PHYSICIAN RELIANCE NETWORK INC
SC 13G/A, 1999-02-16
SPECIALTY OUTPATIENT FACILITIES, NEC
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549



                                  SCHEDULE 13G



                   Under the Securities Exchange Act of 1934

                               (Amendment No. 3)*


                        Physician Reliance Network, Inc.
                                (Name of Issuer)


                                  Common Stock
                         (Title of Class of Securities)


                                  71940G 10 8
                                 (CUSIP Number)




     *The  remainder  of this cover  page  shall be filled  out for a  reporting
person's  initial  filing on this  form with  respect  to the  subject  class of
securities,  and for any subsequent amendment containing information which would
alter the disclosures provided in a prior cover page.

     The  information  required in the remainder of this cover page shall not be
deemed to be "filed"  for the purpose of Section 18 of the  Securities  Exchange
Act of 1934 ("Act") or otherwise  subject to the  liabilities of that section of
the Act but shall be subject to all other  provisions of the Act  (however,  see
the Notes).



<PAGE>


                                  SCHEDULE 13G


CUSIP No.  71940G 10 G
- ---------------------------------------------------------------------------
1    NAMES OF REPORTING PERSON
     S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

     Texas Oncology, P.A. (IRS Employer Identification No. 75-2131429)
- ---------------------------------------------------------------------------
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*              (a) / /
                                                                    (b) / /

- ---------------------------------------------------------------------------
3    SEC USE ONLY

- ---------------------------------------------------------------------------
4    CITIZENSHIP OR PLACE OF ORGANIZATION

     State of Texas
- ---------------------------------------------------------------------------
                    5    SOLE VOTING POWER
  NUMBER OF
                         0
   SHARES           _______________________________________________________
                    6    SHARED VOTING POWER
BENEFICIALLY
                         9,131,427
  OWNED BY          _______________________________________________________
                    7    SOLE DISPOSITIVE POWER
    EACH
                         1,600,000
  REPORTING         _______________________________________________________
                    8    SHARED DISPOSITIVE POWER
 PERSON WITH
                         7,531,427
- ---------------------------------------------------------------------------
9    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     9,131,427
- ---------------------------------------------------------------------------
10   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
     CERTAIN SHARES*                                                    / /

- ---------------------------------------------------------------------------
11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

     17.7%
- ---------------------------------------------------------------------------
12   TYPE OF REPORTING PERSON*

     00 (Professional Association)
- ---------------------------------------------------------------------------

                   *SEE INSTRUCTIONS BEFORE FILLING OUT!

<PAGE>


Item 1(a) Name of Issuer:

     Physician Reliance Network, Inc.

Item 1(b) Address of Issuer's Principal Executive Offices:

     Two Lincoln Center
     5420 LBJ Freeway, Suite 900
     Dallas, TX 75240

Item 2(a) Name of Person Filing:

     Texas Oncology, P.A.

Item 2(b) Address of Principal Business Office

     Two Lincoln Center
     5420 LBJ Freeway, Suite 900
     Dallas, TX 75240

Item 2(c) Citizenship:

     The Reporting Person is a Texas professional association.

Item 2(d) Title of Class of Securities:

     Common Stock

Item 2(e) CUSIP Number:

     7194G 10 8

Item 3.   Not applicable.

Item 4.   Ownership:

          (a)  Amount Beneficially Owned:    9,131,427

          (b)  Percent of Class:  17.7% (based on 51,549,583 shares   of  Common
               Stock of the Issuer outstanding as of December 31, 1998)

          (c) Number of shares as to which such person has:

               (i)  sole power to vote or to direct the vote:  0

               (ii) shared  power to vote to direct the vote:  9,131,427.  As an
                    inducement to American Oncology Resources,  Inc., a Delaware
                    corporation ("AOR"), to enter into the Agreement and Plan of
                    Merger,   dated  as  of  December   11,  1998  (the  "Merger
                    Agreement"),  by and  among  AOR,  Diagnostics  Acquisition,
                    Inc., a Texas corporation and wholly-owned subsidiary of AOR
                    ("AOR Sub"), and Physician  Reliance Network,  Inc., a Texas
                    corporation  (the "Issuer"),  whereby AOR Sub will be merged
                    with and into  the  Issuer  (the  "Merger"),  the  Reporting
                    Person  became a party  to a  certain  Affiliate  Agreement,
                    dated as of December 13, 1998,  as amended by the  Amendment
                    to Affiliate Agreement, dated as of February 12, 1999 (as so
                    amended, the "Affiliate Agreement"),  with AOR. By executing
                    the Affiliate Agreement,  the Reporting Person agreed, among
                    other things,  to vote at a meeting of  stockholders  of the
                    Issuer  all  shares of Common  Stock of the  Issuer  held of
                    record or beneficially  by the Reporting  Person in favor of
                    the Merger and the  adoption  of the Merger  Agreement.  The
                    Reporting  Person also  agreed not to sell or  transfer  the
                    shares of Common  Stock of the Issuer  held  thereby  except
                    pursuant to the terms of the Merger Agreement, provided that
                    the Reporting  Person may distribute to its  shareholders up
                    to 1,600,000  shares of Common Stock of the Issuer  pursuant
                    to stock options issued by, or other contractual commitments
                    of, the Reporting  Person and outstanding as of December 11,
                    1998.  The  Affiliate  Agreement  terminates  if the  Merger
                    Agreement is terminated  in accordance  with its terms other
                    than as a result of the  effectiveness  of the  Merger.  The
                    foregoing summary of the Affiliate Agreement is qualified in
                    its  entirety  by  reference  to the  copy  of the  form  of
                    Affiliate   Agreement,   together   with  the  Amendment  to
                    Affiliate Agreement attached thereto,  included as Exhibit A
                    to this Schedule 13G and incorporated herein it its entirety
                    by reference.

              (iii) sole  power to  dispose  or to direct  the  disposition  of:
                    1,600,000.  Under the  Affiliate  Agreement,  the  Reporting
                    Person  agreed not to sell or transfer  the shares of Common
                    Stock of the Issuer  held  thereby  except  pursuant  to the
                    terms of the Merger  Agreement,  provided that the Reporting
                    Person may  distribute to its  shareholders  up to 1,600,000
                    shares  of  Common  Stock of the  Issuer  pursuant  to stock
                    options issued by, or other contractual  commitments of, the
                    Reporting Person and outstanding as of December 11, 1998.

               (iv) shared power to dispose or to direct the disposition
                    of:  7,531,427

Item 5.   Ownership of Five Percent or Less of a Class:

          Not applicable.

Item 6.   Ownership of More Than Five Percent on Behalf of Another Person:

          Not applicable.

Item 7.   Identification and Classification of the Subsidiary Which
          Acquired the Security Being Reported on by the Parent Holding
          Company:

          Not applicable.

Item 8.   Identification and Classification of Member of the Group:

          Not applicable.

Item 9.   Notice of Dissolution of Group:

          Not applicable.

Item 10.  Certification:

     By signing  below I certify  that,  to the best of my knowledge and belief,
     the securities referred to above were not acquired and are not held for the
     purpose of or with the effect of changing or influencing the control of the
     issuer  of the  securities  and  were  not  acquired  and are  not  held in
     connection with or as a participant in any transaction  having such purpose
     or effect.


                                    SIGNATURE

     After  reasonable  inquiry and to the best of my  knowledge  and belief,  I
certify that the information  set forth in this statement is true,  complete and
correct.


Dated:  February 14, 1999                    TEXAS ONCOLOGY, P.A.



                                             By: /s/ Fred N. Ekerey, M.D.
                                             Title: President






Attention:     Intentional misstatements or omissions of fact constitute
               Federal criminal violations.  (See 18 U.S.C. 1001)







                                                                       EXHIBIT A

                               AFFILIATE AGREEMENT



American Oncology Resources, Inc.
16825 Northchase Drive, Suite 1300
Houston, Texas 77060
Attention:  Phillip H. Watts

Ladies and Gentlemen:

       The  undersigned  has  been  advised  that,  as of the date  hereof,  the
undersigned  may be deemed to be an "affiliate" of Physician  Reliance  Network,
Inc.,  a Texas  corporation  ("PRN"),  as that term is defined  for  purposes of
paragraphs (c) and (d) of Rule 145 of the Rules and Regulations  (the "Rules and
Regulations")  of the Securities and Exchange  Commission  (the "SEC") under the
Securities Act of 1933, as amended (the "Securities Act").

       Pursuant  to the terms and  subject  to the  conditions  of that  certain
Agreement and Plan of Merger by and among  American  Oncology  Resources,  Inc.,
Diagnostics  Acquisition,  Inc., a Texas corporation and wholly owned subsidiary
of American Oncology Resources,  Inc. ("Sub"),  and PRN dated as of December 11,
1998 (the "Merger Agreement"),  providing for, among other things, the merger of
Sub with  and into PRN (the  "Merger"),  the  undersigned  will be  entitled  to
receive shares of Common Stock, par value $0.01 per share, of American  Oncology
Resources,  Inc. ("American  Oncology  Resources,  Inc. Common Stock" or "Parent
Common  Stock") in  exchange  for shares of Common  Stock of PRN  (collectively,
"Company  Stock") owned by the  undersigned at the Effective Time (as defined in
the Merger  Agreement)  of the  Merger,  as  determined  pursuant  to the Merger
Agreement.

       Any capitalized  term not defined herein shall have the meaning  ascribed
to such term in the Merger Agreement.

       The undersigned has been advised by PRN and American Oncology  Resources,
Inc.  that the Merger will be treated  for  financial  accounting  purposes as a
"pooling  of  interests"  in  accordance  with  generally  accepted   accounting
principles  and that the staff of the SEC has  issued  certain  guidelines  that
should be followed to ensure such "pooling of interests" treatment.

       In  consideration  of the Merger  Agreement,  the  agreement  of American
Oncology Resources,  Inc. contained herein, American Oncology Resources,  Inc.'s
reliance on this letter in connection  with the  consummation  of the Merger and
for other good and valuable consideration,  the receipt and sufficiency of which
are hereby acknowledged, the undersigned hereby represents,  warrants and agrees
as follows:

I.     Restrictions on Transfer Relating to Pooling of Interests

       (a) The undersigned will not make any sale, transfer or other disposition
of the Company Stock owned by it during the period commencing 30 days before the
Effective  Time  and  ending  at the  earlier  of the  Effective  Time  and  the
termination of the Merger Agreement.

       (b) The undersigned will not make any sale, transfer or other disposition
of  American  Oncology  Resources,  Inc.  Common  Stock  owned by it  after  the
Effective Time until such time as financial  statements that include at least 30
days of combined operations of the Company and American Oncology Resources, Inc.
after the Merger shall have been published  within the meaning of Section 201.01
of  the  SEC's  Codification  of  Financial  Reporting   Policies,   unless  the
undersigned shall have delivered to American Oncology  Resources,  Inc. prior to
any  such  sale,   transfer  or  other  disposition,   a  written  opinion  from
PricewaterhouseCoopers LLP, independent public accountants for American Oncology
Resources,  Inc., or a written no-action letter from the accounting staff of the
SEC, in either case in form and substance  reasonably  satisfactory  to American
Oncology  Resources,  Inc.,  to the  effect  that such sale,  transfer  or other
disposition  will not  cause the  Merger  not to be  treated  as a  "pooling  of
interests"  for  financial  accounting  purposes in  accordance  with  generally
accepted accounting principles and the rules and regulations and interpretations
thereof of the SEC and the undersigned will not make any sale, transfer or other
disposition  of any shares of American  Oncology  Resources,  Inc.  Common Stock
received by it pursuant to the Merger in violation of the  Securities Act or the
rules and regulations thereunder.

II.    Restrictions on Transfer Relating to Rule 145

       The  undersigned  has been  advised  that the  issuance  of the shares of
American  Oncology  Resources,  Inc.  Common Stock in connection with the Merger
will have been  registered  with the SEC under the  Securities Act pursuant to a
Registration  Statement  on Form S-4.  However,  the  undersigned  has also been
advised,  and it agrees,  that since it may be deemed to be an  affiliate of the
Company at the time the Merger is submitted  for a vote of the  stockholders  of
the Company,  the American Oncology Resources,  Inc. Common Stock received by it
pursuant to the Merger can be sold by the  undersigned  only (i)  pursuant to an
effective  registration  statement  under the Securities Act, (ii) in conformity
with the volume and other  limitations of Rule 145  promulgated by the SEC under
the Securities Act or (iii) in reliance upon an exemption from registration that
is available under the Securities Act. The undersigned understands that American
Oncology Resources,  Inc. is under no obligation to register the transfer,  sale
or other  disposition of the American Oncology  Resources,  Inc. Common Stock by
the  undersigned or on the  undersigned's  behalf under the Securities Act or to
take any other action  necessary in order to make  compliance  with an exemption
from such  registration  available.  The undersigned also understands and agrees
that  stop-transfer  instructions will be given to American Oncology  Resources,
Inc.'s  transfer  agent with respect to the American  Oncology  Resources,  Inc.
Common Stock to be received by the  undersigned  pursuant to the Merger and that
there will be placed on the  certificates  representing  such shares of American
Oncology Resources,  Inc. Common Stock, or any substitutions  therefor, a legend
stating in substance as follows:

               "These  shares  were  issued in a  transaction  to which Rule 145
       promulgated  under the Securities  Act of 1933 applies.  These shares may
       only be  transferred  in  accordance  with the  terms of such Rule and an
       Affiliate  Agreement  between  the  original  holder of such  shares  and
       American Oncology  Resources,  Inc., a copy of which agreement is on file
       at the principal offices of American Oncology Resources, Inc."

       It is  understood  and agreed  that the legend set forth  above  shall be
removed,  upon surrender of certificates bearing such legend, if the undersigned
shall have delivered to American Oncology Resources, Inc. an opinion of counsel,
the  reasonable  cost of which  would be borne by American  Oncology  Resources,
Inc.,  in form  and  substance  reasonably  satisfactory  to  American  Oncology
Resources,  Inc.,  to the  effect  that the sale or  disposition  of the  shares
represented by the surrendered certificates may be effected without registration
of the offering,  sale and delivery of such shares under the Securities  Act. In
the event the undersigned  attempts to transfer the shares of American  Oncology
Resources,  Inc. Common Stock, the undersigned will deliver to American Oncology
Resources,  Inc.  written notice of a proposed  transfer in the form attached as
Exhibit A.

       American Oncology Resources, Inc. agrees to file with the SEC on a timely
basis after the  Effective  Time all reports and data required to be filed by it
under  Section 13 of the  Securities  Exchange Act of 1934,  as amended.  Parent
shall also furnish to the undersigned  from time to time a written  statement as
to its  compliance  with  the  reporting  requirements  of Rule  144  under  the
Securities  Act of 1933,  as  amended  and shall  otherwise  use all  reasonable
efforts to permit such sales under Rule 145.

       It is  understood  and  agreed  that  this  Affiliate's  Agreement  shall
terminate  and be of no further  force and effect and the legend set forth above
shall be removed by delivery of substitute certificates without such legend, and
the related  stop  transfer  restrictions  shall be lifted  forthwith if (i) the
undersigned's shares of Parent Common Stock shall have been registered under the
Securities Act of 1933, as amended,  for sale,  transfer or other disposition by
the undersigned or on the  undersigned's  behalf, or (ii) the undersigned is not
at the time an  affiliate  of Parent  and has held the  shares of Parent  Common
Stock issued in the Merger for at least one year (or such other period as may be
prescribed  by the  Securities  Act of  1933,  as  amended,  and the  rules  and
regulations promulgated thereunder) and Parent has filed with the SEC all of the
reports it is required to file under the  Securities  Exchange  Act of 1934,  as
amended,  during the preceding  twelve months or (iii) the undersigned is not at
the time an  affiliate  of Parent and has not been an affiliate of Parent for at
least three months and has held the shares of Parent  Common Stock issued in the
merger for at least two years (or such other period as may be  prescribed by the
Securities Act of 1933, as amended,  and the rules and  regulations  promulgated
thereunder)  or (iv)  Parent  shall have  received a letter  from the SEC, or an
opinion of counsel reasonably  acceptable to Parent, to the effect that the stop
transfer restrictions and the legend are not required.

III.   Agreements in Respect of Voting

       The  undersigned  hereby further  agrees that,  during the term that this
Agreement  is in effect,  at any  meeting of the  stockholders  of PRN,  however
called,  or in connection with any written  consent of the  stockholders of PRN,
the  undersigned  shall vote (or cause to be voted),  to the extent brought to a
vote of  shareholders,  all voting shares of capital stock of PRN held of record
or  beneficially  by the  undersigned in favor of the Merger and the adoption of
the Merger Agreement.

       The undersigned  further agrees that it will not enter into any agreement
or  understanding  with any person or entity  prior to the  termination  of this
Agreement that is contrary to the foregoing provisions.

IV.    Further Representations and Agreements

       The undersigned  further agrees that the undersigned  shall not, directly
or indirectly:

                      (a) except pursuant to the terms of the Merger  Agreement,
               offer for sale, sell, transfer,  tender, pledge, encumber, assign
               or otherwise  dispose of, or enter into any  contract,  option or
               other arrangement or understanding  with respect to or consent to
               the offer for sale, sale, transfer, tender, pledge,  encumbrance,
               assignment or other  disposition  of, any or all of the shares or
               any other equity  securities of PRN now or hereafter owned by the
               undersigned (the "Shares") or any interest therein;

                      (b) except as contemplated  by this  Agreement,  grant any
               proxies or powers of attorney, deposit any Shares into any voting
               trust or enter  into any  voting  agreement  with  respect to any
               Shares;

                      (c) take any action that would make any  representation or
               warranty  contained herein untrue or incorrect or have the effect
               of  preventing or disabling the  undersigned  from  performing my
               obligations under this Agreement.

V.     Miscellaneous

       The  undersigned  may, after the Effective Time of the Merger  Agreement,
distribute  to its  shareholders  shares  of  Parent  Common  Stock  held by the
undersigned  so  long  as (if  such  distribution  occurs  before  the  date  of
publication  of the combined  financial  results  report  referred to in Section
I(b)) no later than the time of such  distribution  each such shareholder  shall
have  executed and  delivered  to Parent a letter  agreement in the form of this
Agreement.

       This Agreement shall  terminate if the Merger  Agreement is terminated in
accordance  with its terms  other than as a result of the  effectiveness  of the
Merger. Such termination shall not affect the rights of Parent for any breach of
any  covenants,   agreements,   representations  or  warranties  herein  by  the
undersigned during the term hereof.

       This Agreement (i) constitutes the entire  agreement  between the parties
with respect to the subject  matter hereof and thereof and  supersedes all other
prior agreements and understandings,  both written and oral, between the parties
with  respect to the  subject  matter  hereof and (ii) shall not be  assigned by
operation of law or  otherwise  without the prior  written  consent of the other
party.

       This Agreement  shall be governed by and construed in accordance with the
laws of the  State of  Delaware,  regardless  of the laws that  might  otherwise
govern under applicable principles of conflicts of laws thereof.

       Each of the parties hereto  recognizes and acknowledges  that a breach by
it of any covenants or  agreements  contained in this  Agreement  will cause the
other party to sustain  damages  for which there would be no adequate  remedy at
law for money  damages,  and therefore each of the parties hereto agrees that in
the event of any such breach the aggrieved party shall be entitled to the remedy
of specific  performance  of such  covenants and  agreements  and injunctive and
other equitable  relief, in addition to any other remedy to which such party may
be entitled, at law or in equity.

       Whenever  possible,  each  provision or portion of any  provision of this
Agreement  will be interpreted in such manner as to be effective and valid under
applicable  law,  but if any  provision  or  portion  of any  provision  of this
Agreement  is held to be invalid,  illegal or  unenforceable,  such  invalidity,
illegality or unenforceability will not affect any other provision or portion of
any provision,  and this  Agreement will be reformed,  construed and enforced in
such  jurisdiction  as if such invalid,  illegal or  unenforceable  provision or
portion of any provision had never been contained herein.

       Execution of this Agreement by the undersigned  shall not be deemed to be
an admission by the  undersigned  that it is an "affiliate" of PRN, nor a waiver
of any  rights  the  undersigned  may  have to  object  to any  claim  that  the
undersigned is an affiliate on or after the date hereof.

       If you are in agreement with the foregoing, please so indicate by signing
below and returning a copy of this letter to the undersigned, at which time this
letter shall become a binding agreement between us.

       This agreement may be executed in one or more counterparts, each of which
shall be deemed an original,  but all of which together shall constitute one and
the same instrument.

                                             Very truly yours,  TEXAS  ONCOLOGY,
                                             P.A.



                                             By: /s/ Charles S. White, III
                                             Name:   Charles S. White, III
                                             Title:  Chairman of the Board



Accepted this 13th day of December, 1998

American Oncology Resources, Inc.



By: /s/ R. Dale Ross
Name:   R. Dale Ross
Title:  Chief Executive Officer and
          Chairman of the Board


<PAGE>


                                            EXHIBIT A


American Oncology Resources, Inc.
16825 Northchase Drive, Suite 1300
Houston, Texas 77060
Attention:  Phillip H. Watts


Ladies and Gentlemen:

       The undersigned proposes to sell ___________________ shares of the common
stock of American  Oncology  Resources,  Inc. that the  undersigned  received in
connection  with the  transactions  contemplated  by the  Agreement  and Plan of
Merger dated December 11, 1998, by and among American Oncology Resources,  Inc.,
Diagnostic   Acquisitions,   Inc.  and  Physician  Reliance  Network,  Inc.  The
undersigned proposes to effect such sale through its broker, and, if applicable,
warrants  that  such  sale  will be made in  accordance  with  the  requirements
relating to sales by "affiliates"  promulgated  under Rule 145 of the Securities
Act of 1933, as amended.

                                             Very truly yours,



                                                                EXECUTION COPY


                        AMENDMENT TO AFFILIATE AGREEMENT


         This  Amendment,  dated as of February 12, 1999, is entered into by and
between TEXAS ONCOLOGY,  P.A., a Texas professional  association  ("TOPA"),  and
AMERICAN ONCOLOGY RESOURCES, INC., a Delaware corporation ("AOR").

                                    Recitals

         A. In connection  with the  Agreement  and Plan of Merger,  dated as of
December  11,  1998 (the  "Merger  Agreement"),  by and among  AOR,  Diagnostics
Acquisition,  Inc., a Texas corporation and wholly-owned  subsidiary of AOR, and
Physician Reliance Network, Inc., a Texas corporation, TOPA and AOR entered into
the  Affiliate  Agreement,  dated  as  of  December  13,  1998  (the  "Affiliate
Agreement"). Terms used but not defined herein are used herein as defined in the
Affiliate Agreement.

         B.  TOPA and AOR  have  agreed  to amend  the  Affiliate  Agreement  as
hereinafter set forth.

         SECTION 1. Amendments to Affiliate  Agreement.  The Affiliate Agreement
is, effective as of December 13, 1998, hereby
amended as follows:

                  (a) The first  paragraph of Section V  (Miscellaneous)  of the
Affiliate Agreement is hereby amended in its entirety to read as follows:

                  "Notwithstanding  any provision  herein to the  contrary,  the
         undersigned may distribute, grant, sell or transfer to its shareholders
         up to 1,600,000  shares of Company Stock or, after the Effective  Time,
         up to  1,504,000 of Parent  Common  Stock,  in either case  pursuant to
         stock options issued by, or other contractual  commitments of, TOPA and
         outstanding  as of December  11,  1998;  provided  that (i) in no event
         shall (A) the number of shares of Company Stock  distributed,  granted,
         sold or  transferred  pursuant to this paragraph plus (B) the number of
         shares of Parent Common Stock distributed, granted, sold or transferred
         pursuant to this paragraph  divided by 0.94 exceed  1,600,000;  (ii) if
         such shares are issued prior to the  Effective  Time, no later than the
         time  of  such   distribution,   grant,  sale  or  transfer  each  such
         shareholder  shall  have  executed  and  delivered  to  Parent a voting
         agreement in the form  attached  hereto as Exhibit B; and (iii) if such
         shares  are  distributed,   granted,  sold  or  transferred  after  the
         Effective  Time  and if such  distribution  occurs  before  the date of
         publication of the combined  financial  results  report  referred to in
         Section  I(b),  no later than the time of such  distribution  each such
         shareholder  shall  have  executed  and  delivered  to  Parent a letter
         agreement in the form of this Agreement."

                  (b) The voting  agreement  referenced in paragraph (a) of this
Section  1 and  attached  hereto  as  Exhibit  B shall be  attached  to,  and be
incorporated by reference in, the Affiliate Agreement as Exhibit B thereto.

         SECTION 2. Reference to and Effect on the Affiliate  Agreement.  On and
after the date  hereof,  each  reference  in the  Affiliate  Agreement  to "this
Agreement,"  "hereunder,"  "hereof,"  "herein" or words of like import, and each
reference in other agreements related to the Affiliate Agreement, shall mean and
be a reference to the Affiliate  Agreement as amended  hereby.  Except as hereby
expressly  amended,  the  Affiliate  Agreement  shall  remain in full  force and
effect,  and is hereby  ratified and  confirmed in all respects on and as of the
date hereof.

         SECTION 3. Execution in Counterparts. This Amendment may be executed in
any  number  of  counterparts  and  by  different  parties  hereto  in  separate
counterparts, each of which when so executed and delivered shall be deemed to be
an original and all of which taken  together  shall  constitute one and the same
instrument.

         SECTION 4.  GOVERNING  LAW.  THIS  AMENDMENT  SHALL BE GOVERNED BY, AND
CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF DELAWARE.

         IN WITNESS  WHEREOF,  the  parties  have caused  this  Amendment  to be
executed by their duly authorized representatives.



                                                     TEXAS ONCOLOGY, P.A.



                                             By: /s/ Fred N. Ekery, M.D.
                                             Title: President



                        AMERICAN ONCOLOGY RESOURCES, INC.



                                             By: /s/ L. Fred Pounds
                                             Title: Chief Financial Officer



                                    EXHIBIT B

                                VOTING AGREEMENT

                                     [DATE]



American Oncology Resources, Inc.
16825 Northchase Drive, Suite 1300
Houston, Texas 77060
Attention:  Phillip H. Watts

Ladies and Gentlemen:

         The  undersigned  has been advised that Texas  Oncology,  P.A., a Texas
professional  association  ("TOPA"),  has entered into the Affiliate  Agreement,
dated as of  December  13,  1998,  as  amended  by the  Amendment  to  Affiliate
Agreement,  dated  as of  February  10,  1999  (as so  amended,  the  "Affiliate
Agreement"),  with American  Oncology  Resources,  Inc., a Delaware  corporation
("AOR"),  in  connection  with the  Agreement  and Plan of  Merger,  dated as of
December  11,  1998 (the  "Merger  Agreement"),  by and among  AOR,  Diagnostics
Acquisition,  Inc., a Texas corporation and wholly-owned  subsidiary of AOR, and
Physician Reliance Network,  Inc., a Texas corporation  ("PRN"). Any capitalized
term not  defined  herein  shall have the  meaning  ascribed to such term in the
Merger Agreement.

         On the date hereof,  the  undersigned is receiving from TOPA ___ shares
(the "New PRN Shares") of Common Stock of PRN ("Company Stock"). Pursuant to the
Merger Agreement, the undersigned will receive shares of Common Stock, par value
$0.01 per share,  of AOR  ("Parent  Common  Stock") in  exchange  for all of the
shares of Company Stock  (including the New PRN Shares) owned by the undersigned
at the Effective  Time (as defined in the Merger  Agreement)  of the Merger,  as
determined pursuant to the Merger Agreement.

         In  consideration  of the  agreement  of AOR  contained  herein,  AOR's
reliance on this letter in connection  with the  consummation  of the Merger and
for other good and valuable consideration,  the receipt and sufficiency of which
are hereby acknowledged, the undersigned hereby represents,  warrants and agrees
as follows:


I.       AGREEMENTS IN RESPECT OF VOTING

         The undersigned  hereby further agrees that,  during the term that this
Agreement  is in effect,  at any  meeting of the  stockholders  of PRN,  however
called,  or in connection with any written  consent of the  stockholders of PRN,
the  undersigned  shall vote (or cause to be voted),  to the extent brought to a
vote of  shareholders,  all New PRN Shares held of record or beneficially by the
undersigned in favor of the Merger and the adoption of the Merger Agreement.

         The  undersigned  further  agrees  that  it will  not  enter  into  any
agreement or understanding with any person or entity prior to the termination of
this Agreement that is contrary to the foregoing provisions.


II.      FURTHER REPRESENTATIONS AND AGREEMENTS

         The undersigned further agrees that the undersigned shall not, directly
or indirectly:

                                    (a)  except  pursuant  to the  terms  of the
                  Merger  Agreement,  offer for sale,  sell,  transfer,  tender,
                  pledge,  encumber,  assign or  otherwise  dispose of, or enter
                  into   any   contract,   option   or  other   arrangement   or
                  understanding  with  respect  to or  consent  to the offer for
                  sale, sale, transfer, tender, pledge, encumbrance,  assignment
                  or other  disposition of, any or all of the New PRN Shares now
                  or hereafter owned by the undersigned or any interest therein;

                                    (b)   except   as   contemplated   by   this
                  Agreement,  grant any proxies or powers of  attorney,  deposit
                  any New PRN  Shares  into any  voting  trust or enter into any
                  voting agreement with respect to any New PRN Shares; or

                                    (c)  take any  action  that  would  make any
                  representation   or  warranty   contained   herein  untrue  or
                  incorrect or have the effect of  preventing  or disabling  the
                  undersigned   from   performing  my  obligations   under  this
                  Agreement.


III.     MISCELLANEOUS

         This Agreement shall terminate if the Merger Agreement is terminated in
accordance  with its terms  other than as a result of the  effectiveness  of the
Merger.  Such  termination  shall not affect the rights of AOR for any breach of
any  covenants,   agreements,   representations  or  warranties  herein  by  the
undersigned during the term hereof.

         This Agreement (i) constitutes the entire agreement between the parties
with respect to the subject  matter hereof and thereof and  supersedes all other
prior agreements and understandings,  both written and oral, between the parties
with  respect to the  subject  matter  hereof and (ii) shall not be  assigned by
operation of law or  otherwise  without the prior  written  consent of the other
party.

         This  Agreement  shall be governed by and construed in accordance  with
the laws of the State of Delaware,  regardless of the laws that might  otherwise
govern under applicable principles of conflicts of laws thereof.

         Each of the parties hereto recognizes and acknowledges that a breach by
it of any covenants or  agreements  contained in this  Agreement  will cause the
other party to sustain  damages  for which there would be no adequate  remedy at
law for money  damages,  and therefore each of the parties hereto agrees that in
the event of any such breach the aggrieved party shall be entitled to the remedy
of specific  performance  of such  covenants and  agreements  and injunctive and
other equitable  relief, in addition to any other remedy to which such party may
be entitled, at law or in equity.

         Whenever  possible,  each provision or portion of any provision of this
Agreement  will be interpreted in such manner as to be effective and valid under
applicable  law,  but if any  provision  or  portion  of any  provision  of this
Agreement  is held to be invalid,  illegal or  unenforceable,  such  invalidity,
illegality or unenforceability will not affect any other provision or portion of
any provision,  and this  Agreement will be reformed,  construed and enforced in
such  jurisdiction  as if such invalid,  illegal or  unenforceable  provision or
portion of any provision had never been contained herein.

         Execution of this Agreement by the  undersigned  shall not be deemed to
be an  admission  by the  undersigned  that it is an  "affiliate"  of PRN, nor a
waiver of any  rights the  undersigned  may have to object to any claim that the
undersigned is an affiliate on or after the date hereof.

         If you are in  agreement  with the  foregoing,  please so  indicate  by
signing below and returning a copy of this letter to the  undersigned,  at which
time this letter shall become a binding agreement between us.

         This  agreement  may be executed in one or more  counterparts,  each of
which shall be deemed an original,  but all of which together  shall  constitute
one and the same instrument.

                                            Very truly yours,



                                            ---------------------------
                                            [Name of TOPA Shareholder]

                                            Address:___________________





Accepted this _____ day of ______, 1999

American Oncology Resources, Inc.


By:_____________________________
Name:___________________________
Title:__________________________




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