the  relative  fault of the  indemnifying  party on the one hand and of the
     indemnified  party  on the  other in  connection  with  the  statements  or
     omissions that resulted in such loss, liability,  claim, damage, or expense
     as well as any other relevant equitable considerations.  The relative fault
     of the indemnifying  party and of the indemnified party shall be determined
     by reference to, among other things,  whether the untrue or alleged  untrue
     statement  of a material  fact or the  omission  to state a  material  fact
     relates  to  information  supplied  by  the  indemnifying  party  or by the
     indemnified  party and the parties' relative intent,  knowledge,  access to
     information,  and  opportunity  to  correct or prevent  such  statement  or
     omission. Notwithstanding the foregoing, (i) no Holder shall be required to
     contribute  any  amount  in  excess  of the  public  offering  price of all
     Registrable  Securities  offered and sold by such  Holder  pursuant to such
     registration   statement,   and  (ii)  no  person   guilty  of   fraudulent
     misrepresentation (within the meaning of Section 11(f) of the Act) shall be
     entitled  to  contribution  from  any  person  who was not  guilty  of such
     fraudulent misrepresentation.

          (e) The obligations of the Company and Holders under this Section 1.10
     shall survive the completion of any offering of Registrable Securities in a
     registration statement under this Section 1, and otherwise.

     1.11 Reports Under  Securities  Exchange Act of 1934. With a view to making
available to the Holders the benefits of Rule 144 promulgated  under the Act and
any other rule or  regulation of the SEC that may at any time permit a Holder to
sell securities of the Company to the public without registration or pursuant to
a registration on Form S-3, the Company agrees to:



                                       11
<PAGE>
                                                            Page 53 of 92 Pages

          (a) make and keep  public  information  available,  as those terms are
     understood and defined in SEC Rule 144, at all times;

          (b) take such action,  including  the  voluntary  registration  of its
     Common  Stock under  Section 12 of the 1934 Act, as is  necessary to enable
     the  Holders  to  utilize  Form  S-3 for  the  sale  of  their  Registrable
     Securities, such action to be taken as soon as practicable after the end of
     the  fiscal  year in which the first  registration  statement  filed by the
     Company  for the  offering  of its  securities  to the  general  public  is
     declared effective;

          (c)  file  with the SEC in a  timely  manner  all  reports  and  other
     documents required of the Company under the Act and the 1934 Act; and

          (d) furnish to any Holder,  so long as the Holder owns any Registrable
     Securities,  forthwith upon request (i) a written  statement by the Company
     that it has complied with the reporting  requirements  of SEC Rule 144, the
     Act,  and the  1934  Act,  or  that  it  qualifies  as a  registrant  whose
     securities  may be  resold  pursuant  to Form S-3 (at any time  after it so
     qualifies),  (ii) a copy of the most recent  annual or quarterly  report of
     the Company and such other  reports and  documents so filed by the Company,
     and (iii) such other information as may be reasonably requested in availing
     any Holder of any rule or  regulation  of the SEC which permits the selling
     of any such securities without registration or pursuant to such form.

     1.12 Form S-3  Registration.  In case the Company  shall  receive  from any
Holder or  Holders a written  request  or  requests  that the  Company  effect a
registration  on Form  S-3 and any  related  qualification  or  compliance  with
respect to all or a part of the Registrable  Securities  owned by such Holder or
Holders, the Company will:

          (a) promptly give written notice of the proposed registration, and any
     related  qualification  or  compliance,  to all other Holders in accordance
     with Section 3.5 (the "S-3 Notice"); and

          (b) as soon as  practicable,  effect  such  registration  and all such
     qualifications  and  compliances as may be so requested and as would permit
     or  facilitate  the sale and  distribution  of all or such  portion of such
     Holder's  or  Holders'  Registrable  Securities  as are  specified  in such
     request, together with all or such portion of the Registrable Securities of
     any other Holder or Holders  joining in such request as are  specified in a
     written  request  given  within  twenty (20) days after  receipt of the S-3
     Notice;  provided,  however,  that the Company  shall not be  obligated  to
     effect any such registration, qualification or compliance, pursuant to this
     Section 1.12: (1) if Form S-3 is not available for offering by the Holders;
     (2) if the Holders,  together  with the holders of any other  securities of
     the Company  entitled to  inclusion in such  registration,  propose to sell
     Registrable  Securities and such other  securities (if any) at an aggregate
     price to the public (net of any underwriters'  discounts or commissions) of
     less than  $1,000,000;  (3) if the Company  shall  furnish to the Holders a
     certificate signed by the President of the Company stating that in the good
     faith  judgment  of the  Board  of  Directors  of  the  Company,  it  would
     materially  interfere with any material financing,  acquisition,  corporate
     reorganization  or  merger  or other  material  transaction  involving  the
     Company,  in which  event  the  Company  shall  have the


                                       12
<PAGE>
                                                            Page 54 of 92 Pages

     right to defer the  filing  of the Form S-3  registration  statement  for a
     period of not more than one hundred  twenty (120) days after receipt of the
     request  of the  Holder or  Holders  under  this  Section  1.12;  provided,
     however,  that the Company  shall not utilize  this right more than once in
     any twelve (12) month  period;  (4) if the Company has,  within the six (6)
     month  period  preceding  the date of such  request,  already  effected one
     registration on Form S-3 for the Holders  pursuant to this Section 1.12; or
     (5) in any particular  jurisdiction  in which the Company would be required
     to qualify  to do  business  or to execute a general  consent to service of
     process in effecting such registration, qualification or compliance.

          (c) Subject to the  foregoing,  the Company shall file a  registration
     statement  covering the  Registrable  Securities  and other  securities  so
     requested to be  registered  as soon as  practicable  after  receipt of the
     request or requests  of the  Holders.  The  Company  shall bear and pay all
     expenses incurred in connection with a registration  requested  pursuant to
     Section 1.12,  including  (without  limitation) all  registration,  filing,
     qualification,  printer's and accounting  fees, fees and  disbursements  of
     counsel for the Company,  and the reasonable fees and  disbursements of one
     counsel for the selling  Holder or Holders;  provided,  however,  that such
     counsel  shall  submit  reasonably  detailed  invoices  for  review  by the
     Company's  General  Counsel prior to payment;  but  excluding  underwriting
     discounts and commissions relating to Registrable Securities;  and provided
     further,  that the  Company  shall  not be  obligated  to pay  registration
     expenses  under this  paragraph  if the Company has  already  effected  two
     registrations  on Form S-3  pursuant  to this  Section  1.12 after the date
     hereof.  Registrations  effected pursuant to this Section 1.12 shall not be
     counted as registrations effected pursuant to Section 1.2 or 1.3.

     1.13 Assignment of Registration  Rights. The rights to cause the Company to
register Registrable  Securities pursuant to this Section 1 may be assigned (but
only with all related  obligations)  by a Holder to a transferee  or assignee of
such  securities,  provided:  (a) the Company is, within a reasonable time after
such  transfer,  furnished  with written  notice of the name and address of such
transferee  or  assignee  and  the   securities   with  respect  to  which  such
registration rights are being assigned; (b) such transferee or assignee acquires
from the Holder more than 100,000 shares; (c) such transferee or assignee agrees
in  writing  to be bound by and  subject  to the  terms and  conditions  of this
Agreement,  including  without  limitation the provisions of Section 1.15 below;
and (d) such  assignment  shall be effective only if immediately  following such
transfer  the  further  disposition  of such  securities  by the  transferee  or
assignee is restricted under the Act.

     1.14 Limitations on Subsequent Registration Rights. From and after the date
of this Agreement,  the Company shall not,  without the prior written consent of
the Holders of a majority of the outstanding Registrable Securities,  enter into
any agreement  with any holder or  prospective  holder of any  securities of the
Company which would allow such holder or prospective  holder (a) to include such
securities in any registration filed under Section 1.2 hereof,  unless under the
terms of such  agreement,  such holder or  prospective  holder may include  such
securities  in any such  registration  only to the extent that the  inclusion of
such securities will not reduce the amount of the Registrable  Securities of the
Holders  which is  included  or (b) to make a demand  registration  which  could
result in such  registration  statement  being  declared  effective  within  one
hundred  twenty (120) days of the effective  date of any  registration  effected
pursuant to Section 1.2. If the Company grants registration rights to holders of
any  security of


                                       13
<PAGE>
                                                            Page 55 of 92 Pages

the Company  which are more  favorable  to such  holders  than the  registration
rights granted  hereunder  without the prior written consent of the Holders of a
majority of the  outstanding  Registrable  Securities,  then such more favorable
registration  rights  shall  also be  deemed to be  granted  to the  Holders  of
Registrable  Securities hereunder,  and the Company covenants and agrees to take
any and all steps necessary to modify the terms of this Agreement to so provide.

     1.15 [Deleted]

     1.16 Termination of Registration Rights.

     (a) No Holder shall be entitled to exercise any right  provided for in this
Section 1 after December 10, 2009.

     (b) In  addition,  the  right of any  Holder  to  request  registration  or
inclusion in any registration pursuant to Section 1 shall terminate on such date
that all  shares of  Registrable  Securities  held or  entitled  to be held upon
conversion  by such  Holder  may  immediately  be sold under Rule 144 during any
90-day period;  provided,  however,  that the provisions of this Section 1.16(b)
shall  not  apply  to any  Holder  who  owns at least  one  percent  (1%) of the
Company's outstanding Common Stock.

     2. Covenants of the Company.

     2.1 Right of First Offer.  Subject to the terms and conditions specified in
this Section 2.1, the Company  hereby  grants to each holder of at least 300,000
shares of Series 1 Preferred Stock or Common Stock issued upon the conversion of
shares of Series 1 Preferred  Stock (or a combination  thereof) a right of first
offer to purchase  its Pro Rata Share (as  hereinafter  defined) (in whole or in
part) with respect to future sales by the Company of its Shares (as  hereinafter
defined).  For  purposes  of this  Section  2.1, a holder's  "Pro Rata Share" of
Shares shall mean that number of Shares that equals the proportion  that (i) the
number of shares  of Common  Stock  issuable  upon  conversion  of the  Series 1
Preferred Stock plus the Series 1 Warrant Shares plus any other shares of Common
Stock,  in each case,  held by such holder  (other than shares  purchased in the
open market or directly from the Company not pursuant to this Section 2.1) bears
to (ii)  the  total  number  of  shares  of  Common  Stock of the  Company  then
outstanding  (assuming  full  conversion  and  exercise  of all  convertible  or
exercisable securities then outstanding).

     Each time the  Company  proposes  to offer  any  shares  of, or  securities
convertible into, exercisable or exchangeable for any shares of any class of its
capital  stock  ("Shares"),  the  Company  shall  first make an offering of such
Shares to each such holder of Series 1 Preferred  Stock in  accordance  with the
following provisions:

          (a)  The  Company  shall  deliver  a  notice  by  confirmed  facsimile
     transmission,  certified mail or a nationally  recognized overnight courier
     service  ("Notice") to each holder of Series 1 Preferred  Stock stating (i)
     its bona fide  intention  to offer  such  Shares,  (ii) the  number of such
     Shares to be  offered,  and (iii) the price and a summary of the terms,  if
     any, upon which it proposes to offer such Shares.



                                       14
<PAGE>
                                                            Page 56 of 92 Pages

          (b) By written  notification  received by the Company  within ten (10)
     calendar  days  after  receipt  of the  Notice,  each  holder  of  Series 1
     Preferred  Stock may elect to purchase  or obtain,  at the price and on the
     terms specified in the Notice, up to its Pro Rata Share of such Shares.

          (c) If all Shares  that the  holders of Series 1  Preferred  Stock are
     entitled  to obtain  pursuant  to  Section  2.1(b)  are not  elected  to be
     obtained as provided in Section 2.1(b) hereof,  the Company may, during the
     sixty (60)-day  period  following the expiration of the period  provided in
     Section 2.1(b)  hereof,  offer the remaining  unsubscribed  portion of such
     Shares to any person or persons at a price not less than, and upon terms no
     more  favorable to the offeree than those  specified in the Notice.  If the
     Company does not enter into an agreement  for the sale of the Shares within
     such period,  or if such  agreement is not  consummated  within thirty (30)
     days of the execution thereof, the right provided hereunder shall be deemed
     to be revived and such Shares shall not be offered  unless first  reoffered
     to the holders of Series 1 Preferred Stock in accordance herewith.

          (d) The  right  of  first  offer  in this  Section  2.1  shall  not be
     applicable  to (i) shares of Common Stock issued  pursuant to a dividend or
     distribution to shareholders generally, including a split or subdivision of
     the outstanding shares of the Company; (ii) shares of Common Stock issuable
     or  issued to  employees,  consultants  or  directors  of this  corporation
     pursuant to a stock  option  plan or stock  purchase  plan  approved by the
     Board  of  Directors  of the  Corporation  on or  prior to the date of this
     Agreement;  (iii)  shares of Common  Stock  issued  to  Baylor  College  of
     Medicine or assignees in connection  with the sale of software  licenses by
     the  Corporation in the Houston,  Texas market  through  December 31, 2002;
     (iv)  shares of Common  Stock  issuable  or  issued  in  consideration  for
     services rendered to the Corporation or its subsidiaries (other than shares
     issuable or issued pursuant to (ii) above),  in an aggregate  amount not to
     exceed  200,000  shares per annum;  (v) shares of Common Stock  issuable or
     issued in connection with acquisitions,  business combinations or strategic
     alliances, including corporate partnering agreements, not to exceed 500,000
     shares in the  aggregate  (as  adjusted  for stock  dividends,  splits  and
     combinations);  (vi) shares of Common  Stock the issuance of which has been
     approved  in  writing by the  holders  of at least a  majority  of the then
     outstanding  shares of Series 1  Preferred  Stock;  (vii)  shares of Common
     Stock issuable upon (w) the conversion of the Series 1 Preferred Stock, (x)
     the  exercise  of the Series 1  Warrants,  (y) the  exercise of the warrant
     dated  February 15, 2000,  issued to Lazard Freres & Co. LLC, not to exceed
     32,300 shares in the aggregate (as adjusted for stock dividends, splits and
     combinations), or (z) the exercise of the warrants dated September 3, 1999,
     issued to America Online, not to exceed 727,911 shares in the aggregate (as
     adjusted for stock dividends, splits and combinations); (viii) the exercise
     of the Warrant dated September 14, 1999,  issued to Stoel Rives LLP, not to
     exceed  10,000  shares  (as  adjusted  for  stock  dividends,  splits,  and
     combinations);  or (ix) shares of Common Stock issued  pursuant to Sections
     2.3 and 2.4 of the Stock Purchase Agreement,  dated April 17, 2000, between
     the Company and the founders of AnywhereMD.com, Inc. (including pursuant to
     employment  agreements of even date therewith  between the Company and such
     founders),  not to exceed  600,000 shares in the aggregate (as adjusted for
     stock dividends, splits and combinations).


                                       15
<PAGE>
                                                            Page 57 of 92 Pages

     2.2 Tax Matters.

          (a) The Company covenants that it will not become a U.S. real property
     holding  corporation  ("USRPHC")  at any time while any Series 1  Purchaser
     owns  any   Registrable   Securities  or  any  securities   exercisable  or
     convertible into Registrable Securities (the "Stock").

          (b) In the event that a Series 1 Purchaser  desires to sell or dispose
     of any Stock,  and upon  demand by such  Series 1  Purchaser,  the  Company
     agrees to deliver to such Series 1 Purchaser a letter (the "Letter")  which
     complies  with  Sections  1.1445-2(c)(3)  and  1.897-2(h)  of the  Treasury
     Regulations  during  the  period  equal  to the  lesser  of (i) the  period
     beginning  five years  prior to the date of the Letter  through the date of
     the Letter and (ii) the period from the date of this Agreement  through the
     date of the Letter. The Letter shall be delivered to the Series 1 Purchaser
     one business day prior to the close of any sale or disposition of the Stock
     by the Series 1 Purchaser (the "Delivery Date").  The Letter shall be dated
     as of the Delivery  Date and signed by a corporate  officer who must verify
     under  penalties of perjury that the  statement is correct to his knowledge
     and belief pursuant to Section 1.897-2(h) of the Treasury Regulations.

          (c) The  parties  hereto  agree and  acknowledge  that,  unless in the
     opinion of outside  counsel to the relevant  party such action is necessary
     to comply with its obligations  under the Internal Revenue Code of 1986, as
     amended (the  "Code"),  (i) no party hereto will take the position that any
     amount will be  includable in income with respect to the Series 1 Preferred
     Stock  under  Section  305 of the Code and that no  parties  shall file Tax
     Returns  (as  defined  in the  Series 1  Agreement)  to the  contrary  (the
     "Reporting  Agreement")  and (ii) no party  hereto  shall take any position
     inconsistent  with the  Reporting  Agreement  upon  examination  of any Tax
     Return in any refund claim, in any litigation or otherwise.

     3. Agreement to Vote Shares.

     3.1 Voting. Each of the undersigned shareholders agrees that at any meeting
of the shareholders of the Company,  however called,  and in any action taken by
written  consent  of  shareholders  of  the  Company  without  a  meeting,   the
shareholder shall vote the shareholder's  shares of Common Stock and/or Series 1
Preferred  Stock,  and  shall  cause any  holder of record of the  shareholder's
shares of  Common  Stock or Series 1  Preferred  Stock,  to vote in favor of the
shareholder  approval  contemplated by Section 4.2(b) of the Preferred Stock and
Warrant Purchase Agreement dated as of December __, 2000 between the Company and
certain investors named therein.

     4. Miscellaneous.

     4.1 Successors and Assigns.  Except as otherwise provided herein, the terms
and  conditions of this  Agreement  shall inure to the benefit of and be binding
upon the respective successors and assigns of the parties (including transferees
of any shares of Registrable Securities).  Nothing in this Agreement, express or
implied,  is intended to confer upon any party other than the parties  hereto or
their respective successors and assigns any rights,  remedies,


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                                                            Page 58 of 92 Pages

obligations,  or  liabilities  under or by reason of this  Agreement,  except as
expressly provided in this Agreement.

     4.2 Governing Law. This Agreement  shall be governed by and construed under
the laws of the State of Oregon.

     4.3   Counterparts.   This  Agreement  may  be  executed  in  two  or  more
counterparts,  each of  which  shall be  deemed  an  original,  but all of which
together shall constitute one and the same instrument.

     4.4 Titles and  Subtitles.  The titles and subtitles used in this Agreement
are used for  convenience  only and are not to be  considered  in  construing or
interpreting this Agreement.

     4.5 Notices.  Unless otherwise  provided,  any notice required or permitted
under this Agreement  shall be given in writing and shall be deemed  effectively
given upon  personal  delivery to the party to be notified or upon  deposit with
the United States Post Office, by registered or certified mail,  postage prepaid
or upon delivery to a recognized  courier  service and addressed to the party to
be notified  at the  address  indicated  for such party on the  signature  pages
hereof,  or at such other  address as such party may designate by ten (10) days'
advance  written  notice to the other  parties.  Any notice given to the Company
under this Section 3.5 shall be copied via email to [email protected].

     4.6 Expenses.  If any action at law or in equity is necessary to enforce or
interpret the terms of this Agreement, the prevailing party shall be entitled to
reasonable attorneys' fees, costs and necessary disbursements in addition to any
other relief to which such party may be entitled.

     4.7 Amendments  and Waivers.  Any term of this Agreement may be amended and
the observance of any term of this Agreement may be waived (either  generally or
in a particular instance and either  retroactively or prospectively),  only with
the written consent of the Company and the holders of more than two-thirds (2/3)
of the Registrable Securities then outstanding, except as follows:

          (a) any  amendment or waiver  affecting  only the rights of holders of
     Registrable Securities described in subsection 1.1(i)(i) shall require only
     the consent of the Company and the holders of more than fifty percent (50%)
     of such  Registrable  Securities,  except  that  any  amendment  or  waiver
     affecting the rights of Series J Investors shall require the consent of the
     holders of more than fifty percent (50%) of the Registrable Securities held
     by the Series J Investors;

          (b) any  amendment or waiver  affecting  only the rights of holders of
     Registrable  Securities  held by former  Holders  of  Investor  Registrable
     Securities,  excluding Series D Holders and Series E Holders, shall require
     only the consent of the Company and the holders of more than  sixty-six and
     two-thirds percent (66 ?%) of such Registrable Securities;



                                       17
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                                                            Page 59 of 92 Pages

          (c) any  amendment or waiver  affecting  only the rights of holders of
     Registrable  Securities  who were Series D Holders  shall  require only the
     consent  of the  Company  and  the  holders  of  more  than  sixty-six  and
     two-thirds percent (66 2/3%) of such Registrable Securities;

          (d) any  amendment or waiver  affecting  only the rights of holders of
     Registrable  Securities  who were Series E Holders  shall  require only the
     consent of the Company and the holders of more than fifty  percent (50%) of
     such Registrable Securities; and

          (e) any  amendment or waiver  affecting  only the rights of holders of
     Registrable Securities described in subsections  1.1(i)(v),  1.1(i)(vi) and
     1.1(i)(vii)  shall  require only the consent of the Company and the holders
     of more than sixty-six and two-thirds percent (66 2/3%) of such Registrable
     Securities, acting as a single class.

Any amendment or waiver  effected in  accordance  with this  paragraph  shall be
binding upon each holder of any Registrable  Securities then  outstanding,  each
future holder of such Registrable Securities and the Company.

     4.8  Severability.  If one or more provisions of this Agreement are held to
be  unenforceable  under  applicable  law, such provision shall be excluded from
this Agreement and the balance of the Agreement  shall be interpreted as if such
provision  were so excluded  and shall be  enforceable  in  accordance  with its
terms.

     4.9 Aggregation of Stock. All shares of Registrable  Securities  (including
the Common Stock  issuable upon  conversion  thereof),  as  applicable,  held or
acquired by a Holder shall be aggregated together for the purpose of determining
the availability of any rights under this Agreement.

     4.10 Entire Agreement;  Amendment;  Waiver. This Agreement  constitutes the
full and entire  understanding  and agreement between the parties with regard to
the subjects hereof and supersedes the 2000 Agreement.


                                       18
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                                                            Page 60 of 92 Pages


     IN WITNESS WHEREOF, the parties have executed this Agreement as of the date
first above written.

COMPANY:                            MEDICALOGIC, INC.


                                    By:
                                         ---------------------------------------
                                    Printed Name: David Moffenbeier
                                    Title: Chief Executive Officer

SHAREHOLDERS:                       See Attached Signature Pages




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