PARADIGM GENETICS INC
SC 13D, 2000-05-15
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                                  UNITED STATES

                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                  SCHEDULE 13D

                    Under the Securities Exchange Act of 1934

                              (Amendment No. ___)*

                             PARADIGM GENETICS, INC.
- --------------------------------------------------------------------------------
                                (Name of Issuer)


                                  Common Stock
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)


                                   69900R 10 6
- --------------------------------------------------------------------------------
                                 (CUSIP Number)

                                 JOHN J. GANNON
                          C/O POLARIS VENTURE PARTNERS
                         1000 WINTER STREET, SUITE 3350
                             WALTHAM, MA 02451-1215

 (Name, Address and Telephone Number of Person Authorized to Receive Notices and
                                 Communications)

                                   May 5, 2000
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1(e), (f) or (g), check the following box. [ ]

NOTE:  Schedules  filed in paper format shall include a signed original and five
copies of the  Schedule,  including  all  exhibits.  See Rule 13d-1(A) for other
parties to whom copies are to be sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).


<PAGE>

<TABLE>
- --------------------------------------                                               -------------------------------
CUSIP NO.   69900R 10 6                                     13D                                   Page 2 of 25 Pages
- --------------------------------------                                               -------------------------------
<CAPTION>
<S>      <C>                                                                                            <C>
- -------- -----------------------------------------------------------------------------------------------------------
1        NAME OF REPORTING PERSON
         POLARIS VENTURE PARTNERS, L.P.
         I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

         See Item 2 for identification of General Partner
- -------- -----------------------------------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                                                        (a)
                                                                                                        (b) [X]
- -------- -----------------------------------------------------------------------------------------------------------
3        SEC USE ONLY

- -------- -----------------------------------------------------------------------------------------------------------
4        SOURCE OF FUNDS

         WC
- -------- -----------------------------------------------------------------------------------------------------------
5        CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or (e)                 [__]

- -------- -----------------------------------------------------------------------------------------------------------
6        CITIZENSHIP OR PLACE OF ORGANIZATION

         State of Delaware
- -------- -----------------------------------------------------------------------------------------------------------
      NUMBER OF SHARES         7     SOLE VOTING POWER
    BENEFICIALLY OWNED BY            2,210,806(A)
    REPORTING PERSON WITH
                               ----- -------------------------------------------------------------------------------
                               8     SHARED VOTING POWER
                                     0(A)
                               ----- -------------------------------------------------------------------------------
                               9     SOLE DISPOSITIVE POWER
                                     2,210,806(A)
                               ----- -------------------------------------------------------------------------------
                               10    SHARED DISPOSITIVE POWER
                                     0(A)
- -------- -----------------------------------------------------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         2,210,806(A)
- -------- -----------------------------------------------------------------------------------------------------------
12       CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*
                                                                                                            [X]
- -------- -----------------------------------------------------------------------------------------------------------
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         8.9%
- -------- -----------------------------------------------------------------------------------------------------------
14       TYPE OF REPORTING PERSON
         PN
- -------- -----------------------------------------------------------------------------------------------------------
<FN>
(A)      Excludes an  aggregate of 2,551,112  shares owned  beneficially  by the
         other  reporting  persons  indicated in this  Schedule 13D, as to which
         this reporting person disclaims beneficial ownership.
</FN>
</TABLE>
<PAGE>

<TABLE>
- --------------------------------------                                               -------------------------------
CUSIP NO.   69900R 10 6                                     13D                                   Page 3 of 25 Pages
- --------------------------------------                                               -------------------------------
<CAPTION>
<S>      <C>                                                                                            <C>
- -------- -----------------------------------------------------------------------------------------------------------
1        NAME OF REPORTING PERSON
         POLARIS VENTURE PARTNERS FOUNDERS' FUND, L.P.
         I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

         See Item 2 for list of General Partner
- -------- -----------------------------------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                                                        (a)
                                                                                                        (b) [X]
- -------- -----------------------------------------------------------------------------------------------------------
3        SEC USE ONLY

- -------- -----------------------------------------------------------------------------------------------------------
4        SOURCE OF FUNDS

         WC
- -------- -----------------------------------------------------------------------------------------------------------
5        CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or (e)                 [__]

- -------- -----------------------------------------------------------------------------------------------------------
6        CITIZENSHIP OR PLACE OF ORGANIZATION

         State of Delaware
- -------- -----------------------------------------------------------------------------------------------------------
      NUMBER OF SHARES         7     SOLE VOTING POWER
    BENEFICIALLY OWNED BY            132,266(A)
    REPORTING PERSON WITH
                               ----- -------------------------------------------------------------------------------
                               8     SHARED VOTING POWER
                                     0(A)
                               ----- -------------------------------------------------------------------------------
                               9     SOLE DISPOSITIVE POWER
                                     132,266(A)
                               ----- -------------------------------------------------------------------------------
                               10    SHARED DISPOSITIVE POWER
                                     0(A)
- -------- -----------------------------------------------------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         132,266(A)
- -------- -----------------------------------------------------------------------------------------------------------
12       CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*
                                                                                                            [X]
- -------- -----------------------------------------------------------------------------------------------------------
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         0.5%
- -------- -----------------------------------------------------------------------------------------------------------
14       TYPE OF REPORTING PERSON
         PN
- -------- -----------------------------------------------------------------------------------------------------------
<FN>
(A)      Excludes an  aggregate of 4,629,652  shares owned  beneficially  by the
         other  reporting  persons  indicated in this  Schedule 13D, as to which
         this reporting person disclaims beneficial ownership.
</FN>
</TABLE>


<PAGE>

<TABLE>
- --------------------------------------                                               -------------------------------
CUSIP NO.   69900R 10 6                                     13D                                   Page 4of 25 Pages
- --------------------------------------                                               -------------------------------
<CAPTION>
<S>      <C>                                                                                            <C>
- -------- -----------------------------------------------------------------------------------------------------------
1        NAME OF REPORTING PERSON
         POLARIS VENTURE MANAGEMENT CO., L.L.C.
         I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

         See Item 2 for list of Managing Members
- -------- -----------------------------------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                                                        (a)
                                                                                                        (b) [X]
- -------- -----------------------------------------------------------------------------------------------------------
3        SEC USE ONLY

- -------- -----------------------------------------------------------------------------------------------------------
4        SOURCE OF FUNDS

         OO
- -------- -----------------------------------------------------------------------------------------------------------
5        CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or (e)                 [__]

- -------- -----------------------------------------------------------------------------------------------------------
6        CITIZENSHIP OR PLACE OF ORGANIZATION

         State of Delaware
- -------- -----------------------------------------------------------------------------------------------------------
      NUMBER OF SHARES         7     SOLE VOTING POWER
    BENEFICIALLY OWNED BY            2,343,072(A)
    REPORTING PERSON WITH
                               ----- -------------------------------------------------------------------------------
                               8     SHARED VOTING POWER
                                     0(A)
                               ----- -------------------------------------------------------------------------------
                               9     SOLE DISPOSITIVE POWER
                                     2,343,072(A)
                               ----- -------------------------------------------------------------------------------
                               10    SHARED DISPOSITIVE POWER
                                     0(A)
- -------- -----------------------------------------------------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         2,343,072(A)
- -------- -----------------------------------------------------------------------------------------------------------
12       CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*
                                                                                                            [X]
- -------- -----------------------------------------------------------------------------------------------------------
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         9.4%
- -------- -----------------------------------------------------------------------------------------------------------
14       TYPE OF REPORTING PERSON
         OO
- -------- -----------------------------------------------------------------------------------------------------------
<FN>
(A)      Excludes an  aggregate of 2,418,846  shares owned  beneficially  by the
         other  reporting  persons  indicated in this  Schedule 13D, as to which
         this reporting person disclaims beneficial ownership.
</FN>
</TABLE>

<PAGE>

<TABLE>
- --------------------------------------                                               -------------------------------
CUSIP NO.   69900R 10 6                                     13D                                   Page 5 of 25 Pages
- --------------------------------------                                               -------------------------------
<CAPTION>
<S>      <C>                                                                                            <C>
- -------- -----------------------------------------------------------------------------------------------------------
1        NAME OF REPORTING PERSON
         POLARIS VENTURE PARTNERS III, L.P.
         I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

         See Item 2 for identification of General Partner
- -------- -----------------------------------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                                                        (a)
                                                                                                        (b) [X]
- -------- -----------------------------------------------------------------------------------------------------------
3        SEC USE ONLY

- -------- -----------------------------------------------------------------------------------------------------------
4        SOURCE OF FUNDS

         WC
- -------- -----------------------------------------------------------------------------------------------------------
5        CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or (e)                 [__]

- -------- -----------------------------------------------------------------------------------------------------------
6        CITIZENSHIP OR PLACE OF ORGANIZATION

         State of Delaware
- -------- -----------------------------------------------------------------------------------------------------------
      NUMBER OF SHARES         7     SOLE VOTING POWER
    BENEFICIALLY OWNED BY            2,266,519(A)
    REPORTING PERSON WITH
                               ----- -------------------------------------------------------------------------------
                               8     SHARED VOTING POWER
                                     0(A)
                               ----- -------------------------------------------------------------------------------
                               9     SOLE DISPOSITIVE POWER
                                     2,266,519(A)
                               ----- -------------------------------------------------------------------------------
                               10    SHARED DISPOSITIVE POWER
                                     0(A)
- -------- -----------------------------------------------------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         2,266,519(A)
- -------- -----------------------------------------------------------------------------------------------------------
12       CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*
                                                                                                            [X]
- -------- -----------------------------------------------------------------------------------------------------------
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         9.1%
- -------- -----------------------------------------------------------------------------------------------------------
14       TYPE OF REPORTING PERSON
         PN
- -------- -----------------------------------------------------------------------------------------------------------
<FN>
(A)      Excludes an  aggregate of 2,495,399  shares owned  beneficially  by the
         other  reporting  persons  indicated in this  Schedule 13D, as to which
         this reporting person disclaims beneficial ownership.
</FN>
</TABLE>

<PAGE>

<TABLE>
- --------------------------------------                                               -------------------------------
CUSIP NO.   69900R 10 6                                     13D                                   Page 6 of 25 Pages
- --------------------------------------                                               -------------------------------
<CAPTION>
<S>      <C>                                                                                            <C>
- -------- -----------------------------------------------------------------------------------------------------------
1        NAME OF REPORTING PERSON
         POLARIS VENTURE PARTNERS ENTREPRENEURS' FUND III, L.P.
         I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

         See Item 2 for identification of General Partner
- -------- -----------------------------------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                                                        (a)
                                                                                                        (b) [X]
- -------- -----------------------------------------------------------------------------------------------------------
3        SEC USE ONLY

- -------- -----------------------------------------------------------------------------------------------------------
4        SOURCE OF FUNDS

         WC
- -------- -----------------------------------------------------------------------------------------------------------
5        CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or (e)                 [__]

- -------- -----------------------------------------------------------------------------------------------------------
6        CITIZENSHIP OR PLACE OF ORGANIZATION

         State of Delaware
- -------- -----------------------------------------------------------------------------------------------------------
      NUMBER OF SHARES         7     SOLE VOTING POWER
    BENEFICIALLY OWNED BY            58,850(A)
    REPORTING PERSON WITH
                               ----- -------------------------------------------------------------------------------
                               8     SHARED VOTING POWER
                                     0(A)
                               ----- -------------------------------------------------------------------------------
                               9     SOLE DISPOSITIVE POWER
                                     58,850(A)
                               ----- -------------------------------------------------------------------------------
                               10    SHARED DISPOSITIVE POWER
                                     0(A)
- -------- -----------------------------------------------------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         58,850(A)
- -------- -----------------------------------------------------------------------------------------------------------
12       CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*
                                                                                                            [X]
- -------- -----------------------------------------------------------------------------------------------------------
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         0.2%
- -------- -----------------------------------------------------------------------------------------------------------
14       TYPE OF REPORTING PERSON
         PN
- -------- -----------------------------------------------------------------------------------------------------------
<FN>
(A)      Excludes an  aggregate of 4,703,068  shares owned  beneficially  by the
         other  reporting  persons  indicated in this  Schedule 13D, as to which
         this reporting person disclaims beneficial ownership.
</FN>
</TABLE>

<PAGE>

<TABLE>
- --------------------------------------                                               -------------------------------
CUSIP NO.   69900R 10 6                                     13D                                   Page 7 of 25 Pages
- --------------------------------------                                               -------------------------------
<CAPTION>
<S>      <C>                                                                                            <C>
- -------- -----------------------------------------------------------------------------------------------------------
1        NAME OF REPORTING PERSON
         POLARIS VENTURE PARTNERS FOUNDERS' FUND III, L.P.
         I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

         See Item 2 for identification of General Partner
- -------- -----------------------------------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                                                        (a)
                                                                                                        (b) [X]
- -------- -----------------------------------------------------------------------------------------------------------
3        SEC USE ONLY

- -------- -----------------------------------------------------------------------------------------------------------
4        SOURCE OF FUNDS

         WC
- -------- -----------------------------------------------------------------------------------------------------------
5        CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or (e)                 [__]

- -------- -----------------------------------------------------------------------------------------------------------
6        CITIZENSHIP OR PLACE OF ORGANIZATION

         State of Delaware
- -------- -----------------------------------------------------------------------------------------------------------
      NUMBER OF SHARES         7     SOLE VOTING POWER
    BENEFICIALLY OWNED BY            28,477(A)
    REPORTING PERSON WITH
                               ----- -------------------------------------------------------------------------------
                               8     SHARED VOTING POWER
                                     0(A)
                               ----- -------------------------------------------------------------------------------
                               9     SOLE DISPOSITIVE POWER
                                     28,477(A)
                               ----- -------------------------------------------------------------------------------
                               10    SHARED DISPOSITIVE POWER
                                     0(A)
- -------- -----------------------------------------------------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         28,477(A)
- -------- -----------------------------------------------------------------------------------------------------------
12       CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*
                                                                                                            [X]
- -------- -----------------------------------------------------------------------------------------------------------
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         0.1%
- -------- -----------------------------------------------------------------------------------------------------------
14       TYPE OF REPORTING PERSON
         PN
- -------- -----------------------------------------------------------------------------------------------------------
<FN>
(A)      Excludes an  aggregate of 4,733,441  shares owned  beneficially  by the
         other  reporting  persons  indicated in this  Schedule 13D, as to which
         this reporting person disclaims beneficial ownership.
</FN>
</TABLE>

<PAGE>

<TABLE>
- --------------------------------------                                               -------------------------------
CUSIP NO.   69900R 10 6                                     13D                                   Page 8 of 25 Pages
- --------------------------------------                                               -------------------------------
<CAPTION>
<S>      <C>                                                                                            <C>
- -------- -----------------------------------------------------------------------------------------------------------
1        NAME OF REPORTING PERSON
         POLARIS VENTURE MANAGEMENT CO. III, L.L.C.
         I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

         See Item 2 for a list of Managing Members
- -------- -----------------------------------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                                                        (a)
                                                                                                        (b) [X]
- -------- -----------------------------------------------------------------------------------------------------------
3        SEC USE ONLY

- -------- -----------------------------------------------------------------------------------------------------------
4        SOURCE OF FUNDS

         OO
- -------- -----------------------------------------------------------------------------------------------------------
5        CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or (e)                 [__]

- -------- -----------------------------------------------------------------------------------------------------------
6        CITIZENSHIP OR PLACE OF ORGANIZATION

         State of Delaware
- -------- -----------------------------------------------------------------------------------------------------------
      NUMBER OF SHARES         7     SOLE VOTING POWER
    BENEFICIALLY OWNED BY            2,353,846(A)
    REPORTING PERSON WITH
                               ----- -------------------------------------------------------------------------------
                               8     SHARED VOTING POWER
                                     0(A)
                               ----- -------------------------------------------------------------------------------
                               9     SOLE DISPOSITIVE POWER
                                     2,353,846(A)
                               ----- -------------------------------------------------------------------------------
                               10    SHARED DISPOSITIVE POWER
                                     0(A)
- -------- -----------------------------------------------------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         2,353,846(A)
- -------- -----------------------------------------------------------------------------------------------------------
12       CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*
                                                                                                            [X]
- -------- -----------------------------------------------------------------------------------------------------------
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         9.4%
- -------- -----------------------------------------------------------------------------------------------------------
14       TYPE OF REPORTING PERSON
         00
- -------- -----------------------------------------------------------------------------------------------------------
<FN>
(A)      Excludes an  aggregate of 2,408,072  shares owned  beneficially  by the
         other  reporting  persons  indicated in this  Schedule 13D, as to which
         this reporting person disclaims beneficial ownership.
</FN>
</TABLE>

<PAGE>

<TABLE>
- --------------------------------------                                               -------------------------------
CUSIP NO.   69900R 10 6                                     13D                                   Page 9 of 25 Pages
- --------------------------------------                                               -------------------------------
<CAPTION>
<S>      <C>                                                                                            <C>
- -------- -----------------------------------------------------------------------------------------------------------
1        NAME OF REPORTING PERSON
         STEPHEN D. ARNOLD.
         I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

         See Item 2 for a list of Managing Members
- -------- -----------------------------------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                                                        (a)
                                                                                                        (b) [X]
- -------- -----------------------------------------------------------------------------------------------------------
3        SEC USE ONLY

- -------- -----------------------------------------------------------------------------------------------------------
4        SOURCE OF FUNDS

         OO*
- -------- -----------------------------------------------------------------------------------------------------------
5        CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or (e)                 [__]

- -------- -----------------------------------------------------------------------------------------------------------
6        CITIZENSHIP OR PLACE OF ORGANIZATION

         U.S. Citizen
- -------- -----------------------------------------------------------------------------------------------------------
      NUMBER OF SHARES         7     SOLE VOTING POWER
    BENEFICIALLY OWNED BY            5,000(A)
    REPORTING PERSON WITH
                               ----- -------------------------------------------------------------------------------
                               8     SHARED VOTING POWER
                                     4,696,918(A)
                               ----- -------------------------------------------------------------------------------
                               9     SOLE DISPOSITIVE POWER
                                     5,000(A)
                               ----- -------------------------------------------------------------------------------
                               10    SHARED DISPOSITIVE POWER
                                     4,696,918(A)
- -------- -----------------------------------------------------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         4,701,918(A)
- -------- -----------------------------------------------------------------------------------------------------------
12       CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*
                                                                                                            [X]
- -------- -----------------------------------------------------------------------------------------------------------
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         18.8%
- -------- -----------------------------------------------------------------------------------------------------------
14       TYPE OF REPORTING PERSON
         IN
- -------- -----------------------------------------------------------------------------------------------------------
<FN>
*        Personal Funds used to purchase 5,000 shares.

(A)      Excludes an aggregate of 60,000 shares owned  beneficially by the other
         reporting  persons  indicated  in this  Schedule  13D, as to which this
         reporting person disclaims beneficial ownership.
</FN>
</TABLE>

<PAGE>

<TABLE>
- --------------------------------------                                               -------------------------------
CUSIP NO.   69900R 10 6                                     13D                                 Page 10 of 25 Pages
- --------------------------------------                                               -------------------------------
<CAPTION>
<S>      <C>                                                                                            <C>
- -------- -----------------------------------------------------------------------------------------------------------
1        NAME OF REPORTING PERSON
         JONATHAN A. FLINT
         I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

- -------- -----------------------------------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                                                        (a)
                                                                                                        (b) [X]
- -------- -----------------------------------------------------------------------------------------------------------
3        SEC USE ONLY

- -------- -----------------------------------------------------------------------------------------------------------
4        SOURCE OF FUNDS

         OO*
- -------- -----------------------------------------------------------------------------------------------------------
5        CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or (e)                 [__]

- -------- -----------------------------------------------------------------------------------------------------------
6        CITIZENSHIP OR PLACE OF ORGANIZATION

         U.S. Citizen
- -------- -----------------------------------------------------------------------------------------------------------
      NUMBER OF SHARES         7     SOLE VOTING POWER
    BENEFICIALLY OWNED BY            5,000(A)
    REPORTING PERSON WITH
                               ----- -------------------------------------------------------------------------------
                               8     SHARED VOTING POWER
                                     4,696,918(A)
                               ----- -------------------------------------------------------------------------------
                               9     SOLE DISPOSITIVE POWER
                                     5,000(A)
                               ----- -------------------------------------------------------------------------------
                               10    SHARED DISPOSITIVE POWER
                                     4,696,918(A)
- -------- -----------------------------------------------------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         4,701,918(A)
- -------- -----------------------------------------------------------------------------------------------------------
12       CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*
                                                                                                            [X]
- -------- -----------------------------------------------------------------------------------------------------------
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         18.8%
- -------- -----------------------------------------------------------------------------------------------------------
14       TYPE OF REPORTING PERSON
         IN
- -------- -----------------------------------------------------------------------------------------------------------
<FN>
*        Personal Funds used to purchase 5,000 shares.

(A)      Excludes an aggregate of 60,000 shares owned  beneficially by the other
         reporting  persons  indicated  in this  Schedule  13D, as to which this
         reporting person disclaims beneficial ownership.
</FN>
</TABLE>

<PAGE>

<TABLE>
- --------------------------------------                                               -------------------------------
CUSIP NO.   69900R 10 6                                     13D                                 Page 11 of 25 Pages
- --------------------------------------                                               -------------------------------
<CAPTION>
<S>      <C>                                                                                            <C>
- -------- -----------------------------------------------------------------------------------------------------------
1        NAME OF REPORTING PERSON
         TERRANCE G. MCGUIRE
         I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

- -------- -----------------------------------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                                                        (a)
                                                                                                        (b) [X]
- -------- -----------------------------------------------------------------------------------------------------------
3        SEC USE ONLY

- -------- -----------------------------------------------------------------------------------------------------------
4        SOURCE OF FUNDS

         OO*
- -------- -----------------------------------------------------------------------------------------------------------
5        CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or (e)                 [__]

- -------- -----------------------------------------------------------------------------------------------------------
6        CITIZENSHIP OR PLACE OF ORGANIZATION

         U.S. Citizen
- -------- -----------------------------------------------------------------------------------------------------------
      NUMBER OF SHARES         7     SOLE VOTING POWER
    BENEFICIALLY OWNED BY            55,000(A)
    REPORTING PERSON WITH
                               ----- -------------------------------------------------------------------------------
                               8     SHARED VOTING POWER
                                     4,696,918(A)
                               ----- -------------------------------------------------------------------------------
                               9     SOLE DISPOSITIVE POWER
                                     55,000(A)
                               ----- -------------------------------------------------------------------------------
                               10    SHARED DISPOSITIVE POWER
                                     4,696,918(A)
- -------- -----------------------------------------------------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
         4,751,918(A)
- -------- -----------------------------------------------------------------------------------------------------------
12       CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*
                                                                                                            [X]
- -------- -----------------------------------------------------------------------------------------------------------
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         19.0%
- -------- -----------------------------------------------------------------------------------------------------------
14       TYPE OF REPORTING PERSON
         IN
- -------- -----------------------------------------------------------------------------------------------------------
<FN>
*        *Personal Funds used to purchase 55,000 shares.

(A)      Excludes an aggregate of 10,000 shares owned  beneficially by the other
         reporting  persons  indicated  in this  Schedule  13D, as to which this
         reporting person disclaims beneficial ownership.
</FN>
</TABLE>

<PAGE>

- -------------------------                              -------------------------
CUSIP NO.   69900R 10 6                 13D                Page 12 of 25 Pages
- -------------------------                              -------------------------

Item 1.  Security and Issuer.

                  The title of the class of  securities  to which this  Schedule
13D relates is Common  Stock  ("Common  Stock") of Paradigm  Genetics,  Inc.,  a
Delaware  corporation  (the  "Issuer" or  "Company").  The  principal  executive
offices of the Issuer are  located at 104  Alexander  Drive,  Research  Triangle
Park, NC 27709.

Item 2.  Identity and Background.

                  Set forth below is the following  information  with respect to
each of the persons  filing this Schedule 13D (together,  the "Filing  Persons")
and, in addition,  each of such person's  managing partners or managing members,
as the case may be, and, if applicable,  the persons  controlling  such managing
partners or managing members (such additional persons,  together with the Filing
Persons,  the "Item 2 Persons"):  (a) name; (b) address of principal offices (if
entity) or residence or business address (if individual); (c) principal business
(if entity) or principal  occupation and name,  business and address of employer
(if individual); (d) information concerning criminal convictions during the last
five years; (e) information concerning civil or administrative proceedings under
state or federal  securities laws during the past five years with respect to any
state  or  federal  securities  laws  and (f)  citizenship  (if  individual)  or
jurisdiction of organization (if entity).

I.

     (a) Polaris Venture Partners,  L.P., a Delaware limited  partnership ("PVP,
         L.P.").  The General Partner of PVP, L.P. is Polaris Venture Management
         Co.,  L.L.C.,  a Delaware  limited  liability  company  ("PVM I").  The
         Managing Members of PVM I are Stephen D. Arnold ("Arnold"), Terrance G.
         McGuire ("McGuire") and Jonathan A. Flint ("Flint").

     (b) 1000 Winter Street, Suite 3350, Waltham, MA, 02451-1215

     (c) PVP, L.P. is an investment fund.

     (d) No criminal convictions (1).

     (e) No adverse civil judgments for violations of securities laws (1).

     (f) Delaware.

II.

     (a) Polaris  Venture  Partners  Founders'  Fund,  L.P., a Delaware  limited
         partnership  ("Founders' I"). The General Partner of Founders' I is PVM
         I.

     (b) 1000 Winter Street, Suite 3350, Waltham, MA, 02451-1215

     (c) Founders' I is an investment fund.

     (d) No criminal convictions (1).

     (e) No adverse civil judgments for violations of securities laws (1).

<PAGE>

- -------------------------                              -------------------------
CUSIP NO.   69900R 10 6                 13D                Page 13 of 25 Pages
- -------------------------                              -------------------------
     (f) Delaware

III.

     (a) Polaris Venture  Management Co., L.L.C.,  a Delaware limited  liability
         company. The Managing Members of PVM I are Arnold, McGuire and Flint.

     (b) 1000 Winter Street, Suite 3350, Waltham, MA, 02451-1215

     (c) PVM I is an investment fund manager.

     (d) No criminal convictions (1).

     (e) No adverse civil judgments for violations of securities laws (1).

     (f) Delaware.

IV.

     (a) Polaris  Venture  Partners III,  L.P., a Delaware  limited  partnership
         ("PVP III,  L.P.").  The  General  Partner of PVP III,  L.P. is Polaris
         Venture  Management  Co.  III,  L.L.C.,  a Delaware  limited  liability
         company ("PVM III") The Managing Members of PVM III are Arnold, McGuire
         and Flint.

     (b) 1000 Winter Street, Suite 3350, Waltham, MA, 02451-1215

     (c) PVP III, L.P. is an investment fund.

     (d) No criminal convictions (1).

     (e) No adverse civil judgments for violations of securities laws (1).

     (f) Delaware.

V.

     (a) Polaris Venture  Partners  Founders' Fund III, L.P., a Delaware limited
         partnership  ("Founders' III"). The General Partner of Founders' III is
         PVM III.

     (b) 1000 Winter Street, Suite 3350, Waltham, MA, 02451-1215

     (c) Founders' III is an investment fund.

     (d) No criminal convictions (1).

     (e) No adverse civil judgments for violations of securities laws (1).

     (f) Delaware.

<PAGE>

- -------------------------                              -------------------------
CUSIP NO.   69900R 10 6                 13D                Page 14 of 25 Pages
- -------------------------                              -------------------------

VI.

     (a) Polaris  Venture  Partners  Entrepreneurs'  Fund III,  L.P., a Delaware
         limited  partnership  ("Entrepreneurs'  III").  The General  Partner of
         Entrepreneurs' III is PVM III.

     (b) 1000 Winter Street, Suite 3350, Waltham, MA, 02451-1215

     (c) Entrepreneurs' III is an investment fund.

     (d) No criminal convictions (1).

     (e) No adverse civil judgments for violations of securities laws (1).

     (f) Delaware.

VII.

     (a) Polaris  Venture   Management  Co.  III,  L.L.C.,  a  Delaware  limited
         liability company. The Managing Members of PVM III are Arnold,  McGuire
         and Flint.

     (b) 1000 Winter Street, Suite 3350, Waltham, MA, 02451-1215.

     (c) PVM III is an investment fund manager.

     (d) No criminal convictions (1).

     (e) No adverse civil judgments for violations of securities laws (1).

     (f) Delaware.

VIII.

     (a) Stephen D. Arnold

     (b) 1000 Winter Street, Suite 3350, Waltham, MA, 02451-1215

     (c) Arnold is a Managing Member of PVM I and PVM III.

     (d) No criminal convictions (1).

     (e) No adverse civil judgments for violations of securities laws (1).

     (f) Citizen of the United States of America.

IX.

     (a) Jonathan A. Flint

     (b) 1000 Winter Street, Suite 3350, Waltham, MA, 02451-1215.

     (c) Flint is a Managing Member of PVM I and PVM III.

     (d) No criminal convictions (1).


<PAGE>

- -------------------------                              -------------------------
CUSIP NO.   69900R 10 6                 13D                Page 15 of 25 Pages
- -------------------------                              -------------------------

     (e) No adverse civil judgments for violations of securities laws (1).

     (f) Citizen of the United States of America.

X.

     (a) Terrance G. McGuire

     (b) 1000 Winter Street, Suite 3350, Waltham, MA, 02451-1215.

     (c) McGuire is a Managing Member of PVM I and PVM III.

     (d) No criminal convictions (1).

     (e) No adverse civil judgments for violations of securities laws (1).

     (f)      Citizen of the United States of America.

- -----------
(1) During the last five years,  no person listed above has been  convicted in a
criminal proceeding (excluding traffic violations or similar misdemeanors),  nor
has  any  such  person  been a party  to a civil  proceeding  of a  judicial  or
administrative  body of  competent  jurisdiction  that  resulted  in such person
becoming  subject  to  a  judgment,  decree  or  final  order  enjoining  future
violations  of, or prohibiting  or mandating  activities  subject to, federal or
state securities laws or finding any violation with respect to such laws.

Item 3.  Source and Amount of Funds or Other Consideration.
<TABLE>
                  All of the  securities  of the Issuer  disclosed  on the cover
pages to this Schedule 13D are held of record by the entities listed below. With
the  exception  of Arnold,  Flint and  McGuire,  the source of funds used in the
acquisition of such securities, in each case, was the general working capital of
such entities. Such working capital was contributed by such entities' respective
partners. Arnold, Flint and McGuire purchased shares using personal funds.
<CAPTION>
                                                         Aggregate Number     Aggregate Amount    Weighted Average
                         Holder                            of Shares (1)          Paid (2)         Price Per Share
- ------------------------------------------------------- ------------------ --------------------- ------------------
<S>                                                           <C>             <C>                            <C>
PVP, L.P.                                                     2,210,806       $  2,809,795.40                $ 1.27
Founders' I                                                     132,266       $    168,100.10                $ 1.27
PVP III, L.P.                                                 2,266,519       $ 12,591,773.00                $ 5.56
Founders' III                                                    28,477       $    158,205.00                $ 5.56
Entrepreneurs' III                                               58,850       $    326,944.00                $ 5.56
Arnold                                                            5,000       $     35,000.00                $ 7.00
Flint                                                             5,000       $     35,000.00                $ 7.00
McGuire                                                          55,000       $    385,000.00                $ 7.00
- ------------------------------------------------------- ------------------- --------------------- ------------------
TOTALS                                                        4,761,918       $ 16,509,817.50                $ 3.47
                                                         ================== ===================== ==================
<FN>
- -----------
(1)  Includes shares  issuable upon the exercise of options.  Includes both open
     market purchases of Common Stock and Common Stock issued upon conversion of
     Preferred  Stock of the  Issuer.
(2)  Includes exercise price of options  exercisable  within 60 days of the date
     hereof.
</FN>
</TABLE>
Item 4.  Purpose of Transaction.

                  The  acquisitions  of the shares of the Issuer's  Common Stock
that are the subject of this filing were made for the purpose of investment  and
not with a view to  distribution  of


<PAGE>

- -------------------------                              -------------------------
CUSIP NO.   69900R 10 6                 13D                Page 16 of 25 Pages
- -------------------------                              -------------------------

the shares or with a view toward  acquiring  control of the  Issuer.  The Item 2
Persons  with the power to do so may sell,  or cause to be sold,  all or part of
such shares or acquire,  or cause to be acquired,  additional  securities of the
Issuer depending on market conditions and other economic factors.

         Except as described above, no reporting person has any current plans or
proposals that relate to or would result in:

                  (a) The acquisition by any person of additional  securities of
the Issuer, or the disposition of securities of the Issuer;

                  (b) An extraordinary corporate transaction,  such as a merger,
reorganization or liquidation, involving the Issuer or any of its subsidiaries;

                  (c) A sale or transfer  of a material  amount of assets of the
Issuer or any of its subsidiaries;

                  (d) Any change in the present board of directors or management
of the Issuer,  including any plans or proposals to change the number or term of
directors or to fill any existing vacancies on the board;

                  (e) Any  material  change  in the  present  capitalization  or
dividend policy of the Issuer;

                  (f) Any other  material  change in the  Issuer's  business  or
corporate structure;

                  (g) Change in the Issuer's  character,  bylaws or  instruments
corresponding  thereto or other  actions  which may impede  the  acquisition  of
control of the Issuer by any person;

                  (h) Causing a class of securities of the Issuer to be delisted
from a national securities exchange or to cease to be authorized to be quoted in
an  inter-dealer   quotation   system  of  a  registered   national   securities
association;

                  (i) A  class  of  equity  securities  of the  Issuer  becoming
eligible for  termination of  registration  pursuant to Section  12(g)(4) of the
Exchange Act; or

                  (j) Any action similar to any of those enumerated above.

Item 5.  Interest in Securities of the Issuer.

                  (a) AND (b) Except to the extent  otherwise  expressly  stated
herein, this Schedule 13D shall not be construed as an admission that any Item 2
Person is, for  purposes of Section  13(d) or 13(g) of the Act,  the  beneficial
owner of any Common Stock  disclosed in this Schedule 13D. The aggregate  number
and percentage of the class of securities  identified pursuant to Item 1 of this
Schedule 13D that are beneficially owned by each Item 2 Person are as follows:


<PAGE>

- -------------------------                              -------------------------
CUSIP NO.   69900R 10 6                 13D                Page 17 of 25 Pages
- -------------------------                              -------------------------


<TABLE>
<CAPTION>
                                  Common Stock Beneficially Owned
                           ----------------------------------------------
                                                     Shares Subject to              %          Voting    Dispositive
      Item 2 Person          Shares Outstanding      Option or Warrant         of Class (1)     Power       Power
- -------------------------- ----------------------- ----------------------      ------------- --------------------------
<S>                              <C>                       <C>                     <C>        <C>         <C>
PVP, L.P.(2)                     2,210,806                      0                   8.9%        sole         sole
Founders' I(2)                     132,266                      0                   0.5%        sole         sole
PVM I                            2,343,072                      0                   9.4%        sole         sole
PVP III, L.P.(3)                 2,266,519                      0                   9.1%        sole         sole
Founders' III(3)                    28,477                      0                   0.1%        sole         sole
Entrepreneurs' III(3)               58,850                      0                   0.2%        sole         sole
PVM III                          2,353,846                      0                   9.4%        sole         sole
Arnold(4)                        4,701,918                      0                  18.8%      shared(5)   shared(5)
Flint(4)                         4,701,918                      0                  18.8%      shared(5)   shared(5)
McGuire(4)                       4,701,918                 50,000                  19.0%      shared(6)   shared(6)

- -------------
<FN>
(1)      All  percentages in this table are based,  pursuant to Rule 13d-1(j) of
         the Securities Exchange Act of 1934, on the 24,962,372 shares of Common
         Stock of the Company to be outstanding as of May 8, 2000 as reported in
         the  Company's  report on Form 424B4 filed May 9, 2000 pursuant to Rule
         424(b)(4) of the Securities Act of 1933, as Amended.

(2)      Each noted entity (together, the "PVP I Funds") is the holder of record
         of the  securities  set forth  opposite the name of such entity and has
         sole voting and investment power with respect to such  securities.  PVM
         I, as sole General  Partner of PVP,  L.P. and  Founders' I, may also be
         deemed to have sole voting and  investment  power with  respect to such
         securities.

(3)      Each  noted  entity  (together,  the "PVP III  Funds") is the holder of
         record of the securities set forth opposite the name of such entity and
         has sole voting and investment  power with respect to such  securities.
         PVM III, as sole General  Partner of PVP III,  L.P.,  Founders' III and
         Entrepreneurs'  III,  may  also be  deemed  to  have  sole  voting  and
         investment power with respect to such securities.

(4)      Under  the  operating  agreements  of PVM I and PVM III,  the  Managing
         Members  share  voting  and   dispositive   power  over  the  Company's
         securities. As such, each noted individual may be deemed to have shared
         voting and  dispositive  power over the securities of the Company owned
         by the PVP I Funds and the PVP III  Funds.  Each  individual  disclaims
         beneficial  ownership  of such  securities  except to the extent of his
         respective pecuniary interests therein.

(5)      Sole as to 5,000 shares.

(6)      Sole as to 50,000 shares.

(c)      The following is a list of transactions  in the Issuer's  securities by
         the Item 2 Persons  within the last 60 days, all of which were effected
         on the dates set forth below:
</FN>
</TABLE>
                                May 5, 2000
                          Shares         Price Per
    Item 2 Person        Purchased        Share
- --------------------------------------------------
PVP, L.P.                    36,291       $7.00
Founders' I                   2,171       $7.00
PVP III, L.P.               629,589       $7.00
Founders' III                 7,910       $7.00
Entrepreneurs' III           16,347       $7.00


<PAGE>

- -------------------------                              -------------------------
CUSIP NO.   69900R 10 6                 13D                Page 18 of 25 Pages
- -------------------------                              -------------------------

Arnold                        5,000       $7.00
Flint                         5,000       $7.00
McGuire(1)                    5,000       $7.00
Total                       707,308

- -----------------------

(1)      On May 5, 2000, McGuire acquired an option to purchase 50,000 shares of
         the Company's  common stock at an exercise  price of $7.00 per share in
         exchange for service as a director of the Company.

(d)      Inapplicable.

(e)      Inapplicable.

Item 6.  Contracts,  Arrangements,  Understandings or Relationships with Respect
         to Securities of the Issuer.


         There are no contracts, arrangements or understandings among any of the
Item 2 Persons made or entered into specifically with respect to holding, voting
or disposing of the Common Stock of the Issuer.

         Under the terms of the respective  Partnership  Agreements of the PVP I
Funds, PVM I possesses the power to manage the investment  activities of the PVP
I Funds,  including the power to direct the voting and direct the disposition of
the Common Stock of the Issuer.  Under the terms of the  respective  Partnership
Agreements  of the PVP III  Funds,  PVM III  possesses  the power to manage  the
investment  activities  of the PVP III Funds,  including the power to direct the
voting and  disposition  of the Common Stock of the Issuer.  Under the Operating
Agreements of PVM I and PVM III, Arnold, Flint and McGuire (the Managing Members
of each of such  entities)  possess  the  power  to  cause  PVM I and PVM III to
exercise such voting and dispositive power with respect to the securities of the
Issuer held by the PVP I Funds and the PVP III Funds.

Item 7.  Material to be Filed as Exhibits.

         Exhibit  A  -  Agreement  to  File  Jointly  and  Statement  Appointing
Designated Filer and Authorized Signatory

<PAGE>

- -------------------------                              -------------------------
CUSIP NO.   69900R 10 6                 13D                Page 19 of 25 Pages
- -------------------------                              -------------------------

                                    SIGNATURE

                  After  reasonable  inquiry and to the best of my knowledge and
belief,  I certify  that the  information  set forth in this  statement is true,
complete and correct.

Dated:  May 15, 2000

                                   POLARIS VENTURE PARTNERS, L.P.,
                                   a Delaware Limited Partnership


                                   By: /s/ John J. Gannon
                                       --------------------------------
                                       Authorized Signatory


                                   POLARIS VENTURE PARTNERS FOUNDERS'
                                   FUND, L.P., a Delaware Limited Partnership


                                   By: /s/ John J. Gannon
                                       --------------------------------
                                       Authorized Signatory


                                   POLARIS VENTURE MANAGEMENT CO.,
                                   L.L.C., a Delaware Limited Liability Company


                                   By: /s/ John J. Gannon
                                       --------------------------------
                                       Authorized Signatory


<PAGE>

- -------------------------                              -------------------------
CUSIP NO.   69900R 10 6                 13D                Page 20 of 25 Pages
- -------------------------                              -------------------------

                                   POLARIS VENTURE PARTNERS III, L.P., a
                                   Delaware Limited Partnership


                                   By: /s/ John J. Gannon
                                       --------------------------------
                                       Authorized Signatory


                                   POLARIS VENTURE PARTNERS FOUNDERS'
                                   FUND III, L.P.,
                                   a Delaware Limited Partnership


                                   By: /s/ John J. Gannon
                                       --------------------------------
                                       Authorized Signatory


                                   POLARIS VENTURE PARTNERS
                                   ENTREPRENEURS' FUND III, L.P.,
                                   a Delaware Limited Partnership


                                   By: /s/ John J. Gannon
                                       --------------------------------
                                       Authorized Signatory


                                   POLARIS VENTURE MANAGEMENT CO. III,
                                   L.L.C., a Delaware
                                   Limited Liability Company


                                   By: /s/ John J. Gannon
                                       --------------------------------
                                       Authorized Signatory


<PAGE>

- -------------------------                              -------------------------
CUSIP NO.   69900R 10 6                 13D                Page 21 of 25 Pages
- -------------------------                              -------------------------


                                   STEPHEN D. ARNOLD


                                   By: /s/ John J. Gannon
                                       --------------------------------
                                       Authorized Signatory


                                   JONATHAN A. FLINT


                                   By: /s/ John J. Gannon
                                       --------------------------------
                                       Authorized Signatory


                                   TERRANCE G. MCGUIRE


                                   By: /s/ John J. Gannon
                                       --------------------------------
                                       Authorized Signatory


<PAGE>

- -------------------------                              -------------------------
CUSIP NO.   69900R 10 6                 13D                Page 22 of 25 Pages
- -------------------------                              -------------------------

                                    EXHIBIT A

          AGREEMENT TO FILE JOINTLY AND STATEMENT APPOINTING DESIGNATED
                         FILER AND AUTHORIZED SIGNATORY



                  Each   of   the    undersigned    entities   and   individuals
(collectively, the "Reporting Persons") hereby authorizes and designates Polaris
Venture  Management  Co.  III,  L.L.C.  or such  other  person  or  entity as is
designated  in  writing  by John  J.  Gannon  (the  "Designated  Filer")  as the
beneficial  owner  to  prepare  and  file on  behalf  of such  Reporting  Person
individually,  or jointly  together with the other  Reporting  Persons(including
jointly  pursuant to Rule 13d-1(k) under the Exchange Act), any and all reports,
notices,  communications  and other  documents  (including,  but not limited to,
reports on  Schedule  13D,  Schedule  13G,  Form 3, Form 4 and Form 5) that such
Reporting  Person may be required to file with the United States  Securities and
Exchange Commission pursuant to the Securities Act of 1933, as amended (together
with  the  implementing  regulations  thereto,  the  "Act")  and the  Securities
Exchange Act of 1934, as amended  (together  with the  implementing  regulations
thereto, the "Exchange Act")  (collectively,  the "Reports") with respect to the
Reporting  Person's  ownership of, or transactions in,  securities of any entity
whose  securities  are  beneficially  owned  (directly  or  indirectly)  by such
Reporting Person (collectively, the "Companies").

                  Each Reporting Person hereby further authorizes and designates
John J. Gannon  (the  "Authorized  Signatory")  to execute and file on behalf of
such Reporting  Person the Reports and to perform any and all other acts,  which
in the opinion of the Designated Filer or Authorized  Signatory may be necessary
or incidental to the performance of the foregoing powers herein granted.

                  The  authority  of the  Designated  Filer  and the  Authorized
Signatory  under this  Document  with  respect to each  Reporting  Person  shall
continue until such Reporting  Person is no longer  required to file any Reports
with respect to the Reporting  Person's  ownership of, or  transactions  in, the
securities of the Companies,  unless earlier revoked in writing.  Each Reporting
Person  acknowledges that the Designated Filer and the Authorized  Signatory are
not assuming any of the Reporting Person's  responsibilities  to comply with the
Act or the Exchange Act.

May 15, 2000                       POLARIS VENTURE MANAGEMENT CO. III, L.L.C.,
                                   a Delaware Limited Liability Company


                                   By: /s/  Terrance G. McGuire
                                       ------------------------------------
                                       Terrance G. McGuire, Managing Member


<PAGE>

- -------------------------                              -------------------------
CUSIP NO.   69900R 10 6                 13D                Page 23 of 25 Pages
- -------------------------                              -------------------------

May 15, 2000                          POLARIS VENTURE PARTNERS, L.P.,
                                      a Delaware Limited Partnership


                                   By: Polaris Venture Management Co., L.L.C.,
                                       a Delaware Limited Liability Company
                                       Its General Partner



                                   By: /s/  Terrance G. McGuire
                                       ------------------------------------
                                       Terrance G. McGuire, Managing Member


May 15, 2000                       POLARIS VENTURE PARTNERS FOUNDERS' FUND,
                                   L.P., a Delaware Limited Partnership


                                   By: Polaris Venture Management Co., L.L.C.,
                                       a Delaware Limited Liability Company
                                       Its General Partner



                                   By: /s/  Terrance G. McGuire
                                       ------------------------------------
                                       Terrance G. McGuire, Managing Member


May 15, 2000                       POLARIS VENTURE PARTNERS III, L.P.,
                                   a Delaware Limited Partnership


                                   By: Polaris Venture  Management Co. III,
                                       L.L.C., a Delaware Limited Liability
                                       Company
                                       Its General Partner



                                   By: /s/  Terrance G. McGuire
                                       ------------------------------------
                                       Terrance G. McGuire, Managing Member




<PAGE>

- -------------------------                              -------------------------
CUSIP NO.   69900R 10 6                 13D                Page 24 of 25 Pages
- -------------------------                              -------------------------

May 15, 2000                       POLARIS VENTURE  PARTNERS FOUNDERS' FUND III,
                                   L.P.,  a  Delaware  Limited Partnership


                                   By: Polaris Venture  Management Co. III,
                                       L.L.C., a Delaware Limited Liability
                                       Company
                                       Its General Partner



                                   By: /s/  Terrance G. McGuire
                                       ------------------------------------
                                       Terrance G. McGuire, Managing Member


May 15, 2000                       POLARIS VENTURE  PARTNERS ENTREPRENEURS' FUND
                                   III, L.P., a Delaware Limited Partnership


                                   By: Polaris Venture  Management Co. III,
                                       L.L.C., a Delaware Limited Liability
                                       Company
                                       Its General Partner



                                   By: /s/  Terrance G. McGuire
                                       ------------------------------------
                                       Terrance G. McGuire, Managing Member


May 15, 2000                       POLARIS  VENTURE MANAGEMENT CO. III,  L.L.C.,
                                   a Delaware  Limited  Liability Company


                                   By: /s/  Terrance G. McGuire
                                       ------------------------------------
                                       Terrance G. McGuire, Managing Member


May 15, 2000


                                       /s/ Stephen D. Arnold
                                       ------------------------------------
                                       Stephen D. Arnold


<PAGE>

- -------------------------                              -------------------------
CUSIP NO.   69900R 10 6                 13D                Page 25 of 25 Pages
- -------------------------                              -------------------------


May 15, 2000


                                       /s/ Brian Chee
                                       ------------------------------------
                                       Brian Chee

May 15, 2000


                                       /s/ George Conrades
                                       ------------------------------------
                                       George Conrades

May 15, 2000


                                       /s/ Jonathan A. Flint
                                       ------------------------------------
                                       Jonathan A. Flint

May 15, 2000


                                       /s/ John J. Gannon
                                       ------------------------------------
                                       John J. Gannon

May 15, 2000


                                       /s/ Eileen A. McCarthy
                                       ------------------------------------
                                       Eileen A. McCarthy

May 15, 2000


                                       /s/ Terrance G. McGuire
                                       ------------------------------------
                                       Terrance G. McGuire



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