DEUTSCHE BANK AG\
SC 13G/A, 1999-01-29
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                    -----------------------------------------

                                 SCHEDULE 13G/A

                    Under the Securities Exchange Act of 1934

                                (Amendment No. 1)

                                   Qiagen N.V.
                    -----------------------------------------

                                (Name of issuer)




                                 Ordinary Shares
                    -----------------------------------------

                         (Title of class of securities)



                                   000N724821
                    -----------------------------------------

                                 (CUSIP number)

                                 January 1, 1999

             (Date of Event which requires filing of this Statement)

     Check the appropriate box to designate the rule pursuant to which this
                               schedule is filed:

                               | | Rule 13d-1 (b)
                               |X| Rule 13d-1 (c)
                               | | Rule 13d-1 (d)


<PAGE>



- ---------------------------------            ----------------------------
      CUSIP No. 000N724821           13G         Page 2 of 8 Pages
- ---------------------------------            ----------------------------


- -------- -----------------------------------------------------------------------
1        NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Deutsche Bank A.G.
- -------- -----------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP               (a) |_|
                                                                        (b) |_|
- -------- -----------------------------------------------------------------------
3        SEC USE ONLY

- -------- -----------------------------------------------------------------------
4        CITIZENSHIP OR PLACE OF ORGANIZATION

         Federal Republic of Germany
- ---------------------------- ------ --------------------------------------------
NUMBER OF SHARES             5      SOLE VOTING POWER
                                    643,079
                             ------ --------------------------------------------
BENEFICIALLY OWNED BY               SHARED VOTING POWER
                             6      1,144,700
                             ------ --------------------------------------------
EACH REPORTING                      SOLE DISPOSITIVE POWER
                             7      780,124
                             ------ --------------------------------------------
PERSON WITH                         SHARED DISPOSITIVE POWER
                             8      1,143,696
- -------- -----------------------------------------------------------------------
 9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         1,923,820
- -------- -----------------------------------------------------------------------
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
         CERTAIN SHARES                                                 |_|
- -------- -----------------------------------------------------------------------
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

         11.9%
- -------- -----------------------------------------------------------------------
12       TYPE OF REPORTING PERSON

         HC, BK, CO
- -------- -----------------------------------------------------------------------


<PAGE>



- ---------------------------------          -------------------------------
      CUSIP No. 000N724821           13G       Page 3 of 8 Pages
- ---------------------------------          -------------------------------



- -------- -----------------------------------------------------------------------
1        NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Deutsche Gesellschaft fur Wertpapiersparen (DWS) Group
- -------- -----------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP              (a) |_|
                                                                       (b) |_|
- -------- -----------------------------------------------------------------------
3        SEC USE ONLY

- -------- -----------------------------------------------------------------------
4        CITIZENSHIP OR PLACE OF ORGANIZATION

         Federal Republic of Germany
- ---------------------------- ------ --------------------------------------------
NUMBER OF SHARES             5      SOLE VOTING POWER
                                    0
                             ------ --------------------------------------------
BENEFICIALLY OWNED BY               SHARED VOTING POWER
                             6      839,000
                             ------ --------------------------------------------
EACH REPORTING                      SOLE DISPOSITIVE POWER
                             7      0
                             ------ --------------------------------------------
PERSON WITH                         SHARED DISPOSITIVE POWER
                             8      839,000
- -------- -----------------------------------------------------------------------
 9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         839,000
- -------- -----------------------------------------------------------------------
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
         CERTAIN SHARES                                                |_|
- -------- -----------------------------------------------------------------------
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

         5.2%
- -------- -----------------------------------------------------------------------
12       TYPE OF REPORTING PERSON

         HC, CO
- -------- -----------------------------------------------------------------------


<PAGE>


Item 1(a).     Name of Issuer:

               Qiagen N.V. (the "Issuer")

Item 1(b).     Address of Issuer's Principal Executive Offices:

               The  address  of  the  Issuer's  principal   executive  office
               Johannes Vermersplain 9-1, Amsterdam, 1071 DV, Netherlands.

Item 2(a).     Name of Person Filing:

               This  statement  is filed on behalf of Deutsche  Bank AG ("DBAG")
               and Deutsche Gesellschaft fur Wertpapiersparen  (DWS) Group ("DWS
               Group" and, together with DBAG, the "Reporting Persons").

Item 2(b).     Address of Principal Business Office or, if none, Residence:

               The  principal  place of  business  of DBAG is  Taunusanlage  12,
               D-60325, Frankfurt am Main, Federal Republic of Germany.

               The  principal  place of  business  of DWS Group is  Gruneburgweg
               113-115, 60323 Frankfurt, Federal Republic of Germany.

Item 2(c).     Citizenship:

               The citizenship of each of the Reporting  Persons is set forth on
               the applicable cover page.

Item 2(d).     Title of Class of Securities:

               The title of the securities is ordinary  shares (the "Ordinary
Shares").

Item 2(e).     CUSIP Number:

               The  CUSIP  number  of the  Ordinary  Shares  is set forth on the
               applicable cover page.

               Item 3. If this statement is filed pursuant to Rules 13d-1(b), or
               13d-2(b) or (c), check whether the person filing is a:

               (a) |_|  Broker or dealer registered under section 15 of the Act;

               (b) |_| Bank as defined in section 3(a)(6) of the Act;

               (c) |_| Insurance Company as defined in section 3(a)(19) of the
                       Act;

               (d) |_| Investment  Company  registered  under section 8 of the
                       Investment Company Act of 1940;

               (e) |_| An  investment  adviser in  accordance  with Rule 13d-1
                       (b)(1)(ii)(E);

               (f) |_| An  employee  benefit  plan,  or  endowment  fund  in
                       accordance with Rule 13d-1 (b)(1)(ii)(F);

               (g) |_| A  parent  holding   company  or  control  person  in
                       accordance with Rule 13d-1 (b)(1)(ii)(G);

               (h) |_| A savings association as defined in section 3(b) of the
                       Federal Deposit Insurance Act;

               (i) |_| A  church  plan  that  is  excluded  from  the
                       definition of an  investment  company under section
                       3(c)(14) of the Investment Company Act of 1940;

               (j) |_| Group, in accordance with Rule 13d-1 (b)(1)(ii)(J).

               If this statement is filed pursuant to Rule 13d-1 (c), check this
               box. |X|

Item 4.        Ownership.

          (a)  Amount beneficially owned:

                    Each  of  the  Reporting  Persons  owns  the  amount  of the
               Ordinary Shares as set forth on the applicable cover page.

          (b)  Percent of class:

                    Each of the  Reporting  Persons owns the  percentage  of the
               Ordinary Shares as set forth on the applicable cover page.

          (c)  Number of shares as to which such person has:

               (i)  sole power to vote or to direct the vote:

                    Each of the Reporting  Persons has the sole power to vote or
               direct  the  vote of the  Ordinary  Shares  as set  forth  on the
               applicable cover page.

               (ii) shared power to vote or to direct the vote:

                    Each of the  Reporting  Persons has the shared power to vote
               or  direct  the vote of the  Ordinary  Shares as set forth on the
               applicable cover page.

               (iii) sole power to dispose or to direct the disposition of:

                    Each of the Reporting  Persons has the sole power to dispose
               or direct the  disposition of the Ordinary Shares as set forth on
               the applicable cover page.

               (iv) shared power to dispose or to direct the disposition of:

                    Each of the  Reporting  Persons  has  the  shared  power  to
               dispose or direct the  disposition of the Ordinary  Shares as set
               forth on the applicable cover page.

Item 5.        Ownership of Five Percent or Less of a Class.

               Not applicable.

Item 6.        Ownership of More than Five Percent on Behalf of Another Person.

               Other than the 643,079  shares held by DBAG for its own  account,
          investment  management  clients of the  subsidiaries  of the Reporting
          Persons listed in Item 7 have the ultimate right to any dividends from
          Ordinary Shares and the proceeds from the sale of Ordinary Shares.

Item 7.  Identification  and Classification of the Subsidiary Which Acquired the
         Security Being Reported on by the Parent Holding Company.

          The  following are  subsidiaries  of DBAG and/ or DWS Group which hold
     Ordinary Shares included in the figures on the cover pages: Morgan Grenfell
     Investment Services Limited,  Morgan Grenfell International Fund Management
     Limited,  Deutsche  Gesellschaft fur  Wertpapiersparen  mbH,  Deutsche Fund
     Management Inc., Deutsche Vermoegensbildungsgesellschaft mbH, Deutsche Bank
     Investment  Management  S.A.,  DWS (Austria)  Investment-Gesellschaft  mbH,
     Deutsche  Bank  Fonds  S.A.,  Finanza  &  Futuro  S.p.A.,   Deutsche  Asset
     Management Investmentgesellschaft mbH and Deutsche Bank Securities Inc.

Item 8.   Identification and Classification of Members of the Group.

          Not applicable.

Item 9.   Notice of Dissolution of Group.

          Not applicable.

Item 10.  Certification.

          By  signing  below I certify  that,  to the best of my  knowledge  and
     belief, the securities referred to above were not acquired and are not held
     for the  purpose  of or with the  effect of  changing  or  influencing  the
     control of the issuer of the  securities  and were not acquired and are not
     held in connection with or as a participant in any transaction  having that
     purpose or effect.



<PAGE>


                                    SIGNATURE

          After reasonable inquiry and to the best of my knowledge and belief, I
     certify that the information set forth in this statement is true,  complete
     and correct.

Dated:  January 28, 1999



                                      DEUTSCHE BANK AG



                                       By: /s/ Dieter Eisele
                                          ----------------------------------
                                          Name:   Dr. Dieter Eisele
                                          Title:  Group Head of Compliance



                                       By: /s/ Rainer Grimberg
                                          ----------------------------------
                                          Name:   Dr. Rainer Grimberg
                                          Title:  Vice President



<PAGE>


                                                               EXHIBIT 1

        Consent of Deutsche Gesellschaft fur Wertpapiersparen (DWS) Group


          The  undersigned  agrees that the Schedule  13G/A executed by Deutsche
     Bank AG to which  this  statement  is  attached  as an  exhibit is filed on
     behalf of Deutsche Bank AG and Deutsche  Gesellschaft fur  Wertpapiersparen
     (DWS) Group pursuant to Rule 13d-1(f)(1) of the Securities  Exchange Act of
     1934.

Dated:  January 28, 1999



                               DEUTSCHE GESELLSCHAFT FuR
                                 WERTPAPIERSPAREN (DWS) GROUP



                               By: /s/ Udo Behrenwaldt
                                  ----------------------------
                                  Name:   Udo Behrenwaldt
                                  Title:  Managing Director



                               By: /s/ Matthias Geuckler
                                  ----------------------------
                                  Name:   Matthias Geuckler
                                  Title:  Head of Compliance (DWS)




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