HANCOCK JOHN INSTITUTIONAL SERIES TRUST
DEFA14A, 1999-05-28
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Dear Shareholder:


This is to inform you that we inadvertently  omitted certain  investors  holding
greater than 5% of the outstanding  shares of the fund from page 11 of the proxy
statement. On the reverse of this letter is a complete list of investors who own
5% or  more of the  outstanding  shares  of  each  fund.  We  apologize  for any
inconvenience this may have caused you.

Your vote makes a difference!
Just a reminder to let you know that your vote is  critical.  Please  review the
materials previously sent to you and complete,  sign and return the proxy ballot
to us immediately.  Your prompt response will help avoid the need for additional
mailings.

If you have any  additional  questions or need  additional  information,  please
contact your investment professional or call your Client Relationship Officer at
1-800-544-3577,  Monday through  Friday between 8:00 A.M. and 6:00 P.M.  Eastern
Time.
Thank you for your prompt vote on this matter.



<PAGE>


               Supplement to John Hancock Independence Growth Fund
                 and John Hancock Independence Value Fund Proxy

Please replace page 11 of the proxy with the following:

                        OWNERSHIP OF SHARES IN THE FUNDS

As of May 10, 1999,  the  following  investors  held of record 5% or more of the
outstanding  shares  of the  funds.  To the  knowledge  of each  fund,  no other
investors owned of record or  beneficially 5% or more of the outstanding  shares
of the funds.

<TABLE>
<CAPTION>

                 <S>                                  <C>                                <C>
- ----------------------------------------- ------------------------------- -----------------------------------
                                                                          Percentage of
Name and Address of Shareholder           Fund                            Outstanding Shares
- -------------------------------           ----                            ------------------

- ----------------------------------------- ------------------------------- -----------------------------------
Glaval Corporation Savings Plan           Independence Growth Fund        29.34%
55470 County Road
Elkhart, IN  46514
- ----------------------------------------- ------------------------------- -----------------------------------
Independence Investment Associates        Independence Growth Fund        16.90%
53 State Street
Boston, MA  02109
- ----------------------------------------- ------------------------------- -----------------------------------
Elixir Industries 401(k) Plan             Independence Growth Fund        13.63%
17925 S. Broadway
P.O. Box 470
Gardena, CA 90247
- ----------------------------------------- ------------------------------- -----------------------------------
American Radio Association Retirement     Independence Growth Fund        10.59%
Account Plan
360 West 31st Street, 3rd Floor
New York, NY  10001
- ----------------------------------------- ------------------------------- -----------------------------------
The Arden Group Inc.                      Independence Growth Fund        8.66%
401(k) Plan
2020 South Central Avenue
Compton, CA  90220
- ----------------------------------------- ------------------------------- -----------------------------------
City of Highland Park                     Independence Growth Fund        5.50%
401(k) Plan
12050 Woodward Avenue
Highland Park, MI  48203
- ----------------------------------------- ------------------------------- -----------------------------------
Mendes & Mount LLP                        Independence Value Fund         27.04%
Retirement Plan
750 Seventh Avenue
New York, NY  10019
- ----------------------------------------- ------------------------------- -----------------------------------
Mendes & Mount LLP                        Independence Value Fund         26.55%
Retirement Plan II
750 Seventh Avenue
New York, NY  10019
- ----------------------------------------- ------------------------------- -----------------------------------
Glaval Corporation Savings Plan           Independence Value Fund         15.66%
55470 County Road
Elkhart, IN  46514
- ----------------------------------------- ------------------------------- -----------------------------------
Independence Investment Associates        Independence Value Fund         14.42%
53 State Street
Boston, MA  02109
- ----------------------------------------- ------------------------------- -----------------------------------
CG Enterprises EE Sal Savings             Independence Value Fund         9.07%
Retirement Plan
12001 Guilford Road
Annapolis Junction, MD  20701
- ----------------------------------------- ------------------------------- -----------------------------------
5/26/99
</TABLE>



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