DISCOVERY LABORATORIES INC /DE/
PRE 14A, 1999-05-07
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                                  SCHEDULE 14A

                     INFORMATION REQUIRED IN PROXY STATEMENT
                            SCHEDULE 14A INFORMATION

Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

                           Filed by the Registrant [X]

                 Filed by a Party other than the Registrant [ ]

                           Check the appropriate box:

[X] Preliminary Proxy Statement           [ ] Confidential, for Use of the
[ ] Definitive Proxy Statement                Commission Only  (as
[ ] Definitive   Additional   Materials       permitted  by  Rule   14a-6(e)(2))
[ ] Soliciting Material Pursuant to
    Rule 14a-11(c) or Rule 14a-12
       

                          DISCOVERY LABORATORIES, INC.
                          ----------------------------
                (Name of Registrant as Specified in Its Charter)

(Name of Person(s) Filing Proxy Statement, if other than the Registrant): 
 Not Applicable
 --------------

Payment of filing fee (Check the appropriate box):

[X] No fee required.
[ ] Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.

      (1)   Title of each class of securities to which transaction  applies: 
            not applicable
            --------------

      (2)   Aggregate  number of securities to which  transaction  applies:  
            not applicable
            --------------

      (3)   Per unit price or other  underlying  value of  transaction  computed
            pursuant  to  Exchange  Act Rule 0-11 (set forth the amount on which
            the filing fee is calculated and state how it was determined):
            not applicable
            --------------

      (4)   Proposed maximum aggregate value of transaction: not applicable
                                                              --------------

      (5)   Total fee paid: not applicable
                            --------------
            [ ] Fee paid previously with preliminary materials:
            [ ] Check  box if any  part  of the fee is  offset  as  provided  by
            Exchange Act Rule  0-11(a)(2)  and identify the filing for which the
            offsetting fee was paid previously.  Identify the previous filing by
            registration  statement number, or the Form or Schedule and the date
            of its filing.

      (1)   Amount previously paid: not applicable
                                    --------------
      (2)   Form, Schedule or Registration Statement No.: not applicable
                                                          --------------
      (3)   Filing Party: not applicable
                          --------------
      (4)   Date Filed: not applicable
                        --------------

<PAGE>

                        350 South Main Street, Suite 307
                              Doylestown, PA 18901
                        --------------------------------
                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                     To be held on Wednesday, June 16, 1999
                        --------------------------------

To the Stockholders of Discovery Laboratories, Inc.:

The Annual Meeting of Stockholders of Discovery  Laboratories,  Inc., a Delaware
corporation (the  "Corporation"),  will be held on Wednesday,  June 16, 1999, at
10:00 a.m.  Eastern  Standard  Time at the office of Roberts,  Sheridan & Kotel,
P.C.,  12 East 49th  Street,  30th  Floor,  New York,  N.Y.,  for the  following
purposes:

      I.    To elect  nine  members to the Board of  Directors  to serve for the
            ensuing year and until their  respective  successors  have been duly
            elected and qualified;

      II.   To consider and approve an amendment to the Corporation's 1998 Stock
            Incentive Plan (the "1998 Plan") to increase the number of shares of
            Common  Stock  available  for  issuance  under  the 1998  Plan  from
            1,406,024  shares  of  Common  Stock to  2,200,959  shares of Common
            Stock;

      III.  To consider  and approve the entry by the  Corporation  into a stock
            purchase agreement with Crescent  International Limited ("Crescent")
            providing for the sale to Crescent of up to $1 million in new equity
            of the Corporation; and

      IV.   To  transact  such other  business as may  properly  come before the
            meeting and any adjournments or postponements thereof.

Only  stockholders  of record of the  Corporation's  Common  Stock and  Series B
Convertible  Preferred  Stock at the close of  business  on April  20,  1999 are
entitled  to notice of,  and to vote at,  the  meeting  and any  adjournment  or
postponements  thereof.  A complete list of those  stockholders  will be open to
examination by any stockholder,  for any purpose germane to the meeting,  during
ordinary business hours at the Corporation's executive offices at 350 South Main
Street, Suite 307, Doylestown, Pennsylvania 18901, for a period of 10 days prior
to the meeting. The stock transfer books of the Corporation will not be closed.

                                              By Order of the Board of Directors

                                              /s/ Evan Myrianthopoulos
                                              ------------------------
                                              Evan Myrianthopoulos
                                              Corporate Secretary

Doylestown, Pennsylvania
May 20, 1999

<PAGE>

YOUR VOTE IS IMPORTANT.  WHETHER OR NOT YOU EXPECT TO ATTEND THE ANNUAL MEETING,
PLEASE  COMPLETE,  DATE AND SIGN THE ENCLOSED PROXY CARD AND MAIL IT PROMPTLY IN
THE ENCLOSED  ENVELOPE IN ORDER TO ASSURE  REPRESENTATION OF YOUR SHARES. IF YOU
DO ATTEND THE ANNUAL MEETING YOU MAY REVOKE YOUR PROXY AND VOTE BY BALLOT.

<PAGE>

                          Discovery Laboratories, Inc.

                                 PROXY STATEMENT

                         ANNUAL MEETING OF STOCKHOLDERS

                                  June 16, 1999

Proxies in the form  enclosed  with this Proxy  Statement  are  solicited by the
Board of  Directors  of Discovery  Laboratories,  Inc.,  a Delaware  corporation
("Discovery" or the "Corporation"),  with its principal executive offices at 350
South Main Street,  Suite 307,  Doylestown,  Pennsylvania  18901, for use at the
Annual  Meeting  of  Stockholders  and  any  adjournment  thereof  (the  "Annual
Meeting") to be held on Wednesday,  June 16, 1999 at 10:00 a.m. Eastern Standard
Time at the office of Roberts, Sheridan & Kotel, P.C., 12 East 49th Street, 30th
Floor,  New York,  N.Y.  10017. It is expected that this Proxy Statement and the
form of proxy will be mailed to stockholders on or about May 20, 1999.

Only holders of shares of Common  Stock,  par value $.001 per share (the "Common
Stock")  of the  Corporation  and  holders  of shares  of  Series B  Convertible
Preferred Stock, par value $.001 per share (the "Series B Preferred Stock"),  of
the  Corporation  of record as of April 20,  1999 (the  "Record  Date")  will be
entitled to vote at the Annual  Meeting and any  adjournments  or  postponements
thereof.  As of April 20, 1999,  6,427,007  shares of Common Stock and 1,699,886
shares of Series B Preferred  Stock were issued and  outstanding.  Each share of
Common Stock  outstanding as of the Record Date will be entitled to one vote and
each share of Series B Preferred Stock outstanding as of the Record Date will be
entitled to  approximately  3.1132  votes.  As of April 20, 1999,  the 1,699,886
shares of  Series B  Preferred  Stock are  entitled  to  5,292,089  votes in the
aggregate on all matters to be voted on.

Stockholders may vote at the annual meeting in person or by proxy.  Execution of
a proxy  will not in any way affect a  stockholder's  right to attend the Annual
Meeting  and vote in  person.  Any  stockholder  giving a proxy has the right to
revoke it by written  notice to the  Secretary  of the  Corporation  at any time
before it is exercised,  by executing a proxy with a later date, or by attending
and voting at the Annual  Meeting.  The persons  named as proxies in the form of
proxy are directors  and/or officers of the Corporation.  All properly  executed
proxies  that are  returned in time to be counted at the Annual  Meeting will be
voted as stated below under "Voting  Procedures." Any stockholder giving a proxy
has the right to withhold  authority to vote for any  individual  nominee to the
Board of Directors by writing that  nominee's  name in the space provided on the
proxy. In addition to the election of directors,  the stockholders will consider
and vote upon (i) a proposal  to amend the  Corporation's  1998 Stock  Incentive
Plan  (the  "1998  Plan") to  increase  the  number  of  shares of Common  Stock
available for issuance  under the 1998 Plan from 1,406,024 to 2,200,959 and (ii)
a  proposal  to  approve  the  entry by the  Corporation  into a stock  purchase
agreement with Crescent  International  Limited  ("Crescent")  providing for the
sale to Crescent of up to $1 million in new equity of the  Corporation.  Where a
choice has been  specified on the proxy with respect to the  foregoing  matters,
the  shares  represented  by the  proxy  will be  voted in  accordance  with the
specifications  and will be voted FOR a respective matter if no specification is
indicated.

The  Board of  Directors  of the  Corporation  knows of no other  matters  to be
presented at the Annual Meeting.  If any other matter should be presented at the
Annual  Meeting upon which a vote properly may be taken,  shares  represented by
all  proxies  received  by the Board of  Directors  will be voted  with  respect
thereto in  accordance  with the judgment of the persons named as proxies in the
form of proxy.

<PAGE>

                                   PROPOSAL I

                              ELECTION OF DIRECTORS

At the Annual  Meeting,  nine directors will be elected by the  stockholders  to
hold  office  until the next  annual  meeting of  stockholders  and until  their
successors have been elected and qualified,  or until their earlier  resignation
or removal.  Management  recommends  that the persons  named below be elected as
directors of the Corporation and it is intended that the accompanying proxy will
be voted for their  election as directors,  unless the proxy  contains  contrary
instructions.  Shares  represented  by all  proxies  received  by the  Board  of
Directors and not so marked as to withhold  authority to vote for any individual
nominee or for all  nominees  will be voted  (unless  one or more  nominees  are
unable to serve) for the  election of the  nominees  named  below.  The Board of
Directors  knows of no reason why any such nominee should be unable or unwilling
to serve, but if such should be the case, proxies will be voted for the election
of some other  person or the size of the Board of  Directors  will be fixed at a
lower number.  The persons nominated for election to the Corporation's  Board of
Directors are:  Robert J. Capetola,  Steve H. Kanzer,  Max Link,  Richard Power,
Marvin Rosenthale, Herbert McDade, Mark Rogers, David Naveh and Richard Sperber.
Each of the  nominees  currently  serves as a  director  of the  Corporation.  A
plurality of the votes cast by the stockholders  present or represented by proxy
and  entitled  to vote at the Annual  Meeting is  required  for the  election of
directors. See "Voting Procedures."

General Information Concerning the Board of Directors and its Committees

The Board of Directors  met seven times and acted by unanimous  written  consent
two times  during the fiscal  year  ended  December  31,  1998.  Each  incumbent
director attended,  in person or by telephone,  all the meetings of the Board of
Directors  and  committees  of the Board of Directors on which he served  during
such fiscal year.

The Board of Directors  has an Audit  Committee,  a Nominating  Committee  and a
Compensation Committee.  The Audit Committee met one time during the last fiscal
year and the  Compensation  Committee met two times during the last fiscal year,
and otherwise their respective  responsibilities  were assumed by the full Board
of Directors.

Audit  Committee.  The Audit Committee of the Board of Directors,  consisting of
Mr. Herbert McDade Jr., Mr. Richard Power and Mr. Richard Sperber,  oversees the
appointment  and  reappointment  of independent  accountants for the Corporation
from  time  to time  and  addresses  matters  of  accounting  policy  with  such
accountants.  The Audit  Committee  also oversees  management's  response to and
implementation  of  accounting  policy and practice  recommendations.  The Audit
Committee is responsible for the reporting of significant events to the Board of
Directors with respect to the above audit issues.

Compensation  Committee.   The  Board  of  Directors  also  has  a  Compensation
Committee,  of which Dr. Marvin E. Rosenthale,  Mr. Herbert McDade and Mr. Steve
H.  Kanzer  are  members.   The   Compensation   Committee   reviews  and  makes
recommendations  concerning  executive  and  general  compensation  matters  and
administers the 1998 Plan together with the Board of Directors.

Nominating  Committee.  The  Nominating  Committee,   consisting  of  Robert  J.
Capetola,  Ph.D., Mr. Steve H. Kanzer and Max Link,  Ph.D., has the authority to
designate the nominees for director at each annual  meeting of the  stockholders
of the  Corporation,  to fill  vacancies  on the  Board of  Directors  occurring
between  such  annual   meetings  and  to  evaluate  the   performance   of  the
Corporation's directors.


                                       2
<PAGE>

Executive Officers

Executive officers of the Corporation are elected annually and hold office until
the first  meeting  of the Board of  Directors  after  each  annual  meeting  of
stockholders  and until their  successors  are elected and  qualified,  or until
their earlier resignation or removal.

Section 16(a) Beneficial Ownership Reporting Compliance

Section  16(a)  of  the  Exchange  Act  requires  the  Corporation's  directors,
executive  officers  (including a person  performing  a principal  policy-making
function)  and  persons  who own  more  than  10% of a  registered  class of the
Corporation's equity securities (collectively, "Reporting Persons") to file with
the Securities and Exchange  Commission (the "SEC") initial reports of ownership
and reports of changes in ownership of the Corporation's  Common Stock and other
equity  securities  of the  Corporation.  Reporting  Persons are required by SEC
regulations to furnish the  Corporation  with copies of all of the Section 16(a)
reports they file.  Specific due dates for these  reports have been  established
and the Corporation is required to identify in this Proxy Statement those person
who  failed to timely  file these  reports.  Based  solely  upon a review of the
copies of such  filings  received  by it with  respect to the fiscal  year ended
December  31,  1998  and  representations  made by the  Reporting  Persons,  the
Corporation believes that during fiscal year 1998 its Reporting Persons complied
with all substantive filing requirements under Section 16(a) of the Exchange Act
except that Steve H. Kanzer,  Evan  Myrianthopoulos,  Max Link,  Mark Rogers and
Herbert McDade did not timely file Form 5's relating to certain option grants.

Nominees for Election to the Board of Directors

The  following  table sets forth the names and ages,  as of May 4, 1999,  of the
nominees  to be  elected  at the  Annual  Meeting,  their  respective  principal
occupations  during the past three  years and the period  during  which each has
served as a director of the Corporation.  For information  concerning the number
of shares of Common Stock  beneficially  owned by each nominee,  see  "Principal
Stockholders."

Name                                  Age          Position with the Corporation
- ----                                  ---          -----------------------------

Robert J. Capetola                    49           Chief Executive Officer
Steve H. Kanzer                       35           Chairman
Max Link                              55           Director
Richard Power                         68           Director
Marvin Rosenthale                     63           Director
Herbert McDade                        71           Director
Mark Rogers                           55           Director
Richard Sperber                       58           Director
David Naveh                           45           Director

Robert J. Capetola, Ph.D. has served as President, Chief Executive Officer and a
Director  of the  Corporation  since June 1998 and prior to that time  served as
Chairman and Chief Executive  Officer of ATI from its inception in October 1996.
From  February  1994 to May 1996,  Dr.  Capetola was Managing  Director of Delta
Biotechnology,  a  subsidiary  of Ohmeda  Pharmaceutical  Products  Division,  a
division  of The BOC Group,  PLC  ("Ohmeda"),  in the U.K. He also served on the
Board of Directors of Delta Biotechnology. From December 1992 to September 1996,
Dr. Capetola served as Vice President of Research and Development at Ohmeda.  He
served on  Ohmeda's  operating  board and was  responsible  for all  aspects  of
Ohmeda's   research  and  development,   including   preclinical   research  and
development, clinical development,  biometrics and regulatory affairs. From 1977
to 1992, Dr. Capetola held a variety of positions as a drug discovery  scientist
at  Johnson  &  Johnson  Pharmaceutical  Research  Institute,  including  Senior
Worldwide Director of Experimental Therapeutics.  Dr. Capetola received his B.S.
from  the  Philadelphia   College  of  Pharmacy  &  Science  and  his  Ph.D.  in
pharmacology 

                                       3
<PAGE>

from Hahnemann Medical College.

Steve H. Kanzer,  C.P.A.,  Esq. has served as Chairman of the Board of Directors
of the  Corporation  since November 1997.  From June 1996 until such time he was
the Chairman of the Board of  Discovery  Laboratories,  Inc., a former  Delaware
corporation and a predecessor by merger of the Corporation ("Old Discovery"). He
has been a Director of ATI since November 1996. Mr. Kanzer is also President and
Chief  Executive  Officer of the Institute for Drug Research,  Inc., a specialty
pharmaceutical and drug development company headquartered in Budapest,  Hungary.
Mr. Kanzer is a founder and currently a director of Boston Life  Sciences,  Inc.
and Atlantic Pharmaceuticals,  Inc. and is currently a director of Endorex, Inc.
He has  been a  founder  and  director  of  several  other  public  and  private
biotechnology companies including Avigen, Inc., Titan Pharmaceuticals,  Inc. and
Xenometrix,  Inc. Mr. Kanzer was a Senior Managing Director of Paramount Capital
Incorporated  and  Paramount  Capital  Investments,  LLC until March 1998.  From
October 1991 until  January 1995,  Mr. Kanzer was General  Counsel of The Castle
Group Ltd, an affiliate of Paramount Capital.  From 1988 to 1991, Mr. Kanzer was
an attorney at the law firm of Skadden, Arps, Meagher, Slate, & Flom. Mr. Kanzer
received  his J.D.  from  New  York  University  School  of Law and a B.B.A.  in
Accounting  from Baruch  College.  He devotes  only a portion of his time to the
business of the Corporation.

Max Link, Ph.D., has served as a Director of the Corporation since November 1997
and was a Director of Old  Discovery  from October 1996 until such date.  He has
been a  Director  of ATI  since  October  1996.  Dr.  Link has held a number  of
executive positions with pharmaceutical and health care companies.  He currently
serves  on  the  Boards  of  Directors  of  five  publicly-traded  life  science
companies:  Alexion  Pharmaceuticals,  Inc.,  Protein Design Labs,  Inc.,  Human
Genome  Sciences,  Inc.,  Cell  Therapeutics,  Inc.,  Procept,  Inc.  and Access
Pharmaceuticals,  Inc.  From  May 1993  until  June  1994,  Dr.  Link was  Chief
Executive Officer of Corange Limited,  the parent company of Boehringer Mannheim
and DePuy,  an  orthopedic  company.  Prior to joining  Corange,  he served in a
number of positions  within  Sandoz  Pharma,  Ltd.,  including  Chief  Executive
Officer from 1987 until April 1992, and Chairman from April 1992 until May 1993.

Richard G. Power has been a Director  of the  Corporation  since June 1998 and a
Director of ATI since  October  1996.  Mr.  Power is a Principal  and  Executive
Director of The Sage Group,  founded in 1994,  which  specializes  in  providing
strategic  and  transactional  services  to the  managements  and boards of, and
investors in, health care companies.  He serves on the Board of Directors of The
Quantum  Group,  and  Neuromedica,  Inc. From 1980 to 1994,  Mr. Power served as
President of R.G.  Power &  Associates,  Inc.,  which  specializes  in worldwide
business  development and financing strategy for the health care industry.  From
1955  to  1980,  Mr.  Power  held  senior  management   positions  with  several
pharmaceutical  industry firms, including SmithKline,  Searle and as a corporate
officer at J&J. Mr.  Power  received his B.A.  from Loras  College in 1951,  and
attended graduate school at the University of Wisconsin.

Marvin E. Rosenthale,  Ph.D., has been a Director of the Corporation  since June
1998 and a Director of ATI since  October  1996.  He has served as President and
Chief Executive Officer of Allergan Ligand Retinoid Therapeutics,  Inc. ("ALRT")
from 1994 until 1997.  He joined the ALRT joint  venture  formed by Allergan and
Ligand,  the entity  through which they combined  their  resources to pursue the
development of retinoid  research and development  prior to ALRT, in August 1993
as Vice  President.  Prior  to  joining  ALRT,  Dr.  Rosenthale  served  as Vice
President,  Drug Discovery Worldwide,  at R. W. Johnson Pharmaceutical  Research
Institute  from 1990 to 1993.  From  1977 to 1990,  Dr.  Rosenthale  served in a
variety  of  positions  in drug  discovery  research  for  Ortho  Pharmaceutical
Corporation,  including director of the divisions of pharmacology and biological
research and executive director of drug discovery  research.  From 1960 to 1977,
he served in various positions with Wyeth Laboratories.  Dr. Rosenthale received
a Ph.D. in pharmacology from Hahnemann  Medical College & Hospital,  an M.Sc. in
pharmacology  from  Philadelphia  College of Pharmacy and Science and a B.Sc. in
pharmacy from Philadelphia College of Pharmacy.


                                       4
<PAGE>

Herbert  H.  McDade,  Jr.  has served as a  Director  of the  Corporation  since
November 25, 1997 and was a Director of Old Discovery  from June 1996 until such
time.  Mr. McDade is the Chairman of Access  Pharmaceutical  and a member of the
Boards of Directors of two other publicly-held companies,  Cytrx Corporation and
Shaman Pharmaceuticals,  and Clarion  Pharmaceuticals,  Inc., which is privately
held.  Mr. McDade was employed  with the Upjohn  Company for 20 years and for 14
years as President of Revlon Health Care International.

Mark C. Rogers,  M.D. has served as a Director of the Corporation since November
25, 1997 and was a Director of Old Discovery from June 1996 until such time. Dr.
Rogers has been the  President of Paramount  Capital,  Incorporated  since June,
1998.  From May 1996 until June,  1998,  Dr.  Rogers was Senior Vice  President,
Corporate Development and Chief Technology Officer at Perkin-Elmer  Corporation.
Prior to that time,  Dr.  Rogers  was the Vice  Chancellor  for Health  Affairs,
Executive  Director and Chief Executive Officer of Duke University  Hospital and
Health  Network from 1992 to 1996.  Prior to his  employment at Duke, Dr. Rogers
was on the faculty of Johns Hopkins  University  for 15 years where he served as
Distinguished Faculty Professor and Chairman of the Department of Anesthesiology
and Critical Care Medicine,  Associate Dean for Clinical  Practice,  Director of
the  Pediatric  Intensive  Care Unit and  Professor of  Pediatrics.  Dr.  Rogers
received his M.D. from Upstate  Medical  Center and his M.B.A.  from The Wharton
School of Business.  He received his B.A.  from Columbia  University  and held a
Fulbright Scholarship.

Richard  Sperber  has been a Director  of the  Corporation  since May 1994.  Mr.
Sperber has been President and Chief Executive  Officer of The Global  Medicines
Group Inc., a consulting  firm,  since 1991. From 1988 to 1991 Mr. Sperber was a
Director  and Head of Business  Development  and  Strategic  Planning  for Glaxo
Pharmaceuticals  U.K.  Ltd., a subsidiary of Glaxo  Holdings  PLC.  Prior to his
employment  at Glaxo,  Mr.  Sperber held a variety of positions  including  Area
Director for Ayerst International,  responsible for Southeast Asia, and Director
of Marketing for Schering-Plough Corp.  responsible for Canada, Japan, Australia
and Southeast Asia. Mr. Sperber  received his B.S. from the University of Denver
and attended graduate school at Columbia University.

David Naveh,  Ph.D. has been a Director of the  Corporation  since May 1996. Dr.
Naveh is Chief Technical Officer,  Bayer Biologics  Worldwide.  Previously,  Dr.
Naveh has served as Director of Process  Technology  and was Director of Process
Development  of Bayer  Corporation  beginning in 1992. Dr. Naveh was Director of
Biotechnology  Operations  for  Centocor  from 1990 to 1992 and was  Director of
Purification  for Centocor from 1989 to 1990. From 1984 to 1988, Dr. Naveh was a
manager at Schering-Plough  Corp. Dr. Naveh was on the faculty of the University
of Wisconsin,  Madison as Assistant Professor from 1982 to 1984. He received his
B.Sc.  and M.S. in 1980 from the Technion,  Haifa,  Israel and his Ph.D. in 1982
from the University of Minnesota.


                                       5
<PAGE>

                               EXECUTIVE OFFICERS

The following  table sets forth as of the Record Date the names and positions of
the executive officers of the Corporation:

Name                                Age    Position with the Corporation
- ----                                ---    -----------------------------

Robert J. Capetola, Ph.D.           49     President, Chief Executive Officer
                                           and Director

Steve H. Kanzer, C.P.A., Esq.       35     Chairman of the Board of Directors

Harry Brittain, Ph.D.               49     Vice President, Pharmaceutical and
                                           Chemical Development

Laurence B. Katz, Ph.D.             44     Vice President, Project Management 
                                           and Clinical Administration
Lisa Mastroianni                    37     Director of Clinical Research

Evan Myrianthopoulos                34     Vice President, Finance and Secretary

Christopher J. Schaber              32     Vice President, Regulatory Affairs
                                           and Quality Control

Huei Tsai, Ph.D.                    59     Vice President, Biometrics

Thomas E. Wiswell, M.D.             47     Vice President, Clinical Research

Cynthia Davis                       30     Controller

Harry G. Brittain,  Ph.D.,  has served as the Vice President for  Pharmaceutical
and Chemical Development of the Corporation since June 1998. Prior to such time,
he held such position with ATI  commencing in November 1996. He is a graduate of
Queens College (B.S.,  1970; M.S., 1972), and of the City University of New York
(Ph.D.  in  physical  chemistry,  1975).  He was a  postdoctoral  fellow  at the
University  of Virginia,  and has held faculty  positions at Ferrum  College and
Seton Hall University. Prior to joining ATI, Dr,. Brittain served as Director of
Pharmaceutical  Development for the Pharmaceutical  Products Division of Ohmeda,
Inc. Before that, he worked at Bristol-Myers  Squibb,  where he led a variety of
groups within the  Analytical R&D  department.  His research  interests  include
studies  of  molecular   optical   activity  and   chirality,   development   of
pharmaceutical dosage forms, and the physical characterization of pharmaceutical
materials.  He has authored  approximately 195 research  publications,  and is a
member of the editorial boards of numerous journals.

Laurence B. Katz, Ph.D., has served as Vice President of Project  Management and
Clinical  Administration of the Corporation since June 1998. Prior to such time,
he held such position with ATI commencing in November 1996. Prior to joining the
Corporation,  Dr. Katz was employed  from April 1993 to November  1996 by Ohmeda
Pharmaceutical  Products  Division,  a  division  of The BOC  Group,  as  Senior
Director of Project Management and Clinical Administration.  At Ohmeda, Dr. Katz
was project team leader for the inhaled nitric oxide project and was responsible
for  the   administration   of  all  clinical  trials  within  the  Corporation.
Previously,  Dr. Katz was employed by Ortho  Pharmaceutical  Corporation and the
R.W. Johnson Pharmaceutical Research Institute,  divisions of Johnson & Johnson,
Inc.  ("J&J").  While there he served as Senior  Project  Manager in the Project
Planning &  Management  department  from  January  1990 to April 1993,  and as a
Principal  Scientist in the Drug  Discovery  department  from  February  1983 to
January 1990. Dr. Katz received a B.S.  degree in biology from the University of
Pennsylvania,  his M.S. and Ph.D.  degrees in pharmacology form the Philadelphia
College of Pharmacy & Science,  and was a  post-doctoral  research fellow at the
University of Wisconsin-Madison.


                                       6
<PAGE>

Lisa  Mastroianni,  R.N.,  has served as Director  of  Clinical  Research of the
Corporation since June 1998. Prior to such time, she held such position with ATI
commencing in January of 1997. Prior to joining the Corporation, Ms. Mastroianni
was employed from November of 1994 to November of 1996 by Ohmeda  Pharmaceutical
Products  Division,  a  division  of The BOC Group as Senior  Clinical  Research
Associate.  At Ohmeda,  Ms.  Mastroianni  was responsible for the management and
completion  of the  Phase  2/3  clinical  study  in acute  respiratory  distress
syndrome,  supervision of internal personnel as well as management of a Contract
Research  Organization,  and assisting in the  development  and  management of a
Phase 1 clinical study in congestive heart failure.  Previously Ms.  Mastroianni
was employed by Sandoz Pharmaceuticals from March 1992 to November 1994 in their
cardiovascular  clinical research  department and was responsible for monitoring
Phase 3 lipid  studies and managing  and  monitoring  Phase 1 CHF  studies.  Ms.
Mastroianni has her Bachelors degree in Nursing from Bloomfield  College and has
worked as a critical  care nurse in a number of hospitals  in the United  States
from 1985 to 1992.

Evan  Myrianthopoulos  has served as Vice President,  Finance of the Corporation
since June 1998. He served as Chief Financial  Officer of the  Corporation  from
December 1997 until June 1998 and as Chief Operating  Officer of the Corporation
from November 1997 until June 1998. From June 1996 until November 1997 he served
as Chief Operating  Officer and Director of Old Discovery.  Prior to joining Old
Discovery,  he was a  Technology  Associate of  Paramount  Capital  Investments,
L.L.C.  from December 1995 until January 1987.  Before joining Paramount Capital
Investments,  LLC,  Mr.  Myrianthopoulos  managed a hedge fund for S + M Capital
Management in Englewood  Cliffs,  New Jersey.  The fund specialized in syndicate
and  secondary  stock issues and also  engaged in  arbitrage  of  municipal  and
mortgage  bonds.  Prior to his  employment  with S + M Capital  Management,  Mr.
Myrianthopoulos  was employed at the New York Branch of National  Australia Bank
where  he  was  Assistant  Vice  President  of  Foreign  Exchange  trading.  Mr.
Myrianthopoulos   received  a  B.S.  in  Economics  and  Psychology  from  Emory
University in 1986.

Christopher  J. Schaber has served as Vice  President of Regulatory  Affairs and
Quality  Assurance of the  Corporation  since June 1998.  Prior to such time, he
held such position with ATI commencing in November  1996.  Prior to joining ATI,
Mr.  Schaber  was  employed  from  October  1994  to  November  1996  by  Ohmeda
Pharmaceutical  Products  Division,  a division of The BOC Group, as Director of
Regulatory  Affairs.  At Ohmeda,  Mr. Schaber was directly  responsible  for all
regulatory  strategies  with the Food and Drug  Administration  and other Health
Authority  bodies.  From 1989 to 1994,  Mr. Schaber held a variety of regulatory
positions  of  increasing   importance  with  The  Liposome  Company,  Inc.  and
Elkins-Sinn Inc., a division of Wyeth-Ayerst Laboratories.  Mr. Schaber received
his B.A. from Western Maryland College and his M.S. from Temple University.  Mr.
Schaber is currently  pursuing his Ph.D. in  Pharmaceutical  Sciences-Regulatory
Affairs with the Union Graduate School and is estimated to complete his doctoral
program in 1999.  In 1994,  Mr.  Schaber also  received his  Regulatory  Affairs
Certification (RAC) from the Regulatory Affairs Professional Society.

Huei Tsai,  Ph.D., has served as Vice President of Biometrics of the Corporation
since June 1998.  Prior to such time, he held such position with ATI  commencing
in February  1997.  Prior to joining ATI, Dr. Tsai was a statistical  consultant
after  retiring  from the  position  of  Director  of  Biometrics  and  Clinical
Information at Ohmeda  Pharmaceutical  Products Division,  a division of The BOC
Group.  At  Ohmeda,  Dr.  Tsai was  responsible  for all  statistical,  computer
operations,  database and data  coordination.  From 1994 to 1995, Dr. Tsai was a
statistical   consultant   to  a  variety  of   companies,   including   Janssen
Pharmaceutical  Company.  For  seventeen  years  prior to that,  Dr. Tsai held a
variety of  biostatistical  positions at the Robert Wood Johnson  Pharmaceutical
Research  Institute  and Ortho  Pharmaceutical  Corporation  (both  wholly-owned
subsidiaries  of  J&J),   including   Director  of  Biostatistics  for  Clinical
Pharmacology.  Dr.  Tsai  received  a B.A.  degree  in  economics  from  Tunghai
University in 1962 and a Ph.D. in  mathematical  statistics  from Oklahoma State
University in 1976.

Thomas E. Wiswell,  M.D., has served as Vice  President of Clinical  Research of
the Corporation since June 1998 and, prior to that time, held such position with
ATI commencing in April 1997.  Since 1993, he has been a Professor of Pediatrics
at Jefferson  Medical College at Thomas  Jefferson  University in  Philadelphia,
Pennsylvania.  From 1988 to 1993, he was an Associate Professor of Pediatrics at
the F. Edward Herbert School


                                       7
<PAGE>

of Medicine in Bethesda,  Maryland.  He retired as a Lieutenant Colonel from the
U.S. Army on June 30, 1993 after twenty years on active duty.  Dr.  Wiswell is a
graduate of the United States Military  Academy at West Point and the University
of Pennsylvania Medical School.

Cynthia Davis has served as Controller  of the  Corporation  since June 1998 and
was  Controller  of ATI from October  1996 until such time.  Davis was an office
manager with ERD  Environmental  Group from September 1991 until September 1996.
Ms. Davis received her A.A. degree from Lansdale School of Business in May, 1989

All directors hold office until the next annual meeting of  stockholders  of the
Corporation and until their successors have been elected and qualified. Officers
serve at the  discretion of the Board of  Directors.  The  Corporation's  bylaws
provide that  directors and officers shall be  indemnified  against  liabilities
arising  from their  service as  directors  or officers  to the  fullest  extent
permitted by the laws of the State of Delaware,  which  generally  requires that
the individual  act in good faith and in a manner he or she reasonably  believes
to be in, or not opposed to, the Corporation's best interests.

Family Relationships

There are no family  relationships  among directors or executive officers of the
Corporation.

The  Board of  Directors  recommends  a vote FOR the  nominees  to the  Board of
Directors set forth above.


                                       8
<PAGE>

                             PRINCIPAL STOCKHOLDERS

The following table sets forth, as of May 4, 1999, certain information regarding
the  beneficial  ownership  of the Common  Stock (i) by each person known by the
Corporation  to be the  beneficial  owner  of  more  than  five  percent  of the
outstanding  shares of the Common Stock,  (ii) by each of the Named Officers (as
defined  below) and directors of the  Corporation  and (iii) by all officers and
directors of the Corporation as a group.

<TABLE>
<CAPTION>
 Name and Address of Beneficial                             Number of    Percentage of Class
        Owner (1)                       Title of Stock       Shares      Beneficially Owned
- -------------------------------         --------------      ---------    -------------------
<S>                                     <C>                   <C>             <C>    

Robert J. Capetola, Ph.D.(2)            Common Stock          931,443          13.48%
350 South Main Street, Suite 307
Doylestown, Pennsylvania  18901

James S. Kuo, M.D. (3)                  Common Stock          240,145           3.67%
Myriad Genetics, Incorporated
320 Wakara Way
Salt Lake City, Utah  84106

Steve H. Kanzer, C.P.A., Esq. (4)       Common Stock          235,530           3.63%
Institute for Drug Research, Inc.
787 Seventh Avenue, 48th Floor
New York, New York 10019

Evan Myrianthopoulos (5)                Common Stock          154,040           2.37%
350 South Main Street, Suite 307
Doylestown, Pennsylvania  18901

Cynthia Davis (6)                       Common Stock           75,706           1.17%
350 South Main Street, Suite 307
Doylestown, Pennsylvania  18901

Lisa Mastroianni  (7)                   Common Stock           52,640             *
350 South Main Street, Suite 307
Doylestown, Pennsylvania  18901

Thomas Wiswell (8)                      Common Stock          199,644           3.02%
350 South Main Street, Suite 307
Doylestown, Pennsylvania  18901

Chris Schaber (9)                       Common Stock          196,244           2.98%
350 South Main Street, Suite 307
Doylestown, Pennsylvania  18901

Laurence Katz (10)                      Common Stock          197,244           2.99%
350 South Main Street, Suite 307
Doylestown, Pennsylvania  18901

Harry Brittain (11)                     Common Stock          196,744           2.99%
350 South Main Street, Suite 307
Doylestown, Pennsylvania  18901


                                       9
<PAGE>

Marvin Rosenthale (12)                  Common Stock           25,600             *
14 Burning Tree Road
Newport Beach, California 92660

Huei Tsai, Ph. D. (13)                  Common Stock          206,744           3.14%
350 South Main Street, Suite 307
Doylestown, Pennsylvania  18901

Milton Packer (12)                      Common Stock           25,600             *
Columbia University.
College of Physicians
630 West 168th Street
New York, New York 10032

Richard Power (14)                      Common Stock           28,268             *
The Sage Group
245 Route 22 West, Suite 304
Bridgewater, New Jersey 08807

Herbert McDade (15)                     Common Stock           23,619             *
1421 Partridge Place North
Boynton Beach, Florida 33436

Max Link, Ph.D. (16)                    Common Stock           56,819             *
230 Central Park West, Apt.14A
New York, New York  10024

Mark C. Rogers, M.D. (17)               Common Stock           59,683             *
Paramount Capital Incorporated
787 Seventh Avenue, 48th Floor
New York, New York 10019

Richard Sperber (18)                    Common Stock           19,274             *
304 West 75th Street, Suite 16H
New York, New York  10023

David Naveh, Ph.D. (19)                 Common Stock           21,600             *
Bayer Corporation
800 Dwight Way
P.O. Box 1986
Berkeley, California 94701-1986

The Aries Master Fund, a Cayman         Common Stock        1,053,567          14.68%
Island Trust (20)
c/o Mees Pierson (Cayman) Limited
P.O. Box 2003                           Series B Preferred    173,250          10.10%
British American Centre, Phase 3        Stock
Dr. Roy's Drive
George Town, Grand Cayman


                                       10
<PAGE>

Aries Domestic Fund, L.P. (21)          Common Stock          448,384           6.65%
787 Seventh Avenue, 48th Floor
New York, New York 10019

RAQ, LLC (22)                           Common Stock        1,001,739          15.59%
787 Seventh Avenue, 48th Floor                                                 
New York, NY 10019

Lindsay A. Rosenwald, M.D.(22)          Common Stock        2,503,802          33.39%
787 Seventh Avenue, 48th Floor
New York, NY 10019                      Series B Preferred    326,298          18.12%
                                        Stock

Paramount Capital Asset                 Common Stock        1,501,952          20.03%
  Management, Inc. (22)
787 Seventh Avenue, 48th Floor          Series B Preferred    247,500          14.37%
New York, NY 10019                      Stock

All the Corporation directors and       Common Stock        2,941,587          35.39%
officers as a group (19 persons)

- -------------------------------------------------------------------------------------
* Less than 1%
</TABLE>

(1)  Beneficial ownership is determined in accordance  with Rule 13d-3 under the
Securities  Exchange Act of 1934 (the  "Exchange  Act") and includes  voting and
investment  power with  respect to shares of Common Stock and Series B Preferred
Stock. Shares of Common Stock and Series B Preferred Stock subject to options or
warrants currently exercisable or exercisable within 60 days of the date hereof,
are deemed  outstanding  for  computing the  percentage  ownership of the person
holding such options or warrants, but are not deemed outstanding for purposes of
computing the percentage ownership of any other person.

(2)  Includes  21,793  shares  of  Common  Stock  issuable  on the  exercise  of
outstanding  options  granted on April 17, 1997;  43,010  shares of Common Stock
issuable  on the  exercise  of  outstanding  options  granted  on March 5, 1998;
115,090 shares of Common Stock  issuable on the exercise of outstanding  options
granted on June 16, 1998;  and 187,730  shares of Common  Stock  issuable on the
exercise of  outstanding  options  granted on January 1, 1999,  all of which are
immediately  exercisable  and fully  vested,  113,740  shares  of  Common  Stock
issuable on the exercise of outstanding  options  granted on June 16, 1998 which
will vest  subject  to  acceleration  events.  Unvested  shares of Common  Stock
subject to all of the  foregoing  options  remain  subject to the  Corporation's
right to repurchase at the exercise price paid per share.

(3)  Includes  77,831  shares  of  Common  Stock  issuable  on the  exercise  of
outstanding options granted on January 1, 1997 and 30,000 shares of Common Stock
issuable on the exercise of outstanding  options granted on January 2, 1998, all
of which are immediately exercisable and fully vested.

(4)  Includes  15,566  shares  of  Common  Stock  issuable  on the  exercise  of
outstanding  options  granted on January 1, 1997;  30,000 shares of Common Stock
issuable on the exercise of outstanding  options granted on January 2, 1998; and
20,000 shares of Common Stock  issuable on the exercise of  outstanding  options
granted on January 1, 1999.  Shares of Common Stock subject to such options vest
twenty five percent at the time of grant with the balance  vesting in thirty-six
equal monthly installments upon the optionee's  successive completion of service
with the  Corporation.  Unvested  shares of Common Stock subject to such options
remain  subject to the  Corporation's  right to repurchase at the exercise price
paid per share.  Does not include an  additional  35,413  shares of Common 


                                       11
<PAGE>

Stock owned by certain  family  members of Mr.  Kanzer,  as to which Mr.  Kanzer
disclaims beneficial ownership.

(5)  Includes  11,675  shares  of  Common  Stock  issuable  on the  exercise  of
outstanding  options  granted on January 1, 1997;  30,000 shares of Common Stock
issuable on the exercise of outstanding  options granted on January 2, 1998; and
40,000 shares of Common Stock  issuable on the exercise of  outstanding  options
granted on January 1, 1999, all of which are immediately exercisable.  Shares of
Common  Stock  subject to such  options  vest twenty five percent at the time of
grant with the balance vesting in thirty-six equal monthly installments upon the
optionee's  successive  completion  of service  with the  Corporation.  Unvested
shares  of  Common  Stock  subject  to  such  options   remain  subject  to  the
Corporation's right to repurchase at the exercise price paid per share. Does not
include an additional 1,906 shares of Common Stock owned by Mr. Myrianthopoulos'
brother, as to which Mr. Myrianthopoulos disclaims beneficial ownership.

(6)  Includes  1,950  shares  of  Common  Stock  issuable  on  the  exercise  of
outstanding  options  granted on January 2, 1997;  8,775  shares of Common Stock
issuable on the  exercise  of  outstanding  options  granted on January 1, 1998;
4,428 shares of Common Stock  issuable on the  exercise of  outstanding  options
granted on March 5, 1998; 11,848 shares of Common Stock issuable on the exercise
of  outstanding  options  granted on June 16, 1998;  and 28,270 shares of Common
Stock  issuable on the  exercise of  outstanding  options  granted on January 1,
1999, all of which are immediately  exercisable.  Shares of Common Stock subject
to the options granted on March 5, 1998 vest in three equal annual installments,
the first  installment of which will vest on the first year  anniversary of June
16, 1998.  Shares of Common Stock subject to the  remaining  options vest twenty
five percent at the time of grant with the balance  vesting in thirty-six  equal
monthly installments upon the optionee's  successive  completion of service with
the  Corporation.  13,885  shares of Common  Stock  issuable on the  exercise of
outstanding  options  granted  on June 16,  1998,  which  will vest  subject  to
acceleration  events.  Unvested  shares of Common  Stock  subject  to all of the
foregoing options remain subject to the Corporation's right to repurchase at the
exercise price paid per share.

(7)  Includes  7,800  shares  of  Common  Stock  issuable  on  the  exercise  of
outstanding  options  granted on January 2, 1997;  4,326  shares of Common Stock
issuable on the exercise of outstanding options granted on March 5, 1998; 11,577
shares of Common Stock issuable on the exercise of outstanding  options  granted
on June 16, 1998;  and 10,000 shares of Common Stock issuable on the exercise of
outstanding  options  granted on January 1, 1999,  all of which are  immediately
exercisable.  Shares of Common Stock subject to the options  granted on March 5,
1998 vest in three equal annual  installments,  the first  installment  of which
will vest on the first year anniversary of June 16, 1998. Shares of Common Stock
subject to the  remaining  options vest twenty five percent at the time of grant
with the balance  vesting in  thirty-six  equal  monthly  installments  upon the
optionee's successive completion of service with the Corporation.  11,137 shares
of Common Stock issuable on the exercise of outstanding  options granted on June
16, 1998,  which will vest subject to  acceleration  events.  Unvested shares of
Common  Stock  subject to all of the  foregoing  options  remain  subject to the
Corporation's right to repurchase at the exercise price paid per share.

(8)  Includes  3,900  shares  of  Common  Stock  issuable  on  the  exercise  of
outstanding  options  granted on April 17, 1997;  46,800  shares of Common Stock
issuable on the exercise of outstanding  options granted on June 2, 1997; 14,813
shares of Common Stock issuable on the exercise of outstanding  options  granted
on March 5, 1998;  39,638  shares of Common  Stock  issuable on the  exercise of
outstanding  options granted on June 16, 1998; and 40,000 shares of Common Stock
issuable on the exercise of outstanding  options granted on January 1, 1999, all
of which are  immediately  exercisable.  Shares of Common  Stock  subject to the
options  granted on March 5, 1998 vest in three equal annual  installments,  the
first  installment of which will vest on the first year  anniversary of June 16,
1998.  Shares of Common Stock subject to the remaining  options vest twenty five
percent  at the time of grant  with the  balance  vesting  in  thirty-six  equal
monthly installments upon the optionee's  successive  completion of service with
the  Corporation.  38,893  shares of Common  Stock  issuable on the  exercise of
outstanding  options  granted  on June 16,  1998,  which  will vest  subject  to
acceleration  events.  Unvested  shares of Common  Stock  subject  to all of the
foregoing options remain subject to the Corporation's right to repurchase at the
exercise price paid per share.

(9)  Includes  31,200  shares  of  Common  Stock  issuable  on the  exercise  of
outstanding  options granted on October 28, 1996;  14,813 shares of Common Stock
issuable on the exercise of outstanding options granted on


                                       12
<PAGE>

March 5,  1998;  39,638  shares of Common  Stock  issuable  on the  exercise  of
outstanding  options granted on June 16, 1998; and 40,000 shares of Common Stock
issuable on the exercise of outstanding  options granted on January 1, 1999, all
of which are  immediately  exercisable.  Shares of Common  Stock  subject to the
options  granted on March 5, 1998 vest in three equal annual  installments,  the
first  installment of which will vest on the first year  anniversary of June 16,
1998.  Shares of Common Stock subject to the remaining  options vest twenty five
percent  at the time of grant  with the  balance  vesting  in  thirty-six  equal
monthly installments upon the optionee's  successive  completion of service with
the  Corporation.  38,893  shares of Common  Stock  issuable on the  exercise of
outstanding  options  granted  on June 16,  1998,  which  will vest  subject  to
acceleration  events.  Unvested  shares of Common  Stock  subject  to all of the
foregoing options remain subject to the Corporation's right to repurchase at the
exercise price paid per share.

(10)  Includes  31,200  shares of  Common  Stock  issuable  on the  exercise  of
outstanding  options granted on October 28, 1996;  14,813 shares of Common Stock
issuable on the exercise of outstanding options granted on March 5, 1998; 39,638
shares of Common Stock issuable on the exercise of outstanding  options  granted
on June 16, 1998;  and 40,000 shares of Common Stock issuable on the exercise of
outstanding  options  granted on January 1, 1999,  all of which are  immediately
exercisable.  Shares of Common Stock subject to the options  granted on March 5,
1998 vest in three equal annual  installments,  the first  installment  of which
will vest on the first year anniversary of June 16, 1998. Shares of Common Stock
subject to the  remaining  options vest twenty five percent at the time of grant
with the balance  vesting in  thirty-six  equal  monthly  installments  upon the
optionee's successive completion of service with the Corporation.  38,893 shares
of Common Stock issuable on the exercise of outstanding  options granted on June
16, 1998,  which will vest subject to  acceleration  events.  Unvested shares of
Common  Stock  subject to all of the  foregoing  options  remain  subject to the
Corporation's right to repurchase at the exercise price paid per share.

(11)  Includes  15,600  shares of  Common  Stock  issuable  on the  exercise  of
outstanding  options granted on October 28, 1996;  14,813 shares of Common Stock
issuable on the exercise of outstanding options granted on March 5, 1998; 39,638
shares of Common Stock issuable on the exercise of outstanding  options  granted
on June 16, 1998;  and 40,000 shares of Common Stock issuable on the exercise of
outstanding  options  granted on January 1, 1999,  all of which are  immediately
exercisable.  Shares of Common Stock subject to the options  granted on March 5,
1998 vest in three equal annual  installments,  the first  installment  of which
will vest on the first year anniversary of June 16, 1998. Shares of Common Stock
subject to the  remaining  options vest twenty five percent at the time of grant
with the balance  vesting in  thirty-six  equal  monthly  installments  upon the
optionee's successive completion of service with the Corporation.  38,893 shares
of Common Stock issuable on the exercise of outstanding  options granted on June
16, 1998,  which will vest subject to  acceleration  events.  Unvested shares of
Common  Stock  subject to all of the  foregoing  options  remain  subject to the
Corporation's right to repurchase at the exercise price paid per share.

(12)  Consists  of 7,800  shares of Common  Stock  issuable  on the  exercise of
outstanding  options  granted on November 1, 1996;  7,800 shares of Common Stock
issuable on the exercise of outstanding options granted on January 30, 1998; and
10,000 shares of Common Stock  issuable on the exercise of  outstanding  options
granted on June 16, 1998, all of which are  immediately  exercisable.  Shares of
Common  Stock  subject  to the  options  granted  on June 16,  1998 vest in four
successive  equal annual  installments  over the  optionee's  period of service,
beginning six months after the option grant date. Shares of Common Stock subject
to the remaining  options vest twenty five percent at the time of grant with the
balance  vesting  in  three  equal  annual   installments  upon  the  optionee's
successive completion of service with the Corporation. Unvested shares of Common
Stock  subject  to  all  of  the  foregoing   options   remain  subject  to  the
Corporation's right to repurchase at the exercise price paid per share.

(13)  Includes  31,200  shares of  Common  Stock  issuable  on the  exercise  of
outstanding  options granted on February 16, 1997; 14,183 shares of Common Stock
issuable on the exercise of outstanding options granted on March 5, 1998; 39,638
shares of Common Stock issuable on the exercise of outstanding  options  granted
on June 16, 1998;  and 40,000 shares of Common Stock issuable on the exercise of
outstanding  options  granted on January 1, 1999,  all of which are  immediately
exercisable. Shares of Common Stock subject to the options granted on March


                                       13
<PAGE>

5, 1998 vest in three equal annual installments,  the first installment of which
will vest on the first year anniversary of June 16, 1998. Shares of Common Stock
subject to the  remaining  options vest twenty five percent at the time of grant
with the balance  vesting in  thirty-six  equal  monthly  installments  upon the
optionee's successive completion of service with the Corporation.  38,893 shares
of Common Stock issuable on the exercise of outstanding  options granted on June
16, 1998,  which will vest subject to  acceleration  events.  Unvested shares of
Common  Stock  subject to all of the  foregoing  options  remain  subject to the
Corporation's right to repurchase at the exercise price paid per share.

(14)  Includes  4,368  shares  of  Common  Stock  issuable  on the  exercise  of
outstanding  options  granted on October  10,  1996 and 10,000  shares of Common
Stock issuable on the exercise of outstanding  options granted on June 16, 1998,
all of which are immediately exercisable.  Shares of Common Stock subject to the
options  granted  on  June  16,  1998  vest  in  four  successive  equal  annual
installments over the optionee's  period of service,  beginning six months after
the option grant date.  Shares of Common Stock subject to the remaining  options
vest twenty five percent at the time of grant with the balance  vesting in three
equal annual installments upon the optionee's  successive  completion of service
with the  Corporation.  Unvested  shares of Common  Stock  subject to all of the
foregoing options remain subject to the Corporation's right to repurchase at the
exercise price paid per share.

(15)  Includes  13,619  shares of  Common  Stock  issuable  on the  exercise  of
outstanding options, all of which are immediately exercisable and fully vested.

      Also includes  10,000  shares of Common Stock  issuable on the exercise of
outstanding  options  granted  on June 16,  1998,  all of which are  immediately
exercisable and which vest in four successive equal annual installments over the
optionee's period of service,  beginning six months after the option grant date.
Unvested shares of Common Stock subject to the foregoing  options remain subject
to the Corporation's right to repurchase at the exercise price paid per share.

(16)  Includes  23,400  shares of  Common  Stock  issuable  on the  exercise  of
outstanding options granted on October 28, 1996 and 3,891 shares of Common Stock
issuable on the exercise of  outstanding  options  granted on September 1, 1996,
all of which are immediately exercisable.  Shares of Common Stock subject to the
foregoing options vest twenty five percent at the time of grant with the balance
vesting  in three  equal  annual  installments  upon the  optionee's  successive
completion  of service  with the  Corporation.  Unvested  shares of Common Stock
subject to the foregoing  options remain subject to the  Corporation's  right to
repurchase at the exercise price paid per share.

      Also includes  10,000 shares of Common Stock which vest in four successive
equal annual  installments over the optionee's period of service,  beginning six
months after June 16, 1998.  Unvested shares of such Common Stock remain subject
to the Corporation's  right to repurchase such shares at the exercise price paid
per share.

(17)  Includes  13,619  shares of  Common  Stock  issuable  on the  exercise  of
outstanding options, all of which are immediately exercisable and fully vested.

      Also includes  10,000  shares of Common Stock  issuable on the exercise of
outstanding  options  granted  on June 16,  1998,  all of which are  immediately
exercisable and which vest in four successive equal annual installments over the
optionee's  period of service,  beginning six months after the option grant date
and 31,200  shares of Common  Stock  issuable  on the  exercise  of  outstanding
options  granted on October 28, 1996 which vest twenty five  percent at the time
of grant with the balance  vesting in three equal annual  installments  upon the
optionee's successive  completion of service with the Corporation,  all of which
are also immediately exercisable. Unvested shares of Common Stock subject to all
of the foregoing options remain subject to the Corporation's right to repurchase
at the exercise price paid per share.

(18)  Includes  9,274  shares  of  Common  Stock  issuable  on the  exercise  of
outstanding options, all of which are immediately exercisable and fully vested.


                                       14
<PAGE>

      Also includes  10,000 shares of Common Stock which vest in four successive
equal annual  installments over the optionee's period of service,  beginning six
months after June 16, 1998.  Unvested shares of such Common Stock remain subject
to the Corporation's  right to repurchase such shares at the exercise price paid
per share.

(19)  Includes  7,600  shares  of  Common  Stock  issuable  on the  exercise  of
outstanding options, all of which are immediately exercisable and fully vested.

      Also includes  10,000 shares of Common Stock which vest in four successive
equal annual  installments over the optionee's period of service,  beginning six
months after June 16, 1998.  Unvested shares of such Common Stock remain subject
to the Corporation's  right to repurchase such shares at the exercise price paid
per share.

(20)  Beneficial  ownership of Common Stock includes (i) 490,338 shares issuable
on the conversion of Series B Preferred  Stock,  (ii) 6,129 shares issuable upon
exercise of warrants,  all of which are  exercisable  within 60 days of the date
hereof,  (iii) 49,034  shares  issuable on the  conversion of Series B Preferred
Stock issuable on the exercise of warrants,  all of which are exercisable within
60 days of the date hereof and (iv) 204,787  shares  issuable  upon  exercise of
Series C Warrants  issued in the 1999  Financing,  all of which are  exercisable
within 60 days of the date hereof.

     Beneficial  ownership of Series B Preferred  Stock  includes  15,750 shares
     issuable on the exercise of warrants,  all of which are exercisable  within
     60 days of the date hereof.

(21)  Beneficial  ownership of Common Stock includes (i) 210,245 shares issuable
on the conversion of Series B Preferred  Stock,  (ii) 2,626 shares issuable upon
exercise of warrants,  all of which are  exercisable  within 60 days of the date
hereof,  (iii) 21,014  shares  issuable on the  conversion of Series B Preferred
Stock issuable on the exercise of warrants,  all of which are exercisable within
60 days of the date  hereof and (iv) 87,766  shares  issuable  upon  exercise of
Series C Warrants  issued in the 1999  Financing,  all of which are  exercisable
within 60 days of the date hereof.

(22)  Dr. Rosenwald is Chairman,  President  and sole  stockholder  of Paramount
Capital Asset Management,  Inc.  ("PCAM").  PCAM is the general partner of Aries
Domestic Fund, L.P. ("Aries  Domestic") and the investment  manager of The Aries
Master Fund, a Cayman Island Exempted  Corporation  ("Aries Fund" and,  together
with Aries Domestic, "Aries"). As a consequence of these relationships,  each of
Dr. Rosenwald and PCAM may be deemed to share beneficial ownership of the Common
Stock and Series B Preferred Stock beneficially owned by Aries. Dr. Rosenwald is
also the  Managing  Member of RAQ, LLC and,  accordingly,  may be deemed to have
beneficial  ownership of the Common Stock  beneficially  owned by RAQ,  LLC. Dr.
Rosenwald  disclaims  beneficial  ownership  of  any  securities  issuable  upon
exercise of warrants  granted to employees of  Paramount  Capital,  Incorporated
("Paramount Capital").

      PCAM's and Dr. Rosenwald's  beneficial  ownership of Common Stock includes
(i) 700,483 shares  issuable upon conversion of Series B Preferred Stock held by
Aries,  (ii) 8,755 shares  issuable  upon exercise of warrants  exercisable  for
Common Stock held by Aries,  all of which are exercisable  within 60 days of the
date hereof,  (iii) 70,048 shares issuable upon exercise of warrants exercisable
for Series B Preferred Stock held by Aries, all of which are exercisable  within
60 days of the date hereof and (iv) 292,553  shares  issuable  upon  exercise of
Series C Warrants  issued in the 1999  Financing,  all of which are  exercisable
within 60 days of the date hereof.  Dr.  Rosenwald's  beneficial  ownership also
includes (v) 111 shares  issuable upon exercise of  outstanding  options held by
Dr. Rosenwald, (vi) 30,664 shares issuable upon exercise of warrants exercisable
for Common Stock held by Dr.  Rosenwald and (vii) 245,318  shares  issuable upon
exercise of warrants  exercisable for Series B Preferred Stock, all of which are
exercisable within 60 days of the date hereof.


                                       15
<PAGE>

      PCAM's and Dr.  Rosenwald's  beneficial  ownership  of Series B  Preferred
Stock includes 22,500 shares issuable upon exercise of warrants  exercisable for
Series B Preferred Stock held by Aries,  all of which are exercisable  within 60
days of the date hereof.  Dr.  Rosenwald's  beneficial  ownership  also includes
78,798  shares  issuable  upon  exercise  of warrants  exercisable  for Series B
Preferred Stock held by Dr. Rosenwald.


                                       16
<PAGE>

                       COMPENSATION AND OTHER INFORMATION
                        CONCERNING DIRECTORS AND OFFICERS

Executive Compensation

The following Summary  Compensation Table sets forth the compensation  earned by
the persons who served as the  Corporation's  chief executive officer during the
last completed fiscal year and the four most highly compensated  officers of the
Corporation  other than the chief executive  officer (the "Named  Officers") for
services  rendered in all  capacities  to the  Corporation  for each of the last
three completed fiscal years. No executive officer who would have otherwise been
included in such table resigned or terminated employment during that year.

<TABLE>
<CAPTION>
                                                Summary Compensation Table
                                                --------------------------

                                 Annual Compensation                    Long Term Compensation Awards
                                 -------------------                    -----------------------------
                                 

                                                                                  Securities
Name and                                                         Restricted       Underlying       All Other
Principal Position      Year       Salary          Bonus       Stock Award(s)    Options/SARs    Compensation
- ------------------      ----       ------          -----       --------------    ------------    ------------
                                     ($)            ($)              ($)            (#)(1)            ($)
<S>                     <C>          <C>          <C>                <C>            <C>              <C>
Robert J. Capetola,     1998        $231,094      $160,000(2)        --             271,840          --
Ph.D.                   1997        $225,000      $50,000 (3)        --               --             --
President, Chief        1996         $56,250         --              --               --             --
Executive Officer and
Director

James S. Kuo, M.D.      1998         $71,094         --              --             30,000        87,500 (6)
President, Chief        1997        $175,000      $50,000 (4)        (5)            77,831           --
Executive Officer &     1996        $102,708      $30,000 (4)        --               --             --
Director

Harry Brittain          1998        $143,667      $40,000            --             93,344           --
Vice President          1997        $142,000       $5,000            --               --             --
                        1996         $23,267        --               --               --             --

Laurence B. Katz        1998        $143,458        --               --             93,344           --
Vice President          1997        $142,000       $5,000            --               --             --
                        1996         $17,750        --               --               --             --

Christopher Schaber     1998        $133,333      $12,000            --             93,344           --
Vice President          1997        $125,000      $27,340 (7)        --               --             --
                        1996         $17,548                         --               --             --

Thomas Wiswell          1998        $200,000        --               --             93,344           --
Vice President          1997        $116,667       $7,000            --               --             --
                        1996          --            --               --               --             --
</TABLE>

(1) Includes  options granted in connection with the  Corporation's  acquisition
during 1998 of the previously  outstanding  minority interest in ATI. Vesting of
certain such options (the "Contingent Milestone Options") is contingent upon (i)
the market capitalization of the Company (based on the average closing price and
amount of Common Stock  outstanding over a 30-trading-day  period) exceeding $75
million or (ii)  consummation  of a  corporate  partnering  deal  involving  any
portfolio compound having a total value of at least $20 million.

(2) $60,000  represents  1997 bonus paid in 1998;  $100,000  represents  signing
bonus  relating  to Dr.  Capetola's  current  employment  agreement,  which  was
executed in June 1998.

(3) $50,000 represents 1996 signing bonus paid in 1997. 


                                       17
<PAGE>

(4) Bonus  amounts  earned by Dr. Kuo with respect to 1996 and 1997 were paid to
Dr. Kuo in 1997 and 1998, respectively.

(5) In May 1996, Old Discovery  issued  340,000 shares of Old Common Stock,  par
value $0.001 per share ("Old  Discovery  Common Stock") to Dr. Kuo at a purchase
price of $0.002.  At the time of issuance,  there was no market for such shares.
Such shares were  converted  into 132,313  shares of Common Stock in  connection
with the 1997 merger of Old Discovery with and into the Corporation.

(6) Represents a 50% of a total $175,000 severance payment.

(7) $5,340 represents 1996 bonus paid in 1997.

                      Option Grants In Last Fiscal Year (1)
                      -------------------------------------

The following  table  contains  information  concerning  the stock option grants
(including  grants of Contingent  Milestone  Options) made to the Named Officers
for the fiscal year ended December 31, 1998. No stock  appreciation  rights were
granted to these individuals during such year.

<TABLE>
<CAPTION>
                                Number of Securities    % of Total Options     Exercise
                     Expiration Underlying Options     Granted to Employees     or Base
     Name               Date        Granted               in Fiscal Year         Price
     ----            ---------- --------------------   --------------------    --------
                                                                              ($/sh)(2)
                                                                               --------
<S>                    <C>            <C>                  <C>                  <C>    

Robert J. Capetola,    3/05/08         43,010               3.77%               $4.06
Ph.D.                  6/16/08        115,090              10.08%               $4.44
                       6/16/08         59,500               5.21%               $4.44
                       6/16/08         54,240               4.75%               $4.44
                                                                      
                                                                            
James S. Kuo, M.D.     1/02/08         30,000               2.63%               $3.94
                                                     
                                                                            
Harry Brittain         3/05/08         14,813               1.30%               $4.06
                       6/16/08         39,638               3.47%               $4.44
                       6/16/08         20,493               1.79%               $4.44
                       6/16/08         18,400               1.61%               $4.44
                                                                       
                                                                            
Laurence B. Katz       3/05/08         14,813               1.30%               $4.06
                       6/16/08         39,638               3.47%               $4.44
                       6/16/08         20,493               1.79%               $4.44
                       6/16/08         18,400               1.61%               $4.44
                                                                       
                                                                            
Christopher Schaber    3/05/08         14,813               1.30%               $4.06
                       6/16/08         39,638               3.47%               $4.44
                       6/16/08         20,493               1.79%               $4.44
                       6/16/08         18,400               1.61%               $4.44
                                                                       
                                                                            
Thomas Wiswell         3/05/08         14,813               1.30%               $4.06
                       6/16/08         39,638               3.47%               $4.44
                       6/16/08         20,493               1.79%               $4.44
                       6/16/08         18,400               1.61%               $4.44
</TABLE>
                                                                       
                                                                            
(1) The options granted to Dr. Kuo during 1998 are fully vested.


                                       18
<PAGE>

(2) The exercise price of options issued by the Corporation may be paid in cash,
in shares of Common Stock  valued at the fair market value on the exercise  date
or through a  cashless  exercise  procedure  involving  a  same-day  sale of the
purchased  shares.  The  Corporation  may also  finance the  exercise of options
issued by the  Corporation by loaning the optionee  sufficient  funds to pay the
exercise price for the purchased shares.

Aggregate Option Exercises In Last Fiscal Year And Fiscal Year-End Option Values
- --------------------------------------------------------------------------------

The  following  table sets forth  information  concerning  option  exercises and
option holdings  (including  Contingent  Milestone  Options) for the fiscal year
ended  December  31,  1998  with  respect  to  the  Named  Officers.   No  stock
appreciation  rights were exercised  during such year or were outstanding at the
end of that year.

<TABLE>
<CAPTION>
                                           Number of Securities Underlying              Value of Unexercised
                                            Unexercised Options at FY-End         In The Money Options at FY-End(1)
                                           -------------------------------        ---------------------------------
                                                        (#)
                     Shares Acquired               
       Name          on Exercise(#)        Exercisable      Unexercisable         Exercisable     Unexercisable
       ----          --------------        -----------      -------------         -----------     -------------
<S>                     <C>                <C>                 <C>                   <C>                <C>    

Robert J. Capetola,     98,280             367,623             113,740               $46,202             --
Ph.D.                   56,550 (2)

James S. Kuo, M.D.          --             107,831                --                   --                --

Harry Brittain

                        15,600 (2)         14,937              134,007                 --               $39,748
Laurence B. Katz        31,200 (2)
                        31,200 (2)         30,537              134,007               $39,748            $39,748
Christopher Schaber

Thomas Wiswell          31,200 (2)         30,537              134,007               $39,748            $39,748

                        15,600 (2)         34,437              149,607               $49,255            $79,496
</TABLE>

(1)   Based on the fair market value of the Common Stock at year-end,  $2.63 per
      share, less the exercise price payable for such shares.

(2)   Options  exercised  prior  to the  1998  Merger  by  management  of ATI as
      converted.


                                       19
<PAGE>

Compensation of Directors

Pursuant to the Corporation's 1998 Stock Incentive Plan,  non-employee Directors
of the  Corporation are entitled to receive an award of options for the purchase
of 20,000  shares of Common Stock upon their  election to the Board of Directors
of the Corporation  (the  "Discovery  Board") and an annual award of options for
the purchase of 10,000 shares of Common Stock  following  each annual meeting of
stockholders at which they are reelected  provided they have served for at least
six months prior to such meeting.  Each such option has an exercise  price equal
to 60% of the fair market  value of Common  Stock on its date of grant and has a
maximum term of ten years,  subject to earlier  termination  should the optionee
cease to serve as a Director  of the  Corporation.  Each  option is  immediately
exercisable for all of the option shares. However, the option shares are subject
to repurchase by the  Corporation,  at the exercise price paid per share, in the
event of the  optionee's  termination of service prior to vesting in the shares.
Director  options vest in four equal annual  installments  commencing six months
after  the  date of  grant.  In  addition,  each of the  Corporation's  Director
receives cash compensation in the amount of $1,500 per quarter,  $1,000 for each
meeting of the Board of  Directors  attended in person and $500 for each meeting
of the Board of Directors attended  telephonically.  Directors are not precluded
from serving the  Corporation in any other  capacity and receiving  compensation
therefor.

Employment Agreements

Dr. Capetola has been retained as President and Chief  Executive  Officer of the
Corporation for a four-year period that commenced June 16, 1998. Pursuant to Dr.
Capetola's  employment  agreement with the Corporation (the "Capetola Employment
Agreement"), Dr. Capetola is currently entitled to a base salary of $245,700 per
annum and a minimum  increase in such base salary of 5% per annum.  Dr. Capetola
is  entitled  to a minimum  annual  bonus  equal to 20% of his base  salary  and
received a $100,000  signing  bonus upon  execution of the  Capetola  Employment
Agreement.  Dr.  Capetola is also entitled to a $50,000 bonus upon the execution
of each partnering or similar  arrangement  involving Surfaxin having a value to
the  Corporation  in  excess  of  $10  million  and a  discretionary  bonus,  as
determined by the Compensation  Committee,  to be paid in either cash or equity,
upon the completion of Phase 2 or 3 clinical  trials or the receipt of marketing
approval with respect to any portfolio compound of the Corporation.

The  Corporation  has agreed to  provide  Dr.  Capetola  with $2 million in life
insurance and long-term disability insurance,  subject to a combined premium cap
of $15,000 per year, during the term of the Capetola Employment Agreement.

The Capetola  Employment  Agreement  has a term of four years  expiring June 15,
2002. In the event the Capetola Employment Agreement is terminated prior to such
date without cause,  Dr.  Capetola will be entitled to severance pay equal to 18
months  of his  base  salary,  which  will not be  subject  to  set-off  for any
compensation received by Dr. Capetola from subsequent  employment.  Dr. Capetola
has agreed not to engage in certain activities  competitive with the business of
the  Corporation  for a period of 18 months  following  any  termination  of his
employment with the Corporation.

Pursuant to employment  agreements with the Corporation executed  simultaneously
with  the  closing  of the  1998  Merger,  each of  Harry  Brittan,  Ph.D.,  the
Corporation's  Vice  President  of  Pharmaceutical  and  Chemical   Development,
Christopher J. Schaber,  the Corporation's  Vice President of Regulatory Affairs
and Quality  Control,  Laurence B. Katz,  the  Corporation's  Vice  President of
Project  Management  and  Clinical  Administration,   and  Thomas  Wiswell,  the
Corporation's Vice President of Clinical Research,  has been retained for a term
of three years ending June 15, 2001 at the  following  respective  base salaries
currently in effect:  $151,410;  $153,000;  $151,410; and $204,000. Mr. Brittain
was paid a $40,000  relocation  bonus  purusant  to the terms of his  employment
agreement and Mr. Schaber is paid an annual tuition reimbursement payment in the
amount of $12,000.  Each such  officer is entitled to a  discretionary  year-end
cash bonus and a  discretionary  bonus to be paid in either  cash or equity upon
the  completion  of Phase 2 or 3 clinical  trials or the  receipt  of  

                                       20
<PAGE>

marketing approval with respect to any portfolio compound of the Corporation, in
each case as determined by the Compensation Committee.

In the event Dr. Wiswell's employment agreement is terminated by Dr. Wiswell for
good cause, Dr. Wiswell will be entitled to severance pay equal to six months of
his base  salary,  which will not be subject  to  set-off  for any  compensation
received by Dr. Wiswell from subsequent employment. In the event Dr. Brittain's,
Mr. Schaber's or Dr. Katz's employment is terminated by the Corporation  without
good cause,  such officer will be entitled to severance  pay equal to six months
of his base  salary,  which  will be subject  to  set-off  for any  compensation
received from subsequent  employment  during the severance  period.  Each of Dr.
Brittain,  Mr.  Schaber,  Dr.  Katz and Dr.  Wiswell has agreed not to engage in
activities  competitive  with the business of the Corporation for a period of 18
months  following  any  termination  of his  employment  with  the  Corporation,
provided that in the case of Dr. Wiswell, such agreement will be inapplicable if
his  employment is terminated  by the  Corporation  without good cause or by Dr.
Wiswell for cause.


                                       21
<PAGE>

                 CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

During March and April 1999, the Corporation placed with certain  investors,  in
transactions  exempt from  registration  under the  Securities  Act  pursuant to
Section 4(2) thereof and Regulation D thereunder (the "1999 Financing"),  shares
of Common Stock and a newly  created class of warrants of the  Corporation  (the
"Class C Warrants") for an aggregate purchase price of $1,000,000.  Investors in
the 1999 Financing received, for each $100,000 invested, 53,191 shares of Common
Stock at a purchase price of $1.88 and 53,191 Class C Warrants, each of which is
exercisable for the purchase of a share of Common Stock for an exercise price of
$2.30 at any time  prior to the  seventh  anniversary  of the  issuance  of such
warrant. Under certain  circumstances,  the investors in the 1999 Financing will
be  entitled  to  receive  additional  shares of Common  Stock,  and to have the
exercise price applicable to the Class C Warrants  reduced,  without the payment
of further  consideration.  The investors in the 1999  Financing  included Aries
Domestic  Funds,  L.P.  and The Aries  Master  Fund,  each of which was,  or was
affiliated  with, a 5%-or-greater  beneficial owner of the Common Stock prior to
the 1999 Financing.

The Corporation  leases its principal  executive  offices from Huei Tsai, Ph.D.,
the Vice President of Biometrics of the Corporation. Pursuant to such lease, the
Corporation pays Dr. Tsai base rent of $186,200 per annum (subject to escalation
in subsequent  years) and is liable for its  proportionate  share of real estate
taxes  levied and certain  operation  and  maintenance  expenses  incurred  with
respect to the  building in which the  Corporation's  offices are  located.  The
Corporation believes that the terms of its lease with Dr. Tsai are comparable to
the terms that would be obtained form an unrelated third party lessor. The space
leased by the Corporation was renovated in part by a construction  company owned
by the spouse of Cynthia Davis, the Controller of the  Corporation.  The cost of
such portion of the renovations was approximately  $60,000, of which $25,000 was
paid by Dr. Tsai pursuant to the terms of the Corporation's space lease.

In October  1996,  ATI entered into a consulting  agreement  with The Sage Group
pursuant  to which The Sage  Group was paid a monthly  consulting  fee of $7,500
through March 1998. The Corporation's consulting arrangement with The Sage Group
was  modified in April 1998 to provide for a monthly  payment of $4,000,  and to
make  such  agreement  terminable  at any  time  upon  30  days'  notice  by the
Corporation.  In October 1998, such consulting agreement was further modified to
provide  that twice the amount of the  reduced  portion  of the  consulting  fee
(i.e.,  $3,500 per month commencing with October 1998) would be paid to The Sage
Group upon consummation of a corporate partnering transaction.

In  November  1997,  ATI  entered  into a second  agreement  with The Sage Group
relating to the provision of  introductions to and the negotiation of partnering
transactions  with potential  strategic  partners.  Upon the consummation of any
strategic  partnering  transaction with an entity  introduced by The Sage Group.
The Sage Group will be  entitled to receive  options for the  purchase of 19,000
shares of Common Stock at fair market value.  Richard  Power, a director of ATI,
is a principal and the executive director of The Sage Group.

Simultaneously  with and as a  condition  to the  closing  of the  merger of Old
Discovery with and into the  Corporation  in November 1997 (the "1997  Merger"),
the Corporation repaid to Titan Pharmaceuticals, Inc. ("Titan"), which was a 32%
stockholder of the Corporation at such time, all outstanding indebtedness of the
Corporation to Titan (including  indebtedness  under a convertible  debenture in
the original  principal  amount of $1 million  purchased by Titan in March 1997)
pursuant to agreements (the "Titan Agreements")  reached between the Corporation
and Titan at the time the  merger  agreement  relating  to the 1997  Merger  was
executed. Such indebtedness aggregated approximately  $1,200,000.  Also pursuant
to the Titan Agreements,  upon  effectiveness of the 1997 Merger, (i) all of the
capital  stock  of  the  Corporation  owned  by  Titan  was  surrendered  to the
Corporation  for  cancellation  (other  than  certain  shares of  capital  stock
currently held in escrow which will be cancelled upon their release from escrow)
and (ii) the Corporation's  rights pursuant to the a license  underlying certain
drug products that had been subject to  development  efforts by the  Corporation
prior to the 1997  Merger  were  transferred  to Titan in  exchange  for Titan's
agreement  to pay a 2%  royalty  to the  Corporation  on any  sales of such drug
products.  The  Corporation's  development  efforts  with  respect  to such drug
products have since been abandoned.


                                       22
<PAGE>

From the  Corporation's  inception  until the closing of the 1997 Merger,  Titan
provided certain executive, administrative,  financial, business development and
regulatory services to the Corporation. During the year ended December 31, 1997,
the  Corporation  incurred  expenses in the aggregate of  approximately  $35,400
pursuant  to the  services  arrangement.  The  Corporation  has in the past used
certain  facilities and equipment  leased by Titan and reimbursed  Titan for the
expenses  incurred  by Titan with  respect to such use,  in  addition  to having
entered an assignment and sublease with Titan, along with the other subsidiaries
of Titan,  under such equipment lease. The Corporation's  liability with respect
to such equipment lease has been terminated.

Pursuant to a private equity  offering  conducted  during June through  November
1996 (the "Unit Offering") in which Paramount Capital,  Incorporated ("Paramount
Capital")  acted as placement  agent for Old  Discovery,  Old  Discovery  raised
aggregate  gross  proceeds of  approximately  $22,002,000.  In  connection  with
services rendered by Paramount Capital as placement agent for the Unit Offering,
and pursuant to a placement agency agreement (the "Placement Agency  Agreement")
entered  into  by Old  Discovery  and  Paramount  Capital,  Old  Discovery  paid
Paramount   Capital  cash   commissions  of   approximately   $1,980,000  and  a
non-accountable  expense allowance of approximately  $880,000. In addition,  Old
Discovery  issued placement  warrants to Paramount  Capital that were assumed by
the  Corporation  in the 1997 Merger and are currently  exercisable  for 220,026
shares of Series B Convertible  Preferred  Stock at an exercise price of $11 per
share and 85,624 shares of Common Stock at an exercise price of $0.64 per share.
Pursuant to the Placement Agency  Agreement,  on November 7, 1996, Old Discovery
and  Paramount  Capital  entered  into  a  financial   advisory  agreement  (the
"Financial Advisory Agreement"),  pursuant to which Paramount Capital received a
monthly  retainer of $4,000 per month  through  December  1998 (all of which was
pre-paid by the  Corporation),  plus  expenses and success  fees.  The Financial
Advisory Agreement was assumed by the Corporation in the 1997 Merger.

Dr. Lindsay  Rosenwald,  M.D. is the sole  stockholder of PCAM (which in turn is
the general partner of the Aries Domestic Fund, L.P. ("Aries  Domestic") and the
investment  manager of The Aries Fund, a Cayman  Island Trust ("Aries Fund" and,
together  with  Aries  Domestic,  "Aries"))  and the  Chairman  of the  Board of
Directors,  Chief Executive Officer, President and sole stockholder of Paramount
Capital.  Dr.  Rosenwald  is also a  director  of Titan  and,  prior to the 1997
Merger, was a director of the Corporation.

Mark Rogers, M.D., a Director of the Corporation,  is the President of Paramount
Capital.  Steve  H.  Kanzer,  the  Chairman  of the  Board of  Directors,  was a
full-time officer of Paramount Capital and of Paramount Capital Investments, LLC
("Paramount Investments"), an affiliate of Paramount Capital, until March 1998.

The Corporation  has agreed  pursuant to its charter  documents to indemnify its
Directors to the maximum extent permissible under the General Corporation Law of
the State of Delaware.


                                       23
<PAGE>

                                   PROPOSAL II

                 PROPOSAL TO AMEND THE 1998 STOCK INCENTIVE PLAN

          Amendment to Increase the Number of Authorized Shares under
                          the 1998 Stock Incentive Plan

The 1998 Stock Incentive Plan of the  Corporation  (the "1998 Plan") was adopted
by the Board of Directors on March 24, 1998 and was approved by the stockholders
on June 16, 1998.  The 1998 Plan expires by its own terms on March 24, 2008. The
purposes of the 1998 Plan is to provide  incentive to employees and  consultants
of  the  Corporation,   to  encourage  employee  proprietary  interests  in  the
Corporation,  to encourage  employees to remain in the employ of the Corporation
and to attract to the Corporation individuals of experience and ability.

Pursuant  to the 1998 Plan,  as of May 4, 1999,  options to  purchase  1,629,663
shares of Common Stock  (including  options to purchase 233,639 shares of Common
Stock granted to employees of the Corporation subject to stockholder approval of
this proposal) were  outstanding at a weighted average price of $3.76 per share,
and 10,000  options had been  exercised.  As of May 4, 1999, the market value of
the shares was $1.50 per share, based upon the closing price on such date on the
Nasdaq SmallCap Market. In addition there are options to purchase 250,840 shares
of Common Stock with a weighted  average  price of $0.49 per share,  outstanding
under Old  Discovery's  1996 Stock  Option/Stock  Issuance  Plan and  options to
purchase  382,590 shares of Common Stock with a weighted average price of $0.12,
outstanding   under  Acute   Therapeutics   Incorporated   ("ATI")   1996  Stock
Option/Stock Issuance Plan, all of which have been assumed by the Corporation.

Such options do not confer upon  holders  thereof any voting or any other rights
of a stockholder  of the  Corporation.  The shares of Common Stock issuable upon
exercise of the options in accordance  with the terms thereof will be fully paid
and nonassessable.

Currently,  the number of shares  authorized for issuance under the 1998 Plan is
1,406,024  shares  (including  383,458  shares  subject to options  issued under
predecessor  option plans).  The Board of Directors has approved and recommended
to the  stockholders  that they  approve an  amendment to increase the number of
shares of Common Stock  issuable  pursuant to the 1998 Plan to 2,200,959  shares
(including  such 383,458  shares) (the  "Amendment").  The proposed  Amended and
Restated 1998 Stock Incentive Plan is annexed to the Proxy Statement as Annex A.
As of May 4, 1999 there were 15,311,940  shares of Common Stock outstanding on a
fully diluted basis, not including Class A and B warrants  exercisable at $19.50
and $26.25, respectively.

The  purpose  of  the  Amendment  is to  permit  the  Board  of  Directors,  the
Corporation's  Compensation  Committee and its management to continue to provide
long term, equity based incentives to present and future officers, employees and
certain  directors.  If the Amendment is not approved,  the Corporation will not
grant any additional  options to purchase  shares of Common Stock under the 1998
Plan and those  options  that have  been  granted  subject  to  approval  of the
Amendment will be rescinded.  In such event,  the Corporation will in the future
be unable to provide  further  long-term  equity-based  incentives to directors,
officers and employees.

As of May 4,  1999,  of the  1,406,024  shares of Common  Stock  authorized  for
issuance  under the 1998 Plan,  no shares  remained  available for new grants of
options to purchase  shares.  Except for the above  aforementioned  options that
have been granted by the Board of Directors  subject to stockholder  approval of
the Amendment,  the  Corporation has not at the present time determined who will
receive the newly available options, if any, if the Amendment is approved.


                                       24
<PAGE>

Stock Options Granted under the 1998 Plan Since its Inception

The table below shows, as to each of Discovery's executive officers named in the
Summary Compensation Table and the various indicated individuals and groups, the
number of shares of Discovery  Common Stock subject to options granted under the
1998 Plan  (including  the  predecessor  plans  incorporated  therein)  to date,
including  options  granted  subject to  stockholder  approval of the Amendment,
together with the weighted average exercise price payable per share.

================================================================================
                                  STOCK OPTIONS

- --------------------------------------------------------------------------------
       Name and Position                      Options Granted   Weighted Average
                                            (Number of Shares)    Exercise Price
- --------------------------------------------------------------------------------
Robert J. Capetola, Ph.D., Chief Executive         
Officer and Director                                 459,570               $3.82
- --------------------------------------------------------------------------------
All current executive officers 
as a group (10 persons)                            1,341,761               $3.86
- --------------------------------------------------------------------------------
All current non-employee directors 
as a group (8 persons)                                80,000               $2.66
- --------------------------------------------------------------------------------
Steve H. Kanzer, C.P.A., Esq., Director               50,000               $3.56
- --------------------------------------------------------------------------------
Mark G. Rogers, M.D., Director                        10,000               $2.66
- --------------------------------------------------------------------------------
Max Link, Ph.D., Director                             10,000               $2.66
- --------------------------------------------------------------------------------
Herbert H. McDade, Jr., Director                      10,000               $2.66
- --------------------------------------------------------------------------------
Milton Packer, M.D., Director                         10,000               $2.66
- --------------------------------------------------------------------------------
Richard G. Power, Director                            10,000               $2.66
- --------------------------------------------------------------------------------
Marvin E. Rosenthale, Ph.D., Director                 10,000               $2.66
- --------------------------------------------------------------------------------
David Naveh, Ph.D., Director                          10,000               $2.66
- --------------------------------------------------------------------------------
Richard Sperber, Director                             10,000               $2.66
- --------------------------------------------------------------------------------
All employees, including current officers
 who are not executive officers, 
as a group  (3 persons)                                8,000               $3.00
================================================================================


                                       25
<PAGE>

Description of the 1998 Plan

Structure

The 1998  Plan  includes  three  separate  equity  incentive  programs:  (i) the
Discretionary  Option Grant Program,  (ii) the Stock Issuance  Program and (iii)
the Automatic Option Grant Program.  The principal  features of each program are
described below.

Administration

The Compensation  Committee of the Board of Directors of the Corporation  serves
as the Plan  Administrator  with respect to the  Discretionary  Option Grant and
Stock Issuance Programs.  However,  the Board may also administer those programs
or one or more additional  Board committees may be appointed to administer those
programs  with  respect to certain  designated  classes  of  individuals  in the
Corporation's  service.  The term "Plan  Administrator"  as used in this summary
will  mean  the  Compensation  Committee,  the  Board  and any  other  appointed
committee acting within the scope of its administrative authority under the 1998
Stock Incentive Plan.  Administration  of the Automatic  Option Grant Program is
self-executing in accordance with the express provisions of such program.

Share Reserve

The initial share reserve for the 1998 Plan was 1,022,566  shares  (exclusive of
383,458 options  outstanding under  predecessor  plans) shares. In the event any
change  is made to the  outstanding  shares  of  Common  Stock by  reason of any
recapitalization,  stock dividend,  stock split, combination of shares, exchange
of  shares  or  other  change  in  corporate   structure  effected  without  the
Corporation's receipt of consideration,  appropriate adjustments will be made to
the  securities  issuable (in the aggregate and to each  participant)  under the
1998 Plan and to each outstanding option.

Shares subject to any outstanding options under the 1998 Plan (including options
incorporated from predecessor  plans) which expire or otherwise  terminate prior
to exercise are available for subsequent issuance.  Unvested shares issued under
the 1998 Plan and  subsequently  repurchased by the Corporation  pursuant to its
repurchase  rights  under the 1998 Plan will also be  available  for  subsequent
issuance.

Eligibility

Officers and employees,  non-employee Board members and independent  consultants
and advisors in the service of the  Corporation  or its parent and  subsidiaries
(whether now existing or subsequently  established)  are eligible to participate
in the Discretionary Option Grant and Stock Issuance Programs. Only non-employee
members of the Board are eligible to participate  in the Automatic  Option Grant
Program.

As of the date of this Proxy  Statement,  ten  executive  officers,  three other
employees and eight  non-employee  Board members are eligible to  participate in
the 1998 Plan.

Valuation

The fair market value per share of the Corporation  Common Stock on any relevant
date  under the 1998 Plan will be the  closing  selling  price per share on that
date on the Nasdaq  SmallCap  Market.  On May 4, 1999, the closing selling price
per share was $1.50.

Discretionary Option Grant Program

The options granted under the  Discretionary  Option Grant Program may be either
incentive  stock  options under the federal tax laws or  non-statutory  options.
Each granted option has an exercise price per share not less than 100% of


                                       26
<PAGE>

the fair market value per share of the Corporation's  Common Stock on the option
grant date, and no granted option has a term in excess of ten years.  The shares
subject  to each  option  generally  vest in a  series  of  installments  over a
specified period of service measured from the grant date.

Upon cessation of service, the optionee has a limited period of time in which to
exercise any outstanding option to the extent exercisable for vested shares. The
Plan  Administrator  has complete  discretion to extend the period following the
optionee's  cessation of service during which his or her outstanding options may
be exercised and/or to accelerate the  exercisability or vesting of such options
in whole or in part.  Such  discretion  may be  exercised  at any time while the
options  remain  outstanding,  whether  before  or after the  optionee's  actual
cessation of service.

Incentive stock options granted under the Discretionary Option Grant Program may
not be assigned or transferred,  except by the provisions of the optionee's will
or the laws of inheritance following his or her death. Non-statutory options may
be  assigned  or  transferred  pursuant  to the  optionee's  will or the laws of
inheritance  and  may  also be  assigned  during  the  optionee's  lifetime,  in
connection  with the optionee's  estate plan, to members of his or her immediate
family  or  to  a  trust  established   exclusively  for  the  benefit  of  such
individuals.

The  Plan  Administrator  has  the  authority  to  effect  the  cancellation  of
outstanding  options under the  Discretionary  Option Grant  Program  (including
outstanding  options  under  the  Predecessor  Plans)  and to issue  replacement
options  with  an  exercise  price  based  on  the  fair  market  value  of  the
Corporation's Common Stock at the time of the new grant.

Stock Issuance Program

Shares  may  be  issued  under  the  Stock  Issuance   Program  for  such  valid
consideration  under  the  DGCL as the  Plan  Administrator  deems  appropriate,
provided  the  value  of  such   consideration,   as   determined  by  the  Plan
Administrator,  is not less than the fair market  value of the issued  shares on
the date of issuance. Shares may also be issued as a bonus for past services.

Shares issued as a bonus for past  services will be fully vested upon  issuance.
All other shares issued under the program will be subject to a vesting  schedule
tied to the performance of service or the attainment of designated  financial or
key project milestones.

The Plan Administrator has the sole and exclusive authority,  exercisable upon a
participant's  termination of service, to vest any or all unvested shares of the
Corporation's  Common Stock at the time held by that participant,  to the extent
the Plan  Administrator  determines  that such vesting  provides an  appropriate
severance benefit under the circumstances.

Automatic Option Grant Program

Non-employee  Board  members are  eligible to receive  option  grants  under the
Automatic  Option  Grant  Program of the 1998 Plan.  Each  individual  who first
becomes a  non-employee  member of the  Board of the  Corporation  or any of its
subsidiaries, whether through election by the stockholders or appointment by the
Board,  receives,  at the  time of such  initial  election  or  appointment,  an
automatic  option grant for 20,000 shares of Common Stock.  In addition,  on the
date of each annual stockholders meeting, each individual who is re-elected as a
non-employee  Board  member is  automatically  granted  at that  meeting a stock
option to purchase an additional  10,000  shares of Common Stock,  provided that
such  individual  has  served as a  non-employee  Board  member for at least six
months.

Each  option has an  exercise  price per share  equal to 60% of the fair  market
value per share of Common  Stock on the option  grant date and a maximum term of
ten years measured from the grant date.  The option is  immediately  exercisable
for all the option shares, but any purchased shares are subject to repurchase by
the  Corporation,  at the  exercise  price paid per share,  upon the  optionee's
cessation of Board service prior to vesting in those shares.  The shares subject
to each  option vest (and the  Corporation's  repurchase  rights  lapse) in four
successive equal annual


                                       27
<PAGE>

installments over the optionee's  period of Board service,  beginning six months
after the option grant date,  with the first such  installment  vesting upon the
optionee's  completion  of 18 months of Board  service  measured from the option
grant date.

The shares subject to each  outstanding  automatic option grant will immediately
vest should any of the  following  events occur while the optionee  continues in
Board  service:  (i) the  optionee's  death  or  permanent  disability,  (ii) an
acquisition  of the  Corporation by merger or asset sale or (iii) the successful
completion of a hostile tender offer for more than 50% of the outstanding voting
securities  or a change in the majority of the Board  occasioned  by one or more
contested elections for Board membership. Each automatic option grant held by an
optionee upon his or her  termination of Board service will remain  exercisable,
for any or all of the option  shares in which the optionee is vested at the time
of such  termination,  for up to a 12-month  period  following such  termination
date.

Automatic option grants may be assigned by the provisions of the optionee's will
or the laws of  inheritance  following his or her death and may also be assigned
during the optionee's  lifetime,  in connection with the optionee's estate plan,
to members of his or her immediate family or to a trust established  exclusively
for the benefit of such individuals.

General Provisions

Acceleration

In the event that the  Corporation  is acquired  by merger or asset  sale,  each
outstanding option under the Discretionary  Option Grant Program which is not to
be  assumed  or  replaced  by  the  successor   corporation  will  automatically
accelerate in full,  and all unvested  shares under the Stock  Issuance  Program
will immediately vest, except to the extent the Corporation's  repurchase rights
with  respect to those shares are to be assigned to the  successor  corporation.
The Plan  Administrator  will  have  complete  discretion  to grant  one or more
options  under the  Discretionary  Option Grant  Program which will become fully
exercisable  for all the option shares in the event those options are assumed in
the acquisition and the optionee's service with the Corporation or the acquiring
entity is involuntarily terminated or the optionee resigns for good cause within
a designated period following such acquisition. The Plan Administrator will have
similar  discretion to grant options which will become fully exercisable for all
the option shares should the optionee's service terminate, whether involuntarily
or through a resignation for good reason, within a designated period following a
hostile change in control of the Corporation (whether by successful tender offer
for more than 50% of the  outstanding  voting stock or by proxy  contest for the
election of Board  members).  The Plan  Administrator  may also  provide for the
automatic  vesting of any  outstanding  shares under the Stock Issuance  Program
upon similar terms and conditions.

The acceleration of vesting in the event of a change in the ownership or control
of the  Corporation may be seen as an  anti-takeover  provision and may have the
effect of discouraging a merger proposal, a takeover attempt or other efforts to
gain control of the Corporation.

Financial Assistance

The Plan  Administrator  may  institute  a loan  program  to assist  one or more
participants  in  financing  the  exercise  of  outstanding  options  under  the
Discretionary  Option  Grant  Program or the  purchase of shares under the Stock
Issuance Program.  The Plan  Administrator  will determine the terms of any such
assistance.  However,  the maximum amount of financing  provided any participant
may not exceed the cash  consideration  payable  for the issued  shares plus all
applicable taxes incurred in connection with the acquisition of the shares.


                                       28
<PAGE>

Special Tax Election

The Plan  Administrator  may provide one or more  holders of options or unvested
shares with the right to have the  Corporation  withhold a portion of the shares
otherwise  issuable to such  individuals  in  satisfaction  of the tax liability
incurred by such individuals in connection with the exercise of those options or
the vesting of those shares.  Alternatively,  the Plan  Administrator  may allow
such individuals to deliver previously acquired shares of the Corporation Common
Stock in payment of such tax liability.

Amendment and Termination

The Board may amend or modify the 1998 Plan in any or all  respects  whatsoever,
subject to any required stockholder  approval.  The Board may terminate the 1998
Plan at any  time,  and the 1998  Plan  will in all  events  terminate  upon the
expiration  of its ten-year  term  measured from the date of its adoption by the
Board of Directors.

Tax Aspects

The Federal  income tax aspects of ISOs and  non-ISOs  are  generally  described
below.  An employee will generally not be taxed at the time of grant or exercise
of an ISO,  although  the excess of the fair market  value of the stock over the
exercise  price on  exercise of an ISO will taken into  account for  alternative
minimum tax purposes. If the employee holds the shares acquired upon exercise of
an ISO until at least one year after  issuance  and two years after grant of the
Option,  the  employee  will have long term  capital gain (or loss) based on the
difference  between  the  amount  realized  on the sale or  disposition  and the
exercise  price of the Option.  An employee  who realized a capital gain in such
event  will be  entitled  to  capital  gains  tax  treatment  upon  the  sale or
disposition  of the shares.  If these holdings  periods are not satisfied,  then
upon  disposition  of the shares of Common Stock,  the employee  will  recognize
ordinary income equal, in general, to the excess of the fair market value of the
shares at the time of  exercise  over the  exercise  price of the  Option,  plus
capital  gain in  respect  of any  additional  appreciation.  With  respect to a
non-ISO,  an  optionee  will not be taxed at the time of grant;  upon  exercise,
however,  the optionee will generally realize  compensation income to the extent
that the fair market  value of the shares of Common  Stock  exceeds the exercise
price  of the  Option.  The  Corporation  generally  will  have  a  compensation
deduction  to the  extent  that,  and at the time  that,  an  optionee  realizes
compensation income with respect to an Option. In the case of an ISO, this means
that the Corporation ordinarily is not entitled to a compensation deduction.

The Board of Directors  recommends  a vote FOR the approval of the  Amendment to
the 1998 Plan


                                       29
<PAGE>

                                  PROPOSAL III

                       PROPOSAL TO APPROVE STOCK PURCHASE
                  AGREEMENT WITH CRESCENT INTERNATIONAL LIMITED

Overview of the Transaction

The  Corporation  is proposing  to enter into a Stock  Purchase  Agreement  (the
"Stock Purchase Agreement") with Crescent  International  Limited  ("Crescent").
Pursuant to the proposed  Stock  Purchase  Agreement,  the  Corporation  will be
entitled to sell up to  $1,000,000  (the  "Facility  Limit") in shares of Common
Stock  (the  "Shares")  in   installments   (the  "Put")  provided  that  (i)  a
registration  statement  covering  the resale of the Shares  (the  "Registration
Statement")  has been declared  effective by the SEC, (ii) the closing bid price
of the Common Stock is equal to or greater than $1.75 a share as  determined  in
accordance  with the Stock  Purchase  Agreement,  and (iii) the  average  of the
closing bid price of the Common Stock  multiplied  by the total volume of shares
traded (the "Average Daily Trading Value"), as determined in accordance with the
Stock Purchase Agreement, is equal to or greater than $30,000. The conditions in
(ii) and (iii) will not be required to be satisfied in connection  with the sale
of up to  $150,000  in equity  to  Crescent  prior to the date the  Registration
Statement becomes effective;  however,  the purchase price of the Shares sold by
the Corporation to Crescent prior to effectiveness of the Registration Statement
will be  adjusted  to the  trading  price  of the  Common  Stock  at the time of
effectiveness of the Registration  Statement if such trading price is lower than
the purchase price paid by Crescent for such Shares.  The Corporation  will sell
the  Shares  at a  price  equal  to 85%  of the  average  of  the  lowest  three
consecutive  closing bid prices during the 20 days preceding the date set in the
Corporation's Put notice (the "Purchase Price").

In consideration for the Put rights,  the Corporation will issue to Crescent (i)
a five-year  warrant to purchase  30,000  shares of Common  Stock at an exercise
price  equal to 150% of the  Purchase  Price of the  first Put and (ii) a second
such warrant at the time a notice of exercise  corresponding to a cumulative use
of at least half the Facility Limit is issued by the  Corporation.  In addition,
the  Corporation  will pay  Crescent  (i) $20,000 on  commencement  of the Stock
Purchase  Agreement  and (ii) a fee equal to 2% of the amount of each Put at the
time of exercise.

Voting Requirements

The  Corporation's  Common  Stock  is  traded  on  the  Nasdaq  SmallCap  Market
("Nasdaq").  Nasdaq requires the Corporation to obtain  stockholder  approval in
connection  with  the  sale or  issuance  of  shares  of its  Common  Stock  (or
securities  convertible into or exercisable for shares of Common Stock) when (i)
the number of  additional  shares of Common Stock being issued equals or exceeds
20% of the number of shares of Common Stock that are  outstanding  prior to such
sale or issuance and (ii) the shares of Common Stock will be sold at a price per
share  which is less than the greater of the (x) per share book value or (y) per
share  market  value of the  shares of Common  Stock at the time of such sale or
issuance  (the  "Threshold  Price").  The  Corporation  is  seeking  shareholder
approval of this proposal because future issuances of Shares below the Threshold
Price  could,  either  alone or  together  with  shares of Common  Stock  issued
pursuant to the prior transaction described below, exceed 20% of the outstanding
shares of Common Stock as of the relevant date for such determination.

Prior Transactions Involving Potential Issuance below the Threshold Price

During March and April 1999, the  Corporation  placed with certain  investors an
aggregate of 531,915  shares of Common Stock and Class C Warrants to purchase an
equivalent  number of shares of Common Stock for an aggregate  purchase price of
$1,000,000  (the "Prior  Financing").  Shares of Common  Stock sold in the Prior
Financing  were priced above the market price of the Common Stock at the time of
the Prior Financing.

Investors in the Prior  Financing are entitled to receive  additional  shares of
Common Stock for no additional


                                       30
<PAGE>

consideration  and to have the exercise price applicable to the Class C Warrants
reduced if, within 150 days from the effective dates of the respective purchases
pursuant the Prior  Financing,  the  Corporation (i) shall sell shares of Common
Stock in a private offering at less than $1.88 per share,  (ii) shall sell, in a
private  offering,  any shares of  capital  stock or equity  derivatives  of the
Corporation  that are  convertible  into, or exercisable  for,  shares of Common
Stock at a conversion price or exercise price less than $1.88 per share or (iii)
shall not have either (a) raised at least $2 million  through the sale of equity
or equity derivatives or (b) entered into any corporate  partnering  arrangement
having a value of at least $10  million.  In  addition,  if the  average  of the
closing  prices for the 20 trading days preceding the date that is 150 days from
the effective date of a purchase in the Prior Financing is less than $1.88,  the
investor will receive a number of additional  shares of Common Stock  sufficient
to reduce such  investor's per share purchase price to the average of the lowest
three  closing  prices of the Common  Stock  during such period and the exercise
price applicable to such investors Class C Warrants will be reduced. In no event
will the effective purchase price of Common Stock sold in the Prior Financing be
reduced  below  $0.86  per  share,  and in no  event  will  the  exercise  price
applicable  to the Class C Warrants be reduced  below $2.15,  pursuant to any of
the foregoing  adjustments.  The effect of these  provisions is to cap at 20% of
the  outstanding  Common Stock at the time of the Prior  Financing the number of
shares of Common Stock that may be issued below the Threshold  Price pursuant to
the Prior Financing.

The Board of Directors recommends that the stockholders vote FOR the approval of
the Stock Purchase Agreement.


                                       31
<PAGE>

                                VOTING PROCEDURES

The presence,  in person or by proxy,  of at least a majority of the outstanding
shares of Common  Stock  entitled to vote at the Annual  Meeting is necessary to
establish  a quorum for the  transaction  of  business.  Shares  represented  by
proxies  pursuant  to which  votes  have  been  withheld  from any  nominee  for
director,  or which contain one or more  abstentions or broker  "non-votes," are
counted as present for  purposes  of  determining  the  presence or absence of a
quorum  for the  Annual  Meeting.  A  "non-vote"  occurs  when a broker or other
nominee  holding shares for a beneficial  owner votes on one proposal,  but does
not vote on another  proposal  because  the broker  does not have  discretionary
voting power and has not received instructions from the beneficial owner.

The  holders of shares of Series B Preferred  Stock and Common  Stock shall vote
together as one class on all matters  submitted to a vote of the stockholders of
the  Corporation at the Annual Meeting.  On each matter properly  brought before
the Annual  Meeting,  holders of shares of Common  Stock will be entitled to one
vote for each share of Common  Stock held as of the Record  Date and  holders of
Series B Preferred  Stock shall be entitled to  approximately  3.1132  votes for
each share of Series B Preferred Stock held as of the Record Date.

Proposal I. Directors are elected by a plurality of the votes cast, in person or
by proxy, at the Annual Meeting.  The nine nominees receiving the highest number
of affirmative  votes of the shares present,  in person or represented by proxy,
and voting on the election of directors at the Annual Meeting will be elected as
directors.  Shares represented by all proxies received by the Board of Directors
and not so marked as to withhold authority to vote for any individual nominee or
for all nominees will be voted (unless one or more nominees are unable to serve)
for the  election  of the  nominees.  Where the  stockholder  properly  withheld
authority  to vote for a  particular  nominee or  nominees,  such  stockholder's
shares will not be counted toward such nominee's achievement of a plurality.

Proposal II. The proposal to approve the  amendment to the 1998 Plan to increase
the number of shares of Common Stock  available for issuance under the 1998 Plan
must be approved by the vote of a majority of the votes cast,  whether in person
or by proxy.  Abstentions  therefore will have the same effect as a vote against
the proposal.

Proposal  III.  The proposal to approve the proposed  Stock  Purchase  Agreement
between the  Corporation and Crescent must be approved by the vote of a majority
of the votes cast,  whether in person or by proxy.  Abstentions  therefore  will
have the same effect as a vote against the proposal.

Other Matters.  For all other  proposals  described in this Proxy  Statement and
submitted to  stockholders at the Annual  Meeting,  the affirmative  vote of the
majority of shares  present,  in person or represented  by proxy,  and voting on
that matter is required for approval.  Abstentions are included in the number of
shares present or  represented  and voting on each matter and,  therefore,  with
respect to votes on a specific proposal, will have the effect of negative votes.
Shares subject to broker  "non-votes"  are not considered to have been voted for
the  particular  matter and have the practical  effect of reducing the number of
affirmative votes required to achieve a majority for such matter by reducing the
total  number of shares  from which the  majority  is  calculated.  If any other
matter not discussed in this Proxy  Statement  should be presented at the Annual
Meeting  upon which a vote may be  properly  taken,  shares  represented  by all
proxies received by the Board of Directors will be voted with respect thereto in
accordance with the judgment of the persons named in the proxies.


                                       32
<PAGE>

                                  OTHER MATTERS

The Board of Directors is not aware of any matters which will be brought  before
the Annual Meeting other than those  specifically set forth herein. If any other
matter properly comes before the Annual Meeting, it is intended that the persons
named in and acting  under the  enclosed  proxy or their  substitutes  will vote
thereon in accordance with their best judgment.

                              STOCKHOLDER PROPOSALS

Proposals of  stockholders  intended for inclusion in the Proxy  Statement to be
furnished  to all  stockholders  entitled to vote at the next annual  meeting of
stockholders of the Corporation must be received at the Corporation's  principal
executive  offices  not  later  than  January  18,  2000.  In order  to  curtail
controversy as to the date on which a proposal was received by the  Corporation,
it is suggested that proponents submit their proposals by Certified Mail, Return
Receipt Requested.

                            EXPENSES AND SOLICITATION

The cost of  solicitation of proxies will be borne by the  Corporation.  Proxies
will be solicited principally through the mails. Further solicitation of proxies
from some stockholders may be made by directors,  officers and regular employees
of the Corporation  personally,  by telephone,  telegraph or special letter.  No
additional  compensation,  except for reimbursement of reasonable  out-of-pocket
expenses  will be paid for any  such  further  solicitation.  In  addition,  the
Corporation  may request  banks,  brokers  and other  custodians,  nominees  and
fiduciaries  to  solicit  their  customers  who have  stock  of the  Corporation
registered in the name of a nominee. The Corporation will reimburse such persons
for their reasonable out-of-pocket costs.

                          ANNUAL REPORT ON FORM 10-KSB

Copies of the  Corporation's  Annual  Report on Form  10-KSB for the fiscal year
ended December 31, 1998, as filed with the  Securities and Exchange  Commission,
are available to stockholders  without charge upon written request  addressed to
Cynthia Davis, Controller,  Discovery Laboratories, Inc., 350 South Main Street,
Suite 307, Doylestown, Pennsylvania 18901.

Your  cooperation in giving this matter your  immediate  attention and returning
your proxy is appreciated.

                                             By Order of the Board of Directors,

                                                   /s/ Evan Myrianthopoulos
                                                   ------------------------
                                                   Evan Myrianthopoulos
                                                   Corporate Secretary

Doylestown, Pennsylvania
May 20, 1999


                                       33
<PAGE>

                                                                         ANNEX A

                          DISCOVERY LABORATORIES, INC.
                 AMENDED AND RESTATED 1998 STOCK INCENTIVE PLAN
                 ----------------------------------------------

                                   ARTICLE ONE

                               GENERAL PROVISIONS
                               ------------------

    I. PURPOSE OF THE PLAN

          This Amended and Restated  1998 Stock  Incentive  Plan (the "Plan") is
intended to promote the  interests of Discovery  Laboratories,  Inc., a Delaware
corporation,  by providing  eligible  persons with the  opportunity to acquire a
proprietary  interest,  or otherwise increase their proprietary interest, in the
Corporation  as  an  incentive  for  them  to  remain  in  the  service  of  the
Corporation.

          The Plan amends and restates the  Corporation's  1998 Stock  Incentive
Plan and shall serve as the  successor  to the  Corporation's  1995 Stock Option
Plan and 1993 Stock Option Plan (the  "Predecessor  Plans").  No further  option
grants  shall be made under the  Predecessor  Plans after the  Initial  Approval
Date.  All  options  outstanding  under  the  Predecessor  Plans on the  Initial
Approval Date are incorporated into the Plan and shall be treated as outstanding
options under the Plan.  However,  each outstanding option so incorporated shall
continue to be governed  solely by the terms of the  documents  evidencing  such
option,  and no  provision  of the Plan  shall be deemed to affect or  otherwise
modify the rights or  obligations  of the holders of such  incorporated  options
with respect to their acquisition of shares of Common Stock.

          Capitalized  terms shall have the  meanings  assigned to such terms in
the attached Appendix.

    II. STRUCTURE OF THE PLAN

          A.   The Plan shall be divided into three separate equity programs:

          (i) the  Discretionary  Option  Grant  Program  under  which  eligible
persons may, at the discretion of the Plan Administrator,  be granted options to
purchase shares of Common Stock,

          (ii) the Stock Issuance  Program under which eligible  persons may, at
the  discretion  of the Plan  Administrator,  be issued  shares of Common  Stock
directly, either through the immediate purchase of such shares or as a bonus for
services rendered the Corporation (or any Parent or Subsidiary), and

          (iii)  the  Automatic   Option  Grant  Program  under  which  eligible

<PAGE>

non-employee board members shall automatically receive option grants at periodic
intervals to purchase shares of Common Stock.

          B. The  provisions  of Articles One and Five shall apply to all equity
programs  under the Plan and shall govern the interests of all persons under the
Plan.

    III. ADMINISTRATION OF THE PLAN

          A. The Board shall have  authority  to  administer  the  Discretionary
Option Grant and Stock Issuance Programs with respect to Section 16 Insiders but
may delegate  such  authority to the Primary  Committee.  Administration  of the
Discretionary Option Grant and Stock Issuance Programs with respect to all other
persons   eligible  to  participate  in  those  programs  may,  at  the  Board's
discretion,  be vested in the Primary Committee or a Secondary Committee, or the
Board may retain the power to administer those programs with respect to all such
persons.

          B. Members of the Primary  Committee or any Secondary  Committee shall
serve for such period of time as the Board may  determine  and may be removed by
the Board at any time. The Board may also at any time terminate the functions of
any  Secondary  Committee  and  reassume  all  powers and  authority  previously
delegated to such committee.

          C.  Each  Plan   Administrator   shall,   within   the  scope  of  its
administrative  functions under the Plan, have full power and authority (subject
to the provisions of the Plan) to establish such rules and regulations as it may
deem appropriate for proper administration of the Discretionary Option Grant and
Stock Issuance  Programs and to make such  determinations  under, and issue such
interpretations  of, the provisions of such programs and any outstanding options
or stock issuances  thereunder as it may deem necessary or advisable.  Decisions
of the Plan Administrator within the scope of its administrative functions under
the Plan shall be final and  binding on all  parties who have an interest in the
Discretionary Option Grant and Stock Issuance Programs under its jurisdiction or
any option or stock issuance thereunder.

          D. Service on the Primary  Committee or the Secondary  Committee shall
constitute  service as a Board member,  and members of each such committee shall
accordingly  be  entitled to full  indemnification  and  reimbursement  as Board
members for their service on such committee.  No member of the Primary Committee
or the Secondary  Committee shall be liable for any act or omission made in good
faith with respect to the Plan or any option grants or stock issuances under the
Plan.

    IV. ELIGIBILITY

          A. The persons  eligible to  participate in the  Discretionary  Option
Grant and Stock Issuance Programs are as follows:

          (i) Employees,


                                       2
<PAGE>

          (ii)  non-employee  members of the Board or the board of  directors of
any Parent or Subsidiary, and

          (iii) consultants and other independent  advisors who provide services
to the Corporation (or any Parent or Subsidiary).

          B.  Each  Plan   Administrator   shall,   within   the  scope  of  its
administrative  jurisdiction  under the Plan,  have full authority to determine,
(i) with  respect to the option  grants  under the  Discretionary  Option  Grant
Program,  which eligible persons are to receive option grants, the time or times
when such  option  grants are to be made,  the number of shares to be covered by
each such grant,  the status of the granted option as either an Incentive Option
or a  Non-Statutory  Option,  the time or times  when  each  option is to become
exercisable,  the vesting  schedule (if any) applicable to the option shares and
the  maximum  term for which the option is to remain  outstanding  and (ii) with
respect to stock  issuances  under the Stock  Issuance  Program,  which eligible
persons are to receive stock  issuances,  the time or times when such  issuances
are to be made,  the  number of shares  to be  issued to each  Participant,  the
vesting schedule (if any) applicable to the issued shares and the  consideration
for such shares.

          C. The Plan Administrator shall have the absolute discretion either to
grant options in accordance  with the  Discretionary  Option Grant Program or to
effect stock issuances in accordance with the Stock Issuance Program.

          D.  Only  non-employee  members  of the  Board  shall be  eligible  to
participate in the Automatic Option Grant Program.

    V. STOCK SUBJECT TO THE PLAN

          A. The stock issuable under the Plan shall be shares of authorized but
unissued  or  reacquired  Common  Stock,  including  shares  repurchased  by the
Corporation  on the open  market.  The maximum  number of shares of Common Stock
reserved  for  issuance  over the term of the Plan  shall not  exceed  2,200,959
shares.  Such authorized  share reserve is comprised of (i) the number of shares
which  remained  available for issuance  under the  Predecessor  Plans as of the
Initial  Approval  Date,  comprised  of the shares  subject  to the  outstanding
options  incorporated  into the  1998  Stock  Incentive  Plan  upon its  initial
approval by the  stockholders of the Corporation and outstanding  options issued
subsequent to the Initial  Approval  Date,  but not in excess of the  additional
shares which were  otherwise  available  for future grant under the  Predecessor
Plans as of the Initial  Approval Date (403,162 shares in the  aggregate),  plus
(ii) an additional  1,022,566  shares which became issuable under the 1998 Stock
Incentive Plan on the Initial Approval Date plus (iii) an additional increase of
775,231 shares authorized by the Board on December 7, 1998,  subject to approval
by the Corporation's stockholders at the 1999 Annual Meeting.

          B. No one  person  participating  in the  Plan  may  receive  options,
separately


                                       3
<PAGE>

exercisable stock  appreciation  rights and direct stock issuances for more than
250,000  shares of Common Stock in the  aggregate per calendar  year,  beginning
with the 1998 calendar year.

          C. Shares of Common Stock subject to  outstanding  options  (including
options  incorporated  into  this  Plan  from the  Predecessor  Plans)  shall be
available  for  subsequent  issuance  under the Plan to the extent those options
expire or terminate  for any reason prior to exercise in full.  Unvested  shares
issued  under  the  Plan  and  subsequently  cancelled  or  repurchased  by  the
Corporation,  at the  original  issue  price  paid per  share,  pursuant  to the
Corporation's repurchase rights under the Plan shall be added back to the number
of  shares  of  Common  Stock  reserved  for  issuance  under the Plan and shall
accordingly be available for reissuance  through one or more  subsequent  option
grants or direct stock  issuances under the Plan.  However,  should the exercise
price of an option  under the Plan be paid with shares of Common Stock or should
shares of Common  Stock  otherwise  issuable  under the Plan be  withheld by the
Corporation in satisfaction of the withholding taxes incurred in connection with
the  exercise  of an option or the vesting of a stock  issuance  under the Plan,
then the number of shares of Common Stock  available for issuance under the Plan
shall be reduced by the gross number of shares for which the option is exercised
or which vest under the stock  issuance,  and not by the net number of shares of
Common Stock issued to the holder of such option or stock issuance.

          D. If any  change is made to the  Common  Stock by reason of any stock
split,  stock  dividend,  recapitalization,  combination of shares,  exchange of
shares or other change affecting the outstanding Common Stock as a class without
the  Corporation's  receipt of consideration,  appropriate  adjustments shall be
made to (i) the maximum  number  and/or class of securities  issuable  under the
Plan, (ii) the number and/or class of securities for which any one person may be
granted options,  separately  exercisable stock  appreciation  rights and direct
stock issuances under this Plan per calendar year, (iii) the number and/or class
of securities for which grants are  subsequently  to be made under the Automatic
Option Grant Program to new and continuing  non-employee Board members, (iv) the
number  and/or class of  securities  and the exercise  price per share in effect
under each outstanding  option under the Plan and (v) the number and/or class of
securities  and  price  per  share  in  effect  under  each  outstanding  option
incorporated  into this Plan from the Predecessor  Plan. Such adjustments to the
outstanding  options  are to be effected in a manner  which shall  preclude  the
enlargement  or  dilution  of  rights  and  benefits  under  such  options.  The
adjustments  determined by the Plan  Administrator  shall be final,  binding and
conclusive.


                                       4
<PAGE>

                                   ARTICLE TWO

                       DISCRETIONARY OPTION GRANT PROGRAM
                       ----------------------------------

    I. OPTION TERMS

          Each option shall be  evidenced  by one or more  documents in the form
approved by the Plan Administrator;  provided,  however, that each such document
shall  comply  with the terms  specified  below.  Each  document  evidencing  an
Incentive  Option shall,  in addition,  be subject to the provisions of the Plan
applicable to such options.

     A.   Exercise Price.

          1.  The  exercise   price  per  share  shall  be  fixed  by  the  Plan
Administrator  but shall not be less than one hundred percent (100%) of the Fair
Market Value per share of Common Stock on the option grant date.

          2. The exercise  price shall become  immediately  due upon exercise of
the option and shall, subject to the provisions of Section I of Article Five and
the  documents  evidencing  the  option,  be payable in one or more of the forms
specified below:

            (i) cash or check made payable to the Corporation,

            (ii) shares of Common Stock held for the requisite  period necessary
     to avoid a charge to the  Corporation's  earnings for  financial  reporting
     purposes and valued at Fair Market Value on the Exercise Date, or

            (iii) to the  extent  the option is  exercised  for  vested  shares,
     through a  special  sale and  remittance  procedure  pursuant  to which the
     Optionee shall concurrently provide irrevocable written instructions to (a)
     a Corporation-designated brokerage firm to effect the immediate sale of the
     purchased  shares and remit to the  Corporation,  out of the sale  proceeds
     available on the settlement  date,  sufficient funds to cover the aggregate
     exercise  price  payable  for the  purchased  shares  plus  all  applicable
     Federal,  state  and local  income  and  employment  taxes  required  to be
     withheld  by the  Corporation  by  reason  of  such  exercise  and  (b) the
     Corporation to deliver the  certificates  for the purchased shares directly
     to such brokerage firm in order to complete the sale.

          Except to the extent such sale and  remittance  procedure is utilized,
payment  of the  exercise  price for the  purchased  shares  must be made on the
Exercise Date.


                                       5
<PAGE>

          B. Exercise and Term of Options.  Each option shall be  exercisable at
such time or times, during such period and for such number of shares as shall be
determined by the Plan  Administrator and set forth in the documents  evidencing
the  option.  However,  no option  shall have a term in excess of ten (10) years
measured from the option grant date.

          C. Effect of Termination of Service.

          1. The following  provisions  shall govern the exercise of any options
held by the Optionee at the time of cessation of Service or death:

            (i) Any option  outstanding at the time of the Optionee's  cessation
     of Service for any reason shall remain  exercisable for such period of time
     thereafter as shall be determined by the Plan  Administrator  and set forth
     in the  documents  evidencing  the  option,  but no such  option  shall  be
     exercisable after the expiration of the option term.

            (ii) Any option  exercisable  in whole or in part by the Optionee at
     the  time  of  death  may  be   subsequently   exercised  by  the  personal
     representative of the Optionee's estate or by the person or persons to whom
     the option is transferred  pursuant to the Optionee's will or in accordance
     with the laws of descent and distribution.

            (iii) During the applicable post-Service exercise period, the option
     may not be  exercised in the  aggregate  for more than the number of vested
     shares for which the option is  exercisable  on the date of the  Optionee's
     cessation of Service. Upon the expiration of the applicable exercise period
     or (if earlier) upon the  expiration  of the option term,  the option shall
     terminate and cease to be  outstanding  for any vested shares for which the
     option has not been exercised.  However, the option shall, immediately upon
     the Optionee's cessation of Service,  terminate and cease to be outstanding
     to the extent  the option is not  otherwise  at that time  exercisable  for
     vested shares.

            (vi) Should the  Optionee's  Service be terminated  for  Misconduct,
     then  all  outstanding   options  held  by  the  Optionee  shall  terminate
     immediately and cease to remain outstanding.

          2. The Plan Administrator shall have complete discretion,  exercisable
either at the time an option is granted or at any time while the option  remains
outstanding, to:

            (i)  extend  the  period of time for  which the  option is to remain
     exercisable  following the Optionee's cessation of Service from the limited
     exercise period  otherwise in effect for that option to such greater period
     of time as


                                       6
<PAGE>

     the Plan Administrator shall deem appropriate,  but in no event beyond the
     expiration of the option term, and/or

            (ii)  permit  the  option to be  exercised,  during  the  applicable
     post-Service exercise period, not only with respect to the number of vested
     shares of Common Stock for which such option is  exercisable at the time of
     the  Optionee's  cessation  of Service but also with respect to one or more
     additional  installments  in which the  Optionee  would have vested had the
     Optionee continued in Service.

          D.  Stockholder  Rights.  The  holder  of  an  option  shall  have  no
stockholder  rights with respect to the shares  subject to the option until such
person shall have  exercised  the option,  paid the exercise  price and become a
holder of record of the purchased shares.

          E. Repurchase Rights. The Plan Administrator shall have the discretion
to grant  options  which are  exercisable  for unvested  shares of Common Stock.
Should the Optionee  cease  Service  while  holding such  unvested  shares,  the
Corporation  shall have the right to repurchase,  at the exercise price paid per
share, any or all of those unvested shares. The terms upon which such repurchase
right shall be exercisable  (including the period and procedure for exercise and
the appropriate  vesting schedule for the purchased shares) shall be established
by the  Plan  Administrator  and  set  forth  in the  document  evidencing  such
repurchase right.

          F.  Limited  Transferability  of Options.  During the  lifetime of the
Optionee,  Incentive Options shall be exercisable only by the Optionee and shall
not be assignable or  transferable  other than by will or by the laws of descent
and distribution following the Optionee's death. However, a Non-Statutory Option
may, in connection  with the Optionee's  estate plan, be assigned in whole or in
part during the  Optionee's  lifetime to one or more  members of the  Optionee's
immediate  family  or to a trust  established  exclusively  for one or more such
family  members.  The  assigned  portion may only be  exercised by the person or
persons  who  acquire a  proprietary  interest  in the  option  pursuant  to the
assignment.  The terms  applicable to the assigned  portion shall be the same as
those in effect for the option immediately prior to such assignment and shall be
set forth in such documents issued to the assignee as the Plan Administrator may
deem appropriate.

    II. INCENTIVE OPTIONS

          The  terms  specified  below  shall  be  applicable  to all  Incentive
Options.  Except as  modified  by the  provisions  of this  Section  II, all the
provisions  of  Articles  One,  Two and Five shall be  applicable  to  Incentive
Options. Options which are specifically designated as Non-Statutory Options when
issued under the Plan shall not be subject to the terms of this Section II.

          A. Eligibility. Incentive Options may only be granted to Employees.


                                       7
<PAGE>

          B. Dollar Limitation. The aggregate Fair Market Value of the shares of
Common Stock  (determined as of the respective date or dates of grant) for which
one or more options  granted to any Employee under the Plan (or any other option
plan of the  Corporation  or any  Parent or  Subsidiary)  may for the first time
become  exercisable as Incentive  Options during any one calendar year shall not
exceed the sum of One Hundred  Thousand  Dollars  ($100,000).  To the extent the
Employee  holds two (2) or more such options  which become  exercisable  for the
first  time  in  the  same  calendar  year,  the  foregoing  limitation  on  the
exercisability  of such  options as  Incentive  Options  shall be applied on the
basis of the order in which such options are granted.

          C. 10%  Stockholder.  If any Employee to whom an  Incentive  Option is
granted is a 10%  Stockholder,  then the  exercise  price per share shall not be
less than one hundred ten percent  (110%) of the Fair Market  Value per share of
Common Stock on the option grant date, and the option term shall not exceed five
(5) years measured from the option grant date.

    III. CORPORATE TRANSACTION/CHANGE IN CONTROL

          A. In the event of any Corporate Transaction,  each outstanding option
shall automatically accelerate so that each such option shall, immediately prior
to the effective  date of the Corporate  Transaction,  become fully  exercisable
with  respect to the total  number of shares of Common Stock at the time subject
to  such  option  and  may be  exercised  for  any or all  of  those  shares  as
fully-vested shares of Common Stock. However, an outstanding option shall not so
accelerate  if and to the  extent:  (i) such option is, in  connection  with the
Corporate  Transaction,  either to be assumed by the successor  corporation  (or
parent thereof) or to be replaced with a comparable option to purchase shares of
the capital stock of the successor  corporation (or parent  thereof),  (ii) such
option  is to be  replaced  with  a cash  incentive  program  of  the  successor
corporation which preserves the spread existing on the unvested option shares at
the time of the  Corporate  Transaction  and provides for  subsequent  payout in
accordance with the same vesting  schedule  applicable to those option shares or
(iii) the acceleration of such option is subject to other limitations imposed by
the Plan  Administrator  at the time of the option grant.  The  determination of
option  comparability  under  clause  (i)  above  shall  be  made  by  the  Plan
Administrator, and its determination shall be final, binding and conclusive.

          B.  All   outstanding   repurchase   rights   shall   also   terminate
automatically, and the shares of Common Stock subject to those terminated rights
shall  immediately  vest in full,  in the  event of any  Corporate  Transaction,
except to the  extent:  (i) those  repurchase  rights are to be  assigned to the
successor  corporation  (or parent  thereof) in connection  with such  Corporate
Transaction or (ii) such accelerated  vesting is precluded by other  limitations
imposed by the Plan Administrator at the time the repurchase right is issued.

          C. The Plan  Administrator  shall  have  the  discretion,  exercisable
either at the time the option is granted or at any time while the option remains
outstanding,   to  provide  for  the  automatic  acceleration  of  one  or  more
outstanding options upon the occurrence of a Corporate  Transaction,  whether or
not those options are to be assumed or replaced in the Corporate


                                       8
<PAGE>

Transaction.

          D.  Each  option  which is  assumed  in  connection  with a  Corporate
Transaction  shall be appropriately  adjusted,  immediately after such Corporate
Transaction,  to apply to the number and class of  securities  which  would have
been issuable to the Optionee in consummation of such Corporate  Transaction had
the option  been  exercised  immediately  prior to such  Corporate  Transaction.
Appropriate adjustments to reflect such Corporate Transaction shall also be made
to (i) the  exercise  price  payable  per share under each  outstanding  option,
provided the aggregate  exercise price payable for such securities  shall remain
the same,  (ii) the maximum  number  and/or class of  securities  available  for
issuance over the remaining term of the Plan and (iii) the maximum number and/or
class of  securities  for which any one  person may be  granted  stock  options,
separately  exercisable  stock  appreciation  rights and direct stock  issuances
under the Plan per calendar year.

          E.  Notwithstanding  Section  III.A.  of this  Article  Two,  the Plan
Administrator shall have the discretionary authority,  exercisable either at the
time the option is granted or at any time while the option remains  outstanding,
to provide for the automatic  acceleration  of one or more  outstanding  options
under the Discretionary  Option Grant Program upon the occurrence of a Corporate
Transaction,  whether or not those  options are to be assumed or replaced in the
Corporate Transaction.  In addition, the Plan Administrator may provide that one
or more of the  Corporation's  outstanding  repurchase  rights  with  respect to
shares held by the  Optionee  at the time of such  Corporate  Transaction  shall
immediately  terminate,  and the shares subject to those  terminated  repurchase
rights shall  accordingly  vest in full, even in the event the options are to be
assumed.

          F.  The  Plan  Administrator  shall  have  full  power  and  authority
exercisable,  either at the time the  option is granted or at any time while the
option remains outstanding,  to provide for the automatic acceleration of one or
more  outstanding  options under the  Discretionary  Option Grant Program in the
event the Optionee's Service terminates by reason of an Involuntary  Termination
within a designated  period (not to exceed  eighteen (18) months)  following the
effective  date of any Corporate  Transaction in which those options are assumed
or replaced and do not otherwise  accelerate.  Any options so accelerated  shall
remain  exercisable  for  fully-vested  shares  until  the  earlier  of (i)  the
expiration of the option term or (ii) the expiration of the one (1)-year  period
measured from the effective date of the  Involuntary  Termination.  In addition,
the  Plan  Administrator  may  provide  that  one or more  of the  Corporation's
outstanding repurchase rights with respect to shares held by the Optionee at the
time of such Involuntary Termination shall immediately terminate, and the shares
subject to those terminated repurchase rights shall accordingly vest in full.

          G. The  Plan  Administrator  shall  have  full  power  and  authority,
exercisable  either at the time the  option is  granted or at any time while the
option remains outstanding,  to provide for the automatic acceleration of one or
more outstanding options under the Discretionary Option Grant Program upon (i) a
Change in Control or (ii) the termination of the Optionee's Service by reason of
an Involuntary  Termination  within a designated  period (not to exceed eighteen
(18)


                                       9
<PAGE>

months)  following the effective date of such Change in Control.  Each option so
accelerated shall remain  exercisable for fully-vested  shares until the earlier
of (i) the  expiration  of the  option  term or (ii) the  expiration  of the one
(1)-year period measured from the effective date of the Optionee's  cessation of
Service. In addition, the Plan Administrator may provide that one or more of the
Corporation's  outstanding  repurchase rights with respect to shares held by the
Optionee at the time of such Change in Control or Involuntary  Termination shall
immediately  terminate,  and the shares subject to those  terminated  repurchase
rights shall accordingly vest in full.

          H. The portion of any Incentive Option  accelerated in connection with
a Corporate  Transaction  or Change in Control  shall remain  exercisable  as an
Incentive  Option only to the extent the applicable One Hundred  Thousand Dollar
limitation  is not exceeded.  To the extent such dollar  limitation is exceeded,
the  accelerated  portion of such option shall be exercisable as a Non-Statutory
Option under the Federal tax laws.

          I. The  outstanding  options  shall in no way  affect the right of the
Corporation to adjust, reclassify, reorganize or otherwise change its capital or
business  structure  or to merge,  consolidate,  dissolve,  liquidate or sell or
transfer all or any part of its business or assets.

    IV. CANCELLATION AND REGRANT OF OPTIONS

          The Plan Administrator shall have the authority to effect, at any time
and from time to time,  with the consent of the  affected  option  holders,  the
cancellation of any or all outstanding  options under the  Discretionary  Option
Grant Program (including  outstanding options  incorporated from the Predecessor
Plan) and to grant in  substitution  therefor  new options  covering the same or
different  number of shares of Common Stock but with an exercise price per share
based on the Fair Market Value per share of Common Stock on the new grant date.

    V. STOCK APPRECIATION RIGHTS

          A. The Plan Administrator shall have full power and authority to grant
to selected  Optionees  tandem stock  appreciation  rights and/or  limited stock
appreciation rights.

          B. The  following  terms shall govern the grant and exercise of tandem
stock appreciation rights:

            (i) One or more Optionees may be granted the right, exercisable upon
     such terms as the Plan  Administrator  may establish,  to elect between the
     exercise  of the  underlying  option  for  shares of  Common  Stock and the
     surrender  of  that  option  in  exchange  for  a  distribution   from  the
     Corporation  in an amount  equal to the excess of (a) the Fair Market Value
     (on the  option  surrender  date) of the  number  of  shares  in which  the
     Optionee is at the time vested under the surrendered option (or surrendered
     portion  thereof)  over (b) the aggregate  exercise  price payable for such
     shares.


                                       10
<PAGE>

            (ii) No such  option  surrender  shall  be  effective  unless  it is
     approved by the Plan Administrator, either at the time of the actual option
     surrender or at any earlier time. If the surrender is so approved, then the
     distribution  to which the Optionee shall be entitled may be made in shares
     of Common Stock valued at Fair Market Value on the option  surrender  date,
     in cash, or partly in shares and partly in cash, as the Plan  Administrator
     shall in its sole discretion deem appropriate.

            (iii) If the  surrender  of an  option is not  approved  by the Plan
     Administrator,  then the Optionee shall retain whatever rights the Optionee
     had under the surrendered  option (or surrendered  portion  thereof) on the
     option surrender date and may exercise such rights at any time prior to the
     later of (a) five (5)  business  days after the  receipt  of the  rejection
     notice or (b) the last day on which the option is otherwise  exercisable in
     accordance with the terms of the documents  evidencing such option,  but in
     no event may such  rights be  exercised  more than ten (10) years after the
     option grant date.

          C. The following  terms shall govern the grant and exercise of limited
stock appreciation rights:

            (i) One or more  Section 16 Insiders  may be granted  limited  stock
     appreciation rights with respect to their outstanding options.

            (ii) Upon the  occurrence of a Hostile  Take-Over,  each  individual
     holding one or more options with such a limited  stock  appreciation  right
     shall  have the  unconditional  right  (exercisable  for a thirty  (30)-day
     period  following such Hostile  Take-Over) to surrender each such option to
     the  Corporation,  to the extent the option is at the time  exercisable for
     vested shares of Common Stock.  In return for the surrendered  option,  the
     Optionee  shall  receive a cash  distribution  from the  Corporation  in an
     amount  equal to the  excess of (A) the  Take-Over  Price of the  shares of
     Common Stock which are at the time vested under each surrendered option (or
     surrendered  portion thereof) over (B) the aggregate exercise price payable
     for such shares.  Such cash distribution shall be paid within five (5) days
     following the option surrender date.

            (iii) The  balance of the option (if any) shall  remain  outstanding
     and exercisable in accordance with the documents evidencing such option.


                                       11
<PAGE>

                                  ARTICLE THREE

                             STOCK ISSUANCE PROGRAM
                             ----------------------

    I. STOCK ISSUANCE TERMS

          Shares of Common Stock may be issued under the Stock Issuance  Program
through direct and immediate  issuances  without any intervening  option grants.
Each such stock issuance shall be evidenced by a Stock Issuance  Agreement which
complies with the terms specified below.

          A. Purchase Price.

          1.  The  purchase   price  per  share  shall  be  fixed  by  the  Plan
Administrator, but shall not be less than one hundred percent (100%) of the Fair
Market Value per share of Common Stock on the issuance date.

          2. Subject to the  provisions of Section I of Article Five,  shares of
Common  Stock may be issued  under the  Stock  Issuance  Program  for any of the
following  items  of  consideration   which  the  Plan  Administrator  may  deem
appropriate in each individual instance:

            (i) cash or check made payable to the Corporation, or

            (ii) past  services  rendered to the  Corporation  (or any Parent or
     Subsidiary).

          B. Vesting Provisions.

          1. Shares of Common Stock issued under the Stock Issuance Program may,
in the discretion of the Plan  Administrator,  be fully and  immediately  vested
upon  issuance or may vest in one or more  installments  over the  Participant's
period of Service or upon attainment of specified performance objectives.

          2. Any new,  substituted  or additional  securities or other  property
(including  money  paid  other  than  as a  regular  cash  dividend)  which  the
Participant  may have the right to receive  with  respect  to the  Participant's
unvested  shares of Common Stock by reason of any stock  dividend,  stock split,
recapitalization,  combination  of shares,  exchange  of shares or other  change
affecting  the  outstanding  Common Stock as a class  without the  Corporation's
receipt  of  consideration  shall be  issued  subject  to (i) the  same  vesting
requirements applicable to the Participant's unvested shares of Common Stock and
(ii) such escrow arrangements as the Plan Administrator shall deem appropriate.


                                       12
<PAGE>

          3. The Participant shall have full stockholder  rights with respect to
any shares of Common Stock issued to the  Participant  under the Stock  Issuance
Program,  whether or not the  Participant's  interest in those shares is vested.
Accordingly,  the  Participant  shall have the right to vote such  shares and to
receive any regular cash dividends paid on such shares.

          4. Should the Participant cease to remain in Service while holding one
or more unvested shares of Common Stock issued under the Stock Issuance  Program
or should the performance objectives not be attained with respect to one or more
such  unvested  shares of Common Stock,  then those shares shall be  immediately
surrendered to the Corporation for cancellation,  and the Participant shall have
no further  stockholder  rights with respect to those shares.  To the extent the
surrendered  shares were previously  issued to the Participant for consideration
paid in cash or cash  equivalent  (including  the  Participant's  purchase-money
indebtedness),   the  Corporation  shall  repay  to  the  Participant  the  cash
consideration  paid for the  surrendered  shares  and shall  cancel  the  unpaid
principal  balance of any  outstanding  purchase-money  note of the  Participant
attributable to the surrendered shares.

          5. The Plan  Administrator  may in its discretion  waive the surrender
and  cancellation  of one or more  unvested  shares of Common  Stock which would
otherwise  occur  upon  the  cessation  of  the  Participant's  Service  or  the
non-attainment of the performance  objectives  applicable to those shares.  Such
waiver shall result in the immediate  vesting of the  Participant's  interest in
the shares as to which the waiver  applies.  Such  waiver may be effected at any
time,  whether  before or after the  Participant's  cessation  of Service or the
attainment or non-attainment of the applicable performance objectives.

    II. CORPORATE TRANSACTION/CHANGE IN CONTROL

          A. All of the  Corporation's  outstanding  repurchase rights under the
Stock  Issuance  Program shall  terminate  automatically,  and all the shares of
Common Stock subject to those terminated  rights shall immediately vest in full,
in the  event of any  Corporate  Transaction,  except  to the  extent  (i) those
repurchase  rights are to be assigned to the  successor  corporation  (or parent
thereof) in connection with such Corporate  Transaction or (ii) such accelerated
vesting  is  precluded  by  other  limitations  imposed  in the  Stock  Issuance
Agreement.

          B. The Plan  Administrator  shall  have  the  discretion,  exercisable
either at the time the  unvested  shares  are  issued  or at any time  while the
Corporation's repurchase right remains outstanding, to provide for the automatic
termination of one or more of those outstanding rights and the immediate vesting
of the shares of Common Stock  subject to such rights upon the  occurrence  of a
Corporate Transaction.

          C. The Plan  Administrator  shall  have the  discretionary  authority,
exercisable  either at the time the unvested shares are issued or any time while
the Corporation's  repurchase rights remain outstanding under the Stock Issuance
Program, to provide that those rights shall


                                       13
<PAGE>

automatically  terminate  in whole or in part,  and the  shares of Common  Stock
subject to those  terminated  rights shall  immediately  vest,  in the event the
Participant's  Service should terminate by reason of an Involuntary  Termination
within a designated  period (not to exceed  eighteen (18) months)  following the
effective date of any Corporate Transaction in which those repurchase rights are
assigned to the successor corporation (or parent thereof).

          D. The Plan  Administrator  shall  have the  discretionary  authority,
exercisable  either at the time the unvested shares are issued or any time while
the Corporation's  repurchase rights remain outstanding under the Stock Issuance
Program, to provide that those rights shall automatically  terminate in whole or
in part, and the shares of Common Stock subject to those terminated rights shall
immediately  vest upon (i) a Change in  Control or (ii) the  termination  of the
Participant's  Service  by  reason  of  an  Involuntary   Termination  within  a
designated  period (not to exceed eighteen (18) months)  following the effective
date of such Change in Control.

    III. SHARE ESCROW/LEGENDS

          Unvested shares may, in the Plan Administrator's  discretion,  be held
in escrow by the  Corporation  until the  Participant's  interest in such shares
vests or may be issued directly to the Participant with  restrictive  legends on
the certificates evidencing those unvested shares.


                                       14
<PAGE>

                                  ARTICLE FOUR

                         AUTOMATIC OPTION GRANT PROGRAM

    I. OPTION TERMS

          A. Grant Dates.  Option  grants  shall be made on the dates  specified
below:

          1. Each individual who is first elected or appointed as a non-employee
Board member at any time after the Plan  Effective Date shall  automatically  be
granted,  on the date of such initial  election or appointment,  a Non-Statutory
Option to purchase  20,000 shares of Common Stock,  provided that individual has
not  previously  been a director of or in the employ of the  Corporation  or any
Parent or Subsidiary.

          2. On the date of the 1998 Annual  Meeting (the  Stockholder  Approval
Date) and on the date of each Annual Stockholders  Meeting held after such date,
each individual who is to continue to serve as an Eligible Director,  whether or
not that  individual is standing for re-election to the Board at that particular
Annual  Meeting,  shall  automatically  be  granted  a  Non-Statutory  Option to
purchase  10,000 shares of Common Stock,  provided,  with respect to each Annual
Stockholders  Meeting held after the 1998 Annual  Meeting,  such  individual has
served as a non-employee  board member for at least six (6) months.  There shall
be no limit on the number of such  10,000-share  option  grants any one Eligible
Director may receive over his or her period of Board Service,  and  non-employee
board  members  who have  previously  been a director of or in the employ of the
Corporation  (or any Parent or  Subsidiary)  shall be eligible to receive one or
more such annual option grants over their period of continued Board Service.

          B. Exercise  Price.  1. The exercise price per share shall be equal to
sixty  percent  (60%) of the Fair Market  Value per share of Common Stock on the
option grant date.

          2.  The  exercise  price  shall  be  payable  in  one or  more  of the
alternative  forms  authorized  under the  Discretionary  Option Grant  Program.
Except to the extent the sale and remittance  procedure specified  thereunder is
utilized, payment of the exercise price for the purchased shares must be made on
the Exercise Date.

          C.  Option  Term.  Each  option  shall  have a term of ten (10)  years
measured from the option grant date.

          D. Exercise and Vesting of Options.  Each option shall be  immediately
exercisable for any or all of the option shares.  However,  any shares purchased
under the option  shall be  subject to  repurchase  by the  Corporation,  at the
exercise price paid per share,  upon the  Optionee's  cessation of Board Service
prior to vesting in those shares. Each option grant shall vest,


                                       15
<PAGE>

and the  Corporation's  repurchase  right shall  lapse,  in a series of four (4)
successive equal annual installments upon the Optionee's completion of each year
of Board  Service  over the  four  (4)-year  period  commencing  six (6)  months
following  the  option  grant  date,  with the first  such  installment  to vest
eighteen (18) month after the option grant date.

          E. Termination of Board Service. The following provisions shall govern
the exercise of any options held by the Optionee at the time the Optionee ceases
to serve as a Board member:

            (i) The  Optionee  (or, in the event of the  Optionee's  death,  the
     personal  representative  of the Optionee's estate or the person or persons
     to whom the option is  transferred  pursuant to the  Optionee's  will or in
     accordance with the laws of descent and  distribution)  shall have a twelve
     (12)-month  period following the date of such cessation of Board Service in
     which to exercise each such option.

            (ii) During the twelve (12)-month  post-service exercise period, the
     option may not be  exercised in the  aggregate  for more than the number of
     vested  shares of Common Stock for which the option is  exercisable  at the
     time of the Optionee's cessation of Board Service.

            (iii) Should the Optionee cease to serve as a Board member by reason
     of death or  Permanent  Disability,  then all shares at the time subject to
     the option  shall  immediately  vest so that such  option  may,  during the
     twelve  (12)-month  exercise  period  following  such  cessation  of  Board
     Service,   be  exercised  for  all  or  any  portion  of  those  shares  as
     fully-vested shares of Common Stock.

            (iv) In no event  shall  the  option  remain  exercisable  after the
     expiration of the option term. Upon the expiration of the twelve (12)-month
     post-service  exercise  period or (if earlier)  upon the  expiration of the
     option term, the option shall terminate and cease to be outstanding for any
     vested  shares for which the option has not been  exercised.  However,  the
     option shall,  immediately  upon the Optionee's  cessation of Board Service
     for any reason  other than death or  Permanent  Disability,  terminate  and
     cease to be  outstanding  to the extent the option is not otherwise at that
     time exercisable for vested shares.

    II. CORPORATE TRANSACTION/CHANGE IN CONTROL/HOSTILE TAKE-OVER

          A. In the event of any  Corporate  Transaction,  the  shares of Common
Stock at the time subject to each  outstanding  option but not otherwise  vested
shall  automatically  vest in full so that each such option  shall,  immediately
prior to the effective date of the Corporate Transaction,


                                       16
<PAGE>

become  fully  exercisable  for all of the  shares of  Common  Stock at the time
subject to such  option  and may be  exercised  for all or any  portion of those
shares as  fully-vested  shares  of  Common  Stock.  Immediately  following  the
consummation  of the Corporate  Transaction,  each automatic  option grant shall
terminate  and cease to be  outstanding,  except to the  extent  assumed  by the
successor corporation (or parent thereof).

          B. In  connection  with any  Change in  Control,  the shares of Common
Stock at the time subject to each  outstanding  option but not otherwise  vested
shall  automatically  vest in full so that each such option  shall,  immediately
prior to the effective date of the Change in Control,  become fully  exercisable
for all of the shares of Common Stock at the time subject to such option and may
be exercised  for all or any portion of those shares as  fully-vested  shares of
Common Stock.  Each such option shall remain  exercisable for such  fully-vested
option shares until the  expiration or sooner  termination of the option term or
the surrender of the option in connection with a Hostile Take-Over.

          C. Upon the occurrence of a Hostile Take-Over, the Optionee shall have
a thirty (30)-day period in which to surrender to the Corporation each of his or
her  outstanding  automatic  option  grants.  The  Optionee  shall in  return be
entitled to a cash  distribution  from the Corporation in an amount equal to the
excess of (i) the  Take-Over  Price of the  shares  of Common  Stock at the time
subject to each surrendered  option (whether or not the Optionee is otherwise at
the time vested in those shares) over (ii) the aggregate  exercise price payable
for such  shares.  Such cash  distribution  shall be paid  within  five (5) days
following the surrender of the option to the Corporation. No approval or consent
of the Board or any Plan Administrator shall be required in connection with such
option surrender and cash distribution.

          D.  Each  option  which is  assumed  in  connection  with a  Corporate
Transaction  shall be appropriately  adjusted,  immediately after such Corporate
Transaction,  to apply to the number and class of  securities  which  would have
been issuable to the Optionee in consummation of such Corporate  Transaction had
the option  been  exercised  immediately  prior to such  Corporate  Transaction.
Appropriate  adjustments  shall also be made to the exercise  price  payable per
share under each  outstanding  option,  provided the  aggregate  exercise  price
payable for such securities shall remain the same.

          E. The grant of options under the Automatic Option Grant Program shall
in no way affect the right of the Corporation to adjust, reclassify,  reorganize
or otherwise change its capital or business structure or to merge,  consolidate,
dissolve,  liquidate  or sell or  transfer  all or any part of its  business  or
assets.

    III. REMAINING TERMS

          The remaining terms of each option granted under the Automatic  Option
Grant  Program  shall be the same as the terms in effect for option  grants made
under the Discretionary Option Grant Program.


                                       17
<PAGE>

                                  ARTICLE FIVE

                                  MISCELLANEOUS
                                  -------------

    I. FINANCING

          The Plan  Administrator  may permit any Optionee or Participant to pay
the option  exercise price under the  Discretionary  Option Grant Program or the
purchase price of shares issued under the Stock Issuance Program by delivering a
full-recourse,   interest  bearing  promissory  note  payable  in  one  or  more
installments. The terms of any such promissory note (including the interest rate
and the terms of repayment)  shall be established by the Plan  Administrator  in
its sole  discretion.  In no  event  may the  maximum  credit  available  to the
Optionee or  Participant  exceed the sum of (i) the  aggregate  option  exercise
price or purchase price payable for the purchased  shares plus (ii) any Federal,
state and local income and employment tax liability  incurred by the Optionee or
the Participant in connection with the option exercise or share purchase.

    II. TAX WITHHOLDING

          A. The Corporation's obligation to deliver shares of Common Stock upon
the exercise of options or the issuance or vesting of such shares under the Plan
shall be subject to the satisfaction of all applicable Federal,  state and local
income and employment tax withholding requirements.

          B. The Plan Administrator  may, in its discretion,  provide any or all
holders of  Non-Statutory  Options or unvested  shares of Common Stock under the
Plan (other than the options  granted or the shares  issued under the  Automatic
Option  Grant  Program)  with  the  right  to use  shares  of  Common  Stock  in
satisfaction  of all or part of the Taxes incurred by such holders in connection
with the exercise of their  options or the vesting of their  shares.  Such right
may be provided to any such holder in either or both of the following formats:

          Stock Withholding: The election to have the Corporation withhold, from
the  shares  of  Common  Stock  otherwise  issuable  upon the  exercise  of such
Non-Statutory  Option or the vesting of such  shares,  a portion of those shares
with an aggregate Fair Market Value equal to the percentage of the Taxes (not to
exceed one hundred percent (100%)) designated by the holder.

          Stock  Delivery:  The election to deliver to the  Corporation,  at the
time the  Non-Statutory  Option is  exercised  or the shares  vest,  one or more
shares of  Common  Stock  previously  acquired  by such  holder  (other  than in
connection with the option exercise or share vesting  triggering the Taxes) with
an  aggregate  Fair Market  Value equal to the  percentage  of the Taxes (not to
exceed one hundred percent (100%)) designated by the holder.


                                       18
<PAGE>

    III. EFFECTIVE DATE AND TERM OF THE PLAN

          A. The Plan shall become effective immediately upon the Plan Effective
Date.  Options may be granted under the Discretionary  Option Grant or Automatic
Option Grant Program at any time on or after the Plan Effective  Date.  However,
no  options  granted  under the Plan may be  exercised,  and no shares  shall be
issued under the Plan,  until the Stockholder  Approval Date. If the Stockholder
Approval Date does not occur within twelve (12) months after the Plan  Effective
Date,  then all options  previously  granted under this Plan shall terminate and
cease to be  outstanding,  and no further options shall be granted and no shares
shall be issued under the Plan.

          B. One or more provisions of the Plan,  including (without limitation)
the option/vesting  acceleration provisions of Article Two relating to Corporate
Transactions  and  Changes  in  Control,   may,  in  the  Plan   Administrator's
discretion, be extended to one or more options incorporated from the Predecessor
Plan on the  Stockholder  Approval  Date  which do not  otherwise  contain  such
provisions.

          C. The Plan shall  terminate  upon the  earliest of (i) March 24, 2008
(ii) the date on which all shares  available  for issuance  under the Plan shall
have  been  issued  as  fully-vested  shares  or (iii)  the  termination  of all
outstanding options in connection with a Corporate  Transaction.  Upon such plan
termination,  all  outstanding  option grants and unvested stock issuances shall
thereafter  continue to have force and effect in accordance  with the provisions
of the documents evidencing such grants or issuances.

    IV. AMENDMENT OF THE PLAN

          A. The Board shall have complete and exclusive  power and authority to
amend or modify the Plan in any or all respects.  However,  no such amendment or
modification  shall adversely  affect the rights and obligations with respect to
stock options or unvested stock issuances at the time outstanding under the Plan
unless  the  Optionee  or  the   Participant   consents  to  such  amendment  or
modification.  In addition,  certain amendments may require stockholder approval
pursuant to applicable laws or regulations.

          B. Options to purchase shares of Common Stock may be granted under the
Discretionary  Option  Grant  Programs  and shares of Common Stock may be issued
under the Stock  Issuance  Program  that are in each  instance  in excess of the
number of shares then available for issuance under the Plan, provided any excess
shares  actually issued under those programs shall be held in escrow until there
is obtained  stockholder  approval of an amendment  sufficiently  increasing the
number of shares of Common Stock  available for issuance under the Plan. If such
stockholder  approval is not obtained  within  twelve (12) months after the date
the first such  excess  issuances  are made,  then (i) any  unexercised  options
granted  on the basis of such  excess  shares  shall  terminate  and cease to be
outstanding and (ii) the Corporation  shall promptly refund to the Optionees and
the  Participants  the  exercise  or purchase  price paid for any excess  shares
issued  under  the Plan and  held


                                       19
<PAGE>

in escrow,  together with interest (at the  applicable  Short Term Federal Rate)
for the period the shares were held in escrow,  and such shares shall  thereupon
be automatically cancelled and cease to be outstanding.

    V. USE OF PROCEEDS

          Any cash proceeds  received by the Corporation from the sale of shares
of Common Stock under the Plan shall be used for general corporate purposes.

    VI. REGULATORY APPROVALS

          A. The  implementation  of the Plan,  the granting of any stock option
under the Plan and the  issuance  of any  shares  of  Common  Stock (i) upon the
exercise of any granted option or (ii) under the Stock Issuance Program shall be
subject to the  Corporation's  procurement of all approvals and permits required
by regulatory  authorities having  jurisdiction over the Plan, the stock options
granted under it and the shares of Common Stock issued pursuant to it.

          B. No  shares  of  Common  Stock or other  assets  shall be  issued or
delivered  under the Plan unless and until there shall have been compliance with
all applicable  requirements of Federal and state securities laws, including the
filing and  effectiveness of the Form S-8 registration  statement for the shares
of Common Stock issuable under the Plan, and all applicable listing requirements
of any stock exchange (or the Nasdaq  National  Market,  if applicable) on which
Common Stock is then listed for trading.

    VII. NO EMPLOYMENT/SERVICE RIGHTS

          Nothing in the Plan shall confer upon the Optionee or the  Participant
any right to  continue  in Service or Board  Service  for any period of specific
duration or interfere  with or  otherwise  restrict in any way the rights of the
Corporation (or any Parent or Subsidiary  employing or retaining such person) or
of the Optionee or the Participant,  which rights are hereby expressly  reserved
by each, to terminate such person's Service or Board Service at any time for any
reason, with or without cause.


                                       20
<PAGE>

                                    APPENDIX

          The following definitions shall be in effect under the Plan:

          A.  Automatic  Option Grant Program  shall mean the  automatic  option
grant program in effect under the Plan.

          B. Board shall mean the Corporation's Board of Directors.

          C.  Board  Service  shall mean the  performance  of  services  for the
Corporation by a person in the capacity of a non-employee member of the board of
directors.

          D. Change in Control  shall mean a change in  ownership  or control of
the Corporation effected through either of the following transactions:

            (i) the acquisition, directly or indirectly by any person or related
     group of persons  (other than the  Corporation or a person that directly or
     indirectly controls, is controlled by, or is under common control with, the
     Corporation),  of beneficial ownership (within the meaning of Rule 13d-3 of
     the 1934 Act) of securities possessing more than fifty percent (50%) of the
     total combined  voting power of the  Corporation's  outstanding  securities
     pursuant to a tender or exchange  offer made directly to the  Corporation's
     stockholders  which the  Board  does not  recommend  such  stockholders  to
     accept, or

            (ii) a change  in the  composition  of the  Board  over a period  of
     thirty-six  (36)  consecutive  months or less such that a  majority  of the
     Board  members  ceases,  by reason of one or more  contested  elections for
     Board  membership,  to be comprised of individuals who either (A) have been
     Board members  continuously  since the beginning of such period or (B) have
     been elected or nominated for election as Board members  during such period
     by at least a majority  of the Board  members  described  in clause (A) who
     were  still in office  at the time the  Board  approved  such  election  or
     nomination.

          E. Code shall mean the Internal Revenue Code of 1986, as amended.

          F. Common Stock shall mean the Corporation's common stock.

          G.   Corporate   Transaction   shall  mean  either  of  the  following
stockholder-approved transactions to which the Corporation is a party:

            (i) a merger or consolidation  in which  securities  possessing more
     than fifty percent (50%) of the total combined voting power of the


                                      A-1
<PAGE>

     Corporation's  outstanding  securities  are  transferred  to a  person  or
     persons  different from the persons holding those  securities  immediately
     prior to such transaction, or

            (ii) the sale, transfer or other disposition of all or substantially
     all of the Corporation's  assets in complete  liquidation or dissolution of
     the Corporation.

          H.  Corporation  shall mean Discovery  Laboratories,  Inc., a Delaware
corporation, and its successors.

          I.  Discretionary  Option Grant Program  shall mean the  discretionary
option grant program in effect under the Plan.

          J. Eligible Director shall mean a non-employee Board member who is not
a 10% Stockholder.

          K.  Employee  shall  mean an  individual  who is in the  employ of the
Corporation (or any Parent or Subsidiary),  subject to the control and direction
of the employer  entity as to both the work to be  performed  and the manner and
method of performance.

          L.  Exercise Date shall mean the date on which the  Corporation  shall
have received written notice of the option exercise.

          M. Fair Market Value per share of Common  Stock on any  relevant  date
shall be determined in accordance with the following provisions:

            (i) If the Common Stock is at the time traded on the Nasdaq SmallCap
     Market or Nasdaq  National  Market,  then the Fair  Market  Value  shall be
     deemed equal to the closing  selling price per share of Common Stock on the
     date in question, as such price is reported on such market or any successor
     system.  If there is no closing  selling  price for the Common Stock on the
     date in question,  then the Fair Market Value shall be the closing  selling
     price on the last preceding date for which such quotation exists.

            (ii)  If  the  Common  Stock  is at the  time  listed  on any  Stock
     Exchange,  then the Fair Market  Value shall be deemed equal to the closing
     selling  price  per share of Common  Stock on the date in  question  on the
     Stock  Exchange  determined  by the Plan  Administrator  to be the  primary
     market for the Common  Stock,  as such  price is  officially  quoted in the
     composite tape of  transactions  on such  exchange.  If there is no closing
     selling  price for the Common Stock on the date in question,  then the Fair
     Market Value shall be the closing  selling price on the last preceding date
     for which such quotation exists.


                                      A-2
<PAGE>

          N.  Hostile   Take-Over  shall  mean  the  acquisition,   directly  or
indirectly,  by  any  person  or  related  group  of  persons  (other  than  the
Corporation or a person that directly or indirectly controls,  is controlled by,
or is under common  control  with,  the  Corporation)  of  beneficial  ownership
(within the meaning of Rule 13d-3 of the 1934 Act) of securities possessing more
than fifty percent (50%) of the total combined voting power of the Corporation's
outstanding  securities  pursuant to a tender or exchange offer made directly to
the  Corporation's   stockholders  which  the  Board  does  not  recommend  such
stockholders to accept.

          O.  Incentive   Option  shall  mean  an  option  which  satisfies  the
requirements of Code Section 422.

          P. Initial  Approval Date shall mean June 16, 1998,  the date on which
the  Corporation's  1998 Stock  Incentive  Plan was  initially  approved  by the
stockholders of the Corporation.

          Q. Involuntary  Termination  shall mean the termination of the Service
of any individual which occurs by reason of:

            (i) such  individual's  involuntary  dismissal  or  discharge by the
     Corporation for reasons other than Misconduct, or

            (ii)  Optionee's  voluntary  resignation  following  (A) a change in
     Optionee's position with the Corporation (or Parent or Subsidiary employing
     Optionee) which materially reduces  Optionee's duties and  responsibilities
     or the level of management to which  Optionee  reports,  (B) a reduction in
     Optionee's  level of compensation  (including base salary,  fringe benefits
     and target bonus under any corporate  performance-based  bonus or incentive
     programs)  by more  than  fifteen  percent  (15%)  or (C) a  relocation  of
     Optionee's place of employment by more than fifty (50) miles,  provided and
     only if such change, reduction or relocation is effected by the Corporation
     without Optionee's consent.

          R.  Misconduct  shall mean,  unless  otherwise  determined by the Plan
Administrator  and  recorded in the  agreements  evidencing  the option grant or
stock issuance,  the commission of any act of fraud,  embezzlement or dishonesty
by the Optionee or  Participant,  any  unauthorized  use or  disclosure  by such
person of  confidential  information or trade secrets of the Corporation (or any
Parent  or  Subsidiary),  or any other  intentional  misconduct  by such  person
adversely affecting the business or affairs of the Corporation (or any Parent or
Subsidiary) in a material manner.  The foregoing  definition shall not be deemed
to be  inclusive  of all the acts or  omissions  which the  Corporation  (or any
Parent or Subsidiary)  may consider as grounds for the dismissal or discharge of
any Optionee,  Participant or other person in the Service of the Corporation (or
any Parent or Subsidiary).

          S.  1934  Act  shall  mean the  Securities  Exchange  Act of 1934,  as
amended.


                                      A-3
<PAGE>

          T.  Non-Statutory  Option shall mean an option not intended to satisfy
the requirements of Code Section 422.

          U.  Optionee  shall mean any person to whom an option is granted under
the Discretionary Option Grant or Automatic Option Grant Program.

          V. Parent shall mean any corporation  (other than the  Corporation) in
an unbroken chain of  corporations  ending with the  Corporation,  provided each
corporation in the unbroken chain (other than the Corporation) owns, at the time
of the determination,  stock possessing fifty percent (50%) or more of the total
combined  voting power of all classes of stock in one of the other  corporations
in such chain.

          W.  Participant  shall mean any person who is issued  shares of Common
Stock under the Stock Issuance Program.

          X.  Permanent  Disability  or  Permanently  Disabled  shall  mean  the
inability  of the  Optionee  or the  Participant  to engage  in any  substantial
gainful  activity  by reason of any  medically  determinable  physical or mental
impairment expected to result in death or to be of continuous duration of twelve
(12) months or more. However,  solely for purposes of the Automatic Option Grant
Program,  Permanent  Disability or Permanently Disabled shall mean the inability
of the  non-employee  Board member to perform his or her usual duties as a Board
member by reason of any  medically  determinable  physical or mental  impairment
expected  to  result in death or to be of  continuous  duration  of twelve  (12)
months or more.

          Y. Plan shall mean the  Corporation's  Amended and Restated 1998 Stock
Incentive Plan, as set forth in this document.

          Z. Plan Administrator  shall mean the particular  entity,  whether the
Primary Committee, the Board or the Secondary Committee,  which is authorized to
administer  the  Discretionary  Option Grant and Stock  Issuance  Programs  with
respect to one or more classes of eligible persons, to the extent such entity is
carrying out its  administrative  functions under those programs with respect to
the persons under its jurisdiction.

          AA. Plan  Effective  Date shall mean March 24, 1998, the date on which
the Plan was adopted by the Board.

          BB.  Predecessor Plans shall mean the Corporation's  1995 Stock Option
Plan and 1993  Stock  Option  Plan as in  effect  immediately  prior to the Plan
Effective Date hereunder.

          CC.  Primary  Committee  shall mean the  committee  of two (2) or more
non-employee   Board  members   appointed  by  the  Board  to   administer   the
Discretionary  Option Grant and Stock Issuance  Programs with respect to Section
16 Insiders.


                                      A-4
<PAGE>

          DD.  Secondary  Committee  shall mean a  committee  of one (1) or more
Board members  appointed by the Board to  administer  the  Discretionary  Option
Grant and Stock  Issuance  Programs with respect to eligible  persons other than
Section 16 Insiders.

          EE.  Section 16 Insider  shall  mean an  officer  or  director  of the
Corporation  subject to the short-swing  profit liabilities of Section 16 of the
1934 Act.

          FF. Service shall mean the performance of services for the Corporation
(or any Parent or  Subsidiary)  by a person in the  capacity of an  Employee,  a
non-employee  member of the board of directors or a  consultant  or  independent
advisor,  except to the extent otherwise  specifically provided in the documents
evidencing the option grant or stock issuance

          GG. Stock  Exchange  shall mean either the American  Stock Exchange or
the New York Stock Exchange.

          HH. Stockholder Approval Date shall mean the date on which the Plan is
approved by the Corporation's stockholders.

          II. Stock Issuance  Agreement shall mean the agreement entered into by
the  Corporation and the Participant at the time of issuance of shares of Common
Stock under the Stock Issuance Program.

          JJ. Stock Issuance  Program shall mean the stock  issuance  program in
effect under the Plan.

          KK. Subsidiary shall mean any corporation (other than the Corporation)
in an unbroken chain of corporations  beginning with the  Corporation,  provided
each corporation  (other than the last  corporation) in the unbroken chain owns,
at the time of the  determination,  stock possessing fifty percent (50%) or more
of the total  combined  voting power of all classes of stock in one of the other
corporations in such chain.

          LL.  Take-Over  Price  shall mean the  greater of (i) the Fair  Market
Value per share of Common  Stock on the date the  option is  surrendered  to the
Corporation in connection with a Hostile  Take-Over or (ii) the highest reported
price per share of Common  Stock paid by the tender  offeror in  effecting  such
Hostile  Take-Over.  However,  if the surrendered option is an Incentive Option,
the Take-Over Price shall not exceed the clause (i) price per share.

          MM.  Taxes  shall  mean  the  Federal,  state  and  local  income  and
employment tax liabilities  incurred by the holder of  Non-Statutory  Options or
unvested shares of Common Stock in connection with the exercise of those options
or the vesting of those shares.

          NN. 10% Stockholder shall mean the owner of stock (as determined under
Code


                                      A-5
<PAGE>

Section  424(d))  possessing  more than ten percent (10%) of the total  combined
voting  power of all  classes  of stock of the  Corporation  (or any  Parent  or
Subsidiary).


                                      A-6
<PAGE>

                                PRELIMINARY COPY

                                   APPENDIX A

      Please date, sign and mail your proxy card back as soon as possible!

                          DISCOVERY LABORATORIES, INC.

     Annual Meeting of Stockholders to be held on Wednesday, June 16, 1999

           THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

The  undersigned,  revoking all prior proxies,  hereby appoints Steven H. Kanzer
and Robert J. Capetola,  and each of them, with full power of  substitution,  as
proxies  to  represent  and  vote  all  shares  of  Common  Stock  and  Series B
Convertible Preferred Stock of Discovery Laboratories,  Inc. (the "Corporation")
which the  undersigned  would be entitled to vote if  personally  present at the
Annual Meeting of  Stockholders  of the Corporation to be held on June 16, 1999,
at 10:00 a.m. Eastern  Standard Time at Roberts  Sheridan & Kotel,  P.C. 12 East
49th Street 30th Floor, New York, N.Y., and at all adjournments or postponements
thereof,  upon matters set forth in the Notice of Annual Meeting of Stockholders
and Proxy Statement dated May 20, 1999, a copy of which has been received by the
undersigned.  Each share of Series B Convertible  Preferred Stock is entitled to
3.1132 votes. The proxies are further  authorized to vote, in their  discretion,
upon such  other  business  as may  properly  come  before  the  meeting  or any
adjournments or postponements  thereof. Each of Items 1 through 3 is proposed by
the Corporation.

THIS PROXY,  WHEN PROPERLY  EXECUTED WILL BE VOTED IN THE MANNER DIRECTED BY THE
UNDERSIGNED  STOCKHOLDER(S).  IF NO DIRECTION IS GIVEN, THIS PROXY WILL BE VOTED
FOR THE ELECTION OF THE NOMINEES SET FORTH ABOVE AS DIRECTORS,  FOR THE APPROVAL
OF THE  AMENDMENT  TO THE 1998 PLAN AND FOR THE  APPROVAL OF THE STOCK  PURCHASE
AGREEMENT.

                                SEE REVERSE SIDE


<PAGE>


|X|  Please mark your votes as in this example.

1.    To elect a Board of  Directors  to serve until the next Annual  Meeting of
      Stockholders and until their respective  successors have been duly elected
      and qualified, or until their earlier resignation or removal.

    FOR ALL NOMINEES listed                          Nominees -
    at right (except as marked to the                Robert J. Capetola, Ph.D.
    contrary below):                 [ ]             Steve H. Kanzer, Esq.
                                                     Max Link, Ph.D.
                                                     Richard G. Power
                                                     Marvin E. Rosenthale, Ph.D.
                                                     Herbert H. McDade, Jr.
                                                     Mark C. Rogers, M.D.
                                                     David Naveh, Ph.D.
    WITHHOLD AUTHORITY to vote for                   Richard Sperber
    all nominees listed at right:    [ ]

To withhold authority to vote for any individual  nominee,  write that nominee's
name in the space provided below:

2.    To  consider  and approve an  amendment  to the  Corporation's  1998 Stock
      Incentive  Plan (the "1998 Plan") that  increases  the number of shares of
      Common Stock  available for issuance under the 1998 Plan from 1,406,024 to
      2,200,959 shares.

             FOR  [ ]          AGAINST  [ ]            ABSTAIN  [ ]

3.    To  consider  and  approve  the  Stock  Purchase   Agreement  between  the
      Corporation and Crescent International Limited.

             FOR  [ ]          AGAINST  [ ]            ABSTAIN  [ ]

4.   To  transact  such other  business as may  properly  come before the Annual
     Meeting and any adjournment or postponement thereof.

PLEASE  COMPLETE,  SIGN,  DATE AND RETURN  THIS PROXY  CARD  PROMPTLY  USING THE
ENCLOSED ENVELOPE.

I/We will attend the meeting.           [ ] YES        [ ] NO

________________________________                    Date: ______________________
(Signature of Stockholder)

________________________________                    Date: ______________________
(Signature if held jointly)

Note:  Please sign this Proxy  exactly as your name or names appear on the books
of  the  Corporation.  Joint  owners  should  each  sign  personally.  Attorney,
executor, administrator,  trustee or guardian must give full title as such. If a
corporation or partnership, the signature should be that of an authorized person
who should state his or her title.


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