HANCOCK JOHN INSTITUTIONAL SERIES TRUST
497J, 1999-07-02
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EDGAR

July 2, 1999

U.S. Securities and Exchange Commission
Judiciary Plaza
450 Fifth Street, N.W.
Washington, D.C. 20549

Re:    Filing Pursuant to Rule 497(j)
       John Hancock Institutional Series Trust
        John Hancock Active Bond Fund
        John Hancock Dividend Performers Fund
        John Hancock Medium Capitalization Growth Fund
         (fka John Hancock Multi-Sector Growth Fund)
        John Hancock Small Capitalization Value Fund
        John Hancock Small Capitalization Growth Fund
        John Hancock International Equity Fund
        John Hancock Independence Diversified Core Equity Fund II
        John Hancock Independence Medium Capitalization Fund
        John Hancock Independence Balanced Fund
        John Hancock Core Growth Fund
        John Hancock Core Value Fund

      File Nos.  33-86102; 811-8852

Gentlemen:

Pursuant to 497(j) of Regulation C, under the Securities Act of 1933, in lieu of
filing under paragraph (b) or (c) of Rule 497, I hereby certify that the form of
Prospectus dated July 1, 1999 and Statement of Additional Information dated July
1, 1999 for the  above-captioned  registrant  that would  have been filed  under
paragraph  (b) or (c) of Rule 497(j) does not differ from that  contained in the
most recent  registration  statement  amendment  and the text of the most recent
registration statement that has been filed electronically.

                                                 Sincerely,


                                                 /s/Joan O'Neill
                                                 ---------------
                                                 Joan O'Neill





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